Simulated microgravity promotes nitric oxide-supported angiogenesis via the iNOS-cGMP-PKG pathway in macrovascular endothelial cells

FEBS Letters

Volumn 584, Issue 15, 2010, Pages 3415-3423

  Siamwala, Jamila H ^a   Majumder, Syamantak ^a   Tamilarasan, K P ^a   Muley, Ajit ^a   Reddy, Seerapu H ^a   Kolluru, Gopi Krishna ^a   Sinha, Swaraj ^a   Chatterjee, Suvro ^a  

^a ANNA UNIVERSITY   (India)

Author keywords

Angiogenesis; Endothelial cell; INOS; Microgravity; Nitric oxide

Indexed keywords

CYCLIC GMP; CYCLIC GMP DEPENDENT PROTEIN KINASE; INDUCIBLE NITRIC OXIDE SYNTHASE; NITRIC OXIDE; SMALL INTERFERING RNA;

ANGIOGENESIS; ANIMAL CELL; ARTERY ENDOTHELIUM; ARTICLE; CELL ACTIVATION; CONTROLLED STUDY; COW; EMBRYO; ENDOTHELIUM CELL; HEART MUSCLE CELL; HUMAN; HUMAN CELL; MICROGRAVITY; MICROVASCULATURE; NONHUMAN; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; SIMULATION; SWINE; VASCULAR ENDOTHELIUM;

ANIMALS; CATTLE; CELL MOVEMENT; CELL PROLIFERATION; CHICKENS; CYCLIC GMP; CYCLIC GMP-DEPENDENT PROTEIN KINASES; ENDOTHELIAL CELLS; HUMANS; NEOVASCULARIZATION, PHYSIOLOGIC; NITRIC OXIDE; NITRIC OXIDE SYNTHASE TYPE II; NITRIC OXIDE SYNTHASE TYPE III; SIGNAL TRANSDUCTION; SUS SCROFA; WEIGHTLESSNESS; WEIGHTLESSNESS SIMULATION; WOUND HEALING;

EID: 77955276015     PISSN: 00145793     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.febslet.2010.06.039     Document Type: Article

References (18)

1. Unsworth B.R., Lelkes P.I. Growing tissues in microgravity. Nat. Med. 1998, 4:901-907.
2. Bursac N., Papadaki M., Cohen R.J., Schoen F.J., Eisenberg S.R., Carrier R., Vunjak-Novakovic G., Freed L.E. Cardiac muscle tissue engineering: towards an in vitro model for electrophysiological studies. Am. J. Physiol. 1999, 277:H433-H444.
3. Ingbe R.D. How cells (might) sense microgravity. FASEB 1999, 13:3-15.
4. Doolin E.J., Geldziler B., Strande L., Kain M., Hewitt C. Effects of microgravity on growing cultured skin constructs. Tissue Eng. 1999, 573-582.
5. Edgell C.J., McDonald C.C., Graham J.B. Permanent cell line expressing human factor VIII-related antigen established by hybridization. Proc. Natl Acad. Sci. USA 1983, 80:3734-3737.
6. Chung-Welch N., Shepro D., Dunham B., Hechtman H.B. Prostacyclin and prostaglandin E2 secretions by bovine pulmonary microvessel endothelial cells are altered by changes in culture conditions. J. Cell. Physiol. 1988, 135:224-234.
7. Kuruvilla L., Santhosh kumar T.R., Kartha C.C. Immortalization and characterization of porcine ventricular endocardial endothelial cells. Endothelium 2007, 14:35-43.
8. Siamwala J.H., Reddy S.H., Majumder S., Kolluru G.K., Muley A., Sinha S., Chatterjee S. Simulated microgravity perturbs actin polymerization to promote nitric oxide associated migration in human immortalized Eahy926 cells. Protoplasma 2010, 242:3-12.
9. Huijser, R. H. (2000) Desktop RPM: new small size microgravity simulator for the bioscience laboratory. FS-MG-0017, Fokker Space.
10. Ichigi J., Asashima M. Dome formation and tubule morphogenesis by Xenopus kidney A6 cell cultures exposed to microgravity simulated with a 3D-clinostat and to hypergravity. In Vitro Cell. Dev. Biol. Anim. 2002, 37:31-44.
11. Kolluru G.K., Sinha S., Majumder S., Muley A., Siamwala J.H., Gupta R., Chatterjee S. Shear stress promotes nitric oxide production in endothelial cells by sub-cellular delocalization of eNOS: a basis for shear stress mediated angiogenesis. Nitric Oxide 2010, 22:304-315.
12. Dutt K., Sanford G., Harris-Hooker S., Brako L., Kumar R., Sroufe A., Melhado S. Three-dimensional model of angiogenesis: coculture of human retinal cells with bovine aortic endothelial cells in the NASA bioreactor. Tissue Eng. 2003, 9:893-907.
13. Infanger M., Kossmehl P., Shakibaei M., Baatout S., Witzing A., Grosse J., Bauer J., Cogoli A., Faramarzi S., Derradji H., Neefs M., Paul M., Grimm D. Induction of three-dimensional assembly and increase in apoptosis of human endothelial cells by simulated microgravity: impact of vascular endothelial growth factor. Apoptosis 2006, 11:749-764.
14. Volodina A.V., Pozdnyakov O.M. Ultrastructure of skeletal muscle capillaries under conditions of space mission. Bull. Exp. Biol. Med. 2006, 141:755-759.
15. Carlsson S.I., Bertilaccio M.T., Ballabio E., Maier J.A. Endothelial stress by gravitational unloading: effects on cell growth and cytoskeletal organization. Biochim. Biophys. Acta 2003, 1642:173-179.
16. Geary G., Krause D., Purdy R., Duckles S. Simulated microgravity increases myogenic tone in rat cerebral arteries. J. Appl. Physiol. 1998, 85:1615-1621.
17. Cotrupi S., Ranzani D., Maier J.A. Impact of modeled microgravity on microvascular endothelial cells. Biochim. Biophys. Acta 2005, 1746:163-168.
18. Senthilkumar A., Smith R.D., Khitha J.N., Arora Veerareddy S., Langston W., Chidlow J.H., Barlow S.C., Teng X., Patel R.P., Lefer D.J., Kevil C.G. Sildenafil promotes ischemia-induced angiogenesis through a PKG-dependent pathway. Arterioscler. Thromb. Vasc. Biol. 2007, 27:1947-1954.