Contractile reserve and intracellular calcium regulation in mouse myocytes from normal and hypertrophied failing hearts

Circulation Research

Volumn 87, Issue 7, 2000, Pages 588-595

  Ito, Kenta ^a   Yan, Xinhua ^a   Tajima, Minori ^a   Su, Zhi ^b   Barry, William H ^b   Lorell, Beverly H ^a,c  

^a HARVARD MEDICAL SCHOOL   (United States)

^b UNIVERSITY OF UTAH HEALTH SCIENCES CENTER   (United States)

^c BETH ISRAEL DEACONESS MEDICAL CENTER   (United States)

Author keywords

Ca2+ ATPase; Contractility; Heart failure; Hypertrophy; Myocytes; Sarcoplasmic reticulum

Indexed keywords

ADENOSINE TRIPHOSPHATASE (CALCIUM); CALCIUM ION;

ANIMAL CELL; ARTICLE; CALCIUM TRANSPORT; CELL MOTION; CONTROLLED STUDY; GENE EXPRESSION; HEART FAILURE; HEART MUSCLE CELL; HEART MUSCLE CONTRACTILITY; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN CONTENT; SARCOPLASMIC RETICULUM;

EID: 0034730810     PISSN: 00097330     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.RES.87.7.588     Document Type: Article

References (43)

1. Phospholamban: A major determinant of the cardiac force-frequency relationship
2. Targeted ablation of the phospholamban gene is associated with markedly enhanced myocardial contractility and loss of β-agonist stimulation
3. 2+-ATPase activity
4. Pressure overload induces severe hypertrophy in mice treated with cyclosporine, an inhibitor of calcineurin
5. Left ventricular hypertrophy in ascending aortic stenosis mice: Anoikis and the progression to early failure
6. Fractional SR Ca release is regulated by trigger Ca and SR Ca content in cardiac myocytes
7. A simple device for rapidly exchanging solution surrounding a single cell
8. 2+](i) transients in murine ventricular myocytes
9. Ca flux, contractility, and excitation-contraction coupling in hypertrophic rat ventricular myocytes
10. Treatment with growth hormone enhances contractile reserve and intracellular calcium transients in myocytes from rats with postinfarction heart failure
11. Potentiation of fractional sarcoplasmic reticulum calcium release by total and free intra-sarcoplasmic reticulum calcium concentration
12. Calcium cycling and contractile activation in intact mouse cardiac muscle
13. Mechanisms of rate staircase in rat ventricular cells
14. Na-Ca exchange and Ca fluxes during contraction and relaxation in mammalian ventricular muscle
15. Relaxation in rabbit and rat cardiac cells: Species-dependent differences in cellular mechanisms
16. Geometric changes allow normal ejection fraction despite depressed myocardial shortening in hypertensive left ventricular hypertrophy
17. The effects of temperature upon calcium exchange in intact cultured cardiac myocytes
18. Temperature and relative contributions of Ca transport systems in cardiac myocyte relaxation
19. Mechanisms of altered excitation-contraction coupling in canine tachycardia-induced heart failure, I: Experimental studies
20. 2+ homeostasis in rabbit with pacing-induced heart failure
21. Calcium transients in feline left ventricular myocytes with hypertrophy induced by slow progressive pressure overload
22. Depressed intra-cellular calcium transients and contraction in myocytes from hypertrophied and failing guinea pig hearts
23. Alterations in intracellular calcium handling associated with the inverse force-frequency relation in human dilated cardiomyopathy
24. Intracellular calcium handling in isolated ventricular myocytes from patients with terminal heart failure
25. Role of myosin heavy chain composition in kinetics of force development and relaxation in rat myocardium
26. Molecular diversity of myofibrillar proteins: Gene regulation and functional significance
27. Atrial natriuretic peptide has different effects on contractility and intracellular pH in normal and hypertrophied myocytes from pressure-overloaded hearts
28. Phospholamban gene dosage effects in the mammalian heart
29. Monomeric phospholamban overexpression in transgenic mouse hearts
30. 2+/calmodulin-dependent protein kinase is altered in heart failure
31. 2+-ATPase activity and phosphorylation level of phospholamban
32. 2+-sensitivity of SERCA 2a in failing human myocardium due to reduced serin-16 phospholamban phosphorylation
33. 2+ content in isolated failing and nonfailing human myocardium
34. 2+-exchanger protein levels and diastolic function of failing human myocardium
35. Defective excitation-contraction coupling in experimental cardiac hypertrophy and heart failure
36. Calcium sparks and excitation-contraction coupling in phospholamban-deficient mouse ventricular myocytes
37. 2+ accumulation in nonfailing and failing human myocardium
38. The restriction of diffusion of cations at the external surface of cardiac myocytes varies between species
39. 2+ signaling in transgenic mouse cardiac myocytes overexpressing calsequestrin
40. Assessment of intra-SR free [Ca] and buffering in rat heart
41. Cellular mechanisms of altered contractility in the hypertrophied heart: Big hearts, big sparks
42. 2+ fluxes, and sarcoplasmic reticulum loading in pressure-overload hypertrophy
43. 2+ handling in isolated rat myocardium