Withagulatin A inhibits hepatic stellate cell viability and procollagen I production through Akt and Smad signaling pathways

Acta Pharmacologica Sinica

Volumn 31, Issue 8, 2010, Pages 944-952

  Liu, Qiong ^a   Chen, Jing ^a   Wang, Xu ^a   Yu, Liang ^a   Hu, Li Hong ^a   Shen, Xu ^a  

^a SHANGHAI INSTITUTE OF MATERIA MEDICA   (China)

Author keywords

Akt; collagen; hepatic stellate cell; liver fibrosis; Smad

Indexed keywords

BETA ACTIN; CASPASE 3; COLLAGEN TYPE 1; MAMMALIAN TARGET OF RAPAMYCIN; NATURAL PRODUCT; PROTEIN KINASE B; S6 KINASE; SMAD2 PROTEIN; SMAD3 PROTEIN; SULFORHODAMINE B; TRANSFORMING GROWTH FACTOR BETA; UNCLASSIFIED DRUG; WITHAGULATIN A;

ANIMAL CELL; ANIMAL CELL CULTURE; APOPTOSIS; ARTICLE; CELL ASSAY; CELL CYCLE ARREST; CELL CYCLE S PHASE; CELL PROLIFERATION; CELL SURVIVAL; CELL VIABILITY; COLLAGEN SYNTHESIS; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG EFFECT; DRUG INHIBITION; DRUG MECHANISM; DRUG POTENCY; DRUG SCREENING; ENZYME PHOSPHORYLATION; FLOW CYTOMETRY; GENE EXPRESSION REGULATION; HUMAN; HUMAN CELL; HUMAN CELL CULTURE; IN VITRO STUDY; INTRACELLULAR SIGNALING; LIVER FIBROSIS; MALE; NONHUMAN; PROTEIN PHOSPHORYLATION; RAT; REAL TIME POLYMERASE CHAIN REACTION; STELLATE CELL; WESTERN BLOTTING;

ANIMALS; APOPTOSIS; CELL LINE; CELL SURVIVAL; COLLAGEN TYPE I; DOSE-RESPONSE RELATIONSHIP, DRUG; GENE EXPRESSION REGULATION; HEPATIC STELLATE CELLS; HUMANS; MALE; ONCOGENE PROTEIN V-AKT; PREGNENES; RATS; RATS, SPRAGUE-DAWLEY; SIGNAL TRANSDUCTION; SMAD PROTEINS;

EID: 77955438616     PISSN: 16714083     EISSN: 17457254     Source Type: Journal    
DOI: 10.1038/aps.2010.72     Document Type: Article

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