Preclinical challenges in steroid analysis of human samples

Journal of Steroid Biochemistry and Molecular Biology

Volumn 121, Issue 3-5, 2010, Pages 505-512

  Ceglarek, Uta ^a   Werner, Maria ^a   Kortz, Linda ^a   Körner, Antje ^b   Kiess, Wieland ^b   Thiery, Joachim ^a   Kratzsch, Juergen ^a  

^a Clinical Chemistry and Molecular Diagnostics   (Germany)

^b UNIVERSITY HOSPITAL LEIPZIG   (Germany)

Author keywords

Biological influencing factors; Immunoassay; LC MS MS; Steroid analysis; Technical factors

Indexed keywords

STEROID;

AGE; BODY MASS; CIRCADIAN RHYTHM; DIET RESTRICTION; FREEZE THAWING; GENDER; HUMAN; IMMUNOASSAY; LIQUID CHROMATOGRAPHY; MENSTRUAL CYCLE; MENTAL STRESS; PHYSICAL STRESS; PREGNANCY; PUBERTY; REVIEW; SYSTEMATIC REVIEW; TANDEM MASS SPECTROMETRY;

CHROMATOGRAPHY, LIQUID; FEMALE; HORMONES; HUMANS; MALE; STEROIDS; TANDEM MASS SPECTROMETRY;

EID: 77955413273     PISSN: 09600760     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jsbmb.2010.03.039     Document Type: Review

References (91)

1. Vesper H.W., Botelho J.C., Shacklady C., Smith A., Myers G.L. CDC project on standardizing steroid hormone measurements. Steroids 2008, 73(13):1286-1292.
2. Stanczyk F.Z., Lee J.S., Santen R.J. Standardization of steroid hormone assays: why, how, and when?. Cancer Epidemiol. Biomarkers Prev. 2007, 16(9):1713-1719.
3. Wotiz H.H., Clark S.J. Newer developments in the analysis of steroids by gas-chromatography. Methods Biochem. Anal. 1970, 18:339-372.
4. Stenman U. Immunoassay standardization: is it possible, who is responsible, who is capable?. Clin. Chem. 2001, 47(5):815-820.
5. Heald A., Butterworth J., Kane J., Borzomato J., Taylor N., Layton T., Kilpatrick E.S., Rudenski A. Investigation into possible causes of interference in serum testosterone measurement in women. Ann. Clin. Biochem. 2006, 43(3):189-195.
6. Middle J.G. Dehydroepiandrostenedione sulphate interferes in many direct immunoassays for testosterone. Ann. Clin. Biochem. 2007, 44(2):173-177.
7. Gomes R.L., Meredith W., Snape C.E., Sephton M.A. Conjugated steroids: analytical approaches and applications. Anal. Bioanal. Chem. 2009, 393(2):453-458.
8. Soldin S.J., Soldin O.P. Steroid hormone analysis by tandem mass spectrometry. Clin. Chem. 2009, 55(6):1061-1066.
9. Guo T., Chan M., Soldin S.J. Steroid profiles using liquid chromatography-tandem mass spectrometry with atmospheric pressure photoionization source. Arch. Pathol. Lab. Med. 2004, 128(4):469-475.
10. Guo T., Taylor R.L., Singh R.J., Soldin S.J. Simultaneous determination of 12 steroids by isotope dilution liquid chromatography-photospray ionization tandem mass spectrometry. Clin. Chim. Acta 2006, 372(1-2):76-82.
11. Ceglarek U., Kortz L., Leichtle A., Fiedler G.M., Kratzsch J., Thiery J. Rapid quantification of steroid patterns in human serum by on-line solid phase extraction combined with liquid chromatography-triple quadrupole linear ion trap mass spectrometry. Clin. Chim. Acta 2009, 401(1-2):114-118.
12. Tanner J.M., Whitehouse R.H. Clinical longitudinal standards for height, weight, height velocity, weight velocity, and stages of puberty. Arch. Dis. Child 1976, 51(3):170-179.
13. Kushnir M.M., Rockwood A.L., Bergquist J., Varshavsky M., Roberts W.L., Yue B., Bunker A.M., Meikle A.W. High-sensitivity tandem mass spectrometry assay for serum estrone and estradiol. Am. J. Clin. Pathol. 2008, 129(4):530-539.
14. Anttila L., Koskinen P., Irjala K., Kaihola H.L. Reference intervals for serum sex steroids and gonadotropins in regularly menstruating women. Acta Obstet. Gynecol. Scand. 1991, 70(6):475-481.
15. Leung P., Armstrong D. Interactions of steroids and gonadotropins in the control of steroidogenesis in the ovarian follicle. Annu. Rev. Physiol. 1980, 42:71-82.
16. Raff H., Sluss P.M. Pre-analytical issues for testosterone and estradiol assays. Steroids 2008, 73(13):1297-1304.
17. Sinha-Hikim I., Arver S., Beall G., Shen R., Guerrero M., Sattler F., Shikuma C., Nelson C.J., Landgren B.M., Mazer N.A., Bhasin S. The use of a sensitive equilibrium dialysis method for the measurement of free testosterone levels in healthy, cycling women and in human immunodeficiency virus-infected women. J. Clin. Endocrinol. Metab. 1998, 83(4):1312-1318.
18. Normal hormone reference ranges. Greenspan's Basic&Clinical Endocrinology 2007, 933-957. McGrawHill Company Inc., New York. D.G. Gardner, D. Shoback (Eds.).
19. Micheli A., Muti P., Pisani P., Secreto G., Recchione C., Totis A., Fissi R., Cavalleri A., Panico S., Berrino F. Repeated serum and urinary androgen measurements in premenopausal and postmenopausal women. J. Clin. Epidemiol. 1991, 44(10):1055-1061.
20. Resch H., Pietschmann P., Kudlacek S., Woloszczuk W., Krexner E., Bernecker P., Willvonseder R. Influence of sex and age on biochemical bone metabolism parameters. Miner. Electrolyte Metab. 1994, 20(3):117-121.
21. Friedrich N., Völzke H., Rosskopf D., Steveling A., Krebs A., Nauck M., Wallaschofski H. Reference ranges for serum dehydroepiandrosterone sulfate and testosterone in adult men. J. Androl. 2008, 29(6):610-617.
22. Elmlinger M.W., Kühnel W., Wormstall H., Döller P.C. Reference intervals for testosterone, androstenedione and SHBG levels in healthy females and males from birth until old age. Clin. Lab. 2005, 51(11-12):625-632.
23. Trienekens P.H., Schmidt N.A., Thijssen J.H. The effect of age, weight-related parameters and hormonal contraceptives on andrological assays. Contraception 1986, 33(5):503-517.
24. Tietz N.W., Shuey D.F., Wekstein D.R. Laboratory values in fit aging individuals-sexagenarians through centenarians. Clin. Chem. 1992, 38(6):1167-1168.
25. Garcia Zozaya J.L., Padilla Viloria M., Rodriguez L., Castro A. The renin-angiotensin-aldosterone system in normal elderly subjects. Res. Commun. Chem. Pathol. Pharmacol. 1983, 40(2):289-299.
26. Mulkerrin E., Epstein F.H., Clark B.A. Aldosterone responses to hyperkalemia in healthy elderly humans. J. Am. Soc. Nephrol. 1995, 6(5):1459-1462.
27. Davison S.L., Bell R., Donath S., Montalto J.G., Davis S.R. Androgen levels in adult females: changes with age, menopause, and oophorectomy. J. Clin. Endocrinol. Metab. 2005, 90(7):3847-3853.
28. Bolland M.J., Grey A.B., Ames R.W., Horne A.M., Mason B.H., Wattie D.J., Gamble G.D., Bouillon R., Reid I.R. Age-, gender-, and weight-related effects on levels of 25-hydroxyvitamin D are not mediated by vitamin D binding protein. Clin. Endocrinol. (Oxf) 2007, 67(2):259-264.
29. Leblhuber F., Neubauer C., Peichl M., Reisecker F., Steinparz F.X., Windhager E., Dienstl E. Age and sex differences of dehydroepiandrosterone sulfate (DHEAS) and cortisol (CRT) plasma levels in normal controls and Alzheimer's disease (AD). Psychopharmacology 1993, 111(1):23-26.
30. Kage A., Fenner A., Weber B., Schöneshöfer M. Diurnal and ultradian variations of plasma concentrations of eleven adrenal steroid hormones in human males. Klin. Wochenschr. 1982, 60(13):659-666.
31. Yie S.M., Wang R., Zhu Y.X., Liu G.Y., Zheng F.H. Circadian variations of serum sex hormone binding globulin binding capacity in normal adult men and women. J. Steroid Biochem. 1990, 36(1-2):111-115.
32. Brambilla D.J., Matsumoto A.M., Araujo A.B., McKinlay J.B. The effect of diurnal variation on clinical measurement of serum testosterone and other sex hormone levels in men. J. Clin. Endocrinol. Metab. 2009, 94(3):907-913.
33. Carr B.R. Disorders of the ovary and female reproductive tract. Williams Textbook of Endocrinology 1992, 754. W.B. Saunders, Philadelphia. J.D. Wilson, D.W. Foster (Eds.).
34. Ankarberg C., Norjavaara E. Diurnal rhythm of testosterone secretion before and throughout puberty in healthy girls: correlation with 17beta-estradiol and dehydroepiandrosterone sulphate. J. Clin. Endocrinol. Metab. 1999, 84(3):975-984.
35. Ankarberg-Lindgren C., Norjavaara E. Are estradiol results determined by the tandem mass spectrometry assay clinically useful for children?. Am. J. Clin. Pathol. 2009, 131(5):746-747. author reply 747-749.
36. Ankarberg-Lindgren C., Norjavaara E. Twenty-four hours secretion pattern of serum estradiol in healthy prepubertal and pubertal boys as determined by a validated ultra-sensitive extraction RIA. BMC Endocr. Disord. 2008, 8:10.
37. Janfaza M., Sherman T.I., Larmore K.A., Brown-Dawson J., Klein K.O. Estradiol levels and secretory dynamics in normal girls and boys as determined by an ultrasensitive bioassay: a 10 year experience. J. Pediatr. Endocrinol. Metab. 2006, 19(7):901-909.
38. Cartledge S., Lawson N. Aldosterone and renin measurements. Ann. Clin. Biochem. 2000, 37(3):262-278.
39. Bolland M.J., Grey A.B., Ames R.W., Mason B.H., Horne A.M., Gamble G.D., Reid I.R. The effects of seasonal variation of 25-hydroxyvitamin D and fat mass on a diagnosis of vitamin D sufficiency. Am. J. Clin. Nutr. 2007, 86(4):959-964.
40. Vining R.F., McGinley R.A. The measurement of hormones in saliva: possibilities and pitfalls. J. Steroid Biochem. 1987, 27(1-3):81-94.
41. Raff H. Utility of salivary cortisol measurements in Cushing's syndrome and adrenal insufficiency. J. Clin. Endocrinol. Metab. 2009, 94(10):3647-3655.
42. Henry J.P. Biological basis of the stress response. Integr. Physiol. Behav. Sci. 1992, 27(1):66-83.
43. Kudielka B.M., Buske-Kirschbaum A., Hellhammer D.H., Kirschbaum C. HPA axis responses to laboratory psychosocial stress in healthy elderly adults, younger adults, and children: impact of age and gender. Psychoneuroendocrinology 2004, 29(1):83-98.
44. Herbert J., Moore G.F., de la Riva C., Watts F.N. Endocrine responses and examination anxiety. Biol. Psychol. 1986, 22(3):215-226.
45. Phillips G.B. The variability of the serum estradiol level in men: effect of stress (college examinations), cigarette smoking, and coffee drinking on the serum sex hormone and other hormone levels. Steroids 1992, 57(3):135-141.
46. Strollo F., Strollo G., More M., Ferretti C., Mangrossa N., Casarosa E., Luisi M., Riondino G. Changes in human adrenal and gonadal function onboard spacelab. J. Gravit. Physiol. 1997, 4(2):103-104.
47. Halford C., Anderzén I., Arnetz B. Endocrine measures of stress and self-rated health: a longitudinal study. J. Psychosom. Res. 2003, 55(4):317-320.
48. Hasson D., Theorell T., Liljeholm-Johansson Y., Canlon B. Psychosocial and physiological correlates of self-reported hearing problems in male and female musicians in symphony orchestras. Int. J. Psychophysiol. 2009, 74(2):93-100.
49. Hamrahian A.H., Oseni T.S., Arafah B.M. Measurements of serum free cortisol in critically ill patients. N. Engl. J. Med. 2004, 350(16):1629-1638.
50. Sahana P.K., Ghosh A., Mukhopadhyay P., Pandit K., Chowdhury B.R., Chowdhury S. A study on endocrine changes in patients in intensive care unit. J. Indian Med. Assoc. 2008, 106(6):362-364.
51. Spratt D.I., Morton J.R., Kramer R.S., Mayo S.W., Longcope C., Vary C.P. Increases in serum estrogen levels during major illness are caused by increased peripheral aromatization. Am. J. Physiol. Endocrinol. Metab. 2006, 291(3):E631-638.
52. Beitins I.Z., Barkan A., Klibanski A., Kyung N., Reppert S.M., Badger T.M., Veldhuis J., McArthur J.W. Hormonal responses to short term fasting in postmenopausal women. J. Clin. Endocrinol. Metab. 1985, 60(6):1120-1126.
53. Nakajima S.T., Gibson M. The effect of a meal on circulating steady-state progesterone levels. J. Clin. Endocrinol. Metab. 1989, 69(4):917-919.
54. Knoll E., Müller F.W., Ratge D., Bauersfeld W., Wisser H. Influence of food intake on concentrations of plasma catecholamines and cortisol. J. Clin. Chem. Clin. Biochem. 1984, 22(9):597-602.
55. Tegelman R., Lindeskog P., Carlström K., Pousette A., Blomstrand R. Peripheral hormone levels in healthy subjects during controlled fasting. Acta Endocrinol. (Copenh) 1986, 113(3):457-462.
56. Cakir M., Sari R., Tosun O., Karayalcin U. Cortisol levels during an oral glucose tolerance test in lean and obese women. Endocr. Res. 2005, 31(3):213-218.
57. Cameron J.L., Helmreich D.L., Schreihofer D.A. Modulation of reproductive hormone secretion by nutritional intake: stress signals versus metabolic signals. Hum. Reprod. 1993, 8(2):162-167.
58. Lukanova A., Lundin E., Zeleniuch-Jacquotte A., Muti P., Mure A., Rinaldi S., Dossus L., Micheli A., Arslan A., Lenner P., Shore R.E., Krogh V., Koenig K.L., Riboli E., Berrino F., Hallmans G., Stattin P., Toniolo P., Kaaks R. Body mass index, circulating levels of sex-steroid hormones, IGF-I and IGF-binding protein-3: a cross-sectional study in healthy women. Eur. J. Endocrinol. 2004, 150(2):161-171.
59. Haffner S.M., Valdez R.A., Stern M.P., Katz M.S. Obesity, body fat distribution and sex hormones in men. Int. J. Obes. Relat. Metab. Disord. 1993, 17(11):643-649.
60. Al-Harithy R.N. Dehydroepiandrosterone sulfate levels in women. Relationships with body mass index, insulin and glucose levels. Saudi Med. J. 2003, 24(8):837-841.
61. Arunabh S., Pollack S., Yeh J., Aloia J.F. Body fat content and 25-hydroxyvitamin D levels in healthy women. J. Clin. Endocrinol. Metab. 2003, 88(1):157-161.
62. Heil W., Ehrhardt V. Reference Ranges for Children and Adolescents 2007, Roche-Diagnostics GmbH, Mannheim.
63. Nelson R.E., Grebe S.K., OKane D.J., Singh R.J. Liquid chromatography-tandem mass spectrometry assay for simultaneous measurement of estradiol and estrone in human plasma. Clin. Chem. 2004, 50(2):373-384.
64. Chance J., Berube J., Vandersmissen M., Blanckaert N. Evaluation of the BD Vacutainer PST II blood collection tube for special chemistry analytes. Clin. Chem. Lab. Med. 2009, 47(3):358-361.
65. Banfi G., Bauer K., Brand W., Buchberger M., Deom A., et al. Use of Anticoagulants in Diagnostic Investigations and Stability of Blood, Plasma and Serum Samples 2002, WHO/DIL/LAB/99.1 Rev.2, pp. 1-62.
66. Bauman J.E. Comparison of radioimmunoassay results in serum and plasma. Clin. Chem. 1980, 26(5):676-677.
67. Kushnir M.M., Rockwood A.L., Roberts W.L., Pattison E.G., Owen W.E., Bunker A.M., Meikle A.W. Development and performance evaluation of a tandem mass spectrometry assay for 4 adrenal steroids. Clin. Chem. 2006, 52(8):1559-1567.
68. Reinartz J.J., Ramey M.L., Fowler M.C., Killeen A.A. Plastic vs glass SST evacuated serum-separator blood-drawing tubes for endocrinologic analytes. Clin. Chem. 1993, 39(12):2535-2536.
69. Britt J., Collinson P.O. Evaluation of serum separator tubes (SST) as primary sampling tubes for common endocrine tests. Proc. ABC Natl. Meet. 1995, 78-79.
70. Wang S., Ho V., Roquemore-Goins A., Smith F.A. Effects of blood collection tubes, including pediatric devices, on 16 common immunoassays. Clin. Chem. 2006, 52(5):892-893.
71. Kley H.K., Rick W. The effect of storage and temperature on the analysis of steroids in plasma and blood. J. Clin. Chem. Clin. Biochem. 1984, 22(5):371-378.
72. Kley H.K., Schlaghecke R., Krüskemper H.L. Stability of steroids in plasma over a 10-year period. J. Clin. Chem. Clin. Biochem. 1985, 23(12):875-878.
73. Evans M.J., Livesey J.H., Ellis M.J., Yandle T.G. Effect of anticoagulants and storage temperatures on stability of plasma and serum hormones. Clin. Biochem. 2001, 34(2):107-112.
74. Wielders J.P., Wijnberg F.A. Preanalytical stability of 25(OH)-vitamin D3 in human blood or serum at room temperature: solid as a rock. Clin. Chem. 2009, 55(8):1584-1585.
75. Stroud L.R., Solomon C., Shenassa E., Papandonatos G., Niaura R., Lipsitt L.P., Lewinn K., Buka S.L. Long-term stability of maternal prenatal steroid hormones from the National Collaborative Perinatal Project: still valid after all these years. Psychoneuroendocrinology 2007, 32(2):140-150.
76. Bauman J.E. Stability of radioimmunoassayable steroid and protein hormones after repeated freeze-thaw cycles. Clin. Chem. 1982, 28(11):2336-2337.
77. Antoniucci D.M., Black D.M., Sellmeyer D.E. Serum 25-hydroxyvitamin D is unaffected by multiple freeze-thaw cycles. Clin. Chem. 2005, 51(1):258-261.
78. Roche Diagnostics Corporation: Manufacturer's literature on Vitamin D3 for Elecsys 1010, 2010; Modular Analytics E170 and cobas e411 and e611. Manufacturer's Literature V7 (2009) 1-5.
79. Wood L., Ducroq D.H., Fraser H.L., Gillingwater S., Evans C., Pickett A.J., Rees D.W., John R., Turkes A. Measurement of urinary free cortisol by tandem mass spectrometry and comparison with results obtained by gas chromatography-mass spectrometry and two commercial immunoassays. Ann. Clin. Biochem. 2008, 45(4):380-388.
80. Schirpenbach C., Seiler L., Maser-Gluth C., Rüdiger F., Nickel C., Beuschlein F., Reincke M. Confirmatory testing in normokalaemic primary aldosteronism: the value of the saline infusion test and urinary aldosterone metabolites. Eur. J. Endocrinol. 2006, 154(6):865-873.
81. Jiménez C., de la Torre R., Segura J., Ventura R. Stability studies of testosterone and epitestosterone glucuronides in urine. Rapid Commun. Mass Spectrom. 2006, 20(5):858-864.
82. Gröschl M. Current status of salivary hormone analysis. Clin. Chem. 2008, 54(11):1759-1769.
83. Roche Diagnostics Corporation: Manufacturer's literature on estradiol II for Elecsys 1010, 2010; Modular Analytics E170 and cobas e411 and e611. Manufacturer's Literature V15 (2009) 1-4.
84. Ionita I.A., Fast D.M., Akhlaghi F. Development of a sensitive and selective method for the quantitative analysis of cortisol, cortisone, prednisolone and prednisone in human plasma. J. Chromatogr. B: Anal. Technol. Biomed. Life Sci. 2009, 877(8-9):765-772.
85. Roche Diagnostics Corporation: Manufacturer's literature on cortisol for Elecsys 1010, 2010; Modular Analytics E170 and cobas e411 and e611. Manufacturer's Literature V15 (2009) 1-5.
86. Ortho Clinical Diagnostics, Inc. Manufacturer's Literature on Cortisol for Vitros Immundiagnostic Products. Manufacturer's Literature V3.0 2009, pp. 1-14.
87. Ortho Clinical Diagnostics Inc. Manufacturer's Literature on Estradiol for Vitros Immundiagnostic Products. Manufacturer's Literature V2.0 2009, pp. 1-14.
88. Ortho Clinical Diagnostics Inc. Manufacturer's Literature on Testosterone for Vitros Immundiagnostic Products. Manufacturer's Literature V2.0 2009, pp. 1-14.
89. Roche Diagnostics Corporation: Manufacturer's literature on testosterone for Elecsys 1010, 2010; Modular Analytics E170 and cobas e411 and e611. Manufacturer's Literature V11 (2007) 1-3.
90. Ly L.P., Handelsman D.J. Empirical estimation of free testosterone from testosterone and sex hormone-binding globulin immunoassays. Eur. J. Endocrinol. 2005, 152(3):471-478.
91. Mazer N.A. A novel spreadsheet method for calculating the free serum concentrations of testosterone, dihydrotestosterone, estradiol, estrone and cortisol: with illustrative examples from male and female populations. Steroids 2009, 74(6):512-519.