Short communication: Oxidative posttranslational modifications mediate decreased SERCA activity and myocyte dysfunction in gαq-overexpressing mice

Circulation Research

Volumn 107, Issue 2, 2010, Pages 228-232

  Lancel, Steve ^b   Qin, Fuzhong ^b   Lennon, Shannon L ^b   Zhang, Jingmei ^b   Tong, Xiaoyong ^b   Mazzini, Michael J ^b   Kang, Y James ^b   Siwik, Deborah A ^b   Cohen, Richard A ^b   Colucci, Wilson S ^a  

^a BOSTON UNIVERSITY MEDICAL CENTER   (United States)

^b NONE

Author keywords

cardiac myocytes; oxidative modification; sarcoplasmic reticulum ATPase; SERCA

Indexed keywords

CALCIUM; CYSTEINE; GUANINE NUCLEOTIDE BINDING PROTEIN ALPHA SUBUNIT; REACTIVE OXYGEN METABOLITE; SARCOPLASMIC RETICULUM CALCIUM TRANSPORTING ADENOSINE TRIPHOSPHATASE; TYROSINE; 3 NITROTYROSINE; 3-NITROTYROSINE; CATALASE; DRUG DERIVATIVE;

ANIMAL CELL; ARTICLE; CALCIUM TRANSPORT; CARDIOMYOPATHY; HEART MUSCLE CELL; MOUSE; NITRATION; NONHUMAN; OXIDATION; PATHOPHYSIOLOGY; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN PROCESSING; ANIMAL; CALCIUM SIGNALING; CELL CULTURE; DISEASE MODEL; DOWN REGULATION; ENZYMOLOGY; GENETICS; HEART CONTRACTION; HEART LEFT VENTRICLE FUNCTION; METABOLISM; OXIDATION REDUCTION REACTION; TRANSGENIC MOUSE; UPREGULATION;

ANIMALS; CALCIUM SIGNALING; CATALASE; CELLS, CULTURED; CYSTEINE; DISEASE MODELS, ANIMAL; DOWN-REGULATION; GTP-BINDING PROTEIN ALPHA SUBUNITS, GQ-G11; MICE; MICE, TRANSGENIC; MYOCARDIAL CONTRACTION; MYOCYTES, CARDIAC; OXIDATION-REDUCTION; PROTEIN PROCESSING, POST-TRANSLATIONAL; REACTIVE OXYGEN SPECIES; SARCOPLASMIC RETICULUM CALCIUM-TRANSPORTING ATPASES; TYROSINE; UP-REGULATION; VENTRICULAR DYSFUNCTION, LEFT;

EID: 77955175462     PISSN: 00097330     EISSN: 15244571     Source Type: Journal    
DOI: 10.1161/CIRCRESAHA.110.217570     Document Type: Article

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