Quantification of urinary PGEm, 6-keto PGF1α and 2,3-dinor-6-keto PGF1α by UFLC-MS/MS before and after exercise

Prostaglandins and Other Lipid Mediators

Volumn 93, Issue 1-2, 2010, Pages 8-13

  Blatnik, Matthew ^a   Steenwyk, Rick C ^a  

^a PFIZER INC   (United States)

Author keywords

2,3 Dinor 6 keto PGF1 ; 6 Keto PFG1 ; Eicosanoids; Electrospray ionization; ESI; Exercise; Inflammation; MS MS; PGEm; Prostanoids; Tandem mass spectrometry; UFLC; Ultra flow liquid chromatography

Indexed keywords

2,3 DINOR 6 OXOPROSTAGLANDIN F1 ALPHA; 6 OXOPROSTAGLANDIN F1 ALPHA; CREATININE; PROSTAGLANDIN E; PROSTANOID;

ADULT; ARTICLE; CREATININE URINE LEVEL; EXERCISE; FITNESS; HUMAN; HUMAN EXPERIMENT; LIQUID CHROMATOGRAPHY; MALE; NORMAL HUMAN; QUANTITATIVE ANALYSIS; TANDEM MASS SPECTROMETRY; URINALYSIS;

6-KETOPROSTAGLANDIN F1 ALPHA; ADULT; CHROMATOGRAPHY, LIQUID; CREATININE; EXERCISE; HUMANS; MALE; MIDDLE AGED; PROSTAGLANDINS; TANDEM MASS SPECTROMETRY;

EID: 77955422739     PISSN: 10988823     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.prostaglandins.2010.04.002     Document Type: Article

References (29)

1. Mora S., Cook N., Buring J.E., Ridker P.M., Lee I.M. Physical activity and reduced risk of cardiovascular events: potential mediating mechanisms. Circulation 2007, 116(19):2110-2118.
2. Powers S.K., Quindry J.C., Kavazis A.N. Exercise-induced cardioprotection against myocardial ischemia-reperfusion injury. Free Radic Biol Med 2008, 44(2):193-201.
3. Warburton D.E., Nicol C.W., Bredin S.S. Health benefits of physical activity: the evidence. CMAJ 2006, 174(6):801-809.
4. Commoner B., Heise J.J., Lippincott B.B., Norberg R.E., Passonneau J.V., Townsend J. Biological activity of free radicals. Science 1957, 126(3263):57-63.
5. Ploeger H.E., Takken T., de Greef M.H., Timmons B.W. The effects of acute and chronic exercise on inflammatory markers in children and adults with a chronic inflammatory disease: a systematic review. Exerc Immunol Rev 2009, 15:6-41.
6. Suzuki K., Nakaji S., Yamada M., Totsuka M., Sato K., Sugawara K. Systemic inflammatory response to exhaustive exercise. Cytokine kinetics. Exerc Immunol Rev 2002, 8:6-48.
7. Bergstroem S., Samuelsson B. Prostaglandins. Annu Rev Biochem 1965, 34:101-108.
8. Bergstrom S., Samuelsson B. Isolation of prostaglandin E1 from human seminal plasma. Prostaglandins and related factors. 11. J Biol Chem 1962, 237:3005-3006.
9. Serhan C.N., Chiang N., Van Dyke T.E. Resolving inflammation: dual anti-inflammatory and pro-resolution lipid mediators. Nat Rev Immunol 2008, 8(5):349-361.
10. Halliwell B. Superoxide, iron, vascular endothelium and reperfusion injury. Free Radic Res Commun 1989, 5(6):315-318.
11. Nikolaidis M.G., Jamurtas A.Z., Paschalis V., Fatouros I.G., Koutedakis Y., Kouretas D. The effect of muscle-damaging exercise on blood and skeletal muscle oxidative stress: magnitude and time-course considerations. Sports Med 2008, 38(7):579-606.
12. Gomez-Cabrera M.C., Borras C., Pallardo F.V., Sastre J., Ji L.L., Vina J. Decreasing xanthine oxidase-mediated oxidative stress prevents useful cellular adaptations to exercise in rats. J Physiol 2005, 567(Pt 1):113-120.
13. Gomez-Cabrera M.C., Martinez A., Santangelo G., Pallardo F.V., Sastre J., Vina J. Oxidative stress in marathon runners: interest of antioxidant supplementation. Br J Nutr 2006, 96(Suppl. 1):S31-S33.
14. Karamouzis M., Karamouzis I., Vamvakoudis E., et al. The response of muscle interstitial prostaglandin E(2)(PGE(2)), prostacyclin I(2)(PGI(2)) and thromboxane A(2)(TXA(2)) levels during incremental dynamic exercise in humans determined by in vivo microdialysis. Prostag Leukot Essent Fatty Acids 2001, 64(4-5):259-263.
15. Karamouzis I., Grekas D., Karamouzis M., et al. Physical training in patients on hemodialysis has a beneficial effect on the levels of eicosanoid hormone-like substances. Hormones (Athens) 2009, 8(2):129-137.
16. Wu D., Mennerich D., Arndt K., et al. Comparison of microsomal prostaglandin E synthase-1 deletion and COX-2 inhibition in acute cardiac ischemia in mice. Prostag Other Lipid Mediat 2009, 90(1-2):21-25.
17. Cavalca V., Minardi F., Scurati S., et al. Simultaneous quantification of 8-iso-prostaglandin-F(2alpha) and 11-dehydro thromboxane B(2) in human urine by liquid chromatography-tandem mass spectrometry. Anal Biochem 2009, 397(2):168-174.
18. Chu X., Ageishi Y., Nishimura K., et al. Development of enzyme-linked immunosorbent assay for 8-iso-prostaglandin F2alpha, a biomarker of oxidative stress in vivo, and its application to the quantification in aged rats. J Pharm Biomed Anal 2009, 50(5):911-916.
19. Kingsley P.J., Rouzer C.A., Saleh S., Marnett L.J. Simultaneous analysis of prostaglandin glyceryl esters and prostaglandins by electrospray tandem mass spectrometry. Anal Biochem 2005, 343(2):203-211.
20. Murphey L.J., Williams M.K., Sanchez S.C., et al. Quantification of the major urinary metabolite of PGE2 by a liquid chromatographic/mass spectrometric assay: determination of cyclooxygenase-specific PGE2 synthesis in healthy humans and those with lung cancer. Anal Biochem 2004, 334(2):266-275.
21. Tsikas D., Schwedhelm E., Gutzki F.M., Frolich J.C. Gas chromatographic-mass spectrometric discrimination between 8-iso-prostaglandin E2 and prostaglandin E2 through derivatization by O-(2,3,4,5,6-Pentafluorobenzyl)hydroxyl amine. Anal Biochem 1998, 261(2):230-232.
22. Saraslanidis P.J., Manetzis C.G., Tsalis G.A., Zafeiridis A.S., Mougios V.G., Kellis S.E. Biochemical evaluation of running workouts used in training for the 400-m sprint. J Strength Cond Res 2009, 23(8):2266-2271.
23. Pyne D.B. Regulation of neutrophil function during exercise. Sports Med 1994, 17(4):245-258.
24. Radak Z., Chung H.Y., Koltai E., Taylor A.W., Goto S. Exercise, oxidative stress and hormesis. Ageing Res Rev 2008, 7(1):34-42.
25. Sies H., Cadenas E. Oxidative stress: damage to intact cells and organs. Philos Trans R Soc Lond B Biol Sci 1985, 311(1152):617-631.
26. Catella F., Nowak J., Fitzgerald G.A. Measurement of renal and non-renal eicosanoid synthesis. Am J Med 1986, 81(2B):23-29.
27. Barr D.B., Wilder L.C., Caudill S.P., Gonzalez A.J., Needham L.L., Pirkle J.L. Urinary creatinine concentrations in the U.S. population: implications for urinary biologic monitoring measurements. Environ Health Perspect 2005, 113(2):192-200.
28. Kachadorian W.A., Johnson R.E. The effect of exercise on some clinical measures of renal function. Am Heart J 1971, 82(2):278-280.
29. Refsum H.E., Stromme S.B. Relationship between urine flow, glomerular filtration, and urine solute concentrations during prolonged heavy exercise. Scand J Clin Lab Invest 1975, 35(8):775-780.