Study of the polyephysicochemical properties and oral bioavailability of the solid dispersion of cantharidin withylene glycol 4000

Methods and Findings in Experimental and Clinical Pharmacology

Volumn 32, Issue 3, 2010, Pages 157-162

  Dang, Y J ^a   Hu, C H ^a   An, L N ^a   Zhu, C Y ^a  

^a INSTITUTE OF MEDICINAL PLANT DEVELOPMENT   (China)

Author keywords

[No Author keywords available]

Indexed keywords

CANTHARIDIN; MACROGOL 4000; SOLVENT; DRUG CARRIER; ENZYME INHIBITOR; MACROGOL DERIVATIVE;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DIFFERENTIAL SCANNING CALORIMETRY; DISPERSION; DRUG BIOAVAILABILITY; DRUG SOLUBILITY; DRUG STABILITY; DRUG STRUCTURE; DRUG SYNTHESIS; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; IN VITRO STUDY; IN VIVO STUDY; MASS FRAGMENTOGRAPHY; NONHUMAN; PHYSICAL CHEMISTRY; POWDER X RAY DIFFRACTION; RAT; SCANNING ELECTRON MICROSCOPY; SOLID DISPERSION; X RAY DIFFRACTION; ANIMAL; AREA UNDER THE CURVE; BIOAVAILABILITY; CHEMISTRY; COMPARATIVE STUDY; MALE; ORAL DRUG ADMINISTRATION; POWDER DIFFRACTION; SOLUBILITY; SPRAGUE DAWLEY RAT;

ADMINISTRATION, ORAL; ANIMALS; AREA UNDER CURVE; BIOLOGICAL AVAILABILITY; CALORIMETRY, DIFFERENTIAL SCANNING; CANTHARIDIN; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DRUG CARRIERS; ENZYME INHIBITORS; GAS CHROMATOGRAPHY-MASS SPECTROMETRY; MALE; MICROSCOPY, ELECTRON, SCANNING; POLYETHYLENE GLYCOLS; POWDER DIFFRACTION; RATS; RATS, SPRAGUE-DAWLEY; SOLUBILITY;

EID: 77955302991     PISSN: 03790355     EISSN: None     Source Type: Journal    
DOI: 10.1358/mf.2010.32.3.1423886     Document Type: Article

References (11)

1. Pharmacopoeia of People's Republic of China[S]. Beijing: Chemical Industry Press 2005.
2. Zhang, J.P., Ying, K., Xiao, Z.Y. et al. Analysis of gene expression profiles in human HL-60 cell exposed to cantharidin using cDNA microarray. Int J Cancer 2004, 108(2): 212-8.
3. Efferth, T., Rauh, R., Kahl, S. et al. Molecular modes of action of cantharidin in tumor cells. Biochem Pharmacol 2005, 69(5): 811-8.
4. Liu, G.Q., Zhang, K.C. Method for determination of cantharidin from ferment liquid of medicinal fungi using capillary gas chromatography. J Food Sci Biotechnol 2006, 25: 88-90.
5. Chiou, W.L., Riegalman, S. Pharmaceutical applications of solid dispersion systems. J Pharm Sci 1971, 60(9): 1281-302.
6. Ford, J.L. The current status of solid dispersions. Pharm Acta Helv 1986, 61(3): 69-88.
7. Leuner, C., Dressman, J. Improving drug solubility for oral delivery using solid dispersions. Eur J Pharm Biopharm 2000, 50(1): 47-60.
8. Sekiguchi, K., Obi, N. Studies on absorption of eutectic mixtures. I. A comparison of the behaviour of eutectic mixture of sulfathiazole and that of ordinary sulfathiazole in man. Chem Pharm Bull 1961, 9: 866-72.
9. Moneghini, M., Kikic, I., Voinovich, D., Perissutti, B., Filipovic-Grcic, J. Processing of carbamazepine-PEG 4000 solid dispersions with supercritical carbondioxide: Preparation, characterisation, and in vitro dissolution. Int J Pharm 2001, 222(1): 129-38.
10. Leuner, C., Dressman, J. Improving drug solubility for oral delivery using solid dispersions. Eur J Pharm Biopharm 2000, 50(1): 47-60.
11. Okonogi, S., Oguchi T, Yonemochi E, et al. Improved dissolution of ofloxacin via solid dispersion. Int J Pharm 1997, 156(2): 175-80.