Molecular cytogenetic characterization of stem-like cancer cells isolated from established cell lines

Cancer Letters

Volumn 296, Issue 2, 2010, Pages 206-215

  Gasparini, Patrizia ^a   Bertolini, Giulia ^a   Binda, Mara ^a   Magnifico, Alessandra ^a   Albano, Luisa ^a   Tortoreto, Monica ^a   Pratesi, Graziella ^a   Facchinetti, Federica ^a   Abolafio, Gabriella ^a   Roz, Luca ^a   Tagliabue, Elda ^a   Daidone, Maria Grazia ^a   Sozzi, Gabriella ^a  

^a NATIONAL CANCER INSTITUTE   (Italy)

Author keywords

Cancer stem cells; Cell lines; Chromosomal rearrangements; FISH; SKY

Indexed keywords

ALDEHYDE DEHYDROGENASE; BREAST CANCER RESISTANCE PROTEIN; CD133 ANTIGEN; CD24 ANTIGEN; HERMES ANTIGEN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CANCER CELL CULTURE; CANCER STEM CELL; CELL DIFFERENTIATION; CELL ISOLATION; CELL SUBPOPULATION; CHROMOSOME ANALYSIS; CONTROLLED STUDY; CYTOGENETICS; FLOW CYTOMETRY; FLUORESCENCE IN SITU HYBRIDIZATION; GENE EXPRESSION; GENETIC ANALYSIS; GENETIC STABILITY; HUMAN; HUMAN CELL; IN VIVO STUDY; KARYOTYPING; METAPHASE; MOUSE; NONHUMAN; PRIORITY JOURNAL; SOLID TUMOR;

ANTIGENS, CD; CELL ADHESION; CELL CULTURE TECHNIQUES; CELL DIFFERENTIATION; CELL DIVISION; CELL LINE, TUMOR; CHROMOSOME ABERRATIONS; FLOW CYTOMETRY; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; IN SITU HYBRIDIZATION, FLUORESCENCE; KARYOTYPING; NEOPLASMS; STEM CELLS; TUMOR MARKERS, BIOLOGICAL;

EID: 77955274185     PISSN: 03043835     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.canlet.2010.04.009     Document Type: Article

References (34)

1. Clarke M.F., Dick J.E., Dirks P.B., Eaves C.J., Jamieson C.H., Jones D.L., Visvader J., Weissman I.L., Wahl G.M. Cancer stem cells - perspectives on current status and future directions: AACR Workshop on cancer stem cells. Cancer Res. 2006, 66:9339-9344.
2. Tan B.T., Park C.Y., Ailles L.E., Weissman I.L. The cancer stem cell hypothesis: a work in progress. Lab Invest. 2006, 86:1203-1207.
3. Setoguchi T., Taga T., Kondo T. Cancer stem cells persist in many cancer cell lines. Cell Cycle 2004, 3:414-415.
4. Adams J.M., Strasser A. Is tumor growth sustained by rare cancer stem cells or dominant clones?. Cancer Res. 2008, 68:4018-4021.
5. Wicha M.S., Liu S., Dontu G. Cancer stem cells: an old idea - a paradigm shift. Cancer Res. 2006, 66:1883-1890.
6. Reya T., Morrison S.J., Clarke M.F., Weissman I.L. Stem cells, cancer, and cancer stem cells. Nature 2001, 414:105-111.
7. Bonnet D., Dick J.E. Human acute myeloid leukemia is organized as a hierarchy that originates from a primitive hematopoietic cell. Nat. Med. 1997, 3:730-737.
8. Hill R.P., Perris R. " Destemming" cancer stem cells. J. Natl. Cancer Inst. 2007, 99:1435-1440.
9. Dontu G., Al Hajj M., Abdallah W.M., Clarke M.F., Wicha M.S. Stem cells in normal breast development and breast cancer. Cell Proliferat. 2003, 36(Suppl. 1):59-72.
10. Al Hajj M., Wicha M.S., Benito-Hernandez A., Morrison S.J., Clarke M.F. Prospective identification of tumorigenic breast cancer cells. Proc. Natl. Acad. Sci. USA 2003, 100:3983-3988.
11. Ponti D., Costa A., Zaffaroni N., Pratesi G., Petrangiolini G., Coradini D., Pilotti S., Pierotti M.A., Daidone M.G. Isolation and in vitro propagation of tumorigenic breast cancer cells with stem/progenitor cell properties. Cancer Res. 2005, 65:5506-5511.
12. Hemmati H.D., Nakano I., Lazareff J.A., Masterman-Smith M., Geschwind D.H., Bronner-Fraser M., Kornblum H.I. Cancerous stem cells can arise from pediatric brain tumors. Proc. Natl. Acad. Sci. USA 2003, 100:15178-15183.
13. Singh SK., Clarke ID., Terasaki M., Bonn VE., Hawkins C., Squire J., Dirks PB. Identification of a cancer stem cell in human brain tumors. Cancer Res. 2003, 63:5821-5828.
14. Galli R., Binda E., Orfanelli U., Cipelletti B., Gritti A., De Vitis S., Fiocco R., Foroni C., Dimeco F., Vescovi A. Isolation and characterization of tumorigenic, stem-like neural precursors from human glioblastoma. Cancer Res. 2004, 64:7011-7021.
15. Fang D., Nguyen T.K., Leishear K., Finko R., Kulp A.N., Hotz S., Van Belle P.A., Xu X., Elder D.E., Herlyn M. A tumorigenic subpopulation with stem cell properties in melanomas. Cancer Res. 2005, 65:9328-9337.
16. Bapat S.A., Mali A.M., Koppikar C.B., Kurrey N.K. Stem and progenitor-like cells contribute to the aggressive behavior of human epithelial ovarian cancer. Cancer Res. 2005, 65:3025-3029.
17. Collins A.T., Berry P.A., Hyde C., Stower M.J., Maitland N.J. Prospective identification of tumorigenic prostate cancer stem cells. Cancer Res. 2005, 65:10946-10951.
18. Ricci-Vitiani L., Lombardi D.G., Pilozzi E., Biffoni M., Todaro M., Peschle C., De Maria R. Identification and expansion of human colon-cancer-initiating cells. Nature 2007, 445:111-115.
19. O'Brien C.A., Pollett A., Gallinger S., Dick J.E. A human colon cancer cell capable of initiating tumour growth in immunodeficient mice. Nature 2007, 445:106-110.
20. Eramo A., Lotti F., Sette G., Pilozzi E., Biffoni M., Di Virgilio A., Conticello C., Ruco L., Peschle C., De Maria R. Identification and expansion of the tumorigenic lung cancer stem cell population. Cell Death Differ. 2008, 15:504-514.
21. Lee J., Kotliarova S., Kotliarov Y., Li A., Su Q., Donin N.M., Pastorino S., Purow B.W., Christopher N., Zhang W., Park J.K., Fine H.A. Tumor stem cells derived from glioblastomas cultured in bFGF and EGF more closely mirror the phenotype and genotype of primary tumors than do serum-cultured cell lines. Cancer Cell 2006, 9:391-403.
22. Kondo T., Setoguchi T., Taga T. Persistence of a small subpopulation of cancer stem-like cells in the C6 glioma cell line. Proc. Natl. Acad. Sci. USA 2004, 101:781-786.
23. Patrawala L., Calhoun T., Schneider-Broussard R., Zhou J., Claypool K., Tang D.G. Side population is enriched in tumorigenic, stem-like cancer cells, whereas ABCG2+ and A. Cancer Res. 2005, 65:6207-6219.
24. Magnifico A., Albano L., Campaner S., Delia D., Castiglioni F., Gasparini P., Sozzi G., Fontanella E., Menard S., Tagliabue E. Tumor-initiating cells of HER2-positive carcinoma cell lines express the highest oncoprotein levels and are sensitive to trastuzumab. Clin. Cancer Res. 2009, 15:2010-2021.
25. Bertolini G., Roz L., Perego P., Tortoreto M., Fontanella E., Gatti L., Pratesi G., Fabbri A., Andriani F., Tinelli S., Roz E., Caserini R., Lo V.S., Camerini T., Mariani L., Delia D., Calabro E., Pastorino U., Sozzi G. Highly tumorigenic lung cancer CD133+ cells display stem-like features and are spared by cisplatin treatment. Proc. Natl. Acad. Sci. USA 2009, 106:16281-16286.
26. Levina V., Marrangoni A.M., DeMarco R., Gorelik E., Lokshin A.E. Drug-selected human lung cancer stem cells: cytokine network, tumorigenic and metastatic properties. PLoS ONE 2008, 3:e3077.
27. Phillips T.M., McBride W.H., Pajonk F. The response of CD24(-/low)/CD44+ breast cancer-initiating cells to radiation. J. Natl. Cancer Inst. 2006, 98:1777-1785.
28. Bao S., Wu Q., McLendon R.E., Hao Y., Shi Q., Hjelmeland A.B., Dewhirst M.W., Bigner D.D., Rich J.N. Glioma stem cells promote radioresistance by preferential activation of the DNA damage response. Nature 2006, 444:756-760.
29. Schrock E., Veldman T., Padilla-Nash H., Ning Y., Spurbeck J., Jalal S., Shaffer L.G., Papenhausen P., Kozma C., Phelan M.C., Kjeldsen E., Schonberg S.A., O'Brien P., Biesecker L., du M.S., Ried T. Spectral karyotyping refines cytogenetic diagnostics of constitutional chromosomal abnormalities. Human Genet. 1997, 101:255-262.
30. Lualdi E., Modena P., Debiec-Rychter M., Pedeutour F., Teixeira M.R., Facchinetti F., Dagrada G.P., Pilotti S., Sozzi G. Molecular cytogenetic characterization of proximal-type epithelioid sarcoma. Genes Chromosomes Cancer 2004, 41:283-290.
31. Pece S., Tosoni D., Confalonieri S., Mazzarol G., Vecchi M., Ronzoni S., Bernard L., Viale G., Pelicci P.G., Di Fiore P.P. Biological and molecular heterogeneity of breast cancers correlates with their cancer stem cell content. Cell 2010, 140:62-73.
32. Mulholland D.J., Xin L., Morim A., Lawson D., Witte O., Wu H. Lin-Sca-1+CD49fhigh stem/progenitors are tumor-initiating cells in the Pten-null prostate cancer model. Cancer Res. 2009, 69:8555-8562.
33. Dalton W.S., Cress A.E., Alberts D.S., Trent J.M. Cytogenetic and phenotypic analysis of a human colon carcinoma cell line resistant to mitoxantrone. Cancer Res. 1988, 48:1882-1888.
34. Piccirillo S.G., Combi R., Cajola L., Patrizi A., Redaelli S., Bentivegna A., Baronchelli S., Maira G., Pollo B., Mangiola A., Dimeco F., Dalpra L., Vescovi A.L. Distinct pools of cancer stem-like cells coexist within human glioblastomas and display different tumorigenicity and independent genomic evolution. Oncogene 2009, 28:1807-1811.