The proliferative response to CpG-ODN stimulation predicts PFS, TTT and OS in patients with chronic lymphocytic leukemia

Leukemia Research

Volumn 34, Issue 9, 2010, Pages 1189-1194

  Tarnani, Michela ^a   Laurenti, Luca ^a   Longo, Pablo G ^b   Piccirillo, Nicola ^a   Gobessi, Stefania ^b   Mannocci, Alice ^a   Marietti, Sara ^a   Sica, Simona ^a   Leone, Giuseppe ^a   Efremov, Dimitar G ^b  

^a FONDAZIONE POLICLINICO UNIVERSITARIO A GEMELLI IRCCS   (Italy)

^b CNR   (Italy)

Author keywords

Biological prognostic factors; Chronic lymphocytic leukemia; CpG ODN stimulation

Indexed keywords

BREAKPOINT CLUSTER REGION PROTEIN; CD38 ANTIGEN; CPG OLIGODEOXYNUCLEOTIDE; CYCLIN A; IMMUNOGLOBULIN HEAVY CHAIN; PROTEIN KINASE ZAP 70;

ARTICLE; B LYMPHOCYTE; CELL CYCLE PROGRESSION; CELL CYCLE REGULATION; CELL PROLIFERATION; CHRONIC LYMPHATIC LEUKEMIA; CONTROLLED STUDY; CYTOGENETICS; FEMALE; GENE ACTIVATION; GENE EXPRESSION; GENE MUTATION; HUMAN; HUMAN CELL; KARYOTYPE; MAJOR CLINICAL STUDY; MALE; OVERALL SURVIVAL; PREDICTION; PRIORITY JOURNAL; PROGRESSION FREE SURVIVAL; PROTEIN ANALYSIS; SURVIVAL TIME; TIME;

EID: 77955275840     PISSN: 01452126     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.leukres.2009.12.020     Document Type: Article

References (34)

1. Rai K.R., Wasil T., Iqbal U., Driscoll N., Patel D., Janson D., et al. Clinical staging and prognostic markers in chronic lymphocytic leukemia. Hematol Oncol Clin North Am 2004, 18(4):795-805.
2. Rai K.R., Sawitsky A., Cronkite E.P., Chanana A.D., Levy R.N., Pasternack B.S. Clinical staging of chronic lymphocytic leukemia. Blood 1975, 46(2):219-234.
3. Binet J.L., Auquier A., Dighiero G., Chastang C., Piguet H., Goasguen J., et al. A new prognostic classification of chronic lymphocytic leukemia derived from a multivariate survival analysis. Cancer 1981, 48(1):198-206.
4. Damle R.N., Wasil T., Fais F., Ghiotto F., Valetto A., Allen S.L., et al. Ig V gene mutation status and CD38 expression as novel prognostic indicators in chronic lymphocytic leukemia. Blood 1999, 94(6):1840-1847.
5. Hamblin T.J., Davis Z., Gardiner A., Oscier D.G., Stevenson F.K. Unmutated Ig V(H) genes are associated with a more aggressive form of chronic lymphocytic leukemia. Blood 1999, 94(6):1848-1854.
6. Hamblin T.J., Orchard J.A., Gardiner A., Oscier D.G., Davis Z., Stevenson F.K. Immunoglobulin V genes and CD38 expression in CLL. Blood 2000, 95:2455-2457.
7. Ibrahim S., Keating M., Do K.A., O'Brien S., Huh Y.O., Jilani I., et al. CD38 expression as an important prognostic factor in B-cell chronic lymphocytic leukemia. Blood 2001, 98(1):181-186.
8. Del Poeta G., Maurillo L., Venditti A., Buccisano F., Epiceno A.M., Capelli G., et al. Clinical significance of CD38 expression in chronic lymphocytic leukemia. Blood 2001, 98(9):2633-2639.
9. Crespo M., Bosch F., Villamor N., Bellosillo B., Colomer D., Rozman M., et al. ZAP-70 expression as a surrogate for immunoglobulin-variable-region mutations in chronic lymphocytic leukemia. N Engl J Med 2003, 348:1764-1775.
10. Orchard J.A., Ibbotson R.E., Davis Z., Wiestner A., Rosenwald A., Thomas P.W., et al. ZAP-70 expression and prognosis in chronic lymphocytic leukaemia. Lancet 2004, 363:105-111.
11. Rassenti L.Z., Huynh L., Toy T.L., et al. ZAP-70 compared with immunoglobulin heavy-chain gene mutation status as a predictor of disease progression in chronic lymphocytic leukemia. N Engl J Med 2004, 351:893-901.
12. Juliusson G., Oscier D.G., Fitchett M., Ross F.M., Stockdill G., Mackie M.J., et al. Prognostic subgroups in B-cell chronic lymphocytic leukemia defined by specific chromosomal abnormalities. N Engl J Med 1990, 323(11):720-724.
13. Döhner H., Stilgenbauer S., Benner A., Leupolt E., Kröber A., Bullinger L., et al. Genomic aberrations and survival in chronic lymphocytic leukemia. N Engl J Med 2000, 343(26):1910-1916.
14. Lanham S., Hamblin T., Oscier D., Ibbotson R., Stevenson F., Packham G. Differential signaling via surface IgM is associated with VH gene mutational status and CD38 expression in chronic lymphocytic leukemia. Blood 2003, 101:1087-1093.
15. Chen L., Widhopf G., Huynh L., et al. Expression of ZAP-70 is associated with increased B-cell receptor signaling in chronic lymphocytic leukemia. Blood 2002, 100:4609-4614.
16. Chen L., Apgar J., Huynh L., et al. ZAP-70 directly enhances IgM signaling in chronic lymphocytic leukemia. Blood 2005, 105:2036-2041.
17. Ian Mockridge C., Potter K.N., Wheatley I., Neville L.A., Packham G., Stevenson F.K. Reversible anergy of sIgM-mediated signaling in the two subsets of CLL defined by VH-gene mutational status. Blood 2007, 109:4424-4431.
18. Allsup D.J., Kamiguti A.S., Lin K., Sherrington P.D., Matrai Z., Slupsky J.R., et al. B-cell receptor translocation to lipid rafts and associated signaling differ between prognostically important subgroups of chronic lymphocytic leukemia. Cancer Res 2005, 65:7328-7337.
19. Petlickovski A., Laurenti L., Li X., et al. Sustained signaling through the B-cell receptor induces Mcl-1 and promotes survival of chronic lymphocytic leukemia B-cells. Blood 2005, 105:4820-4827.
20. Deglesne P.A., Chevallier N., Letestu R., et al. Survival response to B-cell receptor ligation is restricted to progressive chronic lymphocytic leukemia cells irrespective of Zap70 expression. Cancer Res 2006, 66:7158-7166.
21. Messmer B.T., Messmer D., Allen S.L., Kolitz J.E., Kudalkar P., Cesar D., et al. In vivo measurements document the dynamic cellular kinetics of chronic lymphocytic leukemia B cells. J Clin Invest 2005, 115:755-764.
22. Chiorazzi N. Cell proliferation and death: forgotten features of chronic lymphocytic leukemia B cells. Best Pract Res Clin Haematol 2007, 20:399-413.
23. Longo P.G., Laurenti L., Gobessi S., Petlickovski A., Pelosi M., Chiusolo P., et al. The Akt signaling pathway determines the different proliferative capacity of chronic lymphocytic leukemia B-cells from patients with progressive and stable disease. Leukemia 2007, 21(1):110-120.
24. Jahrsdörfer B., Wooldridge J.E., Blackwell S.E., Taylor C.M., Griffith T.S., Link B.K., et al. Immunostimulatory oligodeoxynucleotides induce apoptosis of B cell chronic lymphocytic leukemia cells. J Leukoc Biol 2005, 77:378-387.
25. Jahrsdorfer B., Blackwell S., Weiner G. The effects of CpG ODN on CLL proliferation, apoptosis or phenotype could have an impact on its clinical utility. Leukemia 2007, 21:2354-2355.
26. Laurenti L., Petlickovski A., Rumi C., Gobessi S., Piccioni P., Tarnani M., et al. Comparison of ZAP-70/Syk mRNA levels with immunoglobulin heavy-chain gene mutation status and disease progression in chronic lymphocytic leukemia. Haematologica 2005, 90:1533-1540.
27. Guarini A., Chiaretti S., Tavolaro S., Maggio R., Peragine N., Citarella F., et al. BCR ligation induced by IgM stimulation results in gene expression and functional changes only in IgV H unmutated chronic lymphocytic leukemia (CLL) cells. Blood 2008, 112:782-792.
28. Vlad A., Deglesne P.A., Letestu R., Saint-Georges S., Chevallier N., Baran-Marszak F., et al. Down-regulation of CXCR4 and CD62L in chronic lymphocytic leukemia cells is triggered by B-cell receptor ligation and associated with progressive disease. Cancer Res 2009, 69:6387-6395.
29. Hammond C.M., Shi Y., White D., Cervi D., Tomic J., Spaner D.E. The B-cell calcium sensor predicts progression of chronic lymphocytic leukemia. Leukemia 2009, 23:426-429.
30. Plander M., Seegers S., Ugocsai P., Diermeier-Daucher S., Iványi J., Schmitz G., et al. Different proliferative and survival capacity of CLL-cells in a newly established in vitro model for pseudofollicles. Leukemia 2009, 23:2118-2128.
31. Stevenson F.K., Caligaris-Cappio F. Chronic lymphocytic leukemia: revelations from the B-cell receptor. Blood 2004, 103:4389-4395.
32. Efremov D.G., Gobessi S., Longo P.G. Signaling pathways activated by antigen-receptor engagement in chronic lymphocytic leukemia B-cells. Autoimmun Rev 2007, 7:102-108.
33. Muzio M., Apollonio B., Scielzo C., Frenquelli M., Vandoni I., Boussiotis V., et al. Constitutive activation of distinct BCR-signaling pathways in a subset of CLL patients: a molecular signature of anergy. Blood 2008, 112:188-195.
34. O'Neill L.A. When signaling pathways collide: positive and negative regulation of toll-like receptor signal transduction. Immunity 2008, 29:12-20.