Scrapie-associated prion protein in the gastrointestinal tract of sheep with natural scrapie

Journal of Comparative Pathology

Volumn 121, Issue 1, 1999, Pages 55-63

  Van Keulen, L J M ^a   Schreuder, B E C ^a   Vromans, M E W ^a   Langeveld, J P M ^a   Smits, M A ^a  

^a WAGENINGEN UNIVERSITY   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

PRION PROTEIN;

ANIMAL TISSUE; ARTICLE; DISEASE PREDISPOSITION; DISEASE TRANSMISSION; GASTROINTESTINAL TRACT; INTESTINE INNERVATION; NONHUMAN; PATHOGENESIS; SCRAPIE; SHEEP;

ANIMALIA; OVIS ARIES;

EID: 0032789804     PISSN: 00219975     EISSN: None     Source Type: Journal    
DOI: 10.1053/jcpa.1998.0300     Document Type: Article

References (24)

1. Baldauf, E., Beekes, M. and Diringer, H. (1997). Evidence for an alternative direct route of access for the scrapie agent to the brain bypassing the spinal cord. Journal of General Virology, 78, 1187-1197.
2. Beekes, M., Baldauf, E. and Diringer, H. (1996). Sequential appearance and accumulation of pathognomonic markers in the central nervous system of hamsters orally infected with scrapie. Journal of General Virology, 77, 1925-1934.
3. Beekes, M., McBride, P. A. and Baldauf, E. (1998). Cerebral targeting indicates vagal spread of infection in hamsters fed with scrapie. Journal of General Virology, 79, 601-607.
4. Belt, P. B. G. M., Muileman, I. H., Schreuder, B. E. C., Bos-de Ruijter, J., Gielkens, A. L. J. and Smits, M. A. (1995). Identification of five allelic variants of the sheep PrP gene and their association with natural scrapie. Journal of General Virology, 76, 509-517.
5. Bueler, H., Aguzzi, A., Sailer, A., Greiner, R. A., Autenried, P., Aguet, M. and Weissmann, C. (1993). Mice devoid of PrP are resistant to scrapie. Cell, 73, 1339-1347.
6. sc. Proceedings of a Consultation on BSE, Brussels, 14-15 September 1993, pp. 301-311.
7. Farquhar, C. F., Somerville, R. A. and Ritchie, L. A. (1989). Post-mortem immunodiagnosis of scrapie and bovine spongiform encephalopathy. Journal of Virological Methods, 24, 215-222.
8. Foster, J. D., Wilson, M. and Hunter, N. (1996). Immunolocalisation of the prion protein (PrP) in the brains of sheep with scrapie. Veterinary Record, 139, 512-515.
9. Hadlow, W. J. (1991). To a better understanding of scrapie. Current Topics in Veterinary Medicine and Animal Science, (Sub-Acute Spongiform Encephalopathies, Proceedings of a Seminar, Brussels, 12-14 November 1990), 55, 117-130.
10. Hadlow, W. J., Kennedy, R. C. and Race, R. E. (1982). Natural infection of Suffolk sheep with scrapie virus. Journal of Infectious Diseases, 146, 657-664.
11. Ikegami, Y., Ito, M., Isomura, H., Momotani, E., Sasaki, K., Muramatsu, Y., Ishiguro, N. and Shinagawa, M. (1991). Pre-clinical and clinical diagnosis of scrapie by detection of PrP protein in tissues of sheep. Veterinary Record, 128, 271-275.
12. Katz, J. B., Pedersen, J. C., Jenny, A. L. and Taylor, W. D. (1992). Assessment of western immunoblotting for the confirmatory diagnosis of ovine scrapie and bovine spongiform encephalopathy (BSE). Journal of Veterinary Diagnostic Investigation, 4, 447-449.
13. Kimberlin, R.H. and Walker, C. A. (1989). Pathogenesis of scrapie in mice after intragastric infection. Virus Research, 12, 213-220.
14. McKinley, M. P., Bolton, D. C. and Prusiner, S. B. (1983). A protease-resistant protein is a structural component of the scrapie prion. Cell, 35, 57-62.
15. Meyer, R. K., McKinley, M. P., Bowman, K. A., Braunfeld, M. B., Barry, R. A. and Prusiner, S. B. (1986). Separation and properties of cellular and scrapie prion proteins. Proceedings of the National Academy of Sciences of the USA, 83, 2310-2314.
16. Miller, J. M., Jenny, A. L., Taylor, W. D., Marsh, R. F., Rubenstein, R., Race, R. E. and Detwiler, L. A. (1993). Immunohistochemical detection of prion protein in sheep with scrapie. Journal of Veterinary Diagnostic Investigation, 5, 309-316.
17. Miller, J. M., Jenny, A. L., Taylor, W. D., Race, R. E., Ernst, D. R., Katz, J. B. and Rubenstein, R. (1994). Detection of prion protein in formalin-fixed brain by hydrated autoclaving immunohistochemistry for the diagnosis of scrapie in sheep. Journal of Veterinary Diagnostic Investigation, 6, 366-368.
18. Mohri, S., Farquhar, C. F., Somerville, R. A., Jeffrey, M., Foster, J. and Hope, J. (1992). Immunodetection of a disease specific PrP fraction in scrapie-affected sheep and BSE-affected cattle. Veterinary Record, 131, 537-539.
19. Muramatsu, Y., Onodera, A. and Horiuchi, M. (1994). Detection of PrPsc in sheep at the preclinical stage of scrapie and its significance for the diagnosis of insidious infection. Archives of Virology, 134, 427-432.
20. Prusiner, S. B., Bolton, D. C., Groth, D. F., Bowman, K. A., Cochran, S. P. and McKinly, M. P. (1982). Further purification and characterization of scrapie prions. Biochemistry, 21, 6942-6950.
21. Somerville, R. A., Birkett, C. R., Farquhar, C. F., Hunter, N., Goldmann, W., Dornan, J., Grover, D., Hennion, R. M., Percy, C., Foster, J. and Jeffrey, M. (1997). Immunodetection of PrPSc in spleens of some scrapie-infected sheep but not BSE-infected cows. Journal of General Virology, 78, 2389-2396.
22. Somerville, R. A., Merz, P. A. and Carp, R. I. (1986). Partial copurification of scrapie-associated fibrils and scrapie infectivity. Intervirology, 25, 48-55.
23. van Keulen, L. J. M., Schreuder, B. E. C., Meloen, R. H., Mooij-Harkes, G., Poelenvan den Berg, M., Vromans, M. E. W. and Langeveld, J. (1995). Immunohistochemical detection and localization of prion protein in brain tissue of sheep with natural scrapie. Veterinary Pathology, 32, 299-308.
24. van Keulen, L. J., Schreuder, B. E., Meloen, R. H., Mooij Harkes, G., Vromans, M. E. and Langeveld, J. P. (1996). Immunohistochemical detection of prion protein in lymphoid tissues of sheep with natural scrapie. Journal of Clinical Microbiology, 34, 1228-1231.