Gemcitabine inhibits viability, growth, and metastasis of osteosarcoma cell lines

Journal of Orthopaedic Research

Volumn 23, Issue 4, 2005, Pages 964-969

  Ando, Takashi ^a   Ichikawa, Jiro ^a   Okamoto, Atsushi ^a   Tasaka, Kachio ^a   Nakao, Atsuhito ^a,b   Hamada, Yoshiki ^a  

^a UNIVERSITY OF YAMANASHI   (Japan)

^b JUNTENDO UNIVERSITY   (Japan)

Author keywords

Apoptosis; Gemcitabine; Metastasis; Osteosarcoma

Indexed keywords

DNA FRAGMENT; GEMCITABINE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER INHIBITION; CELL CULTURE; CELL LINE; CELL VIABILITY; CONCENTRATION RESPONSE; CYTOTOXICITY; DNA SYNTHESIS INHIBITION; DRUG EFFICACY; GIEMSA STAIN; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; LUNG METASTASIS; METASTASIS; MOUSE; NONHUMAN; OSTEOSARCOMA; PRIORITY JOURNAL; TUMOR VOLUME;

ANIMALS; ANTIMETABOLITES, ANTINEOPLASTIC; APOPTOSIS; BONE NEOPLASMS; CELL DIVISION; CELL LINE, TUMOR; CELL SURVIVAL; DEOXYCYTIDINE; DNA; FIBROBLASTS; HUMANS; LUNG NEOPLASMS; MICE; MICE, INBRED C3H; NEOPLASM TRANSPLANTATION; OSTEOSARCOMA;

EID: 21844479544     PISSN: 07360266     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.orthres.2005.01.010     Document Type: Article

References (16)

1. T. Asai T. Ueda K. Itoh Establishment and characterization of a murine osteosarcoma cell line (LM8) with high metastatic potential to the lung Int J Cancer 76 1998 418-422
2. G. Bacci S. Ferrari A. Longhi High dose ifosfamide in combination with high dose methotrexate, adriamycin and cisplatin in the neoadjuvant treatment of extremity osteosarcoma J Chemother 14 2 2002 198-206
3. R.J. Bold J. Chandra D.J. McConkey Gemcitabine-induced programmed cell death (apoptosis) of human pancreatic carcinoma is determined by Bcl-2 content Ann Surg Oncol 6 1999 279-285
4. E. Boven H. Schipper C.A.M. Erkelens The influence of the schedule and the dose of gemcitabine on the anti-tumor efficacy in experimental human cancer Br J Cancer 68 1993 52-56
5. B.J. Braakjuis V.W. Ruiz van Harpere E. Boven Schedule-dependent antitumor effect of gemcitabine in in vivo model systems Semin Oncol 22 1995 42-46
6. B.J.M. Braakuhuis G.A.M.S. Van Dongen J.B. Vermorken G.B. Snow Preclinical in vivo activity of 2′,2′-difluoro-2′-deoxycytidine (gemcitabine) against human head and neck cancer Cancer Res 51 1991 211-214
7. J.M. Buesa R. Losa A. Fernandez Phase I clinical trial of fixed-dose rate infusional gemcitabine and dacarbazine in the treatment of advanced soft tissue sarcoma, with assessment of gemcitabine triphosphate accumulation Cancer 101 10 2004 2261-2269
8. E.S. Casper M.R. Green D.P. Kelsen Invest New Drugs 12 1994 29-34 Phase II trial of gemcitabine (2′,2′-difluoro-2′-deoxycytidine) in patients with adenocarcinoma of the pancreas Invest New Drugs 12 1994 29-34
9. F. Eiber A. Giulian J. Eckardt Adjuvant chemotherapy for osteosarcoma: A randomized prospective study J Clin Oncol 5 1987 21-26
10. L. Gallelli M. Nardi T. Prantera Retrospective analysis of adverse drug reactions induced by gemcitabine treatment in patients with non-small cell lung cancer Pharmacol Res 49 3 2004 259-263
11. L.W. Hertel G.B. Border Cancer Res 50 1990 4417-4422 Evaluation of the antitumor activity of gemcitabine (2′,2′-difluoro-2′-deoxycytidine) Cancer Res 50 1990 4417-4422
12. M.P. Link A.M. Goorin A.W. Miser The effect of adjuvant chemotherapy on relapse-free survival in patients with osteosarcoma of the extremity New Eng J Med 314 1986 1600-1606
13. O. Merimsky I. Meller G. Flusser Gemcitabine in soft tissue or bone sarcoma resistant to standard chemotherapy: A Phase II study Cancer Chemother Pharmacol 45 2000 177-181
14. M. Moore J. Andersen H. Burris A randomized trial of gemcitabine versus 5-FU as first-line therapy in advanced pancreatic cancer Proc Am Soc Clin Oncol 14 1995 199
15. W. Plunkett P. Huang Y. Xu Gemcitabine: Metabolism, mechanisms of action, and self-potentiation Semin Oncol 22 1995 3-10
16. K.S. Skinner F.R. Eliber C. Holmes Surgical treatment and chemotherapy for pulmonary metastasis from osteosarcoma Arch Surg 127 1992 1065-1071