Selective delivery of 2-hydroxy APA to Trypanosoma brucei using the melamine motif

Bioorganic and Medicinal Chemistry Letters

Volumn 20, Issue 15, 2010, Pages 4364-4366

  Klee, Nina ^a   Wong, Pui Ee ^b   Baragaña, Beatriz ^a   Mazouni, Farah El ^c   Phillips, Margaret A ^c   Barrett, Michael P ^b   Gilbert, Ian H ^a  

^a UNIVERSITY OF DUNDEE   (United Kingdom)

^b UNIVERSITY OF GLASGOW   (United Kingdom)

^c UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

Author keywords

Ornithine decarboxylase; P2 transporter; Trypanosoma brucei

Indexed keywords

2 HYDROXY 3 (AMINOOXY)PROPANAMINE; 3 (AMINOOXY)PROPANAMINE; MELAMINE; ORNITHINE DECARBOXYLASE INHIBITOR; PUTRESCINE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANTIPROTOZOAL ACTIVITY; ARTICLE; CELL MEMBRANE; CONTROLLED STUDY; CROSS COUPLING REACTION; DRUG DELIVERY SYSTEM; DRUG POTENCY; DRUG SELECTIVITY; IN VITRO STUDY; NONHUMAN; PARASITE; PARENT; TRYPANOSOMA BRUCEI;

HUMANS; ORNITHINE DECARBOXYLASE; PROPYLAMINES; TRIAZINES; TRYPANOCIDAL AGENTS; TRYPANOSOMA BRUCEI BRUCEI; TRYPANOSOMIASIS, AFRICAN;

TRYPANOSOMA BRUCEI;

EID: 77955428923     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2010.06.070     Document Type: Article

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