No association between FTO or HHEX and endometrial cancer risk

Cancer Epidemiology Biomarkers and Prevention

Volumn 19, Issue 8, 2010, Pages 2106-2109

  Gaudet, Mia M ^a   Yang, Hannah P ^b   Bosquet, Jesus Gonzalez ^c   Healey, Catherine S ^d   Ahmed, Shahana ^d   Dunning, Alison M ^d   Easton, Doug F ^d   Spurdle, Amanda B ^e   Ferguson, Kaltin ^e   O'Mara, Tracy ^e,f   Lambrechts, Diether ^f   Despierre, Evelyn ^g   Vergote, Ignace ^g   Amant, Frederic ^g   Lacey Jr , James V ^g   Lissowska, Jola ^h   Peplonska, Beata ⁱ   Brinton, Louise A ^b   Chanock, Stephen ^b,j   Garcia Closas, Montserrat ^b  

^a ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

^b NATIONAL CANCER INSTITUTE   (United States)

^c H LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE   (United States)

^d UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^e QIMR BERGHOFER MEDICAL RESEARCH INSTITUTE   (Australia)

^f QUEENSLAND UNIVERSITY OF TECHNOLOGY   (Australia)

^g UNIVERSITY OF LEUVEN   (Belgium)

^h CITY OF HOPE NATIONAL MEDICAL CENTER   (United States)

ⁱ INSTITUTE OF ONCOLOGY   (Poland)

^j NOFER INSTITUTE OF OCCUPATIONAL MEDICINE   (Poland)

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Author keywords

[No Author keywords available]

Indexed keywords

ALLELE; ARTICLE; CANCER RISK; CONTROLLED STUDY; ENDOMETRIUM CANCER; FEMALE; FTO GENE; GENE; GENETIC VARIABILITY; GENOTYPE; HAPLOTYPE; HEREDITY; HHEX GENE; HUMAN; MAJOR CLINICAL STUDY; PHENOTYPE; POPULATION RESEARCH; PRIORITY JOURNAL; SINGLE NUCLEOTIDE POLYMORPHISM; VALIDATION STUDY;

ADULT; AGED; AGED, 80 AND OVER; DIABETES MELLITUS, TYPE 2; ENDOMETRIAL NEOPLASMS; FEMALE; GENETIC MARKERS; GENETIC PREDISPOSITION TO DISEASE; GENOTYPE; HOMEODOMAIN PROTEINS; HUMANS; MIDDLE AGED; OBESITY; POLYMORPHISM, SINGLE NUCLEOTIDE; PROTEINS; RISK; TRANSCRIPTION FACTORS; YOUNG ADULT;

EID: 77955457093     PISSN: 10559965     EISSN: None     Source Type: Journal    
DOI: 10.1158/1055-9965.EPI-10-0515     Document Type: Article

References (8)

1. Frayling TM, Timpson NJ, Weedon MN, et al. A common variant in the FTO gene is associated with body mass index and predisposes to childhood and adult obesity. Science 2007;316:889-94.
2. Scott LJ, Mohlke KL, Bonnycastle LL, et al. A genome-wide association study of type 2 diabetes in Finns detects multiple susceptibility variants. Science 2007;316:1341-5.
3. Gaudet MM, Lacey JV, Jr., Lissowska J, et al. Genetic variation in CYP17 and endometrial cancer risk. Hum Genet 2008;123:155-62.
4. Yang HP, Bosquet JG, Li Q, et al. Common genetic variation in the sex hormone metabolic pathway and endometrial cancer risk: pathway-based evaluation of candidate genes. Carcinogenesis 2010;31:827-33.
5. Yu Z, Schaid DJ. Sequential haplotype scan methods for association analysis. Genet Epidemiol 2007;31:553-64. (Pubitemid 350246541)
6. Yang BZ, Kranzler HR, Zhao H, et al. Association of haplotypic variants in DRD2, ANKK1, TTC12 and NCAM1 to alcohol dependence in independent case control and family samples. Hum Mol Genet 2007;16:2844-53. (Pubitemid 350048383)
7. Spurdle A, Webb P. Re: Excess of early onset multiple myeloma in endometrial cancer probands and their relatives suggests common susceptibility. Gynecol Oncol 2008;109:153, author reply 154.
8. Kalogiannidis I, Lambrechts S, Amant F, et al. Laparoscopy-assisted vaginal hysterectomy compared with abdominal hysterectomy in clinical stage I endometrial cancer: safety, recurrence, and long-term outcome. Am J Obstet Gynecol 2007;196:24 8e1-8.