Possible relevance between prohormone convertase 2 expression and tumor growth in human adrenocorticotropin-producing pituitary adenoma

Journal of Clinical Endocrinology and Metabolism

Volumn 95, Issue 8, 2010, Pages 4003-4011

  Iino, Kazumi ^a   Oki, Yutaka ^a   Yamashita, Miho ^a   Matsushita, Fumie ^a   Hayashi, Chiga ^a   Yogo, Kosuke ^a   Nishizawa, Shigeru ^b   Yamada, Shozo ^c   Maekawa, Masato ^a   Sasano, Hironobu ^d   Nakamura, Hirotoshi ^a  

^a HAMAMATSU UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^b UNIVERSITY OF OCCUPATIONAL AND ENVIRONMENTAL HEALTH   (Japan)

^c TORANOMON HOSPITAL   (Japan)

^d TOHOKU UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA INTERMEDIN; CORTICOTROPIN; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; PHOSPHATIDYLINOSITOL 3 KINASE; PROPROTEIN CONVERTASE 2; PROTEIN TYROSINE KINASE;

ADULT; AGED; ARTICLE; CELL CYCLE; CELL PROLIFERATION; CONTROLLED STUDY; CUSHING DISEASE; FEMALE; HUMAN; HYPOPHYSIS ADENOMA; IMMUNOHISTOCHEMISTRY; IMMUNOREACTIVITY; MALE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; QUANTITATIVE ANALYSIS; REAL TIME POLYMERASE CHAIN REACTION; TUMOR GROWTH; TUMOR VOLUME;

EID: 77955407838     PISSN: 0021972X     EISSN: 0021972X     Source Type: Journal    
DOI: 10.1210/jc.2009-2716     Document Type: Article

References (39)

1. Seidah NG, Chrétien M 1999 Proprotein and prohormone convertases: a family of subtilases generating diverse bioactive polypeptides. Brain Res 848:45-62
2. von Eggelkraut-Gottanka R, Beck-Sickinger AG 2004 Biosynthesis of peptide hormones derived from precursor sequences. Curr Med Chem 11:2651-2665
3. Jin L, Kulig E, Qian X, Scheithauer BW, Young Jr WF, Davis DH, Seidah NG, Chrétien M, Lloyd RV 1999 Distribution and regulation of proconvertases PC1 and PC2 in human pituitary adenomas. Pituitary 1:187-195
4. Takumi I, Steiner DF, Sanno N, Teramoto A, Osamura RY 1998 Localization of prohormone convertases 1/3 and 2 in the human pituitary gland and pituitary adenomas: analysis by immunohistochemistry, immunoelectron microscopy, and laser scanning microscopy. Mod Pathol 11:232-238
5. Colao A, Merola B, Cataldi M, La Tessa G, Boudouresque F, Oliver C, Di Renzo G, Annunziato L, Lombardi G 1993 α-Melanocyte-stimulating hormone is present in the inferior petrosal sinuses in patients with Cushing's disease. Neuroendocrinology 58:227-233
6. Vieau D, Seidah NG, Mbikay M, Chrétien M, Bertagna X 1994 Expression of the prohormone convertase PC2 correlates with the presence of corticotropin-like intermediate lobe peptide in human adrenocorticotropin- secreting tumors. J Clin Endocrinol Metab 79:1503-1506
7. Blevins Jr LS, Verity DK, Allen G 1998 Aggressive pituitary tumors. Oncology (Williston Park) 12:1307-1312, 1315; discussion 1315-1308
8. Vallone D, Picetti R, Borrelli E 2000 Structure and function of dopamine receptors. Neurosci Biobehav Rev 24:125-132
9. Iino K, Sasano H, Oki Y, Andoh N, Shin RW, Kitamoto T, Totsune K, Takahashi K, Suzuki H, Nagura H, Yoshimi T 1997 Urocortin expression in human pituitary gland and pituitary adenoma. J Clin Endocrinol Metab 82:3842-3850
10. Carethers JM, Pham TT 2000 Mutations of transforming growth factor β1 type II receptor, BAX, and insulin-like growth factor II receptor genes in microsatellite unstable cell lines. In Vivo 14:13-20
11. Chandler LA, Sosnowski BA, Greenlees L, Aukerman SL, Baird A, Pierce GF 1999 Prevalent expression of fibroblast growth factor (FGF) receptors and FGF2 in human tumor cell lines. Int J Cancer 81:451-458
12. Xu H, Yu Y, Marciniak D, Rishi AK, Sarkar FH, Kucuk O, Majumdar AP 2005 Epidermal growth factor receptor (EGFR)-related protein inhibits multiple members of the EGFR family in colon and breast cancer cells. Mol Cancer Ther 4:435-442
13. Tahara S, Kurotani R, Ishii Y, Sanno N, Teramoto A, Osamura RY 2002 A case of Cushing's disease caused by pituitary adenoma producing adrenocorticotropic hormone and growth hormone concomitantly: aberrant expression of transcription factors NeuroD1 and Pit-1 as a proposed mechanism. Mod Pathol 15:1102-1105
14. Pivonello R, Ferone D, de Herder WW, Kros JM, De Caro ML, Arvigo M, Annunziato L, Lombardi G, Colao A, Hofland LJ, Lamberts SW 2004 Dopamine receptor expression and function in corticotroph pituitary tumors. J Clin Endocrinol Metab 89:2452-2462
15. Pivonello R, Matrone C, Filippella M, Cavallo LM, Di Somma C, Cappabianca P, Colao A, Annunziato L, Lombardi G 2004 Dopamine receptor expression and function in clinically nonfunctioning pituitary tumors: comparison with the effectiveness of cabergoline treatment. J Clin Endocrinol Metab 89:1674-1683
16. Croughs RJ, Thijssen JH, Mol JA 1991 Absence of detectable immunoreactive α melanocyte stimulating hormone in plasma in various types of Cushing's disease. J Endocrinol Invest 14:197-200
17. Kortlandt W, De Rotte AA, Arts CJ, Croughs RJ, Thijssen JH 1986 Characterization of α-MSH-like immunoreactivity in human plasma. Acta Endocrinol (Copenh) 113:175-180
18. Thody AJ, Fisher C, Kendal-Taylor P, Jones MT, Price J, Abraham RR 1985 The measurement and characterisation by high pressure liquid chromatography of immunoreactive α-melanocyte stimulating hormone in human plasma. Acta Endocrinol (Copenh) 110:313-318
19. Gavrila A, Chan JL, Miller LC, Heist K, Yiannakouris N, Mantzoros CS 2005 Circulating melanin-concentrating hormone, agouti-related protein, and α-melanocyte-stimulating hormone levels in relation to body composition: alterations in response to food deprivation and recombinant human leptin administration. J Clin Endocrinol Metab 90:1047-1054
20. Pichler R, Crespillo C, Maschek W, Esteva I, Soriguer F, Sfetsos K, Auböck J 2004 Plasma levels of α-melanotropin and ACTH-like immunoreactivities do not vary by season or skin type in women from southern and central Europe. Neuropeptides 38:325-330
21. Yamaoka-Tojo M, Tojo T, Shioi T, Masuda T, Inomata T, Izumi T 2006 Central neurotranspeptide, α-melanocyte-stimulating hormone (α-MSH) is upregulated in patients with congestive heart failure. Intern Med 45:429-434
22. Abe K, Island DP, Liddle GW, Fleisher N, Nicholson WE 1967 Radioimmunologic evidence for α-MSH (melanocyte stimulating hormone) in human pituitary and tumor tissues. J Clin Endocrinol Metab 27:46-52
23. Bassi DE, Fu J, Lopez de Cicco R, Klein-Szanto AJ 2005 Proprotein convertases: "master switches" in the regulation of tumor growth and progression. Mol Carcinog 44:151-161
24. Bassi DE, Mahloogi H, Klein-Szanto AJ 2000 The proprotein convertases furin and PACE4 play a significant role in tumor progression. Mol Carcinog 28:63-69
25. Cheng M, Watson PH, Paterson JA, Seidah N, Chrétien M, Shiu RP 1997 Pro-protein convertase gene expression in human breast cancer. Int J Cancer 71:966-971
26. North WG, Du J 1998 Key peptide processing enzymes are expressed by a variant form of small-cell carcinoma of the lung. Peptides 19:1743-1747
27. Khatib AM, Siegfried G, Prat A, Luis J, Chrétien M, Metrakos P, Seidah NG 2001 Inhibition of proprotein convertases is associated with loss of growth and tumorigenicity of HT-29 human colon carcinoma cells: importance of insulin-like growth factor-1 (IGF-1) receptor processing in IGF-1-mediated functions. J Biol Chem 276:30686-30693
28. Kobayashi I, Jin L, Ruebel KH, Bayliss JM, Hidehiro O, Lloyd RV 2003 Regulation of cell growth and expression of 7B2, PC2, and PC1/3 by TGFβ1 and sodium butyrate in a human pituitary cell line (HP75). Endocrine 22:285-292
29. Katznelson L, Bogan JS, Trob JR, Schoenfeld DA, Hedley-Whyte ET, Hsu DW, Zervas NT, Swearingen B, Sleeper M, Klibanski A 1998 Biochemical assessment of Cushing's disease in patients with corticotroph macroadenomas. J Clin Endocrinol Metab 83:1619-1623
30. Losa M, Barzaghi RL, Mortini P, Franzin A, Mangili F, Terreni MR, Giovanelli M 2000 Determination of the proliferation and apoptotic index in adrenocorticotropin-secreting pituitary tumors: comparison between micro- and macroadenomas.AmJ Pathol 156:245-251
31. Fresno Vara JA, Casado E, de Castro J, Cejas P, Belda-Iniesta C, González-Barón M 2004 PI3K/Akt signalling pathway and cancer. Cancer Treat Rev 30:193-204
32. Musat M, Korbonits M, Kola B, Borboli N, Hanson MR, Nanzer AM, Grigson J, Jordan S, Morris DG, Gueorguiev M, Coculescu M, Basu S, Grossman AB 2005 Enhanced protein kinase B/Akt signalling in pituitary tumours. Endocr Relat Cancer 12:423-433
33. Chaidarun SS, Eggo MC, Sheppard MC, Stewart PM 1994 Expression of epidermal growth factor (EGF), its receptor, and related oncoprotein (erbB-2) in human pituitary tumors and response to EGF in vitro. Endocrinology 135:2012-2021
34. Onguru O, Scheithauer BW, Kovacs K, Vidal S, Jin L, Zhang S, Ruebel KH, Lloyd RV 2004 Analysis of epidermal growth factor receptor and activated epidermal growth factor receptor expression in pituitary adenomas and carcinomas. Mod Pathol 17:772-780
35. Theodoropoulou M, Arzberger T, Gruebler Y, Jaffrain-Rea ML, Schlegel J, Schaaf L, Petrangeli E, Losa M, Stalla GK, Pagotto U 2004 Expression of epidermal growth factor receptor in neoplastic pituitary cells: evidence for a role in corticotropinoma cells. J Endocrinol 183:385-394
36. Ezzat S, Zheng L, Smyth HS, Asa SL 1997 The c-erbB-2/neu protooncogene in human pituitary tumours. Clin Endocrinol (Oxf) 46:599-606
37. Jin L, Qian X, Kulig E, Sanno N, Scheithauer BW, Kovacs K, Young Jr WF, Lloyd RV 1997 Transforming growth factor-β, transforming growth factor-β receptor II, and p27Kip1 expression in nontumorous and neoplastic human pituitaries. Am J Pathol 151:509-519
38. Abbass SA, Asa SL, Ezzat S 1997 Altered expression of fibroblast growth factor receptors in human pituitary adenomas. J Clin Endocrinol Metab 82:1160-1166
39. Onofri C, Theodoropoulou M, Losa M, Uhl E, Lange M, Arzt E, Stalla GK, Renner U 2006 Localization of vascular endothelial growth factor (VEGF) receptors in normal and adenomatous pituitaries: detection of a nonendothelial function of VEGF in pituitary tumours. J Endocrinol 191:249-261