Design, synthesis, and structure-activity relationship study of conformationally constrained analogs of indole-3-carboxamides as novel CB1 cannabinoid receptor agonists

Bioorganic and Medicinal Chemistry Letters

Volumn 20, Issue 16, 2010, Pages 4918-4921

  Kiyoi, Takao ^a   York, Mark ^a   Francis, Stuart ^a   Edwards, Darren ^a   Walker, Glenn ^a   Houghton, Andrea K ^a   Cottney, Jean E ^a   Baker, James ^a   Adam, Julia M ^a  

^a Schering Plough Research Institute   (United Kingdom)

Author keywords

Cannabinoid; CB1; GPCR agonist

Indexed keywords

CANNABINOID 1 RECEPTOR AGONIST; INDOLE DERIVATIVE; AMIDE; CANNABINOID 1 RECEPTOR;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG ACTIVITY; DRUG DESIGN; DRUG STRUCTURE; DRUG SYNTHESIS; ENANTIOMER; MOUSE; NONHUMAN; STRUCTURE ACTIVITY RELATION; AGONISTS; ANIMAL; CHEMISTRY; HUMAN; METABOLISM; MICROSOME; SYNTHESIS;

AMIDES; ANIMALS; DRUG DESIGN; HUMANS; INDOLES; MICE; MICROSOMES; RECEPTOR, CANNABINOID, CB1; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 77955419347     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2010.06.067     Document Type: Article

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