Empiric antibiotic therapy for Staphylococcus aureus bacteremia may not reduce in-hospital mortality: A retrospective cohort study

PLoS ONE

Volumn 5, Issue 7, 2010, Pages

  Schweizer, Marin L ^a,b   Furuno, Jon P ^a   Harris, Anthony D ^a   Johnson, J Kristie ^a   Shardell, Michelle D ^a   McGregor, Jessina C ^c   Thom, Kerri A ^a   Sakoulas, George ^d   Perencevich, Eli N ^b,e  

^a UNIVERSITY OF MARYLAND SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF IOWA   (United States)

^c OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

^d SHARP MEMORIAL HOSPITAL   (United States)

^e VETERANS AFFAIRS MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBIOTIC AGENT; CEPHALOSPORIN DERIVATIVE; CLINDAMYCIN; DAPTOMYCIN; LINEZOLID; NAFCILLIN; PIPERACILLIN; SULFAMETHOXAZOLE; TAZOBACTAM; TRIMETHOPRIM; VANCOMYCIN; VIRULENCE FACTOR; ANTIINFECTIVE AGENT;

ADULT; ANTIBIOTIC RESISTANCE; ANTIBIOTIC THERAPY; ARTICLE; BACTERIAL STRAIN; BACTERIUM ISOLATION; BLOOD CULTURE; COMORBIDITY; CONTROLLED STUDY; DISEASE SEVERITY; FEMALE; HUMAN; IN VITRO STUDY; LENGTH OF STAY; MAJOR CLINICAL STUDY; MALE; MINIMUM INHIBITORY CONCENTRATION; MORTALITY; NONHUMAN; RETROSPECTIVE STUDY; STAPHYLOCOCCAL BACTEREMIA; STAPHYLOCOCCUS AUREUS; TERTIARY HEALTH CARE; TREATMENT OUTCOME; BACTEREMIA; COHORT ANALYSIS; DRUG EFFECT; MICROBIOLOGY; MIDDLE AGED; PHYSIOLOGY; STAPHYLOCOCCUS INFECTION;

STAPHYLOCOCCUS AUREUS;

ADULT; ANTI-BACTERIAL AGENTS; BACTEREMIA; COHORT STUDIES; FEMALE; HUMANS; MALE; MIDDLE AGED; RETROSPECTIVE STUDIES; STAPHYLOCOCCAL INFECTIONS; STAPHYLOCOCCUS AUREUS;

EID: 77955357200     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0011432     Document Type: Article

References (39)

1. Cosgrove SE, Sakoulas G, Perencevich EN, Schwaber MJ, Karchmer AW, et al. (2003) Comparison of mortality associated with methicillin-resistant and methicillin-susceptible Staphylococcus aureus bacteremia: A meta-analysis. Clin Infect Dis 36(1): 53-59.
2. Cosgrove SE, Qi Y, Kaye KS, Harbarth S, Karchmer AW, et al. (2005) The impact of methicillin resistance in Staphylococcus aureus bacteremia on patient outcomes: Mortality, length of stay, and hospital charges. Infect Control Hosp Epidemiol 26(2): 166-174.
3. Tam VH, Louie A, Fritsche TR, Deziel M, Liu W, et al. (2007) Impact of drug-exposure intensity and duration of therapy on the emergence of Staphylococcus aureus resistance to a quinolone antimicrobial. J Infect Dis 195(12): 1818-1827.
4. Lodise TP, McKinnon PS, Swiderski L, Rybak MJ (2003) Outcomes analysis of delayed antibiotic treatment for hospital-acquired Staphylococcus aureus bacteremia. Clin Infect Dis 36(11): 1418-1423.
5. Schramm GE, Johnson JA, Doherty JA, Micek ST, Kollef MH (2006) Methicillin-resistant Staphylococcus aureus sterile-site infection: The importance of appropriate initial antimicrobial treatment. Crit Care Med 34(8): 2069-2074.
6. Romero-Vivas J, Rubio M, Fernandez C, Picazo JJ (1995) Mortality associated with nosocomial bacteremia due to methicillin-resistant Staphylococcus aureus. Clin Infect Dis 21(6): 1417-1423.
7. Robinson JO, Pearson JC, Christiansen KJ, Coombs GW, Murray RJ (2008) Ommunity-associated versus healthcare-associated methicillin-resistant Staphylo-coccus aureus bacteraemia: A 10-year retrospective review. Eur J Clin Microbiol Infect Dis 28(4): 353-361.
8. Soriano A, Martinez JA, Mensa J, Marco F, Almela M, et al. (2000) Pathogenic significance of methicillin resistance for patients with Staphylococcus aureus bacteremia. Clin Infect Dis 30(2): 368-373.
9. Gomez J, Garcia-Vazquez E, Banos R, Canteras M, Ruiz J, et al. (2007) Predictors of mortality in patients with methicillin-resistant Staphylococcus aureus (MRSA) bacteraemia: The role of empiric antibiotic therapy. Eur J Clin Microbiol Infect Dis 26(4): 239-245.
10. Leibovici L, Shraga I, Drucker M, Konigsberger H, Samra Z, et al. (1998) The benefit of appropriate empirical antibiotic treatment in patients with bloodstream infection. J Intern Med 244(5): 379-386.
11. Shorr AF, Micek ST, KollefMH (2008) Inappropriate therapy for methicillin-resistant Staphylococcus aureus: Resource utilization and cost implications. Crit Care Med 36(8): 2335-2340.
12. Kim SH, Park WB, Lee CS, Kang CI, Bang JW, et al. (2006) Outcome of inappropriate empirical antibiotic therapy in patients with Staphylococcus aureus bacteraemia: Analytical strategy using propensity scores. Clin Microbiol Infect 12(1): 13-21.
13. Lesens O, Methlin C, Hansmann Y, Remy V, Martinot M, et al. (2003) Role of comorbidity in mortality related to Staphylococcus aureus bacteremia: A prospective study using the Charlson weighted index of comorbidity. Infect Control Hosp Epidemiol 24(12): 890-896.
14. Khatib R, Saeed S, Sharma M, Riederer K, Fakih MG, et al. (2006) Impact of initial antibiotic choice and delayed appropriate treatment on the outcome of Staphylococcus aureus bacteremia. Eur JClin Microbiol Infect Dis 25(3): 181-185.
15. Roghmann MC (2000) Predicting methicillin resistance and the effect of inadequate empiric therapy on survival in patients with Staphylococcus aureus bacteremia. Arch Intern Med 160(7): 1001-1004.
16. Ammerlaan H, Seifert H, Harbarth S, Brun-Buisson C, Torres A, et al. (2009) Adequacy of antimicrobial treatment and outcome of Staphylococcus aureus bacteremia in 9 western European countries. Clin Infect Dis 49(7): 997-1005.
17. Ibrahim EH, Sherman G, Ward S, Fraser VJ, Kollef MH (2000) The influence of inadequate antimicrobial treatment of bloodstream infections on patient outcomes in the ICU setting. Chest 118(1): 146-155.
18. McGregor JC, Rich SE, Harris AD, Perencevich EN, Osih R, et al. (2007) A systematic review of the methods used to assess the association between appropriate antibiotic therapy and mortality in bacteremic patients. Clin Infect Dis 45(3): 329-337.
19. McGregor JC, Perencevich EN, Furuno JP, Langenberg P, Flannery K, et al. (2006) Comorbidity risk-adjustment measures were developed and validated for studies of antibiotic-resistant infections. J Clin Epidemiol 59(12): 1266-1273.
20. McGregor JC, Kim PW, Perencevich EN, Bradham DD, Furuno JP, et al. (2005) Utility of the chronic disease score and Charlson comorbidity index as comorbidity measures for use in epidemiologic studies of antibiotic-resistant organisms. Am JEpidemiol 161(5): 483-493.
21. Osih RB, McGregor JC, Rich SE, Moore AC, Furuno JP, et al. (2007) Impact of empiric antibiotic therapy on outcomes in patients with Pseudomonas aeruginosa bacteremia. Antimicrob Agents Chemother 51(3): 839-844.
22. Furuno JP, Harris AD, Wright MO, Hartley DM, McGregor JC, et al. (2007) Value of performing active surveillance cultures on intensive care unit discharge for detection of methicillin-resistant Staphylococcus aureus. Infect Control Hosp Epidemiol 28(6): 666-670.
23. Furuno JP, Perencevich EN, Johnson JA, Wright MO, McGregor JC, et al. (2005) Methicillin-resistant Staphylococcus aureus and vancomycin resistant enterococci co-colonization. Emerg Infect Dis 11(10): 1539-1544.
24. Knaus WA, Wagner DP, Draper EA, Zimmerman JE, Bergner M, et al. (1991) The APACHE III prognostic system. Risk prediction of hospital mortality for critically ill hospitalized adults. Chest 100(6): 1619-1636.
25. Sunenshine RH, Wright MO, Maragakis LL, Harris AD, Song X, et al. (2007) Multidrug-resistant Acinetobacter infection mortality rate and length of hospitalization. Emerg Infect Dis 13(1): 97-103.
26. Forrest GN, Mehta S, Weekes E, Lincalis DP, Johnson JK, et al. (2006) Impact of rapid in situ hybridization testing on coagulase-negative staphylococci positive blood cultures. J Antimicrob Chemother 58(1): 154-158.
27. Clinical and Laboratory Standards Institute (2008) Performance standards for antimicrobial susceptibility testing. In: CLSI document. Nineteenth Informational Supplement. pp M100-S19.
28. Andrews JM (2001) Determination of minimum inhibitory concentrations. J Antimicrob Chemother 48 Suppl 1: 5-16.
29. Diep BA, Gill SR, Chang RF, Phan TH, Chen JH, et al. (2006) Complete genome sequence of USA300, an epidemic clone of community-acquired meticillin-resistant Staphylococcus aureus. Lancet 367(9512): 731-739.
30. Lina G, Piemont Y, Godail-Gamot F, Bes M, Peter MO, et al. (1999) Involvement of Panton-Valentine leukocidin-producing Staphylococcus aureus in primary skin infections and pneumonia. Clin Infect Dis 29(5): 1128-1132.
31. Shopsin B, Gomez M, Montgomery SO, Smith DH, Waddington M, et al. (1999) Evaluation of protein A gene polymorphic region DNA sequencing for typing ofStaphylococcus aureus strains. J Clin Microbiol 37(11): 3556-3563.
32. Harmsen D, Claus H, Witte W, Rothganger J, Claus H, et al. (2003) Typing of methicillin-resistant Staphylococcus aureus in a university hospital setting by using novel software for spa repeat determination and database management. J Clin Microbiol 41(12): 5442-5448.
33. Johnson JK, Khoie T, Shurland S, Kreisel K, Stine OC, et al. (2007) Skin and soft tissue infections caused by methicillin-resistant Staphylococcus aureus USA300 clone. Emerg Infect Dis 13(8): 1195-1200.
34. Kim PW, Perl TM, Keelaghan EF, Langenberg P, Perencevich EN, et al. (2005) Risk ofmortality with a bloodstream infection is higher in the less severely ill at admission. Am J Respir Crit Care Med 171(6): 616-620.
35. Lin MY, Weinstein RA, Hota B (2008) Delay of active antimicrobial therapy and mortality among patients with bacteremia: Impact of severe neutropenia. Antimicrob Agents Chemother 52(9): 3188-3194.
36. Salas M, Hofman A, Stricker BH (1999) Confounding by indication: An example of variation in the use of epidemiologic terminology. Am J Epidemiol 149 (11): 981-983.
37. Chang FY, Peacock JE, Jr., Musher DM, Triplett P, MacDonald BB, et al. (2003) Staphylococcus aureus bacteremia: Recurrence and the impact of antibiotic treatment in a prospective multicenter study. Medicine (Baltimore) 82(5): 333-339.
38. Stryjewski ME, Szczech LA, Benjamin DK, Jr., Inrig JK, Kanafani ZA, et al. (2007) Use of vancomycin or first-generation cephalosporins for the treatment of day mortality in a large cohort. Clin Infect Dis 31(5): 1170-1184.
39. Mylotte JM, Tayara A (2000) Staphylococcus aureus bacteremia: Predictors of 30-hemodialysis-dependent patients with methicillin-susceptible Staphylococcus aureus bacteremia. Clin Infect Dis 44(2): 190-196.