Immunohistochemical evaluation of macrophage activity and its relationship with apoptotic cell death in the polar forms of leprosy

Microbial Pathogenesis

Volumn 49, Issue 4, 2010, Pages 135-140

  Quaresma, Juarez Antônio Simões ^a,b   de Oliveira Lima, Luiz Wagner ^a   Fuzii, Hellen Thais ^a   Libonati, Rosana Maria Feio ^a   Pagliari, Carla ^c   Duarte, Maria Irma Seixas ^c  

^a FEDERAL UNIVERSITY OF PARÁ   (Brazil)

^b Universidade Estadual do Para   (Brazil)

^c UNIVERSITY OF SÃO PAULO   (Brazil)

Author keywords

Apoptosis; Immunopathology; Leprosy; Macrophage

Indexed keywords

CASPASE; CASPASE 3; CD68 ANTIGEN; INDUCIBLE NITRIC OXIDE SYNTHASE; LYSOZYME; TRANSFORMING GROWTH FACTOR BETA;

APOPTOSIS; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; IMMUNOPATHOGENESIS; LEPROSY; MACROPHAGE; MYCOBACTERIUM LEPRAE; PRIORITY JOURNAL; SKIN BIOPSY; SKIN DEFECT; TUBERCULOID LEPROSY;

ANTIGENS, CD; ANTIGENS, DIFFERENTIATION, MYELOMONOCYTIC; APOPTOSIS; BIOPSY; CASPASE 3; HUMANS; IMMUNOHISTOCHEMISTRY; LEPROSY; MACROPHAGES; MICROSCOPY; MURAMIDASE; NITRIC OXIDE SYNTHASE TYPE II; SKIN;

EID: 77955274111     PISSN: 08824010     EISSN: 10961208     Source Type: Journal    
DOI: 10.1016/j.micpath.2010.05.003     Document Type: Article

References (22)

1. Solary E., Dubrez L., Eymin B. The role of apoptosis in the pathogenesis and treatment of diseases. Eur Respir J 1996, 9:1293-1305.
2. Cree I.A., Gardiner C.A., Beck J.S., Mehta J. Studies of cell death (apoptosis) and cell division in leprosy granulomas. Int J Lepr Other Mycobact Dis 1986, 54:607-613.
3. Cree I.A., Nurbhai S., Milne G., Beck J.S. Cell death in granulomata: the role of apoptosis. J Clin Pathol 1987, 40:1314-1319.
4. Walsh D.S., Lane J.E., Abalos R.M., Myint K.S. TUNEL and limited immunophenotypic analyses of apoptosis in paucibacillary and multibacillary leprosy lesions. FEMS Immunol Med Microbiol 2004, 4:265-269.
5. Hernandez M.O., Neves I., Sales J.S., Carvalho D.S., Sarno E.N., Sampaio E.P. Induction of apoptosis in monocytes by Mycobacterium leprae in vitro: a possible role for tumor necrosis factor-alpha. Immunology 2003, 109:156-164.
6. Rambukkana A., Zanazzi G., Tapinos N., Salzer J.L. Contact-dependent demyelination by Mycobacterium leprae in the absence of immune cells. Science 2002, 296:927-931.
7. Oliveira R.B., Ochoa M.T., Sieling P.A., Rea T.H., Rambukkana A., Sarno E.N., et al. Expression of Toll-like receptor 2 on human Schwann cells: a mechanism of nerve damage in leprosy. Infect Immun 2003, 7:1427-1433.
8. Mustafa T., Bjune T.G., Jonsson R., Pando R.H., Nilsen R. Increased expression of fas ligand in human tuberculosis and leprosy lesions: a potential novel mechanism of immune evasion in mycobacterial infection. Scand J Immunol 2001 Dec, 54(6):630-639.
9. Gordon S. Macrophage-restricted molecules: role in differentiation and activation. Immunol Lett 1999, 65:5-8.
10. Moura D.F., Teles R.M., Ribeiro-Carvalho M.M., Teles R.B., Santos I.M., Ferreira H., et al. Long-term culture of multibacillary leprosy macrophages isolated from skin lesions: a new model to study Mycobacterium leprae-human cell interaction. Br J Dermatol 2007, 157:273-283.
11. Gottfried E., Kunz-Schughart L.A., Weber A., Rehli M., Peuker A., Müller A., et al. Expression of CD68 in non-myeloid cell types. Scand J Immunol 2008, 67:453-463.
12. Khanolkar-Young S., Snowdon D., Lockwood D.N. Immunocytochemical localization of inducible nitric oxide synthase and transforming growth factor-beta (TGF-beta) in leprosy lesions. Clin Exp Immunol 1998, 113:438-442.
13. Adams L.B., Job C.K., Krahenbuhl J.L. Role of inducible nitric oxide synthase in resistance to Mycobacterium leprae in mice. Infect Immun 2000, 68:5462-5465.
14. Gown A.M., Willingham M.C. Improved detection of apoptotic cells in archival paraffin sections: immunohistochemistry using antibodies to cleaved caspase 3. J Histochem Cytochem 2002, 50:449-454.
15. Hsu S.M., Raine L., Fanger H. Use of avidin-biotin-peroxidase complex (ABC) in immunoperoxidase techniques: a comparison between ABC and unlabeled antibody (PAP) procedures. J Histochem Cytochem 1981, 29:577-580.
16. Dodson A. Modern methods for diagnostic immunocytochemistry. Curr Diagn Pathol 2002, 8:113-122.
17. Bobrow M.N., Harris T.D., Shaughnessy K.J., Litt G.J. Catalyzed reporter deposition, a novel method of signal amplification. Application to immunoassays. J Immunol Methods 1989, 125:279-285.
18. Niang Mn, Balde At, Perraut R. Apoptosis in leprosy patients. Int J Lep Other Mycobact Dis 1999, 67:473-474.
19. Goulart IMB. Detecção de TGF-b1 em lesões cutâneas de diferentes formas clínicas de hanseníase. Tese de Mestrado. Universidade Federal de Uberlândia, Uberlândia, MG; 1995.
20. Gantt K.R., Schultz-Cherry S., Rodriguez N., Jeronimo S.M., Nascimento E.T., Goldman T.L., et al. Activation of TGF-beta by Leishmania chagasi: importance for parasite survival in macrophages. J Immunol 2003, 170:2613-2620.
21. Lisak R.P., Skundric D., Bealmear B., Ragheb S. The role of cytokines in Schwann cell damage, protection, and repair. J Infect Dis 1997, 176(Suppl. 2):S173-S179.
22. Oliveira R.B., Sampaio E.P., Aarestrup F., Teles R.M., Silva T.P., Oliveira A.L., et al. Cytokines and Mycobacterium leprae induce apoptosis in human Schwann cells. J Neuropathol Exp Neurol 2005, 64:882-890.