Functional identification and structure determination of two novel prolidases from cog1228 in the amidohydrolase superfamily

Biochemistry

Volumn 49, Issue 31, 2010, Pages 6791-6803

  Xiang, Dao Feng ^a   Patskovsky, Yury ^b   Xu, Chengfu ^a   Fedorov, Alexander A ^b   Fedorov, Elena V ^b   Sisco, Abby A ^a   Sauder, J Michael ^c   Burley, Stephen K ^c   Almo, Steven C ^b   Raushel, Frank M ^a  

^a TEXAS A AND M UNIVERSITY   (United States)

^b ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

^c ELI LILLY AND COMPANY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVE SITE; ACYL DERIVATIVES; AMIDOHYDROLASE SUPERFAMILY; BINUCLEAR METAL CENTER; CATALYTIC FUNCTIONS; DI-PEPTIDES; DIVALENT CATION; DNA SAMPLES; FUNCTIONAL IDENTIFICATION; L-AMINO ACIDS; L-ARGININE; OXYGEN ATOM; PHOSPHONATES; SIDE CHAINS; STRUCTURE DETERMINATION; SUBSTRATE BINDING; SUBSTRATE PROFILE; THREE-DIMENSIONAL STRUCTURE; X-RAY DIFFRACTION METHOD;

AMINO ACIDS; CARBOXYLATION; HYDROLYSIS; METAL REFINING; ORGANIC ACIDS; OXYGEN; POSITIVE IONS; PROTEIN FOLDING; X RAY DIFFRACTION;

SUBSTRATES;

ALANINE; AMINO ACID; ARGININE; CARBOXYLIC ACID DERIVATIVE; DNA; HISTIDINE; HYDROLASE; OXYGEN; PROLINE; PROLINE DIPEPTIDASE; TYROSINE;

ALPHA CHAIN; ARTICLE; BETA CHAIN; CATALYSIS; CAULOBACTER CRESCENTUS; CLONING; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME KINETICS; ENZYME PURIFICATION; EVOLUTION; HYDROLYSIS; HYDROPHOBICITY; NONHUMAN; PRIORITY JOURNAL; PROTEIN FAMILY; STRUCTURE ANALYSIS; X RAY DIFFRACTION;

AMIDOHYDROLASES; CATALYTIC DOMAIN; DIPEPTIDASES; KINETICS; OCEANS AND SEAS; PROTEIN CONFORMATION; SUBSTRATE SPECIFICITY; X-RAY DIFFRACTION;

CAULOBACTER;

EID: 77955262343     PISSN: 00062960     EISSN: 15204995     Source Type: Journal    
DOI: 10.1021/bi100897u     Document Type: Article

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