Intermonomer interactions are essential for lysosomal enzyme binding by the cation-dependent mannose 6-phosphate receptor

Biochemistry

Volumn 49, Issue 1, 2010, Pages 236-246

  Olson, Linda J ^a   Sun, Guangjie ^a   Bohnsack, Richard N ^a   Peterson, Francis C ^a   Dahms, Nancy M ^a   Kim, Jung Ja P ^a  

^a MEDICAL COLLEGE OF WISCONSIN   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BINDING AFFINITIES; BINDING POCKETS; EXTRACELLULAR REGION; HOMODIMERS; HYDROLASES; LYSOSOMAL ENZYMES; N-TERMINALS; NMR SPECTROSCOPY; QUATERNARY STRUCTURE; SALT BRIDGES; SECRETORY PATHWAYS; SITE DIRECTED MUTAGENESIS; SURFACE PLASMONS; UNBOUND STATE;

BINDING ENERGY; CATALYSTS; DATA STORAGE EQUIPMENT; ENZYME ACTIVITY; ENZYMES; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; POSITIVE IONS; SURFACE PLASMON RESONANCE;

LIGANDS;

CATION DEPENDENT MANNOSE 6 PHOSPHATE RECEPTOR; GROWTH FACTOR RECEPTOR; LYSOSOME ENZYME; MONOMER; SOMATOMEDIN B RECEPTOR; UNCLASSIFIED DRUG;

ARTICLE; ENZYME BINDING; MOLECULAR INTERACTION; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PURIFICATION; PROTEIN QUATERNARY STRUCTURE; SITE DIRECTED MUTAGENESIS; SURFACE PLASMON RESONANCE;

BINDING SITES; CRYSTALLOGRAPHY, X-RAY; GLUCURONIDASE; HUMANS; KINETICS; LIGANDS; LYSOSOMES; MAGNETIC RESONANCE SPECTROSCOPY; MODELS, MOLECULAR; MUTAGENESIS, SITE-DIRECTED; PROTEIN CONFORMATION; RECEPTORS, CYTOPLASMIC AND NUCLEAR; STRUCTURE-ACTIVITY RELATIONSHIP; SUBSTRATE SPECIFICITY; SURFACE PLASMON RESONANCE;

EID: 73449127633     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi901725x     Document Type: Article

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