Development of an efficient large-scale synthesis for a 4 H-imidazo[5,1- c ][1,4]benzoxazine-3-carboxamide derivative for depression and anxiety

Organic Process Research and Development

Volumn 14, Issue 4, 2010, Pages 859-867

  Giubellina, Nicola ^a   Stabile, Paolo ^a   Laval, Gilles ^a   Perboni, Alcide D ^a   Cimarosti, Zadeo ^a   Westerduin, Pieter ^a   Cooke, Jason W B ^a  

^a GSK   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

AMIDATION; BENZOXAZINE; CARBOXAMIDES; DRUG CANDIDATES; GREEN CHEMISTRY; HIGH COSTS; LARGE SCALE SYNTHESIS; LOW-YIELD; LOWER COST; OPTIMIZED SYNTHESIS; PILOT SCALE; SCALE-UP; SIDE CHAINS; STARTING MATERIALS;

AMIDES; CARBOXYLATION;

DISEASES;

EID: 77955388008     PISSN: 10836160     EISSN: 1520586X     Source Type: Journal    
DOI: 10.1021/op100103v     Document Type: Article

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