Lack of lacto/neolacto-glycolipids enhances the formation of glycolipid-enriched microdomains, facilitating B cell activation

Proceedings of the National Academy of Sciences of the United States of America

Volumn 107, Issue 26, 2010, Pages 11900-11905

  Togayachi, Akira ^a   Kozono, Yuko ^a   Ikehara, Yuzuru ^a   Ito, Hiromi ^a   Suzuki, Nami ^a   Tsunoda, Yuki ^a   Abe, Sumie ^a   Sato, Takashi ^a   Nakamura, Kyoko ^b   Suzuki, Minoru ^b   Goda, Hatsumi M ^c   Ito, Makoto ^c   Kudo, Takashi ^d   Takahashi, Satoru ^d   Narimatsu, Hisashi ^a  

^a NATIONAL INSTITUTE OF ADVANCED INDUSTRIAL SCIENCE AND TECHNOLOGY AIST   (Japan)

^b Japan Science and Technology Agency   (Japan)

^c KYUSHU UNIVERSITY   (Japan)

^d UNIVERSITY OF TSUKUBA   (Japan)

Author keywords

1,3 N acetylglucosaminyltransferase; B cell receptor; Glycosphingolipid; Glycosyltransferase; Polylactosamine

Indexed keywords

BREAKPOINT CLUSTER REGION PROTEIN; GANGLIOSIDE GM1; GLYCOLIPID; GLYCOSPHINGOLIPID; LACTOGLYCOLIPID; LACTOTRIAOSYLCERAMIDE SYNTHASE; NEOLACTOGLYCOLIPID; SYNTHETASE; UNCLASSIFIED DRUG;

ARTICLE; B LYMPHOCYTE ACTIVATION; BLOOD CELL; ENZYME ACTIVITY; FLOW CYTOMETRY; FLUORESCENCE MICROSCOPY; IMMUNOBLOTTING; IN VIVO STUDY; LIPID ANALYSIS; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION;

ANIMALS; B-LYMPHOCYTES; BASE SEQUENCE; DNA PRIMERS; FEMALE; G(M1) GANGLIOSIDE; GLYCOSPHINGOLIPIDS; LACTOSYLCERAMIDES; LYMPHOCYTE ACTIVATION; MALE; MEMBRANE MICRODOMAINS; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MOLECULAR SEQUENCE DATA; N-ACETYLGLUCOSAMINYLTRANSFERASES;

MUS;

EID: 77955345888     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.0914298107     Document Type: Article

References (34)

1. Prinetti A, Loberto N, Chigorno V, Sonnino S (2009) Glycosphingolipid behaviour in complex membranes. Biochim Biophys Acta 1788:184-193.
2. Yohe HC, Coleman DL, Ryan JL (1985) Ganglioside alterations in stimulated murine macrophages. Biochim Biophys Acta 818:81-86.
3. Simons K, Ikonen E (1997) Functional rafts in cell membranes. Nature 387:569-572.
4. Brown DA, London E (2000) Structure and function of sphingolipid- and cholesterolrich membrane rafts. J Biol Chem 275:17221-17224. (Pubitemid 30430750)
5. Hakomori S (2004) Glycosynapses: Microdomains controlling carbohydrate-dependent cell adhesion and signaling. An Acad Bras Cienc 76:553-572.
6. Smith DC, Lord JM, Roberts LM, Johannes L (2004) Glycosphingolipids as toxin receptors. Semin Cell Dev Biol 15:397-408.
7. Hakomori S (2004) Carbohydrate-to-carbohydrate interaction, through glycosynapse, as a basis of cell recognition and membrane organization. Glycoconj J 21:125-137.
8. Nishio M, Tajima O, Furukawa K, Urano T, Furukawa K (2005) Over-expression of GM1 enhances cell proliferation with epidermal growth factor without affecting the receptor localization in the microdomain in PC12 cells. Int J Oncol 26:191-199.
9. Anderson RG, Jacobson K (2002) A role for lipid shells in targeting proteins to caveolae, rafts, and other lipid domains. Science 296:1821-1825.
10. Petrie RJ, Schnetkamp PP, Patel KD, Awasthi-Kalia M, Deans JP (2000) Transient translocation of the B cell receptor and Src homology 2 domain-containing inositol phosphatase to lipid rafts: evidence toward a role in calcium regulation. J Immunol 165:1220-1227. (Pubitemid 30604547)
11. Razzaq TM, et al. (2004) Regulation of T-cell receptor signalling by membrane microdomains. Immunology 113:413-426. (Pubitemid 39593360)
12. Viola A, Schroeder S, Sakakibara Y, Lanzavecchia A (1999) T lymphocyte costimulation mediated by reorganization of membrane microdomains. Science 283:680-682. (Pubitemid 129506235)
13. Xavier R, Brennan T, Li Q, McCormack C, Seed B (1998) Membrane compartmentation is required for efficient T cell activation. Immunity 8:723-732. (Pubitemid 28294519)
14. Yuyama K, Sekino-Suzuki N, Sanai Y, Kasahara K (2003) Lipid rafts in cellular signaling and disease. Trends Glycosci Glycotechnol 15:139-151. (Pubitemid 36928459)
15. Miceli MC, et al. (2001) Co-stimulation and counter-stimulation: Lipid raft clustering controls TCR signaling and functional outcomes. Semin Immunol 13:115-128.
16. Togayachi A, Sato T, Narimatsu H (2006) Comprehensive enzymatic characterization of glycosyltransferases with a β3GT or β4GT motif. Methods Enzymol 416:91-102. (Pubitemid 44750105)
17. Togayachi A, et al. (2001) Molecular cloning and characterization of UDP-GlcNAc: lactosylceramide β1,3-N-acetylglucosaminyltransferase (β3Gn-T5), an essential enzyme for the expression of HNK-1 and Lewis X epitopes on glycolipids. J Biol Chem 276:22032-22040. (Pubitemid 37410865)
18. Henion TR, Zhou D, Wolfer DP, Jungalwala FB, Hennet T (2001) Cloning of a mouse beta 1,3 N-acetylglucosaminyltransferase GlcNAc(beta 1,3)Gal(beta 1,4)Glc-ceramide synthase gene encoding the key regulator of lacto-series glycolipid biosynthesis. J Biol Chem 276:30261-30269. (Pubitemid 37385108)
19. Togayachi A, et al. (2007) Polylactosamine on glycoproteins influences basal levels of lymphocyte and macrophage activation. Proc Natl Acad Sci USA 104:15829-15834.
20. Biellmann F, Hülsmeier AJ, Zhou D, Cinelli P, Hennet T (2008) The Lc3-synthase gene B3gnt5 is essential to pre-implantation development of the murine embryo. BMC Dev Biol 8:109.
21. Tsubata T (1999) Co-receptors on B lymphocytes. Curr Opin Immunol 11:249-255.
22. Kovacic N, Müthing J,Marusic A (2000) Immunohistological and flow cytometric analysis of glycosphingolipid expression in mouse lymphoid tissues. J Histochem Cytochem 48:1677-1690.
23. Schwarting GA (1980) Quantitative analysis of neutral glycosphingolipids from human lymphocyte subpopulations. Biochem J 189:407-412.
24. Janes PW, Ley SC, Magee AI (1999) Aggregation of lipid rafts accompanies signaling via the T cell antigen receptor. J Cell Biol 147:447-461.
25. Ruddock LW, et al. (1996) A pH-dependent conformational change in the B-subunit pentamer of Escherichia coli heat-labile enterotoxin: Structural basis and possible functional role for a conserved feature of the AB5 toxin family. Biochemistry 35:16069-16076.
26. Pralle A, Keller P, Florin EL, Simons K, Hörber JK (2000) Sphingolipid-cholesterol rafts diffuse as small entities in the plasma membrane of mammalian cells. J Cell Biol 148:997-1008.
27. Suzuki KG, Fujiwara TK, Edidin M, Kusumi A (2007) Dynamic recruitment of phospholipase C gamma at transiently immobilized GPI-anchored receptor clusters induces IP3-Ca2+ signaling: single-molecule tracking study 2. J Cell Biol 177:731-742.
28. Rabinovich GA, Toscano MA, Jackson SS, Vasta GR (2007) Functions of cell surface galectin-glycoprotein lattices. Curr Opin Struct Biol 17:513-520.
29. Garner OB, Baum LG (2008) Galectin-glycan lattices regulate cell-surface glycoprotein organization and signalling. Biochem Soc Trans 36:1472-1477.
30. Elola MT, Chiesa ME, Alberti AF, Mordoh J, Fink NE (2005) Galectin-1 receptors in different cell types. J Biomed Sci 12:13-29.
31. Yu X, Siegel R, Roeder RG (2006) Interaction of the B cell-specific transcriptional coactivator OCA-B and galectin-1 and a possible role in regulating BCR-mediated B cell proliferation. J Biol Chem 281:15505-15516.
32. Clark AG, et al. (2007) Multifunctional regulators of cell growth are differentially expressed in anergic murine B cells. Mol Immunol 44:1274-1285.
33. Brown BK, Song W (2001) The actin cytoskeleton is required for the trafficking of the B cell antigen receptor to the late endosomes. Traffic 2:414-427.
34. Hao S, August A (2005) Actin depolymerization transduces the strength of B cell receptor stimulation. Mol Biol Cell 16:2275-2284.