Somatic mutation in the ACK1 ubiquitin association domain enhances oncogenic signaling through EGFR regulation in renal cancer derived cells

Molecular Oncology

Volumn 4, Issue 4, 2010, Pages 323-334

  Chua, Boon Tin ^a   Lim, Shu Jing ^a   Tham, Su Chin ^a   Poh, Wei Jie ^a   Ullrich, Axel ^a,b  

^a INSTITUTE OF MOLECULAR AND CELL BIOLOGY   (Singapore)

^b MAX PLANCK INSTITUTE OF BIOCHEMISTRY   (Germany)

Author keywords

ACK1; EGFR; EMT; Gefitinib; Somatic mutation; Stability

Indexed keywords

EPIDERMAL GROWTH FACTOR RECEPTOR; GEFITINIB; VASCULOTROPIN;

ACK1 GENE; ANCHORAGE INDEPENDENT GROWTH; ARTICLE; CANCER CELL; CELL MIGRATION; CELL PROLIFERATION; CELL STRAIN MCF 7; CONTROLLED STUDY; EPITHELIAL MESENCHYMAL TRANSITION; GENE; GENE AMPLIFICATION; GENE SILENCING; HUMAN; HUMAN CELL; INTRACELLULAR SIGNALING; KIDNEY CARCINOMA; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DOMAIN; PROTEIN INTERACTION; PROTEIN STABILITY; SOMATIC MUTATION; UBIQUITINATION;

EID: 77955275936     PISSN: 15747891     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.molonc.2010.03.001     Document Type: Article

References (25)

1. Chan W., Tian R., Lee Y.F., Sit S.T., Lim L., Manser E. Down-regulation of active ACK1 is mediated by association with the E3 ubiquitin ligase Nedd4-2. J. Biol. Chem. 2009, 284:8185-8194.
2. Chuang M.J., Sun K.H., Tang S.J., Deng M.W., Wu Y.H., Sung J.S., Cha T.L., Sun G.H. Tumor-derived tumor necrosis factor-alpha promotes progression and epithelial-mesenchymal transition in renal cell carcinoma cells. Cancer Sci. 2008, 99:905-913.
3. Eisenmann K.M., McCarthy J.B., Simpson M.A., Keely P.J., Guan J.L., Tachibana K., Lim L., Manser E., Furcht L.T., Iida J. Melanoma chondroitin sulphate proteoglycan regulates cell spreading through Cdc42, Ack-1 and p130cas. Nat. Cell Biol. 1999, 1:507-513.
4. Grovdal L.M., Johannessen L.E., Rodland M.S., Madshus I.H., Stang E. Dysregulation of Ack1 inhibits down-regulation of the EGF receptor. Exp. Cell Res. 2008, 314:1292-1300.
5. van der Horst E.H., Degenhardt Y.Y., Strelow A., Slavin A., Chinn L., Orf J., Rong M., Li S., See L.H., Nguyen K.Q., Hoey T., Wesche H., Powers S. Metastatic properties and genomic amplification of the tyrosine kinase gene ACK1. Proc. Nat. Acad. Sci. U.S.A. 2005, 102:15901-15906.
6. Jemal A., Murray T., Samuels A., Ghafoor A., Ward E., Thun M.J. Cancer statistics, 2003. CA Cancer J. Clin. 2003, 53:5-26.
7. Kato J., Kaziro Y., Satoh T. Activation of the guanine nucleotide exchange factor Dbl following ACK1-dependent tyrosine phosphorylation. Biochem. Biophys. Res. Commun. 2000, 268:141-147.
8. Kato-Stankiewicz J., Ueda S., Kataoka T., Kaziro Y., Satoh T. Epidermal growth factor stimulation of the ACK1/Dbl pathway in a Cdc42 and Grb2-dependent manner. Biochem. Biophys. Res. Commun. 2001, 284:470-477.
9. Mahajan N.P., Whang Y.E., Mohler J.L., Earp H.S. Activated tyrosine kinase Ack1 promotes prostate tumorigenesis: role of Ack1 in polyubiquitination of tumor suppressor Wwox. Cancer Res. 2005, 65:10514-10523.
10. Mahajan N.P., Liu Y., Majumder S., Warren M.R., Parker C.E., Mohler J.L., Earp H.S., Whang Y.E. Activated Cdc42-associated kinase Ack1 promotes prostate cancer progression via androgen receptor tyrosine phosphorylation. Proc. Nat. Acad. Sci. U.S.A. 2007.
11. Manser E., Leung T., Salihuddin H., Tan L., Lim L. A non-receptor tyrosine kinase that inhibits the GTPase activity of p21cdc42. Nature 1993, 363:364-367.
12. Modzelewska K., Newman L.P., Desai R., Keely P.J. Ack1 mediates Cdc42-dependent cell migration and signaling to p130Cas. J. Biol. Chem. 2006, 281:37527-37535.
13. Nur E.K.A., Zhang A., Keenan S.M., Wang X.I., Seraj J., Satoh T., Meiners S., Welsh W.J. Requirement of activated Cdc42-associated kinase for survival of v-Ras-transformed mammalian cells. Mol. Cancer Res. 2005, 3:297-305.
14. Potti A., George D.J. Tyrosine kinase inhibitors in renal cell carcinoma. Clin. Cancer Res. 2004, 10:6371S-6376S.
15. Rosel D., Brabek J., Tolde O., Mierke C.T., Zitterbart D.P., Raupach C., Bicanova K., Kollmannsberger P., Pankova D., Vesely P., Folk P., Fabry B. Up-regulation of Rho/ROCK signaling in sarcoma cells drives invasion and increased generation of protrusive forces. Mol. Cancer Res. 2008, 6:1410-1420.
16. Ruhe J.E., Streit S., Hart S., Wong C.H., Specht K., Knyazev P., Knyazeva T., Tay L.S., Loo H.L., Foo P., Wong W., Pok S., Lim S.J., Ong H., Luo M., Ho H.K., Peng K., Lee T.C., Bezler M., Mann C., Gaertner S., Hoefler H., Iacobelli S., Peter S., Tay A., Brenner S., Venkatesh B., Ullrich A. Genetic alterations in the tyrosine kinase transcriptome of human cancer cell lines. Cancer Res. 2007, 67:11368-11376.
17. Sargent E.R., Gomella L.G., Belldegrun A., Linehan W.M., Kasid A. Epidermal growth factor receptor gene expression in normal human kidney and renal cell carcinoma. J. Urol. 1989, 142:1364-1368.
18. Sequeira L., Dubyk C.W., Riesenberger T.A., Cooper C.R., van Golen K.L. Rho GTPases in PC-3 prostate cancer cell morphology, invasion and tumor cell diapedesis. Clin. Exp. Metastasis 2008, 25:569-579.
19. Shen F., Lin Q., Gu Y., Childress C., Yang W. Activated Cdc42-associated kinase 1 is a component of EGF receptor signaling complex and regulates EGF receptor degradation. Mol. Biol. Cell 2007, 18:732-742.
20. Tang Y., Olufemi L., Wang M.T., Nie D. Role of Rho GTPases in breast cancer. Front. Biosci. 2008, 13:759-776.
21. Teo M., Tan L., Lim L., Manser E. The tyrosine kinase ACK1 associates with clathrin-coated vesicles through a binding motif shared by arrestin and other adaptors. J. Biol. Chem. 2001, 276:18392-18398.
22. Uhlman D.L., Nguyen P., Manivel J.C., Zhang G., Hagen K., Fraley E., Aeppli D., Niehans G.A. Epidermal growth factor receptor and transforming growth factor alpha expression in papillary and nonpapillary renal cell carcinoma: correlation with metastatic behavior and prognosis. Clin. Cancer Res. 1995, 1:913-920.
23. Vega F.M., Ridley A.J. Rho GTPases in cancer cell biology. FEBS Lett. 2008, 582:2093-2101.
24. Wang L., Zhu J.S., Song M.Q., Chen G.Q., Chen J.L. Comparison of gene expression profiles between primary tumor and metastatic lesions in gastric cancer patients using laser microdissection and cDNA microarray. World J. Gastroenterol. 2006, 12:6949-6954.
25. Zhang J., Yang P.L., Gray N.S. Targeting cancer with small molecule kinase inhibitors. Nat. Rev. Cancer 2009, 9:28-39.