Antiviral immune responses in H5N1-infected human lung tissue and possible mechanisms underlying the hyperproduction of interferon-inducible protein IP-10

Biochemical and Biophysical Research Communications

Volumn 398, Issue 4, 2010, Pages 752-758

  Thitithanyanont, Arunee ^a   Engering, Anneke ^b   Uiprasertkul, Monkol ^c   Ekchariyawat, Peeraya ^a   Wiboon ut, Suwimon ^a   Kraivong, Romchat ^a   Limsalakpetch, Amporn ^b   Kum Arb, Utaiwan ^b   Yongvanitchit, Kosol ^b   Sa Ard Iam, Noppadol ^d   Rukyen, Pimprapa ^d   Mahanonda, Rangsini ^d   Kawkitinarong, Kamon ^e   Auewarakul, Prasert ^c   Utaisincharoen, Pongsak ^a   Sirisinha, Stitaya ^a   Mason, Carl J ^b   Fukuda, Mark M ^b   Pichyangkul, Sathit ^b  

^a MAHIDOL UNIVERSITY   (Thailand)

^b ARMED FORCES RESEARCH INSTITUTE OF MEDICAL SCIENCES   (Thailand)

^c MAHIDOL UNIVERSITY   (Thailand)

^d CHULALONGKORN UNIVERSITY   (Thailand)

^e CHULALONGKORN UNIVERSITY   (Thailand)

Author keywords

H5N1 autopsy; H5N1 infected human pulmonary cells; IFN ; IP 10; MxA; TNF

Indexed keywords

ALPHA INTERFERON; CHEMOKINE RECEPTOR CXCR3; METHYLPREDNISOLONE; MYXOVIRUS RESISTANCE PROTEIN A; RETINOIC ACID INDUCIBLE PROTEIN I; TUMOR NECROSIS FACTOR ALPHA;

ANTIVIRAL ACTIVITY; ARTICLE; AUTOPSY; BRONCHUS MUCOSA; COCULTURE; CONTROLLED STUDY; CYTOKINE PRODUCTION; ENDOTHELIUM CELL; EPITHELIUM CELL; GENE; GENE EXPRESSION; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNE RESPONSE; INFLUENZA A (H5N1); INFLUENZA VIRUS A H5N1; INTERFERON PRODUCTION; LUNG ALVEOLUS CELL; LUNG PARENCHYMA; PRIORITY JOURNAL; PROTEIN EXPRESSION; TRACHEA MUCOSA; UPREGULATION; VIRUS IMMUNITY;

CELLS, CULTURED; CHEMOKINE CXCL10; DEAD-BOX RNA HELICASES; GTP-BINDING PROTEINS; HUMANS; INFLUENZA A VIRUS, H5N1 SUBTYPE; INFLUENZA, HUMAN; INTERFERON-ALPHA; LUNG; METHYLPREDNISOLONE; PNEUMONIA, VIRAL; TUMOR NECROSIS FACTOR-ALPHA;

EID: 77955427269     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2010.07.017     Document Type: Article

References (25)

1. Chan M.C., Cheung C.Y., Chui W.H., Tsao S.W., Nicholls J.M., Chan Y.O., Chan R.W., Long H.T., Poon L.L., Guan Y., Peiris J.S. Proinflammatory cytokine responses induced by influenza A (H5N1) viruses in primary human alveolar and bronchial epithelial cells. Respir. Res. 2005, 6:135.
2. Thitithanyanont A., Engering A., Ekchariyawat P., Wiboon-ut S., Limsalakpetch A., Yongvanitchit K., Kum-Arb U., Kanchongkittiphon W., Utaisincharoen P., Sirisinha S., Puthavathana P., Fukuda M.M., Pichyangkul S. High susceptibility of human dendritic cells to avian influenza H5N1 virus infection and protection by IFN-alpha and TLR ligands. J. Immunol. 2007, 179:5220-5227.
3. de Jong M.D., Simmons C.P., Thanh T.T., Hien V.M., Smith G.J., Chau T.N., Hoang D.M., Chau N.V., Khanh T.H., Dong V.C., Qui P.T., Cam B.V., Ha do Q., Guan Y., Peiris J.S., Chinh N.T., Hien T.T., Farrar J. Fatal outcome of human influenza A (H5N1) is associated with high viral load and hypercytokinemia. Nat. Med. 2006, 12:1203-1207.
4. Peiris J.S., Yu W.C., Leung C.W., Cheung C.Y., Ng W.F., Nicholls J.M., Ng T.K., Chan K.H., Lai S.T., Lim W.L., Yuen K.Y., Guan Y. Re-emergence of fatal human influenza A subtype H5N1 disease. Lancet 2004, 363:617-619.
5. To K.F., Chan P.K., Chan K.F., Lee W.K., Lam W.Y., Wong K.F., Tang N.L., Tsang D.N., Sung R.Y., Buckley T.A., Tam J.S., Cheng A.F. Pathology of fatal human infection associated with avian influenza A H5N1 virus. J. Med. Virol. 2001, 63:242-246.
6. Uiprasertkul M., Puthavathana P., Sangsiriwut K., Pooruk P., Srisook K., Peiris M., Nicholls J.M., Chokephaibulkit K., Vanprapar N., Auewarakul P. Influenza A H5N1 replication sites in humans. Emerg. Infect. Dis. 2005, 11:1036-1041.
7. Nagata K., Mibayashi M. The Mx protein that confers the resistance to influenza virus. Nippon Rinsho 1997, 55:2654-2659.
8. Le Goffic R., Pothlichet J., Vitour D., Fujita T., Meurs E., Chignard M., Si-Tahar M. Cutting edge: influenza A virus activates TLR3-dependent inflammatory and RIG-I-dependent antiviral responses in human lung epithelial cells. J. Immunol. 2007, 178:3368-3372.
9. Tumpey T.M., Szretter K.J., Van Hoeven N., Katz J.M., Kochs G., Haller O., Garcia-Sastre A., Staeheli P. The Mx1 gene protects mice against the pandemic 1918 and highly lethal human H5N1 influenza viruses. J. Virol. 2007, 81:10818-10821.
10. Grayson M.H., Ramos M.S., Rohlfing M.M., Kitchens R., Wang H.D., Gould A., Agapov E., Holtzman M.J. Controls for lung dendritic cell maturation and migration during respiratory viral infection. J. Immunol. 2007, 179:1438-1448.
11. Cheung C.Y., Poon L.L., Lau A.S., Luk W., Lau Y.L., Shortridge K.F., Gordon S., Guan Y., Peiris J.S. Induction of proinflammatory cytokines in human macrophages by influenza A (H5N1) viruses: a mechanism for the unusual severity of human disease?. Lancet 2002, 360:1831-1837.
12. Deng R., Lu M., Korteweg C., Gao Z., McNutt M.A., Ye J., Zhang T., Gu J. Distinctly different expression of cytokines and chemokines in the lungs of two H5N1 avian influenza patients. J. Pathol. 2008, 216:328-336.
13. Ichinohe T., Pang I.K., Iwasaki A. Influenza virus activates inflammasomes via its intracellular M2 ion channel. Nat. Immunol. 2010, 11:404-410.
14. Lund J.M., Alexopoulou L., Sato A., Karow M., Adams N.C., Gale N.W., Iwasaki A., Flavell R.A. Recognition of single-stranded RNA viruses by Toll-like receptor 7. Proc. Natl. Acad. Sci. USA 2004, 101:5598-5603.
15. Baskin C.R., Bielefeldt-Ohmann H., Tumpey T.M., Sabourin P.J., Long J.P., Garcia-Sastre A., Tolnay A.E., Albrecht R., Pyles J.A., Olson P.H., Aicher L.D., Rosenzweig E.R., Murali-Krishna K., Clark E.A., Kotur M.S., Fornek J.L., Proll S., Palermo R.E., Sabourin C.L., Katze M.G. Early and sustained innate immune response defines pathology and death in nonhuman primates infected by highly pathogenic influenza virus. Proc. Natl. Acad. Sci. USA 2009, 106:3455-3460.
16. Cameron C.M., Cameron M.J., Bermejo-Martin J.F., Ran L., Xu L., Turner P.V., Ran R., Danesh A., Fang Y., Chan P.K., Mytle N., Sullivan T.J., Collins T.L., Johnson M.G., Medina J.C., Rowe T., Kelvin D.J. Gene expression analysis of host innate immune responses during Lethal H5N1 infection in ferrets. J. Virol. 2008, 82:11308-11317.
17. Chan M.C., Chan R.W., Yu W.C., Ho C.C., Chui W.H., Lo C.K., Yuen K.M., Guan Y.I., Nicholls J.M., Peiris J.S. Influenza H5N1 virus infection of polarized human alveolar epithelial cells and lung microvascular endothelial cells. Respir. Res. 2009, 10:102.
18. Liem N.T., Nakajima N., Phat le P., Sato Y., Thach H.N., Hung P.V., San L.T., Katano H., Kumasaka T., Oka T., Kawachi S., Matsushita T., Sata T., Kudo K., Suzuki K. H5N1-infected cells in lung with diffuse alveolar damage in exudative phase from a fatal case in Vietnam. Jpn. J. Infect. Dis. 2008, 61:157-160.
19. Veckman V., Osterlund P., Fagerlund R., Melen K., Matikainen S., Julkunen I. TNF-alpha and IFN-alpha enhance influenza-A-virus-induced chemokine gene expression in human A549 lung epithelial cells. Virology 2006, 345:96-104.
20. Booth V., Keizer D.W., Kamphuis M.B., Clark-Lewis I., Sykes B.D. The CXCR3 binding chemokine IP-10/CXCL10: structure and receptor interactions. Biochemistry 2002, 41:10418-10425.
21. Brightling C.E., Kaur D., Berger P., Morgan A.J., Wardlaw A.J., Bradding P. Differential expression of CCR3 and CXCR3 by human lung and bone marrow-derived mast cells: implications for tissue mast cell migration. J. Leukoc. Biol. 2005, 77:759-766.
22. Grumelli S., Corry D.B., Song L.Z., Song L., Green L., Huh J., Hacken J., Espada R., Bag R., Lewis D.E., Kheradmand F. An immune basis for lung parenchymal destruction in chronic obstructive pulmonary disease and emphysema. PLoS Med. 2004, 1:e8.
23. Hartl D., Krauss-Etschmann S., Koller B., Hordijk P.L., Kuijpers T.W., Hoffmann F., Hector A., Eber E., Marcos V., Bittmann I., Eickelberg O., Griese M., Roos D. Infiltrated neutrophils acquire novel chemokine receptor expression and chemokine responsiveness in chronic inflammatory lung diseases. J. Immunol. 2008, 181:8053-8067.
24. Penna G., Sozzani S., Adorini L. Cutting edge: selective usage of chemokine receptors by plasmacytoid dendritic cells. J. Immunol. 2001, 167:1862-1866.
25. Kandun I.N., Wibisono H., Sedyaningsih E.R., Yusharmen, Hadisoedarsuno W., Purba W., Santoso H., Septiawati C., Tresnaningsih E., Heriyanto B., Yuwono D., Harun S., Soeroso S., Giriputra S., Blair P.J., Jeremijenko A., Kosasih H., Putnam S.D., Samaan G., Silitonga M., Chan K.H., Poon L.L., Lim W., Klimov A., Lindstrom S., Guan Y., Donis R., Katz J., Cox N., Peiris M., Uyeki T.M. Three Indonesian clusters of H5N1 virus infection in 2005. N. Engl. J. Med. 2006, 355:2186-2194.