Relation of the Wnt/β-catenin signaling pathway with gynecological cancers;Wnt/β-katenin sinyal yolunun jinekolojik kanserlerle olan ilişkisi

Turkish Journal of Biology

Volumn 34, Issue 3, 2010, Pages 227-234

  Tanir, Hanife Güler ^a   Demirezen, Şayeste ^a   Beksaç, Mehmet Sinan ^a  

^a HACETTEPE UNIVERSITY   (Turkey)

Author keywords

catenin; Adhesion; Cancer; Cell proliferation; Wnt catenin signaling pathway

Indexed keywords

EID: 77955366051     PISSN: 13000152     EISSN: None     Source Type: Journal    
DOI: 10.3906/biy-0904-24     Document Type: Review

References (47)

1. Nusse R, Varmus H E. Wnt genes. Cell 69: 1073-1067, 1992.
2. Nusse R. Wnt signaling in disease and in development. Cell Res 15: 28-32, 2005.
3. Mikels AJ, Nusse R. Wnts as ligands: processing, secretion and reception. Oncogene 25: 7461-7468, 2006.
4. Giles RH, Es JH, Clevers H. Caught up in a Wnt storm: Wnt signaling in cancer. Biochim Biophys Acta 1653: 1-24, 2003.
5. Gordon DM, Nusse R. Wnt signaling: Multiple pathways, Multiple receptors, and Multiple transcription factors. J Biol Chem 281: 22429-22433, 2006.
6. Zeng X, Huang H, Tamai K et al. Initiation of Wnt signaling: control of Wnt coreceptor Lrp6 phosphorylation/activation via frizzled, dishevelled and axin functions. Development 135: 367-375, 2008.
7. Chen X, Yang J, Evans MP et al. Wnt signaling: the good and bad. Acta Biochim Biophys Sin 40: 577, 2008.
8. Willert K, Nusse R. β-catenin: a key mediator of Wnt signaling. Curr Opin Genet Dev 8: 95-102, 1998.
9. Huelsken J, Behrens J. The Wnt signaling pathway. J Cell Sci 115: 3977-3978, 2002.
10. Moon TR, Kohn DA, Ferrari VG et al. Wnt and β-catenin signaling: diseases and therapies. Nat Rev Cancer 5: 689-699, 2004.
11. Kawano Y, Kypta R. Secreted antagonists of the Wnt signaling pathway. J Cell Sci 116: 2627-2634, 2003.
12. Daugherty LR, Gottardi CJ. Phospho-regulation of β-catenin adhesion and signaling functions. Physiology 22: 303-309, 2007.
13. Plasencia CP, Gonzalez AD, Tavera BA. Second hit in cervical carcinogenesis process: involvement of wnt/beta catenin pathway. Int Arch Med 1: 1-8, 2008.
14. Wang A. Yanfeng WA, Tan C et al. Phosphorylation of Frizzled-3. J Biol Chem 281: 11603-11609, 2006.
15. Polakis P. Wnt signaling and cancer. Genes Dev 14: 1837-1851, 2000.
16. Chong ZZ, Li F, Maiese K. Employing new cellular therapeutic targets for Alzheimer's disease: a change for the better? Curr Neurovasc Res 2: 55-72, 2005.
17. Oǧuztüzün S, İşcan M, Özhavzali{dotless} M et al. Comparison of GST isoenzyme expression in normal and neoplastic breast tissue: correlation with clinical and prognostic factors. Turk J Biol 33: 89-100, 2009.
18. Yoon WJ, Ham YM, Lee WJ et al. Brown alga Sargassum muticuminhibits proinflammatory cytokines, iNOS, and COX-2 expression in macrophage RAW 264.7 cells Turk J Biol 34: 25-34, 2010.
19. Smith KJ, Johnson KA, Bryan TM et al. The APC gene product in normal and tumor cells. Proc Natl Acad Sci 90: 2846-2850, 1993.
20. Lee AY, He B, You L et al. Expression of the secreted frizzledrelated protein gene family is downregulated in human mesothelioma. Oncogene 23: 6672-6676, 2004.
21. Cowling VH, D'Cruz CM, Chodosh LA et al. c-Myc Transforms Human Mammary Epithelial Cells through Repression of the Wnt Inhibitors DKK1 and SFRP1. Mol Cell Biol 27: 5135-5146, 2007.
22. Lee J, Yoon YS, Chung JH. Epigenetic silencing of the WNT antagonist DICKKOPF-1 in cervical cancer cell lines. Gynecol Oncol 109: 270-274, 2008.
23. Yang F, Li X, Sharma M et al. Linking β-catenin to androgensignaling pathway. J Biol Chem 277: 11336-11344, 2002.
24. Yardy GW, Brewster SF. Wnt signaling and prostate cancer. Prostatic Dis 8: 119-126, 2005.
25. Ilyas M, Tomlinson IPM. The interactions of APC, E-cadherin and β-catenin in tumour development and progression J Pathol 182: 128-137, 1997.
26. Yang J, Zhang W, Evans PM et al. Adenomatous polyposis coli (APC) differentially regulates β-catenin phosphorylation and ubiquitination in colon cancer cells. J Biol Chem 281: 17751-17757, 2006.
27. Parazzino F, Franceschi S, La Vecchia C et al. The epidemiology of female genital tract cancers Int J Gynecol Cancer 7: 169-181, 1997.
28. zur Hausen H. Human papilloma viruses and their possible role in squamous cell carcinomas. Curr Top Microbiol Immunol 78: 1-30, 1977.
29. zur Hausen H. Papillomaviruses in anogenital cancer as a model to understand the role of viruses in human cancers. Cancer Res 49: 4677-4681, 1989.
30. González AD, Lizano M, Candelaria M et al. Epigenetics of cervical cancer. An overview and therapeutic perspectives. Mol Cancer 4: 1-24, 2005.
31. Cai HB, Ding XH, Chen CC. Prevalence of single and multiple human papillomavirus types in cervical cancer and precursor lesions in Hubei, China. Oncology 76: 157-161, 2009.
32. Shinohara A, Yokoyama Y, Wan X et al. Cytoplasmic/nuclear expression without mutation of exon 3 of the β-catenin gene is frequent in the development of the neoplasm of the uterine cervix. Gynecol Oncol 82: 450-455, 2001.
33. Uren A, Fallen S, Yuan H, et al. Activation of the canonical Wnt pathway during genital keratinocyte transformation: a model for cervical cancer progression. Cancer Res 65: 6199-6206, 2005
34. Chung MT, Lai HC, Sytwu HK et al. SFRP1 and SFRP2 suppress the transformation and invasion abilities of cervical cancer cells through Wnt signal pathway. Gynecol Oncol 112: 646-53, 2009.
35. Chung MT, Sytwu HK, Yan MD et al. Promoter methylation of SFRPs gene family in cervical cancer. Gynecol Oncol 112: 301-306, 2009.
36. Ko J, Ryu KS, Lee YH et al. Human secreted frizzled-related protein is down-regulated and induces apoptosis in human cervical cancer. Exp Cell Res 280: 280-287, 2002.
37. Lee EJ, Jo M, Rho SB, et al. Dkk3, downregulated in cervical cancer, functions as a negative regulator of β-catenin. Int J Cancer 124: 287-297, 2009.
38. Koike J, Takagi A, Miwa T et al. Molecular Cloning of Frizzled-10, a Novel Member of the Frizzled Gene Family. Biochem Biophys Res Commun 262: 39-43, 1999.
39. Vincan E. Frizzled/Wnt signalling: the insidious promoter of tumour growth and progression. Front Biosci 9: 1023-1034, 2004.
40. Hardiman G, Kastelein RA, Bazan JF. Isolation, characterization and chromosomal localization of human WNT10B. Cytogenet Cell Genet 77: 278-282, 1997.
41. Okino K, Nagai H, Hatta M et al. Up-regulation and overproduction of DVL-1, the human counterpart of the Drosophila dishevelled gene, in cervical squamous cell carcinoma. Oncol Rep 10: 1219-1223, 2003.
42. Rubinfeld B, Souza B, Albert I et al. Association of the APC gene product with beta-catenin. Science 262: 1731-1734, 1993.
43. Narayan G, Pulido H A, Koul S et al. Frequent promoter methylation of CDH1, DAPK, RARB, and HIC1 genes in carcinoma of cervix uteri: its relationship to clinical outcome. Mol Cancer 2: 1-12, 2003.
44. Menendez L, Walker D, Matyunina LV et al. Identification of candidate methylation-responsive genes in ovarian cancer. Mol Cancer 6: 1-9, 2007.
45. Wu R, Zhai Y, Fearon ER et al. Diverse mechanisms of β-catenin deregulation in ovarian endometrioid adenocarcinomas. Cancer Res 61: 8247-8255, 2001.
46. Karbova E, Davidson B, Metodiev K et al. Adenomatous polyposis coli (APC) protein expression in primary and metastatic serous ovarian carcinoma. Int J Surg Pathol 10: 175-180, 2002.
47. Takada T, Yagi Y, Maekita T et al. Methylation-associated silencing of the Wnt antagonist SFRP1 gene in human ovarian cancers. Cancer Sci 95: 741-744, 2004.