Structural basis for recognition of phosphodiester-containing lysosomal enzymes by the cation-independent mannose 6-phosphate receptor

Proceedings of the National Academy of Sciences of the United States of America

Volumn 107, Issue 28, 2010, Pages 12493-12498

  Olson, Linda J ^a   Peterson, Francis C ^a   Castonguay, Alicia ^a   Bohnsack, Richard N ^a   Kudo, Mariko ^b   Gotschall, Russell R ^b   Canfield, William M ^b   Volkman, Brian F ^a   Dahms, Nancy M ^a  

^a MEDICAL COLLEGE OF WISCONSIN   (United States)

^b GENZYME CORPORATION   (United States)

Author keywords

Carbohydrate recognition; Lectin; Lysosome biogenesis; Protein targeting

Indexed keywords

ACID HYDROLASE; AMINOSUGAR; MANNOSE 6 PHOSPHATE; N ACETYLGLUCOSAMINE PHOSPHATE; PHOSPHODIESTERASE; SOMATOMEDIN B RECEPTOR; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; BINDING AFFINITY; BIOGENESIS; CONTROLLED STUDY; INTERNALIZATION; LYSOSOME; MOUSE; NONHUMAN; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN FOLDING; PROTEIN MODIFICATION; PROTEIN STRUCTURE; PROTEIN TARGETING;

ACETYLGLUCOSAMINE; BINDING SITES; CARBOHYDRATES; CATIONS; GOLGI APPARATUS; HUMANS; HYDROLASES; LIGANDS; LYSOSOMES; MANNOSEPHOSPHATES; PHOSPHORIC DIESTER HYDROLASES; RECEPTOR, IGF TYPE 2; RECEPTORS, SOMATOMEDIN;

EID: 77955444897     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1004232107     Document Type: Article

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