Characterization of VEGF and angiopoietins expression in human corpus cavernosum during aging

Journal of Sexual Medicine

Volumn 7, Issue 4 PART 1, 2010, Pages 1410-1418

  Tomada, Nuno ^a,b   Tomada, Inês ^b   Cruz, Francisco ^a,b   Vendeira, Pedro ^a,b   Neves, Delminda ^b  

^a University of Porto   (Portugal)

^b UNIVERSITY OF PORTO   (Portugal)

Author keywords

Aging; Angiopoietins; Erectile Dysfunction; Erectile Tissue Physiology; Human Corpus Cavernosum; VEGF

Indexed keywords

ALPHA ACTIN; ANGIOPOIETIN 1; ANGIOPOIETIN 2; CELL MARKER; VASCULOTROPIN; VON WILLEBRAND FACTOR;

ADULT; AGE DISTRIBUTION; AGED; AGING; ANIMAL TISSUE; ARTICLE; CLINICAL ARTICLE; CONNECTIVE TISSUE; CONTROLLED STUDY; CORPUS CAVERNOSUM; ERECTILE DYSFUNCTION; FLUORESCENCE MICROSCOPY; HUMAN; HUMAN CELL; IMMUNOHISTOCHEMISTRY; MALE; MOLECULAR BIOLOGY; MORPHOMETRICS; NONHUMAN; ORGAN DONOR; PENIS; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; RISK ASSESSMENT; SMOOTH MUSCLE FIBER; VASCULAR ENDOTHELIUM; WESTERN BLOTTING;

EID: 77955233814     PISSN: 17436095     EISSN: 17436109     Source Type: Journal    
DOI: 10.1111/j.1743-6109.2009.01648.x     Document Type: Article

References (40)

1. Feldman HA, Johannes CB, Derby CA, Kleinman KP, Mohr BA, Araujo AB, McKinlay JB. Erectile dysfunction and coronary risk factors: Prospective results from the Massachusetts Male Aging study. Prev Med 2000, 30:328-38.
2. Seftel AD. Erectile dysfunction in the elderly: Epidemiology etiology and approaches to treatment. J Urol 2003, 169:1999-2007.
3. Kinsey AC, Pomeroy WR, Martin CE. Sexual behavior in the human male. 1948. Am J Public Health 2003, 93:894-8.
4. Wespes E. Erectile dysfunction in the ageing man. Curr Opin Urol 2000, 10:625-8.
5. Gonzalez-Cadavid NF, Rajfer J. Molecular pathophysiology and gene therapy of aging-related erectile dysfunction. Exp Gerontol 2004, 39:1705-12.
6. Brandes RP, Fleming I, Busse R. Endothelial aging. Cardiovasc Res 2005, 66:286-94.
7. Sadoun E, Reed MJ. Impaired angiogenesis in aging is associated with alterations in vessel density, matrix composition, inflammatory response, and growth factor expression. J Hystochem Cytochem 2003, 51:1119-30.
8. Ferrara N, Gerber HP, LeCouter J. The biology of VEGF and its receptors. Nature Med 2003, 9:669-76.
9. Neves D, Santos J, Tomada N, Almeida H, Vendeira P. Aging and orchidectomy modulate expression of VEGF receptors (Flt-1 and Flk-1) on corpus cavernosum of the rat. Ann N Y Acad Sci 2006, 1067:164-72.
10. Rajasekaran M, Kasyan A, Jain A, Kim SW, Monga M. Altered growth factor expression in the aging penis: The Brown-Norway rat model. J Androl 2002, 23:393-9.
11. Park K, Ahn KY, Kim MK, Lee SE, Kang TW, Ryu SB. Intracavernosal injection of vascular endothelial growth factor improves erectile function in aged rats. Eur Urol 2004, 46:403-7.
12. Pettersson A, Nagy JA, Brown LF, Sundberg C, Morgan E, Jungles S, Carter R, Krieger JE, Manseau EJ, Harvey VS, Eckelhoefer IA, Feng D, Dvorak AM, Mulligan RC, Dvorak HF. Heterogeneity of angiogenic response induced in different normal adult tissues by vascular permeability factor/vascular endothelial growth factor. Lab Invest 2000, 80:99-115.
13. Ryu JK, Cho CH, Shin HY, Song SU, Oh SM, Lee M, Piao S, Han JY, Kim IH, Koh GY, Suh JK. Combined angiopoietin-1 and vascular endothelial growth factor gene transfer restores cavernous angiogenesis and erectile function in a rat model of hypercholesterolemia. Mol Ther 2006, 13:705-15.
14. Shim WS, Ho IA, Wong PE. Angiopoietin: A TIE(d) balance in tumor angiogenesis. Mol Cancer Res 2007, 5:655-65.
15. Davis S, Aldrich TH, Jones PF, Acheson A, Compton DL, Jain V, Ryan TE, Bruno J, Radziejewski C, Maisonpierre PC, Yancopoulos GD. Isolation of angiopoietin-1, a ligand for the TIE2 receptor, by secretion-trap expression cloning. Cell 1996, 87:1161-9.
16. Suri C, Jones PF, Patan S, Bartunkova S, Maisonpierre PC, Davis S, Sato TN, Yancopoulos GD. Requisite role of angiopoietin-1, a ligand for the Tie2 receptor, during embryonic angiogenesis. Cell 1996, 87:1171-80.
17. Saito M, Hamasaki M, Shibuya M. Induction of tube formation by angiopoietin-1 in endothelial cell/fibroblast co-culture is dependent on endogenous VEGF. Cancer Sci 2003, 94:782-90.
18. Kwak HJ, So JN, Lee SJ, Kim I, Koh KN, Ahn BC, Kho GY. Angiopoietin-1 is an apoptosis survival factor for endothelial cells. FEBS 1999, 448:249-53.
19. Kim I, Kim HG, So JN, Kim HJ, Ko GY. Angiopoietin-1 regulates endothelial cell survival through the phosphatidylinositol 3′-kinaseAkt signal transduction pathway. Circ Res 2000, 86:24-9.
20. Maisonpierre PC, Suri C, Jones PF, Bartunkova S, Wiegand SJ, Radziejewski C, Compton D, McClain J, Aldrich TH, Papadopoulos N, Daly TJ, Davis S, Sato TN, Yancopoulos GD. Angiopoietin-2, a natural antagonist for Tie2 that disrupts in vivo angiogenesis. Science 1997, 277:55-60.
21. Holash J, Wiegand SJ, Yancopoulos GD. New model of tumor angiogenesis: Dynamic balance between vessel regression and growth mediated by angiopoietins and VEGF. Oncogene 1999, 18:5356-62.
22. Bakircioglu ME, Sievert KD, Nunes L, Lau A, Lin CS, Lue TF. Decreased trabecular smooth muscle and caveolin-1 expression in the penile tissue of aged rats. J Urol 2001, 166:734-8.
23. Lin JS, Tsai YS, Lin YM, Lin CS, Chow NH. Age-associated changes in collagen content and its subtypes within rat corpora cavernosa with computerized histomorphometric analysis. Urology 2001, 57:837-42.
24. Calabrò A, Italiano G, Pescatori ES, Marin A, Gaetano O, Abatangelo G, Abatangelo G, Pagano F. Physiological aging and penile erectile function: A study in the rat. Eur Urol 1996, 29:240-4.
25. Tomada N, Oliveira R, Tomada I, Vendeira P, Neves D. Comparative ultrastructural study of human corpus cavernosum during ageing. Microsc Microanal 2008, 14:152-5.
26. Costa C, Vendeira P. Does erectile tissue angioarchitecture modify with aging? An immunohistological and morphometric approach. J Sex Med 2008, 5:833-40.
27. Rivard A, Fabre JE, Silver M, Chen D, Murohara T, Kearney M, Magner M, Asahara T, Isner JM. Age-dependent impairment of angiogenesis. Circulation 1999, 99:111-20.
28. Musicki B, Palese MA, Crone JK, Burnett AL. Phosphorylated endothelial nitric oxide synthase mediates vascular endothelial growth factor-induced penile erection. Biol Reprod 2004, 70:282-9.
29. Lee RJ, Springer ML, Blanco-Bose WE, Shaw R, Ursell PC, Blau HM. VEGF gene delivery to myocardium: Deleterious effects of unregulated expression. Circulation 2000, 102:898-901.
30. Carmeliet P. VEGF gene therapy: Stimulating angiogenesis or angioma-genesis? Nature Med 2000, 6:1102-3.
31. Arsic N, Zentilin L, Zacchigna S, Santoro D, Stanta G, Salvi A, Sinagra G, Giacca M. Induction of functional neovascularization by combined VEGF and angiopoietin-1 gene transfer using AAV vectors. Mol Ther 2003, 7:450-9.
32. Chae JK, Kim I, Lim ST, Chung MJ, Kim WH, Kim HG, Ko JK, Koh GY. Coadministration of angiopoietin-1 and vascular endothelial growth factor enhances collateral vascularization. Arterioscler Thromb Vasc Biol 2000, 20:2573-8.
33. Shyu KG, Chang H, Isner JM. Synergistic effect of angiopoietin-1 and vascular endothelial growth factor on neoangiogenesis in hypercholesterolemic rabbit model with acute hindlimb ischemia. Life Sci 2003, 73:563-79.
34. Visconti RP, Richardson CD, Sato TN. Orchestration of angiogenesis and arteriovenous contribution by angiopoietins and vascular endothelial growth factor (VEGF). Proc Natl Acad Sci 2002, 99:8219-24.
35. Tomada N, Tomada I, Vendeira P, Neves D. Expression of vascular endothelial growth factor and angiopoietins in human corpus cavernosum. BJU International 2009, doi: 10.1111/j.1464-410X.2009.08663.x
36. Yuan HT, Khankin EV, Karumanchi SA, Parikh SM. Angiopoietin 2 is a partial agonist/antagonist of Tie2 signaling in the endothelium. Mol Cell Biol 2009, 29:2011-22.
37. Stratmann A, Risau W, Plate RH. Cell type-specific expression of angiopoietin-1 and angiopoietin-2 suggests a role in glioblastoma angiogenesis. Am J Pathol 1998, 153:1459-66.
38. Oh H, Takagi H, Suzuma K, Otani A, Matsumura M, Honda Y. Hypoxia and vascular endothelial growth factor selectively up-regulate angiopoietin-2 in bovine microvascular endothelial cells. J Biol Chem 1999, 274:15732-9.
39. Mandriota SJ, Pyke C, Di Sanza C, Quinodoz P, Pittet B, Pepper MS. Hypoxia-inducible angiopoietin-2 expression is mimicked by iodonium compounds and occurs in the rat brain and skin in response to systemic hypoxia and tissue ischemia. Am J Pathol 2000, 156:2077-89.
40. Fiedler U, Scharpfenecker M, Koidl S, Hegen A, Grunow V, Schmidt JM, Kriz W, Thurston G, Augustin HG. The Tie-2 ligand angiopoietin-2 is stored in and rapidly released upon stimulation from endothelial cell Weibel-Palade bodies. Blood 2004, 103:4150-6.