In vitro and in vivo radiosensitization of colorectal cancer HT-29 cells by the smac mimetic JP-1201

Surgery

Volumn 148, Issue 2, 2010, Pages 346-353

  Huerta, Sergio ^a   Gao, Xiaohuan ^a   Livingston, Edward H ^a   Kapur, Payal ^a   Sun, Haizhou ^b   Anthony, Thomas ^a  

^a VETERANS AFFAIRS MEDICAL CENTER   (United States)

^b Joyant Pharmaceuticals   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CASPASE 8; DOUBLE STRANDED DNA; JP 1201 MIMETIC PROTEIN; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE 1; SECOND MITOCHONDRIAL ACTIVATOR OF CASPASE; UNCLASSIFIED DRUG; X LINKED INHIBITOR OF APOPTOSIS; DIABLO PROTEIN, HUMAN; MITOCHONDRIAL PROTEIN; RADIOSENSITIZING AGENT; SIGNAL PEPTIDE; XIAP PROTEIN, HUMAN;

ANIMAL CELL; ARTICLE; CANCER CELL; CANCER SURVIVAL; CELL STRAIN HT29; CLONOGENIC ASSAY; COLORECTAL CANCER; CONTROLLED STUDY; DNA REPAIR; IN VITRO STUDY; IN VIVO STUDY; IONIZING RADIATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN CLEAVAGE; RADIOSENSITIVITY; RADIOSENSITIZATION; SCID MOUSE; TUMOR GROWTH; WESTERN BLOTTING; XENOGRAFT; ADJUVANT THERAPY; ANIMAL; APOPTOSIS; COLORECTAL TUMOR; DOUBLE STRANDED DNA BREAK; DRUG EFFECT; DRUG POTENTIATION; DRUG SCREENING; HUMAN; METABOLISM; MOUSE MUTANT; PATHOLOGY; RADIATION EXPOSURE; TUMOR CELL LINE;

ANIMALS; APOPTOSIS; CELL LINE, TUMOR; COLORECTAL NEOPLASMS; DNA BREAKS, DOUBLE-STRANDED; DNA REPAIR; HUMANS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; MICE; MICE, SCID; MITOCHONDRIAL PROTEINS; NEOADJUVANT THERAPY; RADIATION-SENSITIZING AGENTS; TUMOR STEM CELL ASSAY; X-LINKED INHIBITOR OF APOPTOSIS PROTEIN; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 77955285722     PISSN: 00396060     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.surg.2010.05.006     Document Type: Article

References (14)

1. S. Huerta, J. Hrom, X. Gao, D. Saha, T. Anthony, and H. Reinhart Tissue microarray constructs to predict a response to chemoradiation in rectal cancer Dig Liver Dis 2010 Mar 12 [Epub ahead of print]
2. X. Gao, D. Saha, P. Kapur, T. Anthony, E.H. Livingston, and S. Huerta Radiosensitization of HT-29 cells and xenografts by the nitric oxide donor DETANONOate J Surg Oncol 100 2009 149 158
3. S. Huerta, X. Gao, and D. Saha Mechanisms of resistance to ionizing radiation in rectal cancer Expert Rev Mol Diagn 9 2009 469 480
4. C. Rödel, J. Haas, A. Groth, G.G. Grabenbauer, R. Sauer, and F. Rödel Spontaneous and radiation-induced apoptosis in colorectal carcinoma cells with different intrinsic radiosensitivities: survivin as a radioresistance factor Int J Radiat Oncol Biol Phys 55 2003 1341 1347
5. F. Rödel, J. Hoffmann, L. Distel, M. Herrmann, T. Noisternig, and T. Papadopoulos Survivin as a radioresistance factor, and prognostic and therapeutic target for radiotherapy in rectal cancer Cancer Res 65 2005 4881 4887
6. F. Rödel, B. Frey, W. Leitmann, G. Capalbo, C. Weiss, and C. Rödel Survivin antisense oligonucleotides effectively radiosensitize colorectal cancer cells in both tissue culture and murine xenograft models Int J Radiat Oncol Biol Phys 71 2008 247 255
7. S.M. Russo, J.E. Tepper, A.S. Baldwin Jr., R. Liu, J. Adams, and P. Elliott Enhancement of radiosensitivity by proteasome inhibition: implications for a role of NF-kappaB Int J Radiat Oncol Biol Phys 50 2001 183 193
8. S. Huerta, E.J. Goulet, S. Huerta-Yepez, and E.H. Livingston Screening and detection of apoptosis J Surg Res 139 2007 143 156
9. D.J. Chen, and S. Huerta Smac mimetics as new cancer therapeutics Anticancer Drugs 20 2009 646 658
10. D. Shibata, M.A. Peinado, Y. Ionov, S. Malkhosyan, and M. Perucho Genomic instability in repeated sequences is an early somatic event in colorectal tumorigenesis that persists after transformation Nat Genet 6 1994 273 281
11. S.L. Petersen, L. Wang, A. Yalcin-Chin, L. Li, M. Peyton, and J. Minna Autocrine TNFalpha signaling renders human cancer cells susceptible to Smac-mimetic-induced apoptosis Cancer Cell 12 2007 445 456
12. S. Huerta, B. Murray, and C. Olson Current evidence-based opinions in the management of adenocarcionoma of the rectum Indian J Surg 71 2009 356 362
13. L. Li, R.M. Thomas, H. Suzuki, J.K. De Brabander, X. Wang, and P.G. Harran A small molecule Smac mimic potentiates TRAIL- and TNFalpha-mediated cell death Science 305 2004 1471 1474
14. B.M. Ghadimi, M. Grade, M.J. Difilippantonio, S. Varma, R. Simon, and C. Montagna Effectiveness of gene expression profiling for response prediction of rectal adenocarcinomas to preoperative chemoradiotherapy J Clin Oncol 23 2005 1826 1838