Estranediols profiling in calves' urine after 17β-nandrolone laureate ester administration

Journal of Steroid Biochemistry and Molecular Biology

Volumn 121, Issue 3-5, 2010, Pages 626-632

  Pinel, Gaud ^a   Rambaud, Lauriane ^a   Monteau, Fabrice ^a   Elliot, Christopher ^b   Le Bizec, Bruno ^a  

^a Waters Corporation   (France)

^b QUEEN'S UNIVERSITY BELFAST   (United Kingdom)

Author keywords

17 Nandrolone; Calves; Estranediols; Metabolism; Urine

Indexed keywords

17BETA NANDROLONE LAUREATE ESTER; 5ALPHA ESTRANE 3ALPHA ,17BETA DIOL; 5ALPHA ESTRANE 3BETA,17ALPHA DIOL; 5ALPHA ESTRANE 3BETA,17BETA DIOL; 5BETA ESTRANE 3ALPHA ,17ALPHA DIOL; 5BETA ESTRANE 3ALPHA,17BETA DIOL; ANABOLIC AGENT; ESTRANE DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; CONTROLLED STUDY; COW; FEMALE; GAS CHROMATOGRAPHY; ISOMER; MALE; METABOLITE; NONHUMAN; TANDEM MASS SPECTROMETRY;

ANIMALS; CATTLE; ESTERS; ESTRANES; GAS CHROMATOGRAPHY-MASS SPECTROMETRY; NANDROLONE;

ANIMALIA;

EID: 77955373332     PISSN: 09600760     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jsbmb.2010.01.012     Document Type: Article

References (44)

1. Council Directive 96/22/EC, of 29 April 1996. Off. J. Eur. Commun. (1996) No L 125/3. Concerning the prohibition on the use in stockfarming of certain substances having a hormonal or thyrostatic action and on b-agonists and repealing Directives 81/602/EC, 88/146/EC and 88/299/EC.
2. Dubois M., Taillieu X., Colemonts Y., Lansival B., De Graeve J., Delahaut P. MS determination of anabolic steroids after multi-immunoaffinity purification. Analyst 1998, 123:2611-2616.
3. Impens S., De Wasch K., De Brabander H. Determination of anabolic steroids with gas chromatography-ion trap mass spectrometry using hydrogen as gas carrier. Rapid Commun. Mass Spectrom. 2001, 15:2409-2414.
4. Catlin D., Ahrens B., Kucherova Y. Detection of norbothenone an anabolic steroid never marked in athletes' urine. Rapid Commun. Mass Spectrom. 2002, 16:1273-1275.
5. Thieme D., Anielski P., Grosse J., Sachs H., Mueller R.K. Identification of anabolic steroids in urine, serum sweat and hair-comparison of metabolic pattern. Anal. Chim. Acta 2003, 483:299-306.
6. Munoz-Guerra J., Carreras D., Soriano C., Rodriguez C., Rodriguez A.F. Use of ion trap gas chromatography-tandem mass spectrometry for detection and confirmation of anabolic substances at trace level in doping analysis. J. Chromatogr. B 1997, 704:129-141.
7. Gaillard Y., Vayssette F., Balland A., Pépin G. Gas chromatographic-tandem mass spectrometric determination of anabolic steroids and their esters in hair: application in doping control and meat quality control. J. Chromatogr. B 1999, 735:189-205.
8. Le Bizec B., Bryand F., Gaudin I., Monteau F., Poulain F., André F. Preliminary results to discriminate between endogenous and exogenous origin. Steroids 2002, 67:105-110.
9. Van Eenoo P., Delbeke F.T., de Jong F.H., De Backer P. Endogenous origin of norandrosterone in female urine: indirect evidence for the production of 19-norsteroids as by-products in the conversion from androgen to estrogen. J. Steroid Biochem. Mol. Bio. 2001, 78:351-357.
10. Van Poucke C., Van Peteghem C. Development and validation of a multi-analyte method for detection of anabolic steroids in bovine urine with liquid chromatography-tandem mass spectrometry. J. Chromatogr. B 2002, 772:211-217.
11. Van C., Poucke M., Van De Velde C., Van Peteghem Combination of liquid chromatography/tandem mass spectrometry and gas chromatograph/mass spectrometry for the detection of 21 anabolic steroid residues in bovine urine. J. Mass Spectrom. 2005, 40:731-738.
12. Nielen M.W.F., Rutgers P., Van Bennekom E.O., Lasaroms J.J.P., Van Rhijn J.A. Confirmatory analysis of 17β-boldenone, 17α-boldenone, and androsta-1,4-diene-3,17-dione in bovine urine, faeces, feed and skin swab samples by liquid chromatography-electrospray ionisation tandem mass spectrometry. J. Chromatogr. B 2004, 801:273-283.
13. Leinonen A., Kuuranne T., Kotiaho T., Kostiainen R. Screening of free 17-alkyl-substituted anabolic steroids in human urine by liquid chromatography-electrospray ionization tandem mass spectrometry. Steroids 2004, 69:101-109.
14. Draisci R., Palleschi L., Ferreti E., Lucentini L., Cammarata P. Quantitation of anabolic hormones and their metabolites in bovine serum and urine by liquid chromatography-tandem mass spectrometry. J. Chromatogr. A 2000, 870:511-522.
15. Nielen M.W.F., Lasaroms J.J.P., Essers M.L., Sanders M.B., Heskamp H.H., Bovee T.F.H., van Rhijn J.H., Groot M.J. Multi-residue screening of intact testosterone esters and boldenone undecylenate in bovine hair using liquid chromatography electrospray tandem mass spectrometry. Anal. Chim. Acta 2006, 830:126-134.
16. Mottram D., George A. Anabolic steroids. Clin. Endocrinol. Metab. 2000, 14:55.
17. Le Bizec B., Gaudin I., Monteau F., André F., Impens S., De Wasch K., De Brabander H. Consequence of boar edible tissue consumption on urinary profiles of nandrolone metabolites. I. mass spectrometric detection and quantification of 19-norandrosterone and 19-noretiocholanolone in human urine. Rapid Commun. Mass Spectrom. 2000, 14:1058-1065.
18. Tseng Y.L., Sun C.-Y., Kuo F.-H. Detection and quantification of glucuro- and sulfoconjugated metabolites in human urine following oral administration of xenobiotic 19 norsteroids. Steroids 2006, 71:817-827.
19. Le Bizec B., Monteau F., Gaudin I., André F. Evidence for the presence of endogenous 19-norandrosterone in human urine. J. Chromatogr. B 1999, 723:157-172.
20. Dehennin L., Bonnaire Y., Plou Ph. Human nutritional supplements in horse: comparative effects of 19-norandrostenediol on the 19-norsteroid profile and consequences for doping control. J. Chromatogr. B 2002, 766:287-294.
21. Massé R., Ayotte C., Dugal R. Integrated methodological approach to GC-MS analysis of anabolic steroid metabolites in urine. J. Chromatogr. 1989, 489:23-50.
22. Daeseleire E., De Guesquière A., Van Peteghem C. Metabolism of 1-19-nortestosterone in urine of calves after oral intake and intramuscular administration. Anal. Chim. Acta 1993, 275:95-103.
23. Benoît E., Guyot J.L., Courtot D., Delatour P. Gas chromatographic/mass spectrometric analysis of 19-nortestosterone urinary metabolites in cattle. Ann. Rec. Vet. 1989, 20:485-491.
24. Calvarese S., Rubini P., Urbani G., Ferri N., Ramazza C., Zucchi M. Experimental administration of 19-nortestosterone and dexamethasone in cattle: elimination of the two drugs in different biological matrices. Analyst 1994, 119:2611-2615.
25. Benoit E., Champelle E., Courtot D., Delatour P. Dépistage de l'utilisation de la nandrolone en élevage bovin. Rec. Med. Vet. 1989, 165:737-740.
26. Haasnoot W., Shilt R., Hamers A.R.M., Huf F.A. Determination of b-19-nortestosterone in biological samples at the sub parts per billion level by high-performance liquid chromatography with on-line immunoaffinity sample pretreatment. J. Chromatogr. 1989, 489:157-171.
27. Van Ginkel, Stephany R.W., Rossum H.J., Van Blitterswijk H., Zoontjes P.W., Hooijschuur R.C.M., Zuydendorp J. Effective monitoring of residues of nortestosterone anf its major metabolite in bovine urine and bile. J. Chromatogr. 1989, 489:95-104.
28. Lu H., Conneely G., Crowe M.A., Aherne M., Pravda M., Guilbault G.G. Screening for testosterone, methyltesosterone, 19-nortestosterone residues and their metabolites in bovine urine with enzyme-linked immunosorbent assay (ELISA). Anal. Chim. Acta 2006, 570:116-123.
29. Pinel G., Rambaud L., Cacciatore G., Bergwerff A., Elliot C., Nielen M., Le Bizec B. Elimination kinetic of 17β-estradiol 3-benzoate and 17β-nandrolone laureate ester metabolites in calves' urine. J. Steroid Biochem. Mol. Bio. 2008, 110:30-38.
30. Houghton E. Studies related to metabolism of anabolic steroids in the horse: 19-nortestosterone. Xenobiotica 1977, 7:683-693.
31. Houghton E., Dumasia M.C. Studies related to the metabolism of anabolic steroids in the horse: the identification of some 16 oxygenated metabolites of 19-nortestosterone. Xenobiotica 1980, 10:381-389.
32. Roig M., Segura J., Ventura R. Quantitation of 17β-nandrolone metabolites in boar and horse urine by gas chromatography-mass spectrometry. Anal. Chim. Acta 2007, 586:184-195.
33. Debruyckere G., Van Peteghem C., De Brabander H.F., Debackere G. Gas chromatographic-mass spectrometric confirmation of 19-nortestosterone in the urine of untreated boars-effect of the administration of Laurabolin. Vet. Quart. 1990, 12:246-251.
34. Debruyckere G., Van Peteghem C. Detection of 19-nortestosterone and its urinary metabolites in miniature pigs by gas-chromatography-mass spectrometry. J. Chromatogr. 1991, 564:393-403.
35. Scarth J., Ackre C., Van Ginkel L., Le Bizec B., De Brabander H., Korth W., Points J., Teale P., Kay J. Presence and metabolism of endogenous androgenic-anabolic steroid hormones in meat producing animals: a review. Food Additives Contam. 2009, 26:640-671.
36. Tuinstra T., Kienhuis P., Van Mazijk R.G., Traag W. Proc. Int. Symp. of Veterinary Laboratory Diagnosticans 1986, 765-767.
37. Eisenberg S.W.F., Cacciatore G., Klarenbeek S., Bergwerff A.A., Koets A.P. Influence of 17β-oestradiol, nortestosterone and dexamethasone on the adaptive immune response in veal calves. Res. Vet. Sci. 2008, 84:199-205.
38. Poelmans S., De Wasch K., Noppe H., Van Hoof N., Van Cruchten S., Le Bizec B., Deceuninck Y., Sterck S., Van Rossum H.J., Hoffman M.K., De Brabander H.F. Endogenous occurrence of some anabolic steroids in swine matrices. Food Additives Contam. 2005, 22:808-815.
39. Rosegger J., Schmerold I., Ahmed S., Schuch R., Eppinger G., Steiner S., Baumgartner W., Armstrong H., Schauberger G., McEvoy J.D.G., Kuhn T.W. Natural occurence and elimination of 19-nortestosterone in sheep: pregnant ewes, male and female lambs before and after treatment. Wiener Tierarztliche Monatsschrift 2009, 96:171-183.
40. De Brabander H., Van Hende J., Batjoens P., Hendricks L., Raus J., Smet F., Pottie G., Van Ginkel L., Stephany R.W. Endogenic nortestosterone in cattle?. Analyst 1994, 119:2581-2585.
41. Vandenbroeck M., Van Vyncht G., Gaspar G., Dasnois C., Delahaut P., Pelzer G., De Graeve J., Maghuin-Rogister G. Identification and characterization of 19-nortestosterone in urine of meat-producing animals. J. Chromatogr. 1991, 564:405-412.
42. Meyer H., Falckenberg D., Janowski T., Rapp M., Rösel E.F., Van Look L., Karg H. Acta Endocrinol. 1992, 126:369-373.
43. McEvoy J.D.G., McCaughey W.J., Cooper J., Kennedy D.G., McCarten B.M. Nortestosterone is not a naturally occurring compound in male cattle. Vet. Quart. 1999, 21:8-15.
44. Kennedy D.G., Shortt H.D., Crooks S.R.H., Young P.B., Price H.J., Smyth W.G., Hewitt S.A. The occurrence of α and β-nortestosterone residues In the urine of injured male cattle. Proceedings from Euroresidue VI Conference 2008, Egmond An Zee, The Netherlands.