Replication of the association of chromosomal region 9p21.3 with generalized aggressive periodontitis (gAgP) using an independent case-control cohort

BMC Medical Genetics

Volumn 11, Issue 1, 2010, Pages

  Ernst, Florian D ^a   Uhr, Katharina ^a,g   Teumer, Alexander ^a   Fanghänel, Jutta ^a   Schulz, Susanne ^b   Noack, Barbara ^c   Gonzales, Jose ^d   Reichert, Stefan ^b   Eickholz, Peter ^e   Holtfreter, Birte ^a   Meisel, Peter ^a   Linden, Gerard J ^f   Homuth, Georg ^a   Kocher, Thomas ^a  

^a UNIVERSITY OF GREIFSWALD   (Germany)

^b MARTIN LUTHER UNIVERSITY HALLE WITTENBERG   (Germany)

^c UNIVERSITY HOSPITAL CARL GUSTAV CARUS   (Germany)

^d JUSTUS LIEBIG UNIVERSITY   (Germany)

^e GOETHE UNIVERSITY   (Germany)

^f QUEEN'S UNIVERSITY BELFAST   (United Kingdom)

^g ERASMUS MEDICAL CENTER   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

ADOLESCENT; ADULT; AGGRESSIVE PERIODONTITIS; ARTICLE; CASE CONTROL STUDY; CHROMOSOME 9P; CHROMOSOME REPLICATION; COHORT ANALYSIS; CONTROLLED STUDY; DISEASE SEVERITY; FEMALE; GENETIC ASSOCIATION; GENETIC SUSCEPTIBILITY; GENOTYPE; HUMAN; MAJOR CLINICAL STUDY; MALE; SINGLE NUCLEOTIDE POLYMORPHISM; AGED; CAUCASIAN; CHROMOSOME 9; COMPARATIVE STUDY; CORONARY ARTERY DISEASE; GENE FREQUENCY; GENETIC PREDISPOSITION; GENETICS; MIDDLE AGED; POLYMERASE CHAIN REACTION; RISK FACTOR;

ADOLESCENT; ADULT; AGED; AGED, 80 AND OVER; AGGRESSIVE PERIODONTITIS; CASE-CONTROL STUDIES; CHROMOSOMES, HUMAN, PAIR 9; COHORT STUDIES; CORONARY ARTERY DISEASE; EUROPEAN CONTINENTAL ANCESTRY GROUP; FEMALE; GENE FREQUENCY; GENETIC PREDISPOSITION TO DISEASE; GENOME-WIDE ASSOCIATION STUDY; HUMANS; MALE; MIDDLE AGED; POLYMERASE CHAIN REACTION; POLYMORPHISM, SINGLE NUCLEOTIDE; RISK FACTORS; YOUNG ADULT;

EID: 77955292071     PISSN: None     EISSN: 14712350     Source Type: Journal    
DOI: 10.1186/1471-2350-11-119     Document Type: Article

References (26)

1. Pihlstrom BL, Michalowicz BS, Johnson NW. Periodontal diseases. Lancet 2005, 366(9499):1809-1820. 10.1016/S0140-6736(05)67728-8, 16298220.
2. Reich E, Hiller KA. Reasons for tooth extraction in the western states of Germany. Community dentistry and oral epidemiology 1993, 21(6):379-383. 10.1111/j.1600-0528.1993.tb01103.x, 8306617.
3. Meng H, Xu L, Li Q, Han J, Zhao Y. Determinants of host susceptibility in aggressive periodontitis. Periodontology 2000 2007, 43:133-159. 10.1111/j.1600-0757.2006.00204.x, 17214839.
4. Fiebig A, Jepsen S, Loos BG, Scholz C, Schafer C, Ruhling A, Nothnagel M, Eickholz P, van der Velden U, Schenck K, et al. Polymorphisms in the interleukin-1 (IL1) gene cluster are not associated with aggressive periodontitis in a large Caucasian population. Genomics 2008, 92(5):309-315. 10.1016/j.ygeno.2008.07.004, 18723088.
5. Lopez AD, Mathers CD, Ezzati M, Jamison DT, Murray CJ. Global and regional burden of disease and risk factors, 2001: systematic analysis of population health data. Lancet 2006, 367(9524):1747-1757. 10.1016/S0140-6736(06)68770-9, 16731270.
6. Marenberg ME, Risch N, Berkman LF, Floderus B, de Faire U. Genetic susceptibility to death from coronary heart disease in a study of twins. The New England journal of medicine 1994, 330(15):1041-1046. 10.1056/NEJM199404143301503, 8127331.
7. Bahekar AA, Singh S, Saha S, Molnar J, Arora R. The prevalence and incidence of coronary heart disease is significantly increased in periodontitis: a meta-analysis. American heart journal 2007, 154(5):830-837. 10.1016/j.ahj.2007.06.037, 17967586.
8. Persson GR, Persson RE. Cardiovascular disease and periodontitis: an update on the associations and risk. Journal of clinical periodontology 2008, 35(8 Suppl):362-379. 10.1111/j.1600-051X.2008.01281.x, 18724863.
9. Dave S, Batista EL, Van Dyke TE. Cardiovascular disease and periodontal diseases: commonality and causation. Compend Contin Educ Dent 2004, 25(7 Suppl 1):26-37.
10. Assuma R, Oates T, Cochran D, Amar S, Graves DT. IL-1 and TNF antagonists inhibit the inflammatory response and bone loss in experimental periodontitis. J Immunol 1998, 160(1):403-409.
11. Kaplan RC, Frishman WH. Systemic inflammation as a cardiovascular disease risk factor and as a potential target for drug therapy. Heart disease (Hagerstown, Md) 2001, 3(5):326-332. 10.1097/00132580-200109000-00009, 11975814.
12. McPherson R, Pertsemlidis A, Kavaslar N, Stewart A, Roberts R, Cox DR, Hinds DA, Pennacchio LA, Tybjaerg-Hansen A, Folsom AR, et al. A common allele on chromosome 9 associated with coronary heart disease. Science (New York, NY) 2007, 316(5830):1488-1491.
13. Helgadottir A, Thorleifsson G, Manolescu A, Gretarsdottir S, Blondal T, Jonasdottir A, Jonasdottir A, Sigurdsson A, Baker A, Palsson A. A common variant on chromosome 9p21 affects the risk of myocardial infarction. Science (New York, NY) 2007, 316(5830):1491-1493.
14. WTCCC Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls. Nature 2007, 447(7145):661-678. 10.1038/nature05911, 2719288, 17554300, WTCCC.
15. Samani NJ, Erdmann J, Hall AS, Hengstenberg C, Mangino M, Mayer B, Dixon RJ, Meitinger T, Braund P, Wichmann HE, et al. Genomewide association analysis of coronary artery disease. The New England journal of medicine 2007, 357(5):443-453. 10.1056/NEJMoa072366, 2719290, 17634449.
16. Schunkert H, Gotz A, Braund P, McGinnis R, Tregouet DA, Mangino M, Linsel-Nitschke P, Cambien F, Hengstenberg C, Stark K, et al. Repeated replication and a prospective meta-analysis of the association between chromosome 9p21.3 and coronary artery disease. Circulation 2008, 117(13):1675-1684. 10.1161/CIRCULATIONAHA.107.730614, 2689930, 18362232.
17. Schaefer AS, Richter GM, Groessner-Schreiber B, Noack B, Nothnagel M, El Mokhtari NE, Loos BG, Jepsen S, Schreiber S. Identification of a shared genetic susceptibility locus for coronary heart disease and periodontitis. PLoS genetics 2009, 5(2):e1000378. 10.1371/journal.pgen.1000378, 2632758, 19214202.
18. Loos BG, John RP, Laine ML. Identification of genetic risk factors for periodontitis and possible mechanisms of action. Journal of clinical periodontology 2005, 32(Suppl 6):159-179. 10.1111/j.1600-051X.2005.00806.x, 16128836.
19. John U, Greiner B, Hensel E, Ludemann J, Piek M, Sauer S, Adam C, Born G, Alte D, Greiser E. Study of Health In Pomerania (SHIP): a health examination survey in an east German region: objectives and design. Sozial-und Praventivmedizin 2001, 46(3):186-194. 10.1007/BF01324255, 11565448.
20. Hensel E, Gesch D, Biffar R, Bernhardt O, Kocher T, Splieth C, Born G, John U. Study of Health in Pomerania (SHIP): a health survey in an East German region. Objectives and design of the oral health section. Quintessence Int 2003, 34(5):370-378.
21. Yarnell JW. The PRIME study: classical risk factors do not explain the severalfold differences in risk of coronary heart disease between France and Northern Ireland. Prospective Epidemiological Study of Myocardial Infarction. Qjm 1998, 91(10):667-676. 10.1093/qjmed/91.10.667, 10024924.
22. Linden GJ, McClean K, Young I, Evans A, Kee F. Persistently raised C-reactive protein levels are associated with advanced periodontal disease. Journal of clinical periodontology 2008, 35(9):741-747. 10.1111/j.1600-051X.2008.01288.x, 18647204.
23. Purcell S, Neale B, Todd-Brown K, Thomas L, Ferreira MA, Bender D, Maller J, Sklar P, de Bakker PI, Daly MJ, et al. PLINK: a tool set for whole-genome association and population-based linkage analyses. American journal of human genetics 2007, 81(3):559-575. 10.1086/519795, 1950838, 17701901.
24. Barrett JC, Fry B, Maller J, Daly MJ. Haploview: analysis and visualization of LD and haplotype maps. Bioinformatics (Oxford, England) 2005, 21(2):263-265. 10.1093/bioinformatics/bth457, 15297300.
25. Jarinova O, Stewart AF, Roberts R, Wells G, Lau P, Naing T, Buerki C, McLean BW, Cook RC, Parker JS, et al. Functional analysis of the chromosome 9p21.3 coronary artery disease risk locus. Arteriosclerosis, thrombosis, and vascular biology 2009, 29(10):1671-1677. 10.1161/ATVBAHA.109.189522, 19592466.
26. Liu Y, Sanoff HK, Cho H, Burd CE, Torrice C, Mohlke KL, Ibrahim JG, Thomas NE, Sharpless NE. INK4/ARF transcript expression is associated with chromosome 9p21 variants linked to atherosclerosis. PloS one 2009, 4(4):e5027. 10.1371/journal.pone.0005027, 2660422, 19343170.