Patterns of antidepressant use in Quebec children and adolescents: Trends and predictors

Psychiatry Research

Volumn 179, Issue 1, 2010, Pages 57-63

  Tournier, Marie ^a,b,c   Greenfield, Brian ^d   Galbaud du Fort, Guillaume ^a   Ducruet, Thierry ^e   Zito, Julie Magno ^f   Cloutier, Anne Marie ^e   Moride, Yola ^a,e  

^a MCGILL UNIVERSITY   (Canada)

^b MCGILL UNIVERSITY   (Canada)

^c UNIVERSITÉ DE BORDEAUX   (France)

^d MONTREAL CHILDREN S HOSPITAL   (Canada)

^e UNIVERSITÉ DE MONTRÉAL   (Canada)

^f UNIVERSITY OF MARYLAND SCHOOL OF PHARMACY   (United States)

Author keywords

Adolescent; Antidepressants; Child; Drug utilization; Pharmacoepidemiology

Indexed keywords

AMITRIPTYLINE; ANTICONVULSIVE AGENT; ANTIDEPRESSANT AGENT; ANXIOLYTIC AGENT; CENTRAL STIMULANT AGENT; CITALOPRAM; DEXAMPHETAMINE; FLUOXETINE; IMIPRAMINE; LITHIUM; METHYLPHENIDATE; MOOD STABILIZER; NEUROLEPTIC AGENT; PAROXETINE; PSYCHOTROPIC AGENT; SEROTONIN UPTAKE INHIBITOR; SERTRALINE; TRANQUILIZER; TRAZODONE; TRICYCLIC ANTIDEPRESSANT AGENT; VENLAFAXINE; PRESCRIPTION DRUG;

ADJUSTMENT DISORDER; ADOLESCENT; ADULT; ANXIETY DISORDER; ARTICLE; ATTENTION DEFICIT DISORDER; BIPOLAR DEPRESSION; BULIMIA; CANADA; CHILD; COHORT ANALYSIS; DATA BASE; DEPRESSION; DRUG CHOICE; DRUG EFFICACY; DRUG USE; ENURESIS; FEMALE; HEALTH PROGRAM; HUMAN; INDEPENDENT VARIABLE; JUVENILE; MAJOR CLINICAL STUDY; MAJOR DEPRESSION; MALE; MOOD DISORDER; PRESCRIPTION; PRIORITY JOURNAL; RETROSPECTIVE STUDY; SCHIZOAFFECTIVE PSYCHOSIS; AGE; CLASSIFICATION; DRUG UTILIZATION; PREDICTIVE VALUE; PRESCHOOL CHILD; STATISTICS AND NUMERICAL DATA; TRENDS; YOUNG ADULT;

ADOLESCENT; AGE FACTORS; ANTIDEPRESSIVE AGENTS; CHILD; CHILD, PRESCHOOL; DEPRESSION; DRUG UTILIZATION; FEMALE; HUMANS; MALE; PREDICTIVE VALUE OF TESTS; PRESCRIPTION DRUGS; QUEBEC; RETROSPECTIVE STUDIES; YOUNG ADULT;

EID: 77955417721     PISSN: 01651781     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.psychres.2010.06.007     Document Type: Article

References (53)

1. Aagaard L., Thirstrup S., Hansen E.H. Opening the white boxes: the licensing documentation of efficacy and safety of psychotropic medicines for children. Pharmacoepidemiology and Drug Safety 2009, 18:401-411.
2. Allen N.B., Hetrick S.E., Simmons J.G., Hickie I.B. Early intervention for depressive disorders in young people: the opportunity and the (lack of) evidence. The Medical Journal of Australia 2007, 187:S15-S17.
3. Bhatia S.K., Bhatia S.C. Childhood and adolescent depression. American Family Physician 2007, 75:73-80.
4. Birmaher B., Ryan N.D., Williamson D.E., Brent D.A., Kaufman J., Dahl R.E., Perel J., Nelson B. Childhood and adolescent depression: a review of the past 10years. Part I. Journal of the American Academy of Child and Adolescent Psychiatry 1996, 35:1427-1439.
5. Bostic J.Q., Rubin D.H., Prince J., Schlozman S. Treatment of depression in children and adolescents. Journal of Psychiatric Practice 2005, 11:141-154.
6. Boylan K., Romero S., Birmaher B. Psychopharmacologic treatment of pediatric major depressive disorder. Psychopharmacology (Berl) 2007, 91:27-38.
7. Breton J.J., Plante M.A., St-Georges M. Challenges facing child psychiatry in Quebec at the dawn of the 21st Century. Canadian Journal of Psychiatry 2005, 50:203-212.
8. Bridge J.A., Iyengar S., Salary C.B., Barbe R.P., Birmaher B., Pincus H.A., Ren L., Brent D.A. Clinical response and risk for reported suicidal ideation and suicide attempts in pediatric antidepressant treatment: a meta-analysis of randomized controlled trials. JAMA 2007, 297:1683-1696.
9. Chan R.T., Rey J.M., Hazell P.L. Clinical practice guidelines for depression in young people: are the treatment recommendations outdated?. The Medical Journal of Australia 2002, 177:448-451.
10. Cheung A.H., Emslie G.J., Mayes T.L. Review of the efficacy and safety of antidepressants in youth depression. Journal of Child Psychology and Psychiatry 2005, 46:735-754.
11. Cheung A.H., Zuckerbrot R.A., Jensen P.S., Stein R.E., Laraque D. Expert survey for the management of adolescent depression in primary care. Pediatrics 2008, 121:e101-e107.
12. Cook E.H., Wagner K.D., March J.S., Biederman J., Landau P., Wolkow R., Messig M. Long-term sertraline treatment of children and adolescents with obsessive-compulsive disorder. Journal of the American Academy of Child and Adolescent Psychiatry 2001, 40:1175-1181.
13. Dean A.J., Hendy A., McGuire T. Antidepressants in children and adolescents-changes in utilisation after safety warnings. Pharmacoepidemiology and Drug Safety 2007, 16:1048-1053.
14. DeBar L.L., Clarke G.N., O'Connor E., Nichols G.A. Treated prevalence, incidence, and pharmacotherapy of child and adolescent mood disorders in an HMO. Mental Health Services Research 2001, 3:73-89.
15. Dekker M.C., Ferdinand R.F., van Lang N.D., Bongers I.L., van der Ende J., Verhulst F.C. Developmental trajectories of depressive symptoms from early childhood to late adolescence: gender differences and adult outcome. Journal of Child Psychology and Psychiatry 2007, 48:657-666.
16. Eaton L. European agency approves use of fluoxetine for children and teens. BMJ 2006, 332:1407.
17. Emslie G. Clinical guidelines vs. clinical trials. Journal of Child and Adolescent Psychopharmacology 2004, 14:5-7.
18. Gibbons R.D., Brown C.H., Hur K., Marcus S.M., Bhaumik D.K., Erkens J.A., Herings R.M., Mann J.J. Early evidence on the effects of regulators' suicidality warnings on SSRI prescriptions and suicide in children and adolescents. The American Journal of Psychiatry 2007, 164:1356-1363.
19. Haapasalo-Pesu K.M., Vuola T., Lahelma L., Marttunen M. Mirtazapine in the treatment of adolescents with major depression: an open-label, multicenter pilot study. Journal of Child and Adolescent Psychopharmacology 2004, 14:175-184.
20. Hall W.D. How have the SSRI antidepressants affected suicide risk?. Lancet 2006, 367:1959-1962.
21. Hazell P., O'Connell D., Heathcote D., Robertson J., Henry D. Efficacy of tricyclic drugs in treating child and adolescent depression: a meta-analysis. BMJ 1995, 310:897-901.
22. Hugtenburg J.G., Heerdink E.R., Tso Y.H. Psychoactive drug prescribing by Dutch child and adolescent psychiatrists. Acta Paediatrica 2005, 94:1484-1487.
23. Hunkeler E.M., Fireman B., Lee J., Diamond R., Hamilton J., He C.X., Dea R., Nowell W.B., Hargreaves W.A. Trends in use of antidepressants, lithium, and anticonvulsants in Kaiser Permanente-insured youths, 1994-2003. Journal of Child and Adolescent Psychopharmacology 2005, 15:26-37.
24. Jorm A.F., Kelly C.M., Wright A., Parslow R.A., Harris M.G., McGorry P.D. Belief in dealing with depression alone: results from community surveys of adolescents and adults. Journal of Affective Disorders 2006, 96:59-65.
25. Jureidini J.N., Doecke C.J., Mansfield P.R., Haby M.M., Menkes D.B., Tonkin A.L. Efficacy and safety of antidepressants for children and adolescents. BMJ 2004, 328:879-883.
26. Katz L.Y., Kozyrskyj A.L., Prior H.J., Enns M.W., Cox B.J., Sareen J. Effect of regulatory warnings on antidepressant prescription rates, use of health services and outcomes among children, adolescents and young adults. CMAJ 2008, 178:1005-1011.
27. Kessler R.C., Chiu W.T., Demler O., Merikangas K.R., Walters E.E. Prevalence, severity, and comorbidity of 12-month DSM-IV disorders in the National Comorbidity Survey Replication. Archives of General Psychiatry 2005, 62:617-627.
28. Kurian B.T., Ray W.A., Arbogast P.G., Fuchs D.C., Dudley J.A., Cooper W.O. Effect of regulatory warnings on antidepressant prescribing for children and adolescents. Archives of Pediatrics & Adolescent Medicine 2007, 161:690-696.
29. Libby A.M., Brent D.A., Morrato E.H., Orton H.D., Allen R., Valuck R.J. Decline in treatment of pediatric depression after FDA advisory on risk of suicidality with SSRIs. The American Journal of Psychiatry 2007, 164:884-891.
30. Lyons J.S., MacIntyre J.C., Lee M.E., Carpinello S., Zuber M.P., Fazio M.L. Psychotropic medications prescribing patterns for children and adolescents in New York's public mental health system. Community Mental Health Journal 2004, 40:101-118.
31. Martin R.M., May M., Gunnell D. Did intense adverse media publicity impact on prescribing of paroxetine and the notification of suspected adverse drug reactions? Analysis of routine databases, 2001-2004. British Journal of Clinical Pharmacology 2006, 61:224-228.
32. Murray M.L., de Vries C.S., Wong I.C. A drug utilisation study of antidepressants in children and adolescents using the General Practice Research Database. Archives of Disease in Childhood 2004, 89:1098-1102.
33. Nemeroff C.B., Kalali A., Keller M.B., Charney D.S., Lenderts S.E., Cascade E.F., Stephenson H., Schatzberg A.F. Impact of publicity concerning pediatric suicidality data on physician practice patterns in the United States. Archives of General Psychiatry 2007, 64:466-472.
34. Olfson M., Gameroff M.J., Marcus S.C., Waslick B.D. Outpatient treatment of child and adolescent depression in the United States. Archives of General Psychiatry 2003, 60:1236-1242.
35. Percudani M., Barbui C., Fortino I., Petrovich L. Antidepressant drug use in Lombardy, Italy: a population-based study. Journal of Affective Disorders 2004, 83:169-175.
36. Pfeffer C.R. The FDA pediatric advisories and changes in diagnosis and treatment of pediatric depression. The American Journal of Psychiatry 2007, 164:843-846.
37. Raymond C.B., Morgan S.G., Caetano P.A. Antidepressant utilization in British Columbia from 1996 to 2004: increasing prevalence but not incidence. Psychiatric Services 2007, 58:79-84.
38. Richardson L.P., DiGiuseppe D., Christakis D.A., McCauley E., Katon W. Quality of care for medicaid-covered youth treated with antidepressant therapy. Archives of General Psychiatry 2004, 61:475-480.
39. Ryan N.D. Treatment of depression in children and adolescents. Lancet 2005, 366:933-940.
40. Schirman S., Kronenberg S., Apter A., Brent D., Melhem N., Pick N., Carmel M., Frisch A., Weizman A., Gothelf D. Effectiveness and tolerability of citalopram for the treatment of depression and anxiety disorders in children and adolescents: an open-label study. Journal of Neural Transmission 2010, 117:139-145.
41. Skaer T.L., Sclar D.A., Robison L.M. Trends in prescriptions for antidepressant pharmacotherapy among US children and adolescents diagnosed with depression, 1990 through 2001: an assessment of accordance with treatment recommendations from the American Academy of Child and Adolescent Psychiatry. Clinical Therapeutics 2009, 31(Pt 1):1478-1487.
42. Stein R.E., Zitner L.E., Jensen P.S. Interventions for adolescent depression in primary care. Pediatrics 2006, 118:669-682.
43. Thomsen P.H. The treatment of child and adolescent depression: a matter of concern?. Acta Psychiatrica Scandinavica 2007, 115:169-170.
44. Vitiello B., Zuvekas S.H., Norquist G.S. National estimates of antidepressant medication use among U.S. children, 1997-2002. Journal of the American Academy of Child and Adolescent Psychiatry 2006, 45:271-279.
45. Volkers A.C., Heerdink E.R., van Dijk L. Antidepressant use and off-label prescribing in children and adolescents in Dutch general practice (2001-2005). Pharmacoepidemiology and Drug Safety 2007, 16:1054-1062.
46. Weller E.B., Weller R.A. Treatment options in the management of adolescent depression. Journal of Affective Disorders 2000, 61(Suppl 1):23-28.
47. West S.L., Richter A., Melfi C.A., McNutt M., Nennstiel M.E., Mauskopf J.A. Assessing the Saskatchewan database for outcomes research studies of depression and its treatment. Journal of Clinical Epidemiology 2000, 53:823-831.
48. Wheeler B.W., Gunnell D., Metcalfe C., Stephens P., Martin R.M. The population impact on incidence of suicide and non-fatal self harm of regulatory action against the use of selective serotonin reuptake inhibitors in under 18s in the United Kingdom: ecological study. BMJ 2008, 336:542-545.
49. Whittington C.J., Kendall T., Fonagy P., Cottrell D., Cotgrove A., Boddington E. Selective serotonin reuptake inhibitors in childhood depression: systematic review of published versus unpublished data. Lancet 2004, 363:1341-1345.
50. Zito J.M., Safer D.J., dosReis S., Gardner J.F., Boles M., Lynch F. Trends in the prescribing of psychotropic medications to preschoolers. JAMA 2000, 283:1025-1030.
51. Zito J.M., Safer D.J. Services and prevention: pharmacoepidemiology of antidepressant use. Biological Psychiatry 2001, 49:1121-1127.
52. Zito J.M., Safer D.J., DosReis S., Gardner J.F., Soeken K., Boles M., Lynch F. Rising prevalence of antidepressants among US youths. Pediatrics 2002, 109:721-727.
53. Zito J.M., Tobi H., de Jong-van den Berg, L.T., Fegert J.M., Safer D.J., Janhsen K., Hansen D.G., Gardner J.F., Glaeske G. Antidepressant prevalence for youths: a multi-national comparison. Pharmacoepidemiology and Drug Safety 2006, 15:793-798.