Comparative effectiveness of medical interventions in adults versus children

Journal of Pediatrics

Volumn 157, Issue 2, 2010, Pages

  Contopoulos Ioannidis, Despina G ^a   Baltogianni, Maria S ^a,b   Ioannidis, John P A ^a,c,d,e  

^a UNIVERSITY OF IOANNINA   (Greece)

^b UNIVERSITY HOSPITAL OF IOANNINA   (Greece)

^c TUFTS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d INSTITUTE OF COMPUTER SCIENCE   (Greece)

^e HARVARD SCHOOL OF PUBLIC HEALTH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADULT; AGE DISTRIBUTION; ARTICLE; CHILD; CLINICAL TRIAL; COCHRANE LIBRARY; COMPARATIVE STUDY; HUMAN; INTERVENTION STUDY; META ANALYSIS; PRIORITY JOURNAL; RISK; SYSTEMATIC REVIEW; TREATMENT OUTCOME; AGE; COMPARATIVE EFFECTIVENESS; HEALTH SERVICE; METHODOLOGY; OUTCOME ASSESSMENT; RANDOMIZED CONTROLLED TRIAL; UTILIZATION REVIEW;

ADULT; AGE FACTORS; CHILD; COMPARATIVE EFFECTIVENESS RESEARCH; HEALTH SERVICES; HUMANS; INTERVENTION STUDIES; META-ANALYSIS AS TOPIC; ODDS RATIO; OUTCOME ASSESSMENT (HEALTH CARE); RANDOMIZED CONTROLLED TRIALS AS TOPIC; RESEARCH DESIGN; TREATMENT OUTCOME;

EID: 77955289685     PISSN: 00223476     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jpeds.2010.02.011     Document Type: Article

References (154)

1. P.P. Budetti Ensuring safe and effective medications for children JAMA 290 2003 950 951
2. R. Roberts, W. Rodriguez, D. Murphy, and T. Crescenzi Pediatric drug labeling: improving the safety and efficacy of pediatric therapies JAMA 290 2003 905 911
3. S. Conroy, I. Choonara, P. Impicciatore, A. Mohn, H. Arnell, and A. Rane Survey of unlicensed and off label drug use in paediatric wards in European countries. European Network for Drug Investigation in Children BMJ 320 2000 79 82
4. A. Ceci, M. Felisi, M. Catapano, P. Baiardi, L. Cipollina, and S. Ravera Medicines for children licensed by the European Agency for the Evaluation of Medicinal Products Eur J Clin Pharmacol 58 2002 495 500
5. C.P. Milne, and J.B. Bruss The economics of pediatric formulation development for off-patent drugs Clin Ther 30 2008 2133 2145
6. Specific requirements on content and format of labeling for human prescription drugs: revision of "pediatric use: subsection in the labeling, 59 Federal Register 64240 (1994).
7. C.A. Mullen, D. Petropoulos, W.M. Roberts, M. Rytting, T. Zipf, and K.W. Chan Outpatient treatment of fever and neutropenia for low risk pediatric cancer patients Cancer 86 1999 126 134
8. C. Macfadyen, C. Gamble, P. Garner, I. Macharia, I. Mackenzie, and P. Mugwe Topical quinolone vs antiseptic for treating chronic suppurative otitis media: a randomized controlled trial Trop Med Int Health 10 2005 190 197 (Pubitemid 40269170)
9. http://www.childrenshospital.org/.
10. R. DerSimonian, and N. Laird Meta-analysis in clinical trials Control Clin Trials 7 1986 177 188
11. J. Lau, J.P. Ioannidis, and C.H. Schmid Quantitative synthesis in systematic reviews Ann Intern Med 127 1997 820 826
12. J.P. Ioannidis, N.A. Patsopoulos, and E. Evangelou Uncertainty in heterogeneity estimates in meta-analyses BMJ 335 2007 914 916
13. J.A. Sterne, P. Jüni, K.F. Schulz, D.G. Altman, C. Bartlett, and M. Egger Statistical methods for assessing the influence of study characteristics on treatment effects in 'meta-epidemiological' research Stat Med 21 2002 1513 1524
14. J.P. Higgins, and S.G. Thompson Quantifying heterogeneity in a meta-analysis Stat Med 21 2002 1539 1558
15. M. Ni Chroinin, T.J. Lasserson, I. Greenstone, and F.M. Ducharme Addition of long-acting beta-agonists to inhaled corticosteroids for chronic asthma in children Cochrane Database Syst Rev 2009 3 (CD007949)
16. E.M. Molyneux, A.L. Walsh, H. Forsyth, M. Tembo, J. Mwenechanya, and K. Kayira Dexamethasone treatment in childhood bacterial meningitis in Malawi: a randomised controlled trial Lancet 360 2002 211 218
17. J. Mongelluzzo, Z. Mohamad, T.R. Ten Have, and S.S. Shah Corticosteroids and mortality in children with bacterial meningitis JAMA 299 2008 2048 2055
18. E. Cohen, E. Uleryk, M. Jasuja, and P.C. Parkin An absence of pediatric randomized controlled trials in general medical journals, 1985-2004 J Clin Epidemiol 60 2007 118 123
19. C. Martinez-Castaldi, M. Silverstein, and H. Bauchner Child versus adult research: the gap in high-quality study design Pediatrics 122 2008 52 57
20. G. Sinha EU law mandates drug testing in children J Natl Cancer Inst 100 2008 84 85
21. World Health Organization. Make medicines child size. 2007. Available at: www.who.int/childmedicines/en/.
22. I. Choonara Regulation of drugs for children in Europe BMJ 335 2007 1221 1222
23. D.K. Benjamin Jr., P.B. Smith, M.D. Murphy, R. Roberts, L. Mathis, and D. Avant Peer-reviewed publication of clinical trials completed for pediatric exclusivity JAMA 296 2006 1266 1273
24. C. Pandolfini, and M. Bonati A literature review on off-label drug use in children Eur J Pediatr 164 2005 552 558
25. I. Boots, R.N. Sukhai, R.H. Klein, R.A. Holl, J.M. Wit, and A.F. Cohen Stimulation programs for pediatric drug research: do children really benefit? Eur J Pediatr 166 2007 849 855
26. A.T. Bazzano, R. Mangione-Smith, M. Schonlau, M.J. Suttorp, and R.H. Brook Off-label prescribing to children in the United States outpatient setting Acad Pediatr 9 2009 81 88
27. C. Pandolfini, and M. Bonati European paediatric research and children's therapeutic needs: a trial review Acta Paediatr 97 2008 1232 1237
28. D.K. Benjamin Jr., P.B. Smith, P. Jadhav, J.V. Gobburu, M.D. Murphy, and V. Hasselblad Pediatric antihypertensive trial failures: analysis of end points and dose range Hypertension 51 2008 834 840
29. P.H. Caldwell, S.B. Murphy, P.N. Butow, and J.C. Craig Clinical trials in children Lancet 364 2004 803 811
30. Food and Drug Administration. Breakdown of requested studies report (as of March 31, 2009) at: www.fda.gov/Drugs/DevelopmentApprovalProcess/ DevelopmentResources/ucm050001.htm.
31. K. Cramer, N. Wiebe, V. Moyer, L. Hartling, K. Williams, and G. Swingler Children in reviews: methodological issues in child-relevant evidence syntheses BMC Pediatr 5 2005 38
32. W. Rodriguez, A. Selen, D. Avant, C. Chaurasia, T. Crescenzi, and G. Gieser Improving pediatric dosing through pediatric initiatives: what we have learned Pediatrics 121 2008 530 539
33. G.L. Kearns, S.M. Abdel-Rahman, S.W. Alander, D.L. Blowey, J.S. Leeder, and R.E. Kauffman Developmental pharmacology-drug disposition, action, and therapy in infants and children N Engl J Med 349 2003 1157 1167
34. R.E. Shaddy, M.M. Boucek, D.T. Hsu, R.J. Boucek, C.E. Canter, and L. Mahony Carvedilol for children and adolescents with heart failure: a randomized controlled trial JAMA 298 2007 1171 1179
35. O. Olsen, P. Middleton, J. Ezzo, P.C. Gøtzsche, V. Hadhazy, and A. Herxheimer Quality of Cochrane reviews: assessment of sample from 1998 BMJ 323 2001 829 832
36. P. Jüni, A. Witschi, R. Bloch, and M. Egger The hazards of scoring the quality of clinical trials for meta-analysis JAMA 282 1999 1054 1060
37. J.P. Ioannidis, and J. Lau Can quality of clinical trials and meta-analyses be quantified? Lancet 352 1998 590 591
38. J.P. Ioannidis, and J. Lau Completeness of safety reporting in randomized trials: an evaluation of 7 medical areas JAMA 285 2001 437 443
39. J.P. Ioannidis, S.J. Evans, P.C. Gøtzsche, R.T. O'Neill, D.G. Altman, and K. Schulz Better reporting of harms in randomized trials: an extension of the CONSORT statement Ann Intern Med 141 2004 781 788
40. J.P. Ioannidis Adverse events in randomized trials: neglected, restricted, distorted, and silenced Arch Intern Med 169 2009 1737 1739
41. P.N. Papanikolaou, and J.P. Ioannidis Availability of large-scale evidence on specific harms from systematic reviews of randomized trials Am J Med 117 2004 582 589
42. European Medicines Agency Evidence of harm from off-label or unlicensed medicines in children. European Medicines Agency preauthorisation evaluation of medicines for human use 2004 EMA London (EMEA /126327/2004)
43. B.L. Strom How the US drug safety system should be changed JAMA 295 2006 2072 2075
44. P.B. Fontanarosa, D. Rennie, and C.D. DeAngelis Postmarketing surveillance: lack of vigilance, lack of trust JAMA 292 2004 2647 2650
45. P.B. Smith, D.K. Benjamin Jr., M.D. Murphy, R. Johann-Liang, S. Iyasu, and B. Gould Safety monitoring of drugs receiving pediatric marketing exclusivity Pediatrics 122 2008 e628 e633
46. J.S. Li, E.L. Eisenstein, H.G. Grabowski, E.D. Reid, B. Mangum, and K.A. Schulman Economic return of clinical trials performed under the pediatric exclusivity program JAMA 297 2007 480 488
47. M.C. Sturkenboom, K.M. Verhamme, A. Nicolosi, M.L. Murray, A. Neubert, and D. Caudri Drug use in children: cohort study in three European countries BMJ 337 2008 a2245
48. T.P. Klassen, L. Hartling, J.C. Craig, and M. Offringa Children are not just small adults: the urgent need for high-quality trial evidence in children PLoS Med 5 2008 e172
49. C.B. Del Mar, P.P. Glasziou, and A.B. Spinks Antibiotics for sore throat Cochrane Database Syst Rev 2006 (4):CD000023. (ID1)
50. I. Roberts Barbiturates for acute traumatic brain injury Cochrane Database Syst Rev 2000 (2):CD000033. (ID2)
51. K. Wahlbeck, M. Cheine, and M.A. Essali Clozapine versus typical neuroleptic medication for schizophrenia Cochrane Database Syst Rev 2000 (2):CD000059. (ID3)
52. B.H. Rowe, C.H. Spooner, F.M. Ducharme, J.A. Bretzlaff, and G.W. Bota Corticosteroids for preventing relapse following acute exacerbations of asthma Cochrane Database Syst Rev 2001 (1):CD000195. (ID4)
53. P. Alderson, and I. Roberts Corticosteroids for acute traumatic brain injury Cochrane Database Syst Rev 2005 (1):CD000196. (ID5)
54. B. Arroll, and T. Kenealy Antibiotics for the common cold and acute purulent rhinitis Cochrane Database Syst Rev 2005 (3):CD000247. (ID6)
55. H.M. McIntosh, and P. Olliaro Artemisinin derivatives for treating uncomplicated malaria Cochrane Database Syst Rev 2000 (2):CD000256. (ID7)
56. A. Otley, and A.H. Steinhart Budesonide for induction of remission in Crohn's disease Cochrane Database Syst Rev 2005 (4):CD000296. (ID8)
57. M.T. Mellerup, K. Krogsgaard, P. Mathurin, C. Gluud, and T. Poynard Sequential combination of glucocorticosteroids and alfa interferon versus alfa interferon alone for HBeAg-positive chronic hepatitis B Cochrane Database Syst Rev 2005 (3):CD000345. (ID9)
58. C.J. Cates, T.O. Jefferson, A.I. Bara, and B.H. Rowe Vaccines for preventing influenza in people with asthma Cochrane Database Syst Rev 2004 (2):CD000364. (ID10)
59. H.M. McIntosh, and P. Olliaro Artemisinin derivatives for treating severe malaria Cochrane Database Syst Rev 2000 (2):CD000527. (ID11 and ID12)
60. P. Graves, J. Deeks, V. Demicheli, M. Pratt, and T. Jefferson Vaccines for preventing cholera Cochrane Database Syst Rev 2000 (4):CD000974. (ID13)
61. R.M. Douglas, H. Hemila, R. D'Souza, E.B. Chalker, and B. Treacy Vitamin C for preventing and treating the common cold Cochrane Database Syst Rev 2004 (4):CD000980. (ID14)
62. B.P. Markovitz, and A.G. Randolph Corticosteroids for the prevention and treatment of post-extubation stridor in neonates, children and adults Cochrane Database Syst Rev 2000 (2):CD001000. (ID15)
63. A.G. Marson, P.R. Williamson, J.L. Hutton, H.E. Clough, and D.W. Chadwick Carbamazepine versus valproate monotherapy for epilepsy Cochrane Database Syst Rev 2000 (3):CD001030. (ID16)
64. M.M. Alejandria, M.A. Lansang, L.F. Dans, and J.B. Mantaring Intravenous immunoglobulin for treating sepsis and septic shock Cochrane Database Syst Rev 2002 (1):CD001090. (ID17)
65. M. Patel, and C.K. Lee Polysaccharide vaccines for preventing serogroup A meningococcal meningitis Cochrane Database Syst Rev 2005 (1):CD001093. (ID18)
66. P. Morris, and A. Leach Antibiotics for persistent nasal discharge (rhinosinusitis) in children Cochrane Database Syst Rev 2002 (4):CD001094. (ID19 combined with CD000243)
67. J.W. Williams Jr., C. Aguilar, J. Cornell, E.D. Chiquette, M. Makela, and D.R. Holleman Antibiotics for acute maxillary sinusitis Cochrane Database Syst Rev 2003 (2):CD000243. (ID19 combined with CD001094)
68. S. Sirinavin, and P. Garner Antibiotics for treating salmonella gut infections Cochrane Database Syst Rev 2000 (2):CD001167. (ID20)
69. M.J. Abramson, R.M. Puy, and J.M. Weiner Allergen immunotherapy for asthma Cochrane Database Syst Rev 2003 (4):CD001186. (ID21)
70. P. Alderson, F. Bunn, C. Lefebvre, W.P. Li, L. Li, and I. Roberts Albumin Reviewers. Human albumin solution for resuscitation and volume expansion in critically ill patients Cochrane Database Syst Rev 2004 (4):CD001208. (ID22)
71. A. Sheikh, and B. Hurwitz Antibiotics versus placebo for acute bacterial conjunctivitis Cochrane Database Syst Rev 2006 (2):CD001211. (ID23)
72. V. Demicheli, D. Rivetti, J.J. Deeks, and T.O. Jefferson Vaccines for preventing influenza in healthy adults Cochrane Database Syst Rev 2004 (3):CD001269. (ID24 combined with CD004879)
73. S. Smith, V. Demicheli, C. Di Pietrantonj, A.R. Harnden, T. Jefferson, and N.J. Matheson Vaccines for preventing influenza in healthy children Cochrane Database Syst Rev 2006 (1):CD004879. (ID24 combined with CD001269)
74. F. Bunn, P. Alderson, and V. Hawkins Colloid solutions for fluid resuscitation Cochrane Database Syst Rev 2003 (1):CD001319. (ID25)
75. E.H. Walters, P.G. Gibson, T.J. Lasserson, and J.A. Walters Long-acting beta2-agonists for chronic asthma in adults and children where background therapy contains varied or no inhaled corticosteroid Cochrane Database Syst Rev 2007 (1):CD001385. (ID26)
76. A.G. Marson, Z.A. Kadir, J.L. Hutton, and D.W. Chadwick Gabapentin add-on for drug-resistant partial epilepsy Cochrane Database Syst Rev 2000 (3):CD001415. (ID27)
77. N.J. Jette, A.G. Marson, and J.L. Hutton Topiramate add-on for drug-resistant partial epilepsy Cochrane Database Syst Rev 2002 (3):CD001417. (ID28)
78. B.R. Andersen, F.L. Kallehave, and H.K. Andersen Antibiotics versus placebo for prevention of postoperative infection after appendicectomy Cochrane Database Syst Rev 2005 (3):CD001439. (ID29)
79. B.H. Rowe, J.A. Bretzlaff, C. Bourdon, G.W. Bota, and C.A. Camargo Jr. Magnesium sulfate for treating exacerbations of acute asthma in the emergency department Cochrane Database Syst Rev 2000 (2):CD001490. (ID30)
80. J. Smucny, L. Becker, and R. Glazier Beta2-agonists for acute bronchitis Cochrane Database Syst Rev 2006 (4):CD001726. (ID31)
81. I. Medeiros, and H. Saconato Antibiotic prophylaxis for mammalian bites Cochrane Database Syst Rev 2001 (2):CD001738. (ID32)
82. C. Tudur Smith, A.G. Marson, and P.R. Williamson Phenytoin versus valproate monotherapy for partial onset seizures and generalized onset tonic-clonic seizures Cochrane Database Syst Rev 2001 (4):CD001769. (ID33)
83. S. Gibbs, and I. Harvey Topical treatments for cutaneous warts Cochrane Database Syst Rev 2006 (3):CD001781. (ID34 and ID35)
84. D. Mabey, N. Fraser-Hurt, and C. Powell Antibiotics for trachoma Cochrane Database Syst Rev 2005 (2):CD001860. (ID36)
85. C. Tudur Smith, A.G. Marson, and P.R. Williamson Carbamazepine versus phenobarbitone monotherapy for epilepsy Cochrane Database Syst Rev 2003 (1):CD001904. (ID37)
86. S. Ramaratnam, A.G. Marson, and G.A. Baker Lamotrigine add-on for drug-resistant partial epilepsy Cochrane Database Syst Rev 2001 (3):CD001909. (ID38)
87. C. Tudur Smith, A.G. Marson, H.E. Clough, and P.R. Williamson Carbamazepine versus phenytoin monotherapy for epilepsy Cochrane Database Syst Rev 2002 (2):CD001911. (ID39)
88. R.A. Salinas, G. Alvarez, and J. Ferreira Corticosteroids for Bell's palsy (idiopathic facial paralysis) Cochrane Database Syst Rev 2004 (4):CD001942. (ID40)
89. R. Panpanich, P. Lerttrakarnnon, and M. Laopaiboon Azithromycin for acute lower respiratory tract infections Cochrane Database Syst Rev 2004 (4):CD001954. (ID41)
90. J.E. Clarkson, H.V. Worthington, and O.B. Eden Interventions for treating oral candidiasis for patients with cancer receiving treatment Cochrane Database Syst Rev 2004 (1):CD001972. (ID42)
91. S. Castillo, D.B. Schmidt, and S. White Oxcarbazepine add-on for drug-resistant partial epilepsy Cochrane Database Syst Rev 2000 (3):CD002028. (ID43)
92. F. Bunn, I. Roberts, R. Tasker, and E. Akpa Hypertonic versus near isotonic crystalloid for fluid resuscitation in critically ill patients Cochrane Database Syst Rev 2004 (3):CD002045. (ID44 and ID45)
93. L.M. Bjerre, T.J. Verheij, and M.M. Kochen Antibiotics for community acquired pneumonia in adult outpatients Cochrane Database Syst Rev 2004 (2):CD002109. (ID46 combined with CD004874)
94. S.K. Kabra, R. Lodha, and R.M. Pandey Antibiotics for community acquired pneumonia in children Cochrane Database Syst Rev 3 2006 CD004874. (ID46 combined with CD002109)
95. M. Meremikwu, and A.G. Marson Routine anticonvulsants for treating cerebral malaria Cochrane Database Syst Rev 2002 (2):CD002152. (ID47)
96. B.H. Rowe, C. Spooner, F.M. Ducharme, J.A. Bretzlaff, and G.W. Bota Early emergency department treatment of acute asthma with systemic corticosteroids Cochrane Database Syst Rev 2001 (1):CD002178. (ID48)
97. S. Taylor, C. Tudur Smith, P.R. Williamson, and A.G. Marson Phenobarbitone versus phenytoin monotherapy for partial onset seizures and generalized onset tonic-clonic seizures Cochrane Database Syst Rev 2001 (4):CD002217. (ID49)
98. J. Manyemba, and B.M. Mayosi Penicillin for secondary prevention of rheumatic fever Cochrane Database Syst Rev 2002 (3):CD002227. (ID50)
99. G. De Bruyn, S. Hahn, and A. Borwick Antibiotic treatment for travellers' diarrhoea Cochrane Database Syst Rev 2000 (3):CD002242. (ID51)
100. D. Annane, E. Bellissant, P.E. Bollaert, J. Briegel, D. Keh, and Y. Kupfer Corticosteroids for treating severe sepsis and septic shock Cochrane Database Syst Rev 2004 (1):CD002243. (ID52)
101. M.L. Edmonds, C.A. Camargo Jr., C.V. Pollack Jr., and B.H. Rowe Early use of inhaled corticosteroids in the emergency department treatment of acute asthma Cochrane Database Syst Rev 2003 (3):CD002308. (ID53)
102. D. Ng, F. Salvio, and G. Hicks Anti-leukotriene agents compared to inhaled corticosteroids in the management of recurrent and/or chronic asthma in adults and children Cochrane Database Syst Rev 2004 (2):CD002314. (ID54)
103. M.L. Edmonds, C.A. Camargo, L.D. Saunders, B.E. Brenner, and B.H. Rowe Inhaled steroids in acute asthma following emergency department discharge Cochrane Database Syst Rev 2000 (3):CD002316. (ID55)
104. J. Perry, J. Lee, and G. Wells Rocuronium versus succinylcholine for rapid sequence induction intubation Cochrane Database Syst Rev 2003 (1):CD002788. (ID56)
105. A. Travers, A.P. Jones, K. Kelly, S.J. Barker, C.A. Camargo, and B.H. Rowe Intravenous beta2-agonists for acute asthma in the emergency department Cochrane Database Syst Rev 2001 (2):CD002988. (ID57)
106. M. Paul, K. Soares-Weiser, S. Grozinsky, and L. Leibovici Beta-lactam versus betalactam-aminoglycoside combination therapy in cancer patients with neutropaenia Cochrane Database Syst Rev 2003 (3):CD003038. (ID58)
107. O.A. Clark, G. Lyman, A.A. Castro, L.G. Clark, and B. Djulbegovic Colony stimulating factors for chemotherapy induced febrile neutropenia Cochrane Database Syst Rev 2003 (3):CD003039. (ID59)
108. S.J. Allen, B. Okoko, E. Martinez, G. Gregorio, and L.F. Dans Probiotics for treating infectious diarrhoea Cochrane Database Syst Rev 2004 (2):CD003048. (ID60)
109. K. Grimwade, and G. Swingler Cotrimoxazole prophylaxis for opportunistic infections in adults with HIV Cochrane Database Syst Rev 2003 (3):CD003108. (ID61 combined with CD003508)
110. K. Grimwade, and G.H. Swingler Cotrimoxazole prophylaxis for opportunistic infections in children with HIV infection Cochrane Database Syst Rev 2006 (1):CD003508. (ID61 combined with CD003108)
111. F. Ducharme, Z. Schwartz, G. Hicks, and R. Kakuma Addition of anti-leukotriene agents to inhaled corticosteroids for chronic asthma Cochrane Database Syst Rev 2004 (2):CD003133. (ID62)
112. S. Koning, A.P. Verhagen, L.W. van Suijlekom-Smit, A. Morris, C.C. Butler, and J.C. van der Wouden Interventions for impetigo Cochrane Database Syst Rev 2004 (2):CD003261. (ID63 and ID64)
113. N. Adams, J. Bestall, and P.W. Jones Budesonide for chronic asthma in children and adults Cochrane Database Syst Rev 2001 (4):CD003274. (ID65)
114. A. Lesi, and M. Meremikwu High first dose quinine regimen for treating severe malaria Cochrane Database Syst Rev 2004 (3):CD003341. (ID66)
115. J. Bohlius, J. Wilson, J. Seidenfeld, M. Piper, G. Schwarzer, and J. Sandercock Erythropoietin or darbepoetin for patients with cancer Cochrane Database Syst Rev 3 2006 CD003407. (ID67)
116. R. Nelson Non surgical therapy for anal fissure Cochrane Database Syst Rev 2006 (4):CD003431. (ID68 and ID69)
117. J.C. Villar, J.A. Marin-Neto, S. Ebrahim, and S. Yusuf Trypanocidal drugs for chronic asymptomatic Trypanosoma cruzi infection Cochrane Database Syst Rev 2002 (1):CD003463. (ID70)
118. J.P. Guevara, F.M. Ducharme, R. Keren, S. Nihtianova, and J. Zorc Inhaled corticosteroids versus sodium cromoglycate in children and adults with asthma Cochrane Database Syst Rev 2006 (2):CD003558. (ID71)
119. S. Walker, M. Monteil, K. Phelan, T.J. Lasserson, and E.H. Walters Anti-IgE for chronic asthma in adults and children Cochrane Database Syst Rev 2006 (2):CD003559. (ID72)
120. M. Muller, A.G. Marson, and P.R. Williamson Oxcarbazepine versus phenytoin monotherapy for epilepsy Cochrane Database Syst Rev 2006 (2):CD003615. (ID73)
121. K. Prasad, K. Al-Roomi, P.R. Krishnan, and R. Sequeira Anticonvulsant therapy for status epilepticus Cochrane Database Syst Rev 2005 (4):CD003723. (ID74)
122. C. Murphy, S. Hahn, and J. Volmink Reduced osmolarity oral rehydration solution for treating cholera Cochrane Database Syst Rev 2004 (4):CD003754. (ID75)
123. J.E. Clarkson, H.V. Worthington, and O.B. Eden Interventions for preventing oral candidiasis for patients with cancer receiving treatment Cochrane Database Syst Rev 2007 (1):CD003807. (ID76 and ID77 and ID78)
124. R. Fernandez, R. Griffiths, and C. Ussia Water for wound cleansing Cochrane Database Syst Rev 2002 (4):CD003861 (ID79)
125. E.H. Walters, J.A. Walters, and P.W. Gibson Regular treatment with long acting beta agonists versus daily regular treatment with short acting beta agonists in adults and children with stable asthma Cochrane Database Syst Rev 2002 (4):CD003901. (ID80)
126. E.D. Pienaar, T. Young, and H. Holmes Interventions for the prevention and management of oropharyngeal candidiasis associated with HIV infection in adults and children Cochrane Database Syst Rev 3 2006 CD003940. (ID81)
127. J.A. Samuels, G.F. Strippoli, J.C. Craig, F.P. Schena, and D.A. Molony Immunosuppressive agents for treating IgA nephropathy Cochrane Database Syst Rev 2003 (4):CD003965. (ID82)
128. A. Hróbjartsson, and P.C. Gøtzsche Placebo interventions for all clinical conditions Cochrane Database Syst Rev 2004 (3):CD003974. (ID83)
129. L. Vidal, M. Paul, I. Ben-Dor, E. Pokroy, K. Soares-Weiser, and L. Leibovici Oral versus intravenous antibiotic treatment for febrile neutropenia in cancer patients Cochrane Database Syst Rev 2004 (4):CD003992. (ID84)
130. K. Macritchie, J.R. Geddes, J. Scott, D. Haslam, M. de Lima, and G. Goodwin Valproate for acute mood episodes in bipolar disorder Cochrane Database Syst Rev 2003 (1):CD004052. (ID85 and ID86)
131. J.B. Carlisle, and C.A. Stevenson Drugs for preventing postoperative nausea and vomiting Cochrane Database Syst Rev 3 2006 CD004125. (ID87, ID88, ID89, ID90, ID91, ID92, ID93, ID94, ID95, ID96, ID97, ID98, ID99, ID100, ID101, ID102, ID103, ID104, ID105, ID106, ID107, ID108, and ID109)
132. S.J. Stanworth, C. Hyde, N. Heddle, P. Rebulla, S. Brunskill, and M.F. Murphy Prophylactic platelet transfusion for haemorrhage after chemotherapy and stem cell transplantation Cochrane Database Syst Rev 2004 CD004269. (ID110)
133. L.N. Ranganathan, and S. Ramaratnam Vitamins for epilepsy Cochrane Database Syst Rev 2005 (2):CD004304. (ID111)
134. E.G. Berenstein, and Z. Ortiz Megestrol acetate for the treatment of anorexiacachexia syndrome Cochrane Database Syst Rev 2005 (2):CD004310. (ID112)
135. A. Gafter-Gvili, A. Fraser, M. Paul, M. van de Wetering, L. Kremer, and L. Leibovici Antibiotic prophylaxis for bacterial infections in afebrile neutropenic patients following chemotherapy Cochrane Database Syst Rev 2005 (4):CD004386. (ID113 and 114)
136. H. Bukirwa, P. Garner, and J. Critchley Chlorproguanil-dapsone for treating uncomplicated malaria Cochrane Database Syst Rev 2004 (4):CD004387. (ID115)
137. G.N. Galappaththy, A.A. Omari, and P. Tharyan Primaquine for preventing relapses in people with Plasmodium vivax malaria Cochrane Database Syst Rev 2007 (1):CD004389. (ID116)
138. D. van de Beek, J. de Gans, P. McIntyre, and K. Prasad Corticosteroids for acute bacterial meningitis Cochrane Database Syst Rev 2007 (1):CD004405. (ID117)
139. A. Osei-Akoto, L. Orton, and S.P. Owusu-Ofori Atovaquone-proguanil for treating uncomplicated malaria Cochrane Database Syst Rev 2005 (4):CD004529. (ID118)
140. D. Thaver, A.K. Zaidi, J. Critchley, S.A. Madni, and Z.A. Bhutta Fluoroquinolones for treating typhoid and paratyphoid fever (enteric fever) Cochrane Database Syst Rev 2005 (2):CD004530. (ID119)
141. C.A. Macfadyen, J.M. Acuin, and C. Gamble Topical antibiotics without steroids for chronically discharging ears with underlying eardrum perforations Cochrane Database Syst Rev 2005 (4):CD004618. (ID120 and ID121)
142. T. Wu, J. Zhang, Y. Qiu, L. Xie, and G.J. Liu Chinese medicinal herbs for the common cold Cochrane Database Syst Rev 2007 (1):CD004782. (ID122)
143. A. Fraser, A. Gafter-Gvili, M. Paul, and L. Leibovici Antibiotics for preventing meningococcal infections Cochrane Database Syst Rev 2006 (4):CD004785. (ID123)
144. I. Abubakar, S.H. Aliyu, C. Arumugam, P.R. Hunter, and N.K. Usman Prevention and treatment of cryptosporidiosis in immunocompromised patients Cochrane Database Syst Rev 2007 (1):CD004932. (ID124)
145. M.G. Lucero, V.E. Dulalia, R.N. Parreno, D.M. Lim-Quianzon, H. Nohynek, and H. Makela Pneumococcal conjugate vaccines for preventing vaccine-type invasive pneumococcal disease and pneumonia with consolidation on x-ray in children under two years of age Cochrane Database Syst Rev 2004 (4):CD004977 (ID125 combined with CD000422)
146. K. Dear, J. Holden, R. Andrews, and D. Tatham Vaccines for preventing pneumococcal infection in adults Cochrane Database Syst Rev 2003 (4):CD000422. (ID125 combined with CD004977)
147. E.C. van Dalen, H.J. van der Pal, H.N. Caron, and L.C. Kremer Different dosage schedules for reducing cardiotoxicity in cancer patients receiving anthracycline chemotherapy Cochrane Database Syst Rev 2006 (4):CD005008. (ID126)
148. O.S. Jesner, M. Aref-Adib, and E. Coren Risperidone for autism spectrum disorder Cochrane Database Syst Rev 2007 (1):CD005040. (ID127)
149. E.M. Haddad, V.C. McAlister, E. Renouf, R. Malthaner, M.S. Kjaer, and L.L. Gluud Cyclosporin versus tacrolimus for liver transplanted patients Cochrane Database Syst Rev 2006 (4):CD005161. (ID128)
150. B. Ratilal, J. Costa, and C. Sampaio Antibiotic prophylaxis for surgical introduction of intracranial ventricular shunts Cochrane Database Syst Rev 3 2006 CD005365. (ID129)
151. I.R. Greenstone, M.N. Ni Chroinin, V. Masse, A. Danish, H. Magdalinos, and X. Zhang Combination of inhaled long-acting beta2-agonists and inhaled steroids versus higher dose of inhaled steroids in children and adults with persistent asthma Cochrane Database Syst Rev 2005 (4):CD005533. (ID130)
152. M. Ni Chroinin, I.R. Greenstone, A. Danish, H. Magdolinos, V. Masse, and X. Zhang Long-acting beta2-agonists versus placebo in addition to inhaled corticosteroids in children and adults with chronic asthma Cochrane Database Syst Rev 2005 (4):CD005535. (ID131 and ID132)
153. A.A. Omari, C. Gamble, and P. Garner Artemether-lumefantrine (four-dose regimen) for treating uncomplicated falciparum malaria Cochrane Database Syst Rev 2006 (2):CD005965. (ID133)
154. P. Graves, and H. Gelband Vaccines for preventing malaria (pre-erythrocytic) Cochrane Database Syst Rev 2006 (4):CD006198. (ID134 and ID135)