Gemcitabine aerosol: In vitro antitumor activity and deposition imaging for preclinical safety assessment in baboons

Cancer Chemotherapy and Pharmacology

Volumn 58, Issue 2, 2006, Pages 237-244

  Gagnadoux, Frédéric ^a,b   Leblond, Valérie ^a   Vecellio, Laurent ^a   Hureaux, José ^b   Le Pape, Alain ^a,c   Boisdron Celle, Michèle ^a   Montharu, Jérome ^a   Majorai, Caroline ^a   Fournier, Joseph ^a   Urban, Thierry ^b   Diot, Patrice ^a   Racineux, Jean Louis ^b   Lemarié, Etienne ^a  

^a INSERM   (France)

^b ANGERS UNIVERSITY HOSPITAL   (France)

^c Biopharmconsulting ARAIR   (France)

Author keywords

Aerosol; Chemotherapy; Gemcitabine; Lung cancer; Safety; Scintigraphy

Indexed keywords

ALBUMIN TC 99M; GEMCITABINE; PENTETATE TECHNETIUM TC 99M;

AEROSOL; ANTINEOPLASTIC ACTIVITY; ARTICLE; BABOON; BIOASSAY; CANCER CELL CULTURE; CELL STRAIN; CELL STRAIN A549; CELL STRAIN NCI H460; CONTROLLED STUDY; CYTOTOXICITY; DEPOSITION IMAGING; DOSE RESPONSE; DRUG ACCUMULATION; DRUG BLOOD LEVEL; DRUG DELIVERY SYSTEM; DRUG DEPOSITION; DRUG SAFETY; DRUG SCREENING; DRUG TOLERABILITY; FEMALE; GROWTH INHIBITION; GROWTH INHIBITION ASSAY; IN VITRO STUDY; ISOTOPE LABELING; JET NEBULIZATION; JET VENTILATION; LUNG CANCER; MASS; MAXIMUM PLASMA CONCENTRATION; NEBULIZATION; NEBULIZER; NONHUMAN; PARTICLE SIZE; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; QUANTITATIVE NUCLEAR IMAGING; RADIOACTIVITY; SCINTISCANNING;

EID: 33646486081     PISSN: 03445704     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00280-005-0146-9     Document Type: Article

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