Relevance of oral experimental challenge with classical scrapie in sheep

Journal of General Virology

Volumn 91, Issue 8, 2010, Pages 2139-2144

  Tabouret, Guillaume ^a   Lacroux, Caroline ^a   Lugan, Séverine ^a   Costes, Pierrette ^a   Corbière, Fabien ^a   Weisbecker, Jean Louis ^b   Schelcher, François ^a   Andréoletti, Olivier ^a  

^a UNIVERSITÉ DE TOULOUSE   (France)

^b INRA Domaine de Langlade   (France)

Author keywords

[No Author keywords available]

Indexed keywords

PRION PROTEIN;

ADOLESCENT; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN SPONGIOSIS; CONTROLLED STUDY; INCUBATION TIME; INOCULATION; LAMB; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN LOCALIZATION; SCRAPIE AGENT; SHEEP; VIRUS INFECTION; VIRUS TRANSMISSION; ANIMAL; CHEMISTRY; COMPARATIVE STUDY; DISEASE MODEL; DISEASE TRANSMISSION; LYMPHOID TISSUE; NERVOUS SYSTEM; SCRAPIE; SHEEP DISEASE; TIME;

ANIMALIA; OVIS ARIES;

ANIMALS; DISEASE MODELS, ANIMAL; LYMPHOID TISSUE; NERVOUS SYSTEM; PRPSC PROTEINS; SCRAPIE; SHEEP; SHEEP DISEASES; TIME FACTORS;

EID: 77955302690     PISSN: 00221317     EISSN: 14652099     Source Type: Journal    
DOI: 10.1099/vir.0.021311-0     Document Type: Article

References (25)

1. Sc in gut-associated lymphoid and nervous tissues of susceptible sheep from a Romanov flock with natural scrapie. J Gen Virol 81, 3115-3126.
2. Andréoletti, O., Berthon, P., Levavasseur, E., Marc, D., Lantier, F., Monks, E., Elsen, J. M. & Schelcher, F. (2002a). Phenotyping of protein-prion (PrPsc)-accumulating cells in lymphoid and neural tissues of naturally scrapie-affected sheep by double-labeling immunohistochemistry. J Histochem Cytochem 50, 1357-1370. (Pubitemid 35191480)
3. Sc accumulation in placentas of ewes exposed to natural scrapie: influence of foetal PrP genotype and effect on ewe-to-lamb transmission. J Gen Virol 83, 2607-2616.
4. Andréoletti, O., Simon, S., Lacroux, C., Morel, N., Tabouret, G., Chabert, A., Lugan, S., Corbiere, F., Ferre, P. & other authors (2004). PrPSc accumulation in myocytes from sheep incubating natural scrapie. Nat Med 10, 591-593.
5. Baron, T., Biacabe, A. G., Arsac, J. N., Benestad, S. & Groschup, M. H. (2007). Atypical transmissible spongiform encephalopathies (TSEs) in ruminants. Vaccine 25, 5625-5630. (Pubitemid 47033943)
6. Bellworthy, S. J., Dexter, G., Stack, M., Chaplin, M., Hawkins, S. A., Simmons, M. M., Jeffrey, M., Martin, S., Gonzalez, L. & Hill, P. (2005a). Natural transmission of BSE between sheep within an experimental flock. Vet Rec 157, 206. (Pubitemid 41195237)
7. Bellworthy, S. J., Hawkins, S. A., Green, R. B., Blamire, I., Dexter, G., Dexter, I., Lockey, R., Jeffrey, M., Ryder, S. & other authors (2005b). Tissue distribution of bovine spongiform encephalopathy infectivity in Romney sheep up to the onset of clinical disease after oral challenge. Vet Rec 156, 197-202. (Pubitemid 40309672)
8. Detwiler, L. A. & Baylis, M. (2003). The epidemiology of scrapie. Rev Sci Tech 22, 121-143.
9. Elsen, J. M., Amigues, Y., Schelcher, F., Ducrocq, V., Andréoletti, O., Eychenne, F., Khang, J. V., Poivey, J. P., Lantier, F. & Laplanche, J. L. (1999). Genetic susceptibility and transmission factors in scrapie: detailed analysis of an epidemic in a closed flock of Romanov. Arch Virol 144, 431-445. (Pubitemid 29172699)
10. Foster, J. D., Bruce, M., McConnell, I., Chree, A. & Fraser, H. (1996). Detection of BSE infectivity in brain and spleen of experimentally infected sheep. Vet Rec 138, 546-548. (Pubitemid 126702902)
11. Foster, J. D., Parnham, D., Chong, A., Goldmann, W. & Hunter, N. (2001a). Clinical signs, histopathology and genetics of experimental transmission of BSE and natural scrapie to sheep and goats. Vet Rec 148, 165-171. (Pubitemid 33607737)
12. Foster, J. D., Parnham, D. W., Hunter, N. & Bruce, M. (2001b). Distribution of the prion protein in sheep terminally affected with BSE following experimental oral transmission. J Gen Virol 82, 2319-2326. (Pubitemid 32936765)
13. Groschup, M. H., Lacroux, C., Buschmann, A., Luhken, G., Mathey, J., Eiden, M., Lugan, S., Hoffmann, C., Espinosa, J. C. & other authors (2007). Classic scrapie in sheep with the ARR/ARR prion genotype in Germany and France. Emerg Infect Dis 13, 1201-1207. (Pubitemid 47359165)
14. Hoffmann, C., Ziegler, U., Buschmann, A., Weber, A., Kupfer, L., Oelschlegel, A., Hammerschmidt, B. & Groschup, M. H. (2007). Prions spread via the autonomic nervous system from the gut to the central nervous system in cattle incubating bovine spongiform encephalopathy. J Gen Virol 88, 1048-1055. (Pubitemid 46359577)
15. Jeffrey, M., Begara-McGorum, I., Clark, S., Martin, S., Clark, J., Chaplin, M. & Gonzalez, L. (2002). Occurrence and distribution of infection-specific PrP in tissues of clinical scrapie cases and cull sheep from scrapie-affected farms in Shetland. J Comp Pathol 127, 264-273. (Pubitemid 35373409)
16. Konold, T., Moore, S. J., Bellworthy, S. J. & Simmons, H. A. (2008). Evidence of scrapie transmission via milk. BMC Vet Res 4, 14.
17. Lacroux, C., Simon, S., Benestad, S. L., Maillet, S., Mathey, J., Lugan, S., Corbiere, F., Cassard, H., Costes, P. & other authors (2008). Prions in milk from ewes incubating natural scrapie. PLoS Pathog 4, e1000238.
18. Lasmezas, C. I., Cesbron, J. Y., Deslys, J. P., Demaimay, R., Adjou, K. T., Rioux, R., Lemaire, C., Locht, C. & Dormont, D. (1996). Immune system-dependent and -independent replication of the scrapie agent. J Virol 70, 1292-1295. (Pubitemid 26029059)
19. Ligios, C., Cancedda, M. G., Madau, L., Santucciu, C., Maestrale, C., Agrimi, U., Ru, G. & Di Guardo, G. (2006). PrPSc deposition in nervous tissues without lymphoid tissue involvement is frequently found in ARQ/ARQ Sarda breed sheep preclinically affected with natural scrapie. Arch Virol 151, 2007-2020. (Pubitemid 44440500)
20. Maignien, T., Lasmezas, C. I., Beringue, V., Dormont, D. & Deslys, J. P. (1999). Pathogenesis of the oral route of infection of mice with scrapie and bovine spongiform encephalopathy agents. J Gen Virol 80, 3035-3042. (Pubitemid 29504678)
21. Ryder, S. J., Dexter, G. E., Heasman, L., Warner, R. & Moore, S. J. (2009). Accumulation and dissemination of prion protein in experimental sheep scrapie in the natural host. BMC Vet Res 5, 9.
22. van Keulen, L. J., Schreuder, B. E., Vromans, M. E., Langeveld, J. P. & Smits, M. A. (1999). Scrapie-associated prion protein in the gastrointestinal tract of sheep with natural scrapie. J Comp Pathol 121, 55-63. (Pubitemid 29332701)
23. van Keulen, L. J., Schreuder, B. E., Vromans, M. E., Langeveld, J. P. & Smits, M. A. (2000). Pathogenesis of natural scrapie in sheep. Arch Virol Suppl 16, 57-71.
24. Vilotte, J. L., Soulier, S., Essalmani, R., Stinnakre, M. G., Vaiman, D., Lepourry, L., Da Silva, J. C., Besnard, N., Dawson, M. & other authors (2001). Markedly increased susceptibility to natural sheep scrapie of transgenic mice expressing ovine PrP. J Virol 75, 5977-5984.
25. Wells, G. A., Konold, T., Arnold, M. E., Austin, A. R., Hawkins, S. A., Stack, M., Simmons, M. M., Lee, Y. H., Gavier-Widen, D. & other authors (2007). Bovine spongiform encephalopathy: the effect of oral exposure dose on attack rate and incubation period in cattle. J Gen Virol 88, 1363-1373.