메뉴 건너뛰기




Volumn 44, Issue 7, 2010, Pages e154-e161

An Epidemiologic Study on the Incidence and Significance of HFE Mutations in a Korean Cohort With Nonalcoholic Fatty Liver Disease

Author keywords

HFE gene; Iron; Nonalcoholic fatty liver disease

Indexed keywords

HFE PROTEIN; IRON; HFE PROTEIN, HUMAN; HLA ANTIGEN CLASS 1; MEMBRANE PROTEIN;

EID: 77955175909     PISSN: 01920790     EISSN: 15392031     Source Type: Journal    
DOI: 10.1097/MCG.0b013e3181d347d9     Document Type: Article
Times cited : (16)

References (52)
  • 1
    • 84984562986 scopus 로고    scopus 로고
    • How common is non-alcoholic fatty liver disease in the Asia-Pacific region and are there local differences?
    • Amarapurkar DN, Hashimoto E, Lesmana LA, et al. How common is non-alcoholic fatty liver disease in the Asia-Pacific region and are there local differences? J Gastroenterol Hepatol. 2007;22:788-793.
    • (2007) J Gastroenterol Hepatol , vol.22 , pp. 788-793
    • Amarapurkar, D.N.1    Hashimoto, E.2    Lesmana, L.A.3
  • 2
    • 44649095633 scopus 로고    scopus 로고
    • Review article: current management of non-alcoholic fatty liver disease and non-alcoholic steatohepatitis
    • Younossi ZM. Review article: current management of non-alcoholic fatty liver disease and non-alcoholic steatohepatitis. Aliment Pharmacol Ther. 2008;28:2-12.
    • (2008) Aliment Pharmacol Ther , vol.28 , pp. 2-12
    • Younossi, Z.M.1
  • 3
    • 0035078484 scopus 로고    scopus 로고
    • Etiopathogenesis of nonalcoholic steatohepatitis
    • Chitturi S, Farrell GC. Etiopathogenesis of nonalcoholic steatohepatitis. Semin Liver Dis. 2001;21:27-41.
    • (2001) Semin Liver Dis , vol.21 , pp. 27-41
    • Chitturi, S.1    Farrell, G.C.2
  • 4
    • 0031947715 scopus 로고    scopus 로고
    • Steatohepatitis: a tale of two “hits”?
    • Day CP, James OF. Steatohepatitis: a tale of two “hits”? Gastroenterology. 1998;114:842-845.
    • (1998) Gastroenterology , vol.114 , pp. 842-845
    • Day, C.P.1    James, O.F.2
  • 5
    • 56649083495 scopus 로고    scopus 로고
    • Mechanisms of disease progression in nonalcoholic fatty liver disease
    • Jou J, Choi SS, Diehl AM. Mechanisms of disease progression in nonalcoholic fatty liver disease. Semin Liver Dis. 2008;28:370-379.
    • (2008) Semin Liver Dis , vol.28 , pp. 370-379
    • Jou, J.1    Choi, S.S.2    Diehl, A.M.3
  • 6
    • 33846845125 scopus 로고    scopus 로고
    • Liver and iron metabolism—a comprehensive hypothesis for the pathogenesis of genetic hemochromatosis
    • Stremmel W, Karner M, Manzhalii E, et al. Liver and iron metabolism—a comprehensive hypothesis for the pathogenesis of genetic hemochromatosis. Z Gastroenterol. 2007;45:71-75.
    • (2007) Z Gastroenterol , vol.45 , pp. 71-75
    • Stremmel, W.1    Karner, M.2    Manzhalii, E.3
  • 7
    • 0141656292 scopus 로고    scopus 로고
    • Increased susceptibility to nonalcoholic fatty liver disease in heterozygotes for the mutation responsible for hereditary hemochromatosis
    • Valenti L, Dongiovanni P, Fracanzani AL, et al. Increased susceptibility to nonalcoholic fatty liver disease in heterozygotes for the mutation responsible for hereditary hemochromatosis. Dig Liver Dis. 2003;35:172-178.
    • (2003) Dig Liver Dis , vol.35 , pp. 172-178
    • Valenti, L.1    Dongiovanni, P.2    Fracanzani, A.L.3
  • 8
    • 34548797040 scopus 로고    scopus 로고
    • HFE C282Y mutations are associated with advanced hepatic fibrosis in Caucasians with nonalcoholic steatohepatitis
    • Nelson JE, Bhattacharya R, Lindor KD, et al. HFE C282Y mutations are associated with advanced hepatic fibrosis in Caucasians with nonalcoholic steatohepatitis. Hepatology. 2007;46:723-729.
    • (2007) Hepatology , vol.46 , pp. 723-729
    • Nelson, J.E.1    Bhattacharya, R.2    Lindor, K.D.3
  • 9
    • 33947238446 scopus 로고    scopus 로고
    • Restriction of dietary calories, fat and iron improves non-alcoholic fatty liver disease
    • Yamamoto M, Iwasa M, Iwata K, et al. Restriction of dietary calories, fat and iron improves non-alcoholic fatty liver disease. J Gastroenterol Hepatol. 2007;22:498-503.
    • (2007) J Gastroenterol Hepatol , vol.22 , pp. 498-503
    • Yamamoto, M.1    Iwasa, M.2    Iwata, K.3
  • 10
    • 33747469042 scopus 로고    scopus 로고
    • How different is the dietary pattern in non-alcoholic steatohepatitis patients?
    • Cortez-Pinto H, Jesus L, Barros H, et al. How different is the dietary pattern in non-alcoholic steatohepatitis patients? Clin Nutr. 2006;25:816-823.
    • (2006) Clin Nutr , vol.25 , pp. 816-823
    • Cortez-Pinto, H.1    Jesus, L.2    Barros, H.3
  • 11
    • 34848830434 scopus 로고    scopus 로고
    • Long term nutritional intake and the risk for non-alcoholic fatty liver disease (NAFLD): a population based study
    • Zelber-Sagi S, Nitzan-Kaluski D, Goldsmith R, et al. Long term nutritional intake and the risk for non-alcoholic fatty liver disease (NAFLD): a population based study. J Hepatol. 2007;47:711-717.
    • (2007) J Hepatol , vol.47 , pp. 711-717
    • Zelber-Sagi, S.1    Nitzan-Kaluski, D.2    Goldsmith, R.3
  • 12
    • 34249098685 scopus 로고    scopus 로고
    • Iron depletion by phlebotomy improves insulin resistance in patients with nonalcoholic fatty liver disease and hyperferritinemia: evidence from a case-control study
    • Valenti L, Fracanzani AL, Dongiovanni P, et al. Iron depletion by phlebotomy improves insulin resistance in patients with nonalcoholic fatty liver disease and hyperferritinemia: evidence from a case-control study. Am J Gastroenterol. 2007;102:1251-1258.
    • (2007) Am J Gastroenterol , vol.102 , pp. 1251-1258
    • Valenti, L.1    Fracanzani, A.L.2    Dongiovanni, P.3
  • 13
    • 0036211032 scopus 로고    scopus 로고
    • Effect of iron depletion in carbohydrate-intolerant patients with clinical evidence of nonalcoholic fatty liver disease
    • Facchini FS, Hua NW, Stoohs RA. Effect of iron depletion in carbohydrate-intolerant patients with clinical evidence of nonalcoholic fatty liver disease. Gastroenterology. 2002;122:931-939.
    • (2002) Gastroenterology , vol.122 , pp. 931-939
    • Facchini, F.S.1    Hua, N.W.2    Stoohs, R.A.3
  • 14
    • 0032881292 scopus 로고    scopus 로고
    • Hepatic iron and nonalcoholic fatty liver disease
    • Younossi ZM, Gramlich T, Bacon BR, et al. Hepatic iron and nonalcoholic fatty liver disease. Hepatology. 1999;30:847-850.
    • (1999) Hepatology , vol.30 , pp. 847-850
    • Younossi, Z.M.1    Gramlich, T.2    Bacon, B.R.3
  • 15
    • 0032695030 scopus 로고    scopus 로고
    • Independent predictors of liver fibrosis in patients with nonalcoholic steatohepatitis
    • Angulo P, Keach JC, Batts KP, et al. Independent predictors of liver fibrosis in patients with nonalcoholic steatohepatitis. Hepatology. 1999;30:1356-1362.
    • (1999) Hepatology , vol.30 , pp. 1356-1362
    • Angulo, P.1    Keach, J.C.2    Batts, K.P.3
  • 16
    • 41549138894 scopus 로고    scopus 로고
    • The HFE gene heterozygosis H63D: a cofactor for liver damage in patients with steatohepatitis? Epidemiological and clinical considerations
    • Neri S, Pulvirenti D, Signorelli S, et al. The HFE gene heterozygosis H63D: a cofactor for liver damage in patients with steatohepatitis? Epidemiological and clinical considerations. Intern Med J. 2008;38:254-358.
    • (2008) Intern Med J , vol.38 , pp. 254-358
    • Neri, S.1    Pulvirenti, D.2    Signorelli, S.3
  • 17
    • 1442281989 scopus 로고    scopus 로고
    • Relative contribution of iron burden, HFE mutations, and insulin resistance to fibrosis in nonalcoholic fatty liver
    • Bugianesi E, Manzini P, D'Antico S, et al. Relative contribution of iron burden, HFE mutations, and insulin resistance to fibrosis in nonalcoholic fatty liver. Hepatology. 2004;39:179-187.
    • (2004) Hepatology , vol.39 , pp. 179-187
    • Bugianesi, E.1    Manzini, P.2    D'Antico, S.3
  • 18
    • 0036291809 scopus 로고    scopus 로고
    • HFE mutations, hepatic iron, and fibrosis: ethnic-specific association of NASH with C282Y but not with fibrotic severity
    • Chitturi S, Weltman M, Farrell GC, et al. HFE mutations, hepatic iron, and fibrosis: ethnic-specific association of NASH with C282Y but not with fibrotic severity. Hepatology. 2002;36:142-149.
    • (2002) Hepatology , vol.36 , pp. 142-149
    • Chitturi, S.1    Weltman, M.2    Farrell, G.C.3
  • 19
    • 20244372858 scopus 로고    scopus 로고
    • Hemochromatosis and iron-overload screening in a racially diverse population
    • Adams PC, Reboussin DM, Barton JC, et al. Hemochromatosis and iron-overload screening in a racially diverse population. N Engl J Med. 2005;352:1769-1778.
    • (2005) N Engl J Med , vol.352 , pp. 1769-1778
    • Adams, P.C.1    Reboussin, D.M.2    Barton, J.C.3
  • 20
    • 22644438762 scopus 로고    scopus 로고
    • Prevalence of HFE mutations and relation to serum iron status in patients with chronic hepatitis C and patients with nonalcoholic fatty liver disease in Taiwan
    • Lin TJ, Lin CL, Wang CS, et al. Prevalence of HFE mutations and relation to serum iron status in patients with chronic hepatitis C and patients with nonalcoholic fatty liver disease in Taiwan. World J Gastroenterol. 2005;11:3905-3908.
    • (2005) World J Gastroenterol , vol.11 , pp. 3905-3908
    • Lin, T.J.1    Lin, C.L.2    Wang, C.S.3
  • 21
    • 34447116520 scopus 로고    scopus 로고
    • Frequency of primary iron overload and HFE gene mutations (C282Y, H63D and S65C) in chronic liver disease patients in north India
    • Dhillon BK, Das R, Garewal G, et al. Frequency of primary iron overload and HFE gene mutations (C282Y, H63D and S65C) in chronic liver disease patients in north India. World J Gastroenterol. 2007;13:2956-2959.
    • (2007) World J Gastroenterol , vol.13 , pp. 2956-2959
    • Dhillon, B.K.1    Das, R.2    Garewal, G.3
  • 22
    • 0035460063 scopus 로고    scopus 로고
    • C282Y and H63D mutations in the HFE gene have no effect on iron overload disorders in Japan
    • Shiono Y, Ikeda R, Hayashi H, et al. C282Y and H63D mutations in the HFE gene have no effect on iron overload disorders in Japan. Intern Med. 2001;40:852-856.
    • (2001) Intern Med , vol.40 , pp. 852-856
    • Shiono, Y.1    Ikeda, R.2    Hayashi, H.3
  • 23
    • 0036361354 scopus 로고    scopus 로고
    • Frequencies of C282Y and H63D mutations and transferrin saturation indices in the Korean population
    • Choi SJ, Min WK, Chun S, et al. Frequencies of C282Y and H63D mutations and transferrin saturation indices in the Korean population. Clin Chem Lab Med. 2002;40:689-692.
    • (2002) Clin Chem Lab Med , vol.40 , pp. 689-692
    • Choi, S.J.1    Min, W.K.2    Chun, S.3
  • 25
    • 34249682613 scopus 로고    scopus 로고
    • Role of radiologic modalities in the management of non-alcoholic steatohepatitis
    • Charatcharoenwitthaya P, Lindor KD. Role of radiologic modalities in the management of non-alcoholic steatohepatitis. Clin Liver Dis. 2007;11:37-54.
    • (2007) Clin Liver Dis , vol.11 , pp. 37-54
    • Charatcharoenwitthaya, P.1    Lindor, K.D.2
  • 26
    • 33644639840 scopus 로고    scopus 로고
    • Criteria and classification of obesity in Japan and Asia-Oceania
    • Kanazawa M, Yoshiike N, Osaka T, et al. Criteria and classification of obesity in Japan and Asia-Oceania. World Rev Nutr Diet. 2005;94:1-12.
    • (2005) World Rev Nutr Diet , vol.94 , pp. 1-12
    • Kanazawa, M.1    Yoshiike, N.2    Osaka, T.3
  • 27
    • 34848867888 scopus 로고    scopus 로고
    • HFE gene mutation, chronic liver disease, and iron overload in Turkey
    • Yonal O, Hatirnaz O, Akyuz F, et al. HFE gene mutation, chronic liver disease, and iron overload in Turkey. Dig Dis Sci. 2007;52:3298-3302.
    • (2007) Dig Dis Sci , vol.52 , pp. 3298-3302
    • Yonal, O.1    Hatirnaz, O.2    Akyuz, F.3
  • 28
    • 0034821062 scopus 로고    scopus 로고
    • Reference centiles for serum ferritin and percentage of transferrin saturation, with application to mutations of the HFE gene
    • Koziol JA, Ho NJ, Felitti VJ, et al. Reference centiles for serum ferritin and percentage of transferrin saturation, with application to mutations of the HFE gene. Clin Chem. 2001;47:1804-1810.
    • (2001) Clin Chem , vol.47 , pp. 1804-1810
    • Koziol, J.A.1    Ho, N.J.2    Felitti, V.J.3
  • 29
    • 33947138074 scopus 로고    scopus 로고
    • Association of HFE mutations (C282Y and H63D) with iron overload in blood donors from Mexico City
    • Baptista-Gonzalez HA, Rosenfeld-Mann F, Trueba-Gomez R, et al. Association of HFE mutations (C282Y and H63D) with iron overload in blood donors from Mexico City. Ann Hepatol. 2007;6:55-60.
    • (2007) Ann Hepatol , vol.6 , pp. 55-60
    • Baptista-Gonzalez, H.A.1    Rosenfeld-Mann, F.2    Trueba-Gomez, R.3
  • 30
    • 63249083936 scopus 로고    scopus 로고
    • HFE gene mutations, serum ferritin level, transferrin saturation, and their clinical correlates in a Korean population
    • Lee SH, Kim JW, Shin SH, et al. HFE gene mutations, serum ferritin level, transferrin saturation, and their clinical correlates in a Korean population. Dig Dis Sci. 2009;54:879-886.
    • (2009) Dig Dis Sci , vol.54 , pp. 879-886
    • Lee, S.H.1    Kim, J.W.2    Shin, S.H.3
  • 31
    • 9344224529 scopus 로고    scopus 로고
    • A novel MHC class I-like gene is mutated in patients with hereditary haemochromatosis
    • Feder JN, Gnirke A, Thomas W, et al. A novel MHC class I-like gene is mutated in patients with hereditary haemochromatosis. Nat Genet. 1996;13:399-408.
    • (1996) Nat Genet , vol.13 , pp. 399-408
    • Feder, J.N.1    Gnirke, A.2    Thomas, W.3
  • 32
    • 0037199788 scopus 로고    scopus 로고
    • A solution to the problem of separation in logistic regression
    • Heinze G, Schemper M. A solution to the problem of separation in logistic regression. Stat Med. 2002;21:2409-2419.
    • (2002) Stat Med , vol.21 , pp. 2409-2419
    • Heinze, G.1    Schemper, M.2
  • 33
    • 0033198317 scopus 로고    scopus 로고
    • Non-alcoholic steatohepatitis and iron: increased prevalence of mutations of the HFE gene in non-alcoholic steatohepatitis
    • Bonkovsky HL, Jawaid Q, Tortorelli K, et al. Non-alcoholic steatohepatitis and iron: increased prevalence of mutations of the HFE gene in non-alcoholic steatohepatitis. J Hepatol. 1999;31:421-429.
    • (1999) J Hepatol , vol.31 , pp. 421-429
    • Bonkovsky, H.L.1    Jawaid, Q.2    Tortorelli, K.3
  • 34
    • 0031915149 scopus 로고    scopus 로고
    • Increased hepatic iron concentration in nonalcoholic steatohepatitis is associated with increased fibrosis
    • George DK, Goldwurm S, MacDonald GA, et al. Increased hepatic iron concentration in nonalcoholic steatohepatitis is associated with increased fibrosis. Gastroenterology. 1998;114:311-318.
    • (1998) Gastroenterology , vol.114 , pp. 311-318
    • George, D.K.1    Goldwurm, S.2    MacDonald, G.A.3
  • 35
    • 0038446874 scopus 로고    scopus 로고
    • Lack of evidence for the pathogenic role of iron and HFE gene mutations in Brazilian patients with nonalcoholic steatohepatitis
    • Deguti MM, Sipahi AM, Gayotto LC, et al. Lack of evidence for the pathogenic role of iron and HFE gene mutations in Brazilian patients with nonalcoholic steatohepatitis. Braz J Med Biol Res. 2003;36:739-745.
    • (2003) Braz J Med Biol Res , vol.36 , pp. 739-745
    • Deguti, M.M.1    Sipahi, A.M.2    Gayotto, L.C.3
  • 36
    • 9144248397 scopus 로고    scopus 로고
    • Contribution of the H63D mutation in HFE to murine hereditary hemochromatosis
    • Tomatsu S, Orii KO, Fleming RE, et al. Contribution of the H63D mutation in HFE to murine hereditary hemochromatosis. Proc Natl Acad Sci USA. 2003;100:15788-15793.
    • (2003) Proc Natl Acad Sci USA , vol.100 , pp. 15788-15793
    • Tomatsu, S.1    Orii, K.O.2    Fleming, R.E.3
  • 37
    • 33845902249 scopus 로고    scopus 로고
    • H63D homozygotes with hyperferritinaemia: is this genotype, the primary cause of iron overload?
    • de Diego C, Opazo S, Murga MJ, et al. H63D homozygotes with hyperferritinaemia: is this genotype, the primary cause of iron overload? Eur J Haematol. 2007;78:66-71.
    • (2007) Eur J Haematol , vol.78 , pp. 66-71
    • de Diego, C.1    Opazo, S.2    Murga, M.J.3
  • 38
    • 33645861936 scopus 로고    scopus 로고
    • Individuals homozygous for the H63D mutation have significantly elevated iron indexes
    • Samarasena J, Winsor W, Lush R, et al. Individuals homozygous for the H63D mutation have significantly elevated iron indexes. Dig Dis Sci. 2006;51:803-807.
    • (2006) Dig Dis Sci , vol.51 , pp. 803-807
    • Samarasena, J.1    Winsor, W.2    Lush, R.3
  • 39
    • 0037366790 scopus 로고    scopus 로고
    • A population-based study of the effect of the HFE C282Y and H63D mutations on iron metabolism
    • Njajou OT, Houwing-Duistermaat JJ, Osborne RH, et al. A population-based study of the effect of the HFE C282Y and H63D mutations on iron metabolism. Eur J Hum Genet. 2003;11:225-231.
    • (2003) Eur J Hum Genet , vol.11 , pp. 225-231
    • Njajou, O.T.1    Houwing-Duistermaat, J.J.2    Osborne, R.H.3
  • 40
    • 0036177909 scopus 로고    scopus 로고
    • A population-based study of the biochemical and clinical expression of the H63D hemochromatosis mutation
    • Gochee PA, Powell LW, Cullen DJ, et al. A population-based study of the biochemical and clinical expression of the H63D hemochromatosis mutation. Gastroenterology. 2002;122:646-651.
    • (2002) Gastroenterology , vol.122 , pp. 646-651
    • Gochee, P.A.1    Powell, L.W.2    Cullen, D.J.3
  • 41
    • 0034999045 scopus 로고    scopus 로고
    • Variable phenotypic presentation of iron overload in H63D homozygotes: are genetic modifiers the cause?
    • Aguilar-Martinez P, Bismuth M, Picot MC, et al. Variable phenotypic presentation of iron overload in H63D homozygotes: are genetic modifiers the cause? Gut. 2001;48:836-842.
    • (2001) Gut , vol.48 , pp. 836-842
    • Aguilar-Martinez, P.1    Bismuth, M.2    Picot, M.C.3
  • 42
    • 0036293879 scopus 로고    scopus 로고
    • Underdiagnosis of hereditary haemochromatosis: lack of presentation or penetration?
    • Ryan E, Byrnes V, Coughlan B, et al. Underdiagnosis of hereditary haemochromatosis: lack of presentation or penetration? Gut. 2002;51:108-112.
    • (2002) Gut , vol.51 , pp. 108-112
    • Ryan, E.1    Byrnes, V.2    Coughlan, B.3
  • 43
    • 18544376989 scopus 로고    scopus 로고
    • Gender-specific phenotypic expression and screening strategies in C282Y-linked haemochromatosis: a study of 9396 French people
    • Deugnier Y, Jouanolle AM, Chaperon J, et al. Gender-specific phenotypic expression and screening strategies in C282Y-linked haemochromatosis: a study of 9396 French people. Br J Haematol. 2002;118:1170-1178.
    • (2002) Br J Haematol , vol.118 , pp. 1170-1178
    • Deugnier, Y.1    Jouanolle, A.M.2    Chaperon, J.3
  • 44
    • 0034939115 scopus 로고    scopus 로고
    • The role of oxidative stress in the onset and progression of diabetes and its complications: a summary of a Congress Series sponsored by UNESCO-MCBN, the American Diabetes Association and the German Diabetes Society
    • Rosen P, Nawroth PP, King G, et al. The role of oxidative stress in the onset and progression of diabetes and its complications: a summary of a Congress Series sponsored by UNESCO-MCBN, the American Diabetes Association and the German Diabetes Society. Diabetes Metab Res Rev. 2001;17:189-212.
    • (2001) Diabetes Metab Res Rev , vol.17 , pp. 189-212
    • Rosen, P.1    Nawroth, P.P.2    King, G.3
  • 45
    • 0035012387 scopus 로고    scopus 로고
    • Oxidative stress impairs insulin internalization in endothelial cells in vitro
    • Bertelsen M, Anggard EE, Carrier MJ. Oxidative stress impairs insulin internalization in endothelial cells in vitro. Diabetologia. 2001;44:605-613.
    • (2001) Diabetologia , vol.44 , pp. 605-613
    • Bertelsen, M.1    Anggard, E.E.2    Carrier, M.J.3
  • 46
    • 33745812430 scopus 로고    scopus 로고
    • Transferrin and iron induce insulin resistance of glucose transport in adipocytes
    • Green A, Basile R, Rumberger JM. Transferrin and iron induce insulin resistance of glucose transport in adipocytes. Metabolism. 2006;55:1042-1045.
    • (2006) Metabolism , vol.55 , pp. 1042-1045
    • Green, A.1    Basile, R.2    Rumberger, J.M.3
  • 47
    • 2642608680 scopus 로고    scopus 로고
    • Serum ferritin as a component of the insulin resistance syndrome
    • Fernandez-Real JM, Ricart-Engel W, Arroyo E, et al. Serum ferritin as a component of the insulin resistance syndrome. Diabetes Care. 1998;21:62-68.
    • (1998) Diabetes Care , vol.21 , pp. 62-68
    • Fernandez-Real, J.M.1    Ricart-Engel, W.2    Arroyo, E.3
  • 48
    • 18744424296 scopus 로고    scopus 로고
    • Relation between iron stores and non-insulin dependent diabetes in men: case-control study
    • Salonen JT, Tuomainen TP, Nyyssonen K, et al. Relation between iron stores and non-insulin dependent diabetes in men: case-control study. BMJ. 1998;317:727.
    • (1998) BMJ , vol.317 , pp. 727
    • Salonen, J.T.1    Tuomainen, T.P.2    Nyyssonen, K.3
  • 49
    • 23444453550 scopus 로고    scopus 로고
    • Iron stores, blood donation, and insulin sensitivity and secretion
    • Fernandez-Real JM, Lopez-Bermejo A, Ricart W. Iron stores, blood donation, and insulin sensitivity and secretion. Clin Chem. 2005;51:1201-1205.
    • (2005) Clin Chem , vol.51 , pp. 1201-1205
    • Fernandez-Real, J.M.1    Lopez-Bermejo, A.2    Ricart, W.3
  • 50
    • 3042741819 scopus 로고
    • Serum iron and iron-binding capacity in adolescents. Ii. Comparison of obese and nonobese subjects
    • Seltzer CC, Mayer J. Serum iron and iron-binding capacity in adolescents. Ii. Comparison of obese and nonobese subjects. Am J Clin Nutr. 1963;13:354-361.
    • (1963) Am J Clin Nutr , vol.13 , pp. 354-361
    • Seltzer, C.C.1    Mayer, J.2
  • 51
    • 34548306788 scopus 로고    scopus 로고
    • Inflammation and iron deficiency in the hypoferremia of obesity
    • Yanoff LB, Menzie CM, Denkinger BS, et al. Inflammation and iron deficiency in the hypoferremia of obesity. Int J Obes. 2007;31:1412-1419.
    • (2007) Int J Obes , vol.31 , pp. 1412-1419
    • Yanoff, L.B.1    Menzie, C.M.2    Denkinger, B.S.3
  • 52
    • 33748265283 scopus 로고    scopus 로고
    • Increased adipose tissue expression of hepcidin in severe obesity is independent from diabetes and NASH
    • Bekri S, Gual P, Anty R, et al. Increased adipose tissue expression of hepcidin in severe obesity is independent from diabetes and NASH. Gastroenterology. 2006;131:788-796.
    • (2006) Gastroenterology , vol.131 , pp. 788-796
    • Bekri, S.1    Gual, P.2    Anty, R.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.