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Volumn 46, Issue 6, 2010, Pages 371-378

Niacin and laropiprant

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLSALICYLIC ACID; FIBRIC ACID DERIVATIVE; FISH OIL; HIGH DENSITY LIPOPROTEIN; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; LAROPIPRANT; MIDAZOLAM; NICOTINIC ACID; NONSTEROID ANTIINFLAMMATORY AGENT; PLACEBO; SIMVASTATIN; IMMUNOGLOBULIN RECEPTOR; INDOLE DERIVATIVE; MK-0524; PROSTAGLANDIN D2 RECEPTOR; PROSTAGLANDIN RECEPTOR;

EID: 77955439526     PISSN: 16993993     EISSN: 16994019     Source Type: Journal    
DOI: 10.1358/dot.2010.46.6.1464844     Document Type: Review
Times cited : (17)

References (45)
  • 1
    • 0035897696 scopus 로고    scopus 로고
    • Executive summary of the third report of the national cholesterol education program (NCEP) expert panel on detection, evaluation, and treatment of high blood cholesterol in adults (adult treatment panel III)
    • Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults
    • Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults. Executive summary of the third report of the national cholesterol education program (NCEP) expert panel on detection, evaluation, and treatment of high blood cholesterol in adults (adult treatment panel III). JAMA 2001, 285(19): 2486-97.
    • (2001) JAMA , vol.285 , Issue.19 , pp. 2486-2497
  • 2
    • 27744576421 scopus 로고    scopus 로고
    • High-density lipoprotein as a therapeutic target: Clinical evidence and treatment strategies
    • discussion 34K-35K
    • Toth, P.P. High-density lipoprotein as a therapeutic target: Clinical evidence and treatment strategies. Am J Cardiol 2005, 96(9A): 50K-58K, discussion 34K-35K.
    • (2005) Am J Cardiol , vol.96 , Issue.9 A
    • Toth, P.P.1
  • 3
    • 0029759109 scopus 로고    scopus 로고
    • High-density lipoprotein cholesterol as a predictor of coronary heart disease risk. The PROCAM experience and pathophysiological implications for reverse cholesterol transport
    • Assmann, G., Schulte, H., von Eckardstein, A., Huang, Y. High-density lipoprotein cholesterol as a predictor of coronary heart disease risk. The PROCAM experience and pathophysiological implications for reverse cholesterol transport. Atherosclerosis 1996, 124(Suppl.): S11-20.
    • (1996) Atherosclerosis , vol.124 , Issue.SUPPL.
    • Assmann, G.1    Schulte, H.2    Von Eckardstein, A.3    Huang, Y.4
  • 4
    • 34748887666 scopus 로고    scopus 로고
    • HDL cholesterol, very low levels of LDL cholesterol, and cardiovascular events
    • Treating to New Targets Investigators
    • Barter, P., Gotto, A.M., LaRosa, J.C. et al.; Treating to New Targets Investigators. HDL cholesterol, very low levels of LDL cholesterol, and cardiovascular events. N Engl J Med 2007, 357(13): 1301-10.
    • (2007) N Engl J Med , vol.357 , Issue.13 , pp. 1301-1310
    • Barter, P.1    Gotto, A.M.2    LaRosa, J.C.3
  • 5
    • 0029931463 scopus 로고    scopus 로고
    • Molecular mechanisms of reverse cholesterol transport
    • Barter, P.J., Rye, K.A. Molecular mechanisms of reverse cholesterol transport. Curr Opin Lipidol 1996, 7(2): 82-7.
    • (1996) Curr Opin Lipidol , vol.7 , Issue.2 , pp. 82-87
    • Barter, P.J.1    Rye, K.A.2
  • 7
    • 0037485460 scopus 로고    scopus 로고
    • Assessment of peripheral vascular endothelial function with finger arterial pulse wave amplitude
    • Kuvin, J.T., Patel, A.R., Sliney, K.A. et al. Assessment of peripheral vascular endothelial function with finger arterial pulse wave amplitude. Am Heart J 2003, 146(1): 168-74.
    • (2003) Am Heart J , vol.146 , Issue.1 , pp. 168-174
    • Kuvin, J.T.1    Patel, A.R.2    Sliney, K.A.3
  • 8
    • 0037126526 scopus 로고    scopus 로고
    • Third report of the national cholesterol education program (NCEP) expert panel on detection, evaluation, and treatment of high blood cholesterol in adults (adult treatment panel III) final report
    • National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III)
    • National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III). Third report of the national cholesterol education program (NCEP) expert panel on detection, evaluation, and treatment of high blood cholesterol in adults (adult treatment panel III) final report. Circulation 2002, 106(25): 3143-421.
    • (2002) Circulation , vol.106 , Issue.25 , pp. 3143-3421
  • 9
    • 0016630250 scopus 로고
    • Clofibrate and niacin in coronary heart disease
    • Clofibrate and niacin in coronary heart disease. JAMA 1975, 231(4): 360-81.
    • (1975) JAMA , vol.231 , Issue.4 , pp. 360-381
  • 11
    • 0035969564 scopus 로고    scopus 로고
    • Simvastatin and niacin, antioxidant vitamins, or the combination for the prevention of coronary disease
    • Brown, B.G., Zhao, X.Q., Chait, A. et al. Simvastatin and niacin, antioxidant vitamins, or the combination for the prevention of coronary disease. N Engl J Med 2001, 345(22): 1583-92.
    • (2001) N Engl J Med , vol.345 , Issue.22 , pp. 1583-1592
    • Brown, B.G.1    Zhao, X.Q.2    Chait, A.3
  • 12
    • 10044281651 scopus 로고    scopus 로고
    • Arterial biology for the investigation of the treatment effects of reducing cholesterol (ARBITER) 2: A double-blind, placebo-controlled study of extended-release niacin on atherosclerosis progression in secondary prevention patients treated with statins
    • Taylor, A.J., Sullenberger, L.E., Lee, H.J., Lee, J.K., Grace, K.A. Arterial biology for the investigation of the treatment effects of reducing cholesterol (ARBITER) 2: A double-blind, placebo-controlled study of extended-release niacin on atherosclerosis progression in secondary prevention patients treated with statins. Circulation 2004, 110(23): 3512-7.
    • (2004) Circulation , vol.110 , Issue.23 , pp. 3512-3517
    • Taylor, A.J.1    Sullenberger, L.E.2    Lee, H.J.3    Lee, J.K.4    Grace, K.A.5
  • 13
    • 72049129430 scopus 로고    scopus 로고
    • Extended-release niacin or ezetimibe and carotid intima-media thickness
    • Taylor, A.J., Villines, T.C., Stanek, E.J. et al. Extended-release niacin or ezetimibe and carotid intima-media thickness. N Engl J Med 2009, 361(22): 2113-22.
    • (2009) N Engl J Med , vol.361 , Issue.22 , pp. 2113-2122
    • Taylor, A.J.1    Villines, T.C.2    Stanek, E.J.3
  • 14
    • 33748038025 scopus 로고    scopus 로고
    • Effects of extended-release niacin on lipoprotein particle size, distribution, and inflammatory markers in patients with coronary artery disease
    • Kuvin, J.T., Dave, D.M., Sliney, K.A. et al. Effects of extended-release niacin on lipoprotein particle size, distribution, and inflammatory markers in patients with coronary artery disease. Am J Cardiol 2006, 98(6): 743-5.
    • (2006) Am J Cardiol , vol.98 , Issue.6 , pp. 743-745
    • Kuvin, J.T.1    Dave, D.M.2    Sliney, K.A.3
  • 15
    • 60349085760 scopus 로고    scopus 로고
    • Patients' experiences of niacin-induced flushing in clinical practice: A structured telephone interview
    • Kamal-Bahl, S., Watson, D.J., Ambegaonkar, B.M. Patients' experiences of niacin-induced flushing in clinical practice: A structured telephone interview. Clin Ther 2009, 31(1): 130-40.
    • (2009) Clin Ther , vol.31 , Issue.1 , pp. 130-140
    • Kamal-Bahl, S.1    Watson, D.J.2    Ambegaonkar, B.M.3
  • 16
    • 3242717055 scopus 로고    scopus 로고
    • Safety and compliance with once-daily niacin extended-release/lovastatin as initial therapy in the impact of medical subspecialty on patient compliance to treatment (IMPACT) study
    • Impact of Medical Subspecialty on Patient Compliance to Treatment Study Group
    • Rubenfire, M. Impact of Medical Subspecialty on Patient Compliance to Treatment Study Group. Safety and compliance with once-daily niacin extended-release/lovastatin as initial therapy in the impact of medical subspecialty on patient compliance to treatment (IMPACT) study. Am J Cardiol 2004, 94(3): 306-11.
    • (2004) Am J Cardiol , vol.94 , Issue.3 , pp. 306-311
    • Rubenfire, M.1
  • 17
    • 0024335924 scopus 로고
    • Release of markedly increased quantities of prostaglandin D2 in vivo in humans following the administration of nicotinic acid
    • Morrow, J.D., Parsons, W.G. 3rd, Roberts, L.J. 2nd. Release of markedly increased quantities of prostaglandin D2 in vivo in humans following the administration of nicotinic acid. Prostaglandins 1989, 38(2): 263-74.
    • (1989) Prostaglandins , vol.38 , Issue.2 , pp. 263-274
    • Morrow, J.D.1    Parsons III, W.G.2    Roberts II, L.J.3
  • 19
    • 0018728611 scopus 로고
    • Prostaglandins contribute to the vasodilation induced by nicotinic acid
    • Eklund, B., Kaijser, L., Nowak, J., Wennmalm, A. Prostaglandins contribute to the vasodilation induced by nicotinic acid. Prostaglandins 1979, 17(6): 821-30.
    • (1979) Prostaglandins , vol.17 , Issue.6 , pp. 821-830
    • Eklund, B.1    Kaijser, L.2    Nowak, J.3    Wennmalm, A.4
  • 20
    • 0018747350 scopus 로고
    • Dissociation of the effects of nicotinic acid on vasodilatation and lipolysis by a prostaglandin synthesis inhibitor, indomethacin, in man
    • Kaijser, L., Eklund, B., Olsson, A.G., Carlson, L.A. Dissociation of the effects of nicotinic acid on vasodilatation and lipolysis by a prostaglandin synthesis inhibitor, indomethacin, in man. Med Biol 1979, 57(2): 114-7.
    • (1979) Med Biol , vol.57 , Issue.2 , pp. 114-117
    • Kaijser, L.1    Eklund, B.2    Olsson, A.G.3    Carlson, L.A.4
  • 21
    • 0020559072 scopus 로고
    • Prostacyclin production augmented in the short term by nicotinic acid
    • Olsson, A.G., Carlson, L.A., Anggard, E., Ciabattoni, G. Prostacyclin production augmented in the short term by nicotinic acid. Lancet 1983, 2(8349): 565-6.
    • (1983) Lancet , vol.2 , Issue.8349 , pp. 565-566
    • Olsson, A.G.1    Carlson, L.A.2    Anggard, E.3    Ciabattoni, G.4
  • 22
    • 0037352280 scopus 로고    scopus 로고
    • PUMA-G and HM74 are receptors for nicotinic acid and mediate its anti-lipolytic effect
    • Tunaru, S., Kero, J., Schaub, A.,Wufka, C., Blaukat, A., Pfeffer, K., Offermanns, S. PUMA-G and HM74 are receptors for nicotinic acid and mediate its anti-lipolytic effect. Nat Med 2003, 9(3): 352-5.
    • (2003) Nat Med , vol.9 , Issue.3 , pp. 352-355
    • Tunaru, S.1    Kero, J.2    Schaub, A.3    Wufka, C.4    Blaukat, A.5    Pfeffer, K.6    Offermanns, S.7
  • 23
    • 31044448925 scopus 로고    scopus 로고
    • GPR109A (PUMA-G/HM74A) mediates nicotinic acid-induced flushing
    • Benyo, Z., Gille, A., Kero, J. et al. GPR109A (PUMA-G/HM74A) mediates nicotinic acid-induced flushing. J Clin Invest 2005, 115(12): 3634-40.
    • (2005) J Clin Invest , vol.115 , Issue.12 , pp. 3634-3640
    • Benyo, Z.1    Gille, A.2    Kero, J.3
  • 24
    • 0026508010 scopus 로고
    • Identification of skin as a major site of prostaglandin D2 release following oral administration of niacin in humans
    • Morrow, J.D., Awad, J.A., Oates, J.A., Roberts, L.J. 2nd. Identification of skin as a major site of prostaglandin D2 release following oral administration of niacin in humans. J Invest Dermatol 1992, 98(5): 812-5.
    • (1992) J Invest Dermatol , vol.98 , Issue.5 , pp. 812-815
    • Morrow, J.D.1    Awad, J.A.2    Oates, J.A.3    Roberts II, L.J.4
  • 25
    • 33751087034 scopus 로고    scopus 로고
    • Nicotinic acid-induced flushing is mediated by activation of epidermal langerhans cells
    • Benyo, Z., Gille, A., Bennett, C.L., Clausen, B.E., Offermanns, S. Nicotinic acid-induced flushing is mediated by activation of epidermal langerhans cells. Mol Pharmacol 2006, 70(6): 1844-9.
    • (2006) Mol Pharmacol , vol.70 , Issue.6 , pp. 1844-1849
    • Benyo, Z.1    Gille, A.2    Bennett, C.L.3    Clausen, B.E.4    Offermanns, S.5
  • 26
    • 0035862329 scopus 로고    scopus 로고
    • Prostaglandin D2 selectively induces chemotaxis in T helper type 2 cells, eosinophils, and basophils via seven-transmembrane receptor CRTH2
    • Hirai, H., Tanaka, K., Yoshie, O. et al. Prostaglandin D2 selectively induces chemotaxis in T helper type 2 cells, eosinophils, and basophils via seven-transmembrane receptor CRTH2. J Exp Med 2001, 193(2): 255-61.
    • (2001) J Exp Med , vol.193 , Issue.2 , pp. 255-261
    • Hirai, H.1    Tanaka, K.2    Yoshie, O.3
  • 27
    • 0027974137 scopus 로고
    • Molecular characterization of a mouse prostaglandin D receptor and functional expression of the cloned gene
    • Hirata, M., Kakizuka, A., Aizawa, M., Ushikubi, F., Narumiya, S. Molecular characterization of a mouse prostaglandin D receptor and functional expression of the cloned gene. Proc Natl Acad Sci U S A 1994, 91(23): 11192-6.
    • (1994) Proc Natl Acad Sci U S A , vol.91 , Issue.23 , pp. 11192-11196
    • Hirata, M.1    Kakizuka, A.2    Aizawa, M.3    Ushikubi, F.4    Narumiya, S.5
  • 28
    • 0035883174 scopus 로고    scopus 로고
    • Prostaglandin D2 is a potent chemoattractant for human eosinophils that acts via a novel DP receptor
    • Monneret, G., Gravel, S., Diamond, M., Rokach, J., Powell, W.S. Prostaglandin D2 is a potent chemoattractant for human eosinophils that acts via a novel DP receptor. Blood 2001, 98(6): 1942-8.
    • (2001) Blood , vol.98 , Issue.6 , pp. 1942-1948
    • Monneret, G.1    Gravel, S.2    Diamond, M.3    Rokach, J.4    Powell, W.S.5
  • 29
    • 33646258753 scopus 로고    scopus 로고
    • Antagonism of the prostaglandin D2 receptor 1 suppresses nicotinic acid-induced vasodilation in mice and humans
    • Cheng, K., Wu, T.J., Wu, K.K. et al. Antagonism of the prostaglandin D2 receptor 1 suppresses nicotinic acid-induced vasodilation in mice and humans. Proc Natl Acad Sci U S A 2006, 103(17): 6682-7.
    • (2006) Proc Natl Acad Sci U S A , vol.103 , Issue.17 , pp. 6682-6687
    • Cheng, K.1    Wu, T.J.2    Wu, K.K.3
  • 30
    • 1842338863 scopus 로고
    • Low-dose aspirin and ibuprofen reduce the cutaneous reactions following niacin administration
    • Dunn, R.T., Ford, M.A., Rindone, J.P., Kwiecinski, F.A. Low-dose aspirin and ibuprofen reduce the cutaneous reactions following niacin administration. Am J Ther 1995, 2(7): 478-80.
    • (1995) Am J Ther , vol.2 , Issue.7 , pp. 478-480
    • Dunn, R.T.1    Ford, M.A.2    Rindone, J.P.3    Kwiecinski, F.A.4
  • 31
    • 33947118734 scopus 로고    scopus 로고
    • Safety considerations with niacin therapy
    • Guyton, J.R., Bays, H.E. Safety considerations with niacin therapy. Am J Cardiol 2007, 99(6A): 22C-31C.
    • (2007) Am J Cardiol , vol.99 , Issue.6 A
    • Guyton, J.R.1    Bays, H.E.2
  • 32
    • 34250713349 scopus 로고    scopus 로고
    • Absorption, metabolism, and excretion of [(14)C]MK-0524, a prostaglandin D(2) receptor antagonist, in humans
    • Karanam, B., Madeira, M., Bradley, S. et al. Absorption, metabolism, and excretion of [(14)C]MK-0524, a prostaglandin D(2) receptor antagonist, in humans. Drug Metab Dispos 2007, 35(7): 1196-202.
    • (2007) Drug Metab Dispos , vol.35 , Issue.7 , pp. 1196-1202
    • Karanam, B.1    Madeira, M.2    Bradley, S.3
  • 34
    • 68949107831 scopus 로고    scopus 로고
    • Pharmacokinetics of laropiprant and glucuronide metabolite in patients with severe renal insufficiency
    • Stroh, M., Wenning, L., Luo, W.L. et al. Pharmacokinetics of laropiprant and glucuronide metabolite in patients with severe renal insufficiency. Am J Ther 2009, 16(5): 379-84.
    • (2009) Am J Ther , vol.16 , Issue.5 , pp. 379-384
    • Stroh, M.1    Wenning, L.2    Luo, W.L.3
  • 35
    • 43949145969 scopus 로고    scopus 로고
    • Pharmacokinetics, pharmacodynamics, and safety of a prostaglandin D2 receptor antagonist
    • Lai, E., Wenning, L.A., Crumley, T.M. et al. Pharmacokinetics, pharmacodynamics, and safety of a prostaglandin D2 receptor antagonist. Clin Pharmacol Ther 2008, 83(6): 840-7.
    • (2008) Clin Pharmacol Ther , vol.83 , Issue.6 , pp. 840-847
    • Lai, E.1    Wenning, L.A.2    Crumley, T.M.3
  • 36
    • 67649372666 scopus 로고    scopus 로고
    • Flushing profile of extended-release niacin/laropiprant versus gradually titrated niacin extended-release in patients with dyslipidemia with and without ischemic cardiovascular disease
    • Maccubbin, D., Koren, M.J., Davidson, M. et al. Flushing profile of extended-release niacin/laropiprant versus gradually titrated niacin extended-release in patients with dyslipidemia with and without ischemic cardiovascular disease. Am J Cardiol 2009, 104(1): 74-81.
    • (2009) Am J Cardiol , vol.104 , Issue.1 , pp. 74-81
    • Maccubbin, D.1    Koren, M.J.2    Davidson, M.3
  • 37
    • 53149118986 scopus 로고    scopus 로고
    • Extended-release niacin/laropiprant: Reducing niacin-induced flushing to better realize the benefit of niacin in improving cardiovascular risk factors
    • Paolini, J.F., Bays, H.E., Ballantyne, C.M. et at. Extended-release niacin/laropiprant: Reducing niacin-induced flushing to better realize the benefit of niacin in improving cardiovascular risk factors. Cardiol Clin 2008, 26(4): 547-60.
    • (2008) Cardiol Clin , vol.26 , Issue.4 , pp. 547-560
    • Paolini, J.F.1    Bays, H.E.2    Ballantyne, C.M.3
  • 38
    • 67049172683 scopus 로고    scopus 로고
    • Lipid-modifying efficacy of extended release niacin/laropiprant in Asian patients with primary hypercholesterolemia or mixed hyperlipidemia
    • Kush, D., Kim, H.S., Hu, D.Y. et at. Lipid-modifying efficacy of extended release niacin/laropiprant in Asian patients with primary hypercholesterolemia or mixed hyperlipidemia. Journal of Clinical Lipidology 2009, 3(3): 179-86.
    • (2009) Journal of Clinical Lipidology , vol.3 , Issue.3 , pp. 179-186
    • Kush, D.1    Kim, H.S.2    Hu, D.Y.3
  • 39
    • 67650132974 scopus 로고    scopus 로고
    • Flushing profile of extended-release niacin/laropiprant at initiation of therapy in asian lipid clinic patients
    • Kush, D., Hu, D.Y., Ye, P. et al. Flushing profile of extended-release niacin/laropiprant at initiation of therapy in asian lipid clinic patients. Cardiology 2009, 114(3): 192-8.
    • (2009) Cardiology , vol.114 , Issue.3 , pp. 192-198
    • Kush, D.1    Hu, D.Y.2    Ye, P.3
  • 40
    • 53149118030 scopus 로고    scopus 로고
    • Lipid-modifying efficacy and tolerability of extended-release niacin/laropiprant in patients with primary hypercholesterolemia or mixed dyslipidaemia
    • Maccubbin, D., Bays, H.E., Olsson, A.G. et al. Lipid-modifying efficacy and tolerability of extended-release niacin/laropiprant in patients with primary hypercholesterolemia or mixed dyslipidaemia. Int J Clin Pract 2008, 62(12): 1959-70.
    • (2008) Int J Clin Pract , vol.62 , Issue.12 , pp. 1959-1970
    • Maccubbin, D.1    Bays, H.E.2    Olsson, A.G.3
  • 41
    • 63849228890 scopus 로고    scopus 로고
    • Effects of aspirin when added to the prostaglandin D2 receptor antagonist laropiprant on niacin-induced flushing symptoms
    • Dishy, V., Liu, F., Ebel, D.L. et al. Effects of aspirin when added to the prostaglandin D2 receptor antagonist laropiprant on niacin-induced flushing symptoms. J Clin Pharmacol 2009, 49(4): 416-22.
    • (2009) J Clin Pharmacol , vol.49 , Issue.4 , pp. 416-422
    • Dishy, V.1    Liu, F.2    Ebel, D.L.3
  • 42
    • 65249130554 scopus 로고    scopus 로고
    • Efficacy and safety profile of coadministered ER niacin/laropiprant and simvastatin in dyslipidaemia
    • Gleim, G., Liu, N., Thompson-Bell, S. et al. Efficacy and safety profile of coadministered ER niacin/laropiprant and simvastatin in dyslipidaemia. Br J Cardiol 2009, 16(2): 90-7.
    • (2009) Br J Cardiol , vol.16 , Issue.2 , pp. 90-97
    • Gleim, G.1    Liu, N.2    Thompson-Bell, S.3
  • 43
    • 0037413638 scopus 로고    scopus 로고
    • Ectopic β-chain of ATP synthase is an apolipoprotein A-I receptor in hepatic HDL endocytosis
    • Martinez, L.O., Jacquet, S., Esteve, J.P. et al. Ectopic β-chain of ATP synthase is an apolipoprotein A-I receptor in hepatic HDL endocytosis. Nature 2003, 421(6918): 75-9.
    • (2003) Nature , vol.421 , Issue.6918 , pp. 75-79
    • Martinez, L.O.1    Jacquet, S.2    Esteve, J.P.3
  • 44
    • 33749246651 scopus 로고    scopus 로고
    • Niacin inhibits β chain ATP synthase cell surface expression in HepG2 cells. Mechanistic implications for raising HDL
    • Zhang, L.H., Meyers, C.D., Kamanna, V.S., Kashyap, M.L. Niacin inhibits β chain ATP synthase cell surface expression in HepG2 cells. Mechanistic implications for raising HDL.Aterioscler Thromb Vasc Biol 2006, 26: E-53.
    • (2006) Aterioscler Thromb Vasc Biol , vol.26
    • Zhang, L.H.1    Meyers, C.D.2    Kamanna, V.S.3    Kashyap, M.L.4


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