The human immunodeficiency virus type 1 Rev protein: Ménage à trois during the early phase of the lentiviral replication cycle

Journal of General Virology

Volumn 91, Issue 8, 2010, Pages 1893-1897

  Grewe, Bastian ^a   Überla, Klaus ^a  

^a RUHR UNIVERSITY BOCHUM   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

COMPLEMENTARY DNA; INTEGRASE; LENS EPITHELIUM DERIVED GROWTH FACTOR; PROTEIN P75; REV PROTEIN; PSIP1 PROTEIN, HUMAN; SIGNAL TRANSDUCING ADAPTOR PROTEIN; TRANSCRIPTION FACTOR;

GENOME; GENOTOXICITY; HOST CELL; HUMAN IMMUNODEFICIENCY VIRUS 1; MIXED INFECTION; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN FUNCTION; REVIEW; SUPERINFECTION; VIRUS DNA CELL DNA INTERACTION; VIRUS INHIBITION; VIRUS REPLICATION; DRUG ANTAGONISM; GENE EXPRESSION REGULATION; HUMAN; PHYSIOLOGY;

HUMAN IMMUNODEFICIENCY VIRUS; HUMAN IMMUNODEFICIENCY VIRUS 1;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; GENE EXPRESSION REGULATION, VIRAL; HIV-1; HUMANS; PROTEIN BINDING; REV GENE PRODUCTS, HUMAN IMMUNODEFICIENCY VIRUS; TRANSCRIPTION FACTORS; VIRUS INTEGRATION; VIRUS REPLICATION;

EID: 77955290826     PISSN: 00221317     EISSN: 14652099     Source Type: Journal    
DOI: 10.1099/vir.0.022509-0     Document Type: Review

References (30)

1. Blackard, J. T., Cohen, D. E. & Mayer, K. H. (2002). Human immunodeficiency virus superinfection and recombination: current state of knowledge and potential clinical consequences. Clin Infect Dis 34, 1108-1114.
2. Blissenbach, M., Grewe, B., Hoffmann, B., Brandt, S. & Überla, K. (2010). Nuclear RNA export and packaging functions of HIV-1 Rev revisited. J Virol 84, 6598-6604.
3. Bocharov, G., Ford, N. J., Edwards, J., Breinig, T., Wain-Hobson, S. & Meyerhans, A. (2005). A genetic-algorithm approach to simulating human immunodeficiency virus evolution reveals the strong impact of multiply infected cells and recombination. J Gen Virol 86, 3109-3118. (Pubitemid 41555577)
4. Brandt, S., Blissenbach, M., Grewe, B., Konietzny, R., Grunwald, T. & Überla, K. (2007). Rev proteins of human and simian immunodeficiency virus enhance RNA encapsidation. PLoS Pathog 3, e54. (Pubitemid 46683487)
5. Burke, D. S. (1997). Recombination in HIV: an important viral evolutionary strategy. Emerg Infect Dis 3, 253-259.
6. Butler, S. L., Hansen, M. S. & Bushman, F. D. (2001). A quantitative assay for HIV DNA integration in vivo. Nat Med 7, 631-634.
7. Engelman, A. & Cherepanov, P. (2008). The lentiviral integrase binding protein LEDGF/p75 and HIV-1 replication. PLoS Pathog 4, e1000046. (Pubitemid 351631084)
8. Fox, C. H., Tenner-Racz, K., Racz, P., Firpo, A., Pizzo, P. A. & Fauci, A. S. (1991). Lymphoid germinal centers are reservoirs of human immunodeficiency virus type 1 RNA. J Infect Dis 164, 1051-1057.
9. Freed, E. O. (2001). HIV-1 replication. Somat Cell Mol Genet 26, 13-33.
10. Gelderblom, H. C., Vatakis, D. N., Burke, S. A., Lawrie, S. D., Bristol, G. C. & Levy, D. N. (2008). Viral complementation allows HIV-1 replication without integration. Retrovirology 5, 60.
11. Gratton, S., Cheynier, R., Dumaurier, M. J., Oksenhendler, E. & Wain- Hobson, S. (2000). Highly restricted spread of HIV-1 and multiply infected cells within splenic germinal centers. Proc Natl Acad Sci U S A 97, 14566-14571. (Pubitemid 32016616)
12. Grewe, B. & Überla, K. (2010). Rev revisited: additional functions of the HIV-1 Rev protein. In Recent Advances in Human Retroviruses: Principles of Replication and Pathogenesis, chapter 14. Edited by A. M. L. Lever, K. T. Jeang & B. Berkhout. New Jersey, London, Singapore: World Scientific Publishing (in press).
13. Groom, H. C., Anderson, E. C. & Lever, A. M. (2009). Rev: beyond nuclear export. J Gen Virol 90, 1303-1318.
14. Hayouka, Z., Rosenbluh, J., Levin, A., Maes, M., Loyter, A. & Friedler, A. (2008). Peptides derived from HIV-1 Rev inhibit HIV-1 integrase in a shiftide mechanism. Biopolymers 90, 481-487.
15. Jolly, C. & Sattentau, Q. J. (2004). Retroviral spread by induction of virological synapses. Traffic 5, 643-650. (Pubitemid 39199128)
16. Jolly, C., Kashefi, K., Hollinshead, M. & Sattentau, Q. J. (2004). HIV-1 cell to cell transfer across an Env-induced, actin-dependent synapse. J Exp Med 199, 283-293. (Pubitemid 38129707)
17. Levesque, K., Finzi, A., Binette, J. & Cohen, E. A. (2004). Role of CD4 receptor down-regulation during HIV-1 infection. Curr HIV Res 2, 51-59. (Pubitemid 38854923)
18. Levin, A., Hayouka, Z., Brack-Werner, R., Volsky, D. J., Friedler, A. & Loyter, A. (2009a). Novel regulation of HIV-1 replication and pathogenicity: Rev inhibition of integration. Protein Eng Des Sel 22, 753-763.
19. Levin, A., Hayouka, Z., Helfer, M., Brack-Werner, R., Friedler, A. & Loyter, A. (2009b). Peptides derived from HIV-1 integrase that bind Rev stimulate viral genome integration. PLoS One 4, e4155.
20. Levin, A., Rosenbluh, J., Hayouka, Z., Friedler, A. & Loyter, A. (2010a). Integration of HIV-1 DNA is regulated by interplay between viral rev and cellular LEDGF/p75 proteins. Mol Med 16, 34-44.
21. Levin, A., Hayouka, Z., Friedler, A., Brack-Werner, R., Volsky, D. J. & Loyter, A. (2010b). A novel role for the viral Rev protein in promoting resistance to superinfection by human immunodeficiency virus type 1. J Gen Virol 91, 1503-1513.
22. Lindwasser, O. W., Chaudhuri, R. & Bonifacino, J. S. (2007). Mechanisms of CD4 downregulation by the Nef and Vpu proteins of primate immunodeficiency viruses. Curr Mol Med 7, 171-184. (Pubitemid 46488189)
23. Malim, M. H. & Emerman, M. (2008). HIV-1 accessory proteins - ensuring viral survival in a hostile environment. Cell Host Microbe 3, 388-398.
24. McDonald, D., Wu, L., Bohks, S. M., KewalRamani, V. N., Unutmaz, D. & Hope, T. J. (2003). Recruitment of HIV and its receptors to dendritic cell-T cell junctions. Science 300, 1295-1297. (Pubitemid 36618241)
25. Najera, R., Delgado, E., Perez-Alvarez, L. & Thomson, M. M. (2002). Genetic recombination and its role in the development of the HIV-1 pandemic. AIDS 16 (Suppl. 4), S3-S16. (Pubitemid 36278921)
26. Nekhai, S. & Jeang, K. T. (2006). Transcriptional and post-transcriptional regulation of HIV-1 gene expression: role of cellular factors for Tat and Rev. Future Microbiol 1, 417-426.
27. Nethe, M., Berkhout, B. & van der Kuyl, A. C. (2005). Retroviral superinfection resistance. Retrovirology 2, 52.
28. Rosenbluh, J., Hayouka, Z., Loya, S., Levin, A., Armon-Omer, A., Britan, E., Hizi, A., Kotler, M., Friedler, A. & other authors (2007). Interaction between HIV-1 Rev and integrase proteins: a basis for the development of anti-HIV peptides. J Biol Chem 282, 15743-15753.
29. Wagner, R., Matrosovich, M. & Klenk, H. D. (2002). Functional balance between haemagglutinin and neuraminidase in influenza virus infections. Rev Med Virol 12, 159-166. (Pubitemid 34516947)
30. Wu, Y. (2004). HIV-1 gene expression: lessons from provirus and non-integrated DNA. Retrovirology 1, 13.