Biocompatibility of nanostructured chitosan/poly(vinyl alcohol) blends chemically crosslinked with genipin for biomedical applications

Journal of Biomedical Nanotechnology

Volumn 6, Issue 2, 2010, Pages 166-175

  Bispo, Viviane M ^a   Mansur, Alexandra A P ^a   Barbosa Stancioli, Edel F ^a   Mansur, Herman S ^a  

^a FEDERAL UNIVERSITY OF MINAS GERAIS   (Brazil)

Author keywords

Biomaterial; Chitosan; Genipin; Nanostructured hydrogels; Natural crosslinker; Poly(vinyl alcohol)

Indexed keywords

AMINO GROUP; BIOMEDICAL APPLICATIONS; CARBOXYMETHYL GROUP; CELL VIABILITY; CHEMICAL CROSS-LINKING; CROSSLINKED; CROSSLINKER; GENIPIN; MICRO AND NANOSTRUCTURES; MTT ASSAYS; NANO-STRUCTURED; NANOSTRUCTURED HYDROGELS; NON-TOXICITY; NOVEL POLYMERS; POLYMER NETWORKS; POLYMERIC NETWORKS; RELATIVE INTENSITY; SWELLING INDEX; SWELLING TEST; VINYLALCOHOL;

AMIDES; BIOCOMPATIBILITY; BIOLOGICAL MATERIALS; CELL CULTURE; CHITIN; CHITOSAN; CROSSLINKING; FOURIER TRANSFORM INFRARED SPECTROSCOPY; FOURIER TRANSFORMS; FUNCTIONAL POLYMERS; NANOSTRUCTURES; POLYMER BLENDS; WAVELET TRANSFORMS;

HYDROGELS;

CHITOSAN; GENIPIN; NANOMATERIAL; POLYVINYL ALCOHOL;

ANIMAL CELL; ANIMAL CELL CULTURE; ARTICLE; BIOCOMPATIBILITY; BIOMEDICINE; CELL ADHESION; CELL PROLIFERATION; CELL VIABILITY; CONTROLLED STUDY; CROSS LINKING; CYTOTOXICITY; FOURIER TRANSFORM MASS SPECTROMETRY; HYDROGEL; NONHUMAN; VERO CELL;

AMIDES; ANIMALS; BIOCOMPATIBLE MATERIALS; BIOTECHNOLOGY; CELL SURVIVAL; CERCOPITHECUS AETHIOPS; CHITOSAN; CROSS-LINKING REAGENTS; HYDROGEL; IRIDOIDS; MATERIALS TESTING; NANOSTRUCTURES; POLYVINYL ALCOHOL; SPECTROSCOPY, FOURIER TRANSFORM INFRARED; VERO CELLS;

EID: 77955447560     PISSN: 15507033     EISSN: 15507041     Source Type: Journal    
DOI: 10.1166/jbn.2010.1110     Document Type: Article

References (42)

1. J. Gao and B. Xu, Applications of nanomaterials inside cells. Nano Today 4, 37 (2009).
2. J. H. Park, S. Lee, J.-H. Kim, K. Parkb, K. Kimb, and I. C. Kwon, Polymeric nanomedicine for cancer therapy. Prog. Polym. Sci. 33, 113 (2008).
3. I. O. Smith, X. H. Liu, L. A. Smithand, and P. X. Ma, Nanostructured polymer scaffolds for tissue engineering and regenerative medicine. WIREs Nanomedicine and Nanobiotechnology 1, 226 (2009).
4. S. K. Sahoo, S. Parveen, and J. J. Panda, The present and future of nanotechnology in human health care. Nanomedicine: Nanotechnology, Biology, and Medicine 3, 20 (2007).
5. H. Mansur, Quantum dots and Nanocomposites. WIREs Nanomedicine and Nanobiotechnology 2, 113 (2010).
6. K. A. Davis and K. S. Anseth, Controlled Release from Crosslinked Degradable Networks. Critical Reviews in Therapeutic Drug Carrier Systems 19, 385 (2002).
7. T. Wang and M. Turhan, and S. Gunasekaran, Selected properties of pH-sensitive, biodegradable chitosan-poly(vinyl alcohol) hydrogel. Polymer International 53, 911 (2004).
8. S. J. Hollister, Porous scaffold design for tissue engineering. Nature Materials 4, 518 (2005).
9. E. B. Lavik, H. Klassen, K. Warfvinge, R. Langer, and M. J. Young, Fabrication of degradable polymer scaffold to direct the integration and differentiation of retinal progenitors. Biomaterials 26, 3187 (2005).
10. E. S. C. Costa, Jr. and H. S. Mansur, Preparation and characterization of chitosan/poly(vinyl alcohol) blend chemically crosslinked by glutaraldehyde for tissue engineering application, Anais of 9° Congresso Brasileiro de Polímeros, Campina Grande, PB Brazil (2007), p. 86.
11. H. S. Mansur, R. L. Oréfice, and A. P. Mansur, Characterization of poly(vinyl alcohol)/poly(ethylene glycol) hydrogels and pva-derived hybrids by small-angle X-ray scattering and FTIR spectroscopy. Polymer 45, 7193 (2004).
12. H. S. Mansur and H. S. Costa, Nanostructured poly(vinyl alcohol)bioactive glass and poly(vinyl alcohol)/chitosan/bioactive glass hybrid scaffold for biomedical application. Chemical Engineering Journal 137, 72 (2008).
13. C. Muzzarelli and R. A. A. Muzzarelli, Natural and artificial chitosan-inorganic composites. Journal Inorganic Biochemistry 2002, 89 (2002).
14. N. A. Peppas and N. K. Mongia, Ultrapure poly(vinyl alcohol) hydrogels with mucoadhesive drug delivery characteristics. European Journal Pharmaceutics and Biopharmaceutics 43, 51 (1997).
15. R. Hejazi and M. Amiji, Chitosan-based gastrointestinal delivery systems. Journal Controlled Release 89, 151 (2003).
16. J. K. F. Suh and H. W. T. Matthew, Application of chitosan-based polysaccharide biomaterials in cartilage tissue engineering: A review. Biomaterials 21, 2589 (2000).
17. R. A. A. Muzzarelli, Genipin-crosslinked chitosan hydrogels as biomedical and pharmaceutical aids. Carbohydrate Polymers 77, 1 (2009).
18. F.-L. Mi, S.-S. Shyu, and C.-K. Peng, Characterization of ring-opening polymerization of genipin and pH-dependent cross-linking reactions between chitosan and genipin. J. Polym. Sci., Part A: Polym. Chem. 43, 1985 (2005).
19. H. S. Mansur and A. A. P. Mansur, Synchrotron SAXS, XRD and FTIR characterization of nanostructured PVA/TEOS hybrid cross-linked with glutaraldehyde. Solid State Phenomena 121-123, 855 (2007).
20. H. S. Mansur, C. M. Sadahira, A. N. Souza, and A. A. P. Mansur, FTIR spectroscopy characterization of poly (vinyl alcohol hydrogel with different hydrolysis degree and chemically crosslinked with glutaraldehyde. Mater. Sci. Eng., C 28, 539 (2008).
21. Y. Shigemasa, H. Matsuura, H. Sashiwa, and H. Saimoto, Evaluation of different absorbance ratios from infrared spectroscopy for analyzing the degree of deacetylation in chitin. Int. J. Biol. Macromol. 18, 237 (1996).
22. D. Wang, C. G. Williams, F. Yang, and J. H. Elisseeff, Enhancing the tissue-biomaterial interface: Tissue-initiated integration of biomaterials. Adv. Funct. Mater. 14, 1152 (2004).
23. E. S. C. Costa, Jr. and H. S. Mansur, Preparação e caracterização de blendas de quitosana/poli(Álcool vinílico) reticulados quimicamente com glutaraldeído para aplicação em engenharia de tecido. Química Nova 31, 1460 (2008).
24. J. Brugnerotto, J. Lizardi, F. M. Goycoolea, A. Monal, J. Desbrières, and M. Rinaudo, An infrared investigation in relation with chitin and chitosan characterization. Polymer 42, 3569 (2001).
25. K. S. V. K. Rao, B. V. K. Naidu, M. C. S. Subha, M. Sairam, and T. M. Aminabhavi, Novel chitosan-based ph-sensitive interpenetrating network microgels for the controlled release of Cefadroxil. Carbohydrate Polymers 66, 333 (2006).
26. B. S. Liu, C. H. Yao, and S. H. Hsu, A novel use of genipinfixed gelatin as extracellular matrix for peripheral nerve regeneration. J. Biomater. Appl. 19, 21 (2004).
27. S. I. Lima, Quitosanas e quitosanas química e morfologicamente modificadas com anidrido Succínico-propriedades, adsorção e termoquímica, Tese de doutorado, Universidade Estadual de Campinas, Campinas (2005).
28. D. A. Skoog, F. J. Holler, and T. A. Nieman, Princípios de Análise Instrumental, Editora Bookman, Porto Alegre (2002).
29. N. J. Elizondo, P. J. A. Sobral, and F. C. Menegalli, Development of films based on blends of Amaranthus cruentus flour and poly(vinyl alcohol). Carbohydr. Polym. 75, 592 (2009).
30. F. L. Mi, H. W. Sung, S. S. Shyu, Synthesis and characterization of a novel chitosan-based network prepared using naturally occurring crosslinker. J. Polym. Sci., Part A: Polym. Chem. 38, 2804 (2000).
31. E. S. Costa, S. E, Barbosa, W. Vasconcelos, H. Mansur, and A. A. P. Mansur, Preparation and characterization of chitosan/poly(vinyl alcohol) chemically crosslinked blends for biomedical applications. Carbohydr. Polym. 76, 472 (2009).
32. D. L. Butler, S. A. Goldstein, and F. Guilak, Functional tissue engineering: The role of biomechanics. Journal of Biomechanicat Engineering 122, 570 (2000).
33. J. Berger, M. Reist, J. M. Mayer, O. Felt, N. A. Peppas, and R. Gurny, Structure and interactions in covalently and ionically crosslinked chitosan hydrogels for biomedical applications. European Journal of Pharmaceutics Biopharmaceutics 57, 19 (2004).
34. J. D. Claper, J. M. Skeie, R. F. Mullins, and C. A. Guymon, Development and characterization of photopolymerizable biodegradable materials from PEG-PLA-PEG block macromonomers. Polymer 48, 6554 (2007).
35. K. C. Grupta and F. H. Jabrail, Glutaraldehyde cross-linked chitosan microspheres for controlled release of centchroman. Carbohydr. Res. 342, 2244 (2007).
36. Y. Zhang, X. Huang, B. Duan, L. Wu, S. Li, and X. Yuan, Preparation of electrospun chitosan/poly(vinyl alcohol) membranes. Colloid. Polym. Sci. 285, 855 (2007).
37. G. A. Dunn and D. Zicha, Dynamics of fibroblast spreading. J. Cell. Sci. 108, 1239 (1995).
38. Y.-J. Yeo, D.-W. Jeon, C.-S. Kim, S.-H. Choi, K.-S. Cho, Y.-K. Lee, and C.-K. Kim, Effects of chitosan nonwoven membrane on periodontal healing of surgically created one-wall intrabony defects in beagle dogs. Journal of Biomedical Materials Research Part B: Applied Biomaterials 72B, 86 (2004).
39. S. Bose, J. Darsell, H. L. Hosick, L. Yang, D. K. Sarkar, and A. Bandyopadhyay, Processing and characterization of porous alumina scaffolds. J. Mater. Sci. Mater. Med. 13, 23 (2002).
40. S. Hannah, S. I. Samuel, Cellular response to zinc-containing organoapatite: An in vitro study of proliferation, alkaline phosphatase activity and biomineralization. Biomaterials 26, 5492 (2005).
41. H. S. Costa, A. A. P. Mansur, E. F. Barbosa-Stancioli, M. M. Pereira, and H. S. Mansur, Morphological, mechanical, and biocompatibility characterization of macroporous alumina scaffolds coated with calcium phosphate/PVA. J. Mater. Sci. 43, 510 (2008).
42. H. S. Costa, M. F. Rocha, G. I. Andrade, E. F. Barbosa-Stancioli, M. M. Pereira, R. L. Oréfice, W. L. Vasconcelos, and H. S. Mansur, Sol-gel derived composite from bioactive glass-polyvinyl alcohol. J. Mater. Sci. 43, 494 (2008).