Expression patterns of 5-HT receptor subtypes 1A and 2A on GABAergic neurons within the spinal dorsal horn of GAD67-GFP knock-in mice

Journal of Chemical Neuroanatomy

Volumn 38, Issue 1, 2009, Pages 75-81

  Wang, Ya Yun ^a   Wei, Yan Yan ^a   Huang, Jing ^a   Wang, Wei ^a   Tamamaki, Nobuaiki ^b   Li, Yun Qing ^a   Wu, Sheng Xi ^a  

^a FOURTH MILITARY MEDICAL UNIVERSITY   (China)

^b KUMAMOTO UNIVERSITY   (Japan)

Author keywords

Descending antinociceptive system; Double immunofluorescent staining; GABAergic interneuron; Nociceptive modulation; Single cell RT PCR

Indexed keywords

4 AMINOBUTYRIC ACID; GLUTAMATE DECARBOXYLASE 67; GREEN FLUORESCENT PROTEIN; MESSENGER RNA; SEROTONIN 1A RECEPTOR; SEROTONIN 2A RECEPTOR;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; GABAERGIC SYSTEM; GABAERGIC TRANSMISSION; GENE EXPRESSION; IMMUNOFLUORESCENCE TEST; IMMUNOHISTOCHEMISTRY; INTERNEURON; MALE; MOUSE; MOUSE STRAIN; NEUROMODULATION; NOCICEPTION; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SPINAL CORD DORSAL HORN; SPINAL CORD NERVE CELL;

ANIMALS; FEMALE; FLUORESCENT ANTIBODY TECHNIQUE; GAMMA-AMINOBUTYRIC ACID; GENE EXPRESSION REGULATION; GENE KNOCK-IN TECHNIQUES; GLUTAMATE DECARBOXYLASE; GREEN FLUORESCENT PROTEINS; INTERNEURONS; MALE; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; NEURAL INHIBITION; NOCICEPTORS; PAIN; POSTERIOR HORN CELLS; RECEPTOR, SEROTONIN, 5-HT1A; RECEPTOR, SEROTONIN, 5-HT2A; RECOMBINANT FUSION PROTEINS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SEROTONIN; SYNAPTIC TRANSMISSION;

EID: 67549109088     PISSN: 08910618     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jchemneu.2009.04.003     Document Type: Article

References (41)

1. Alhaider A.A., and Wilcox G.L. Differential roles of 5-hydroxytryptamine1A and 5-hydroxytryptamine1B receptor subtypes in modulating spinal nociceptive transmission in mice. J. Pharmacol. Exp. Ther. 265 (1993) 378-385
2. Antal M., Petko M., Polgar E., Heizmann C., and Stormmathisen W.J. Direct evidence of an extensive GABAergic innervation of the spinal dorsal horn by fibers descending from the rostral ventromedial medulla. Neuroscience 73 (1996) 509-518
3. Barber R.P., Vaughn J.E., Saito K., Mclaughlin B.J., and Roberts E. GABAergic terminals are presynaptic to primary afferent terminals in the substantia gelatinosa of the rat spinal cord. Brain Res. 141 (1978) 135-155
4. Bardin L., Lavarenne J., and Eschalier A. Serotonin receptor subtypes involved in the spinal antinociceptive effect of 5-HT in rats. Pain 86 (2000) 11-18
5. Basbaum A.I., Ralston D.D., and Ralston III H.J. Bulbospinal projections in the primates: a light and electromicroscopic study of a pain modulation system. J. Comp. Neurol. 250 (1986) 311-323
6. Bohlhalter S., Weinmann O., Mohler H., and Fritchy J.M. Laminar compartmentalization of GABAA receptor subtypes in the spinal cord: an immunohistochemical study. J. Neurosci. 16 (1996) 283-297
7. Carlton S.M., Westlund K.N., Zhang D., and Willis W.D. GABA-immunoreactive terminals synapse on primate spinothalamic tract cells. J. Comp. Neurol. 322 (1992) 528-537
8. Cervero F., Bennett G.J., and Headley P.M. Processing of sensory information in the superficial dorsal horn of the spinal cord (1995), Plenum Press, New York
9. Coggeshall R.E., and Carlton S.M. Receptor localization in the mammalian dorsal horn and primary afferent neurons. Brain Res. Brain Res. Rev. 24 1 (1997) 28-66
10. de Almeida J., and Mengod G. Quantitative analysis of glutamatergic and GABAergic neurons expressing 5-HT2A receptors in human and monkey prefrontal cortex. J. Neurochem. 103 (2007) 475-486
11. Erlander M.G., Tillakaratne N.J.K., Feldblum S., Patel N., and Tobin A.J. Two genes encode distinct glutamate decarboxylases. Neuron 7 (1991) 91-100
12. Erlander M.G., and Tobin A.J. The structural and functional heterogeneity of glutamic acid decarboxylase: a review. Neurochem. Res. 16 (1991) 215-226
13. Fields H.L., and Basbaum A.I. Central nervous system mechanisms of pain modulation. In: Wall P.D., and Melzack R. (Eds). Textbook of Pain. 3rd ed. (1994), Churchill Livingstone, New York 243-257
14. A receptors subtypes during postnatal development: an immunohistochemical study. J. Neurosci. 14 (1994) 5302-5324
15. Griffiths J.L., and Lovick T.A. Co-localization of 5-HT2A-receptor- and GABA-immunoreactivity in neurones in the periaqueductal grey matter of the rat. Neurosci. Lett. 326 (2002) 151-154
16. Hiura A., Ishizuka H., and Villalobos E.L. GABAergic neurons in the mouse superficial dorsal horn with special emphasis on their relation to primary afferent central terminals. Arch. Histol. Cytol. 54 (1991) 195-206
17. Huang J., Feng F., Tamamaki N., Yanagawa Y., Obata K., Li Y.Q., and Wu S.X. Prenatal and postnatal development of GABAergic neurons in the spinal cord revealed by green fluorescence protein expression in the GAD67-GFP knock-in mouse. Neuroembryol. Aging 4 (2007) 147-154
18. 3A receptor subunit is expressed in a subpopulation of GABAergic and enkephalinergic neurons in the mouse dorsal spinal cord. Neurosci. Lett. 441 (2008) 1-6
19. Ingram R.A., Fitzgerald M., and Baccei M.L. Developmental changes in the fidelity and short-term plasticity of GABAergic synapses in the neonatal rat dorsal horn. J. Neurophysiol. 99 (2008) 3144-3150
20. Jones S.L., and Light A.R. Termination patterns of serotoninergic medullary raphe-spinal fibres in the rat lumbar spinal cord: an anterograde immunohistochemical study. J. Comp. Neurol. 297 (1990) 267-282
21. Kang J.F., Pang Z.P., and Li Y.Q. Enhancement of glycine-activated whole-cell currents by serotonin in the superficial laminae neurons of the rat spinal dorsal horn. Chin. J. Neuroanat. 14 (1998) 333-339
22. Koyama S., Kubom C., Rhee J.S., and Akaike N. Presynaptic serotonergic inhibition of GABAergic synaptic transmission in mechanically dissociated rat basolateral amygdala neurons. J. Physiol. 518 (1999) 525-538
23. Kwiat G.C., and Basbaum A.I. The origin of brainstem noradrenergic and serotoninergic projections to the spinal cord dorsal horn in the rat. Somatosens. Mot. Res. 9 (1992) 157-173
24. Levy R.A. The role of GABA in primary afferent depolarization. Prog. Neurobiol. 9 (1977) 211-267
25. Li H., Lang B., Kang J.F., and Li Y.Q. Serotonin potentiates the response of neurons of the superficial laminae of the rat spinal dorsal horn to γ-aminobutyric acid. Brain Res. Bull. 52 (2000) 559-565
26. Li J.L., Kaneko T., Nomura S., Li Y.Q., and Mizuno N. Association of serotonin-like immunoreactive axons with nociceptive projection neurons in the caudal spinal trigeminal nucleus of the rat. J. Comp. Neurol. 384 (1997) 127-141
27. Light A.R., and Kavookjian A.M. The ultrastructure and synaptic connections of the spinal terminations from single, physiologically characterized axons descending in the dorsolateral funiculus from the midline, pontomedullary region. J. Comp. Neurol. 234 (1985) 549-560
28. McDonald A.J., and Mascagni F. Neuronal localization of 5-HT type 2A receptor immunoreactivity in the rat basolateral amygdale. Neuroscience 146 (2007) 306-320
29. Mitchell K., Spike R.C., and Todd A.J. An immunocytochemical study of glycine receptor and GABA in laminae I-III of rat spinal dorsal horn. J. Neurosci. 13 (1993) 2371-2381
30. Murase K., and Randic M. Electrophysiological properties of rat spinal dorsal horn neurons in vitro: calcium-dependent action potentials. J. Physiol. 334 (1983) 141-153
31. Pompeiano M., Palacios J.M., and Mengod G. Distribution of the serotonin 5-HT2 receptor family mRNAs: comparison between 5-HT2A and 5-HT2C receptors. Brain Res. Mol. Brain Res. 23 1-2 (1994) 163-178
32. Potrebic S.B., Fields H.L., and Mason P. Serotonin immunoreactivity is contained in one physiological cell class in the rat rostral ventromedial medulla. J. Neurosci. 14 (1994) 1655-1665
33. Roberts E. Disinhibition as an organizing principle in the neurons system-the role of the GABA system. In: Roberts E., Chase T.N., and Tower D.B. (Eds). GABA in Nervous System Function (1976), Raven Press, New York 515-539
34. Roberts E. GABA neurons in the mammalian central nervous system: model for a minimal basic unit. Neurosci. Lett. 47 (1984) 195-200
35. Tamamaki N., Nakamura K., Furuta T., Asamoto K., and Kaneko T. Neurons in Golgi-stainlike images revealed by GFP-adenovirus infection in vivo. Neurosci. Res. 38 (2000) 231-236
36. Tamamaki N., Yanagawa Y., Tomioka R., Miyazaki J.I., Obata K., and Kaneko T. Green fluorescent protein expression and colocalization with calretinin, parvalbumin, and somatostatin in the GAD67-GFP knock-in mouse. J. Comp. Neurol. 467 (2003) 60-79
37. Thibault K., Van Steenwinckel J., Brisorgueil M.J., Fischer J., Hamon M., Calvino B., and Conrath M. Serotonin 5-HT2A receptor involvement and Fos expression at the spinal level in vincristine-induced neuropathy in the rat. Pain 140 2 (2008) 305-322
38. Van Steenwinckel J., Brisorgueil M.J., Fischer J., Vergé D., Gingrich D.A., and Bourgoin S. Role of spinal serotonin 5-HT2A receptor in 2′,3′-dideoxycytidine-induced neuropathic pain in the rat and the mouse. Pain 137 (2008) 66-80
39. Willis W.D., and Coggeshall D. Sensory Mechanisms of the Spinal Cord. 2nd ed. (1991), Plenum Press, New York
40. Xie H., Dong Z.Q., Ma F., Bauer W.R., Wang X., and Wu G.C. Involvement of serotonin 2A receptors in the analgesic effect of tramadol in mono-arthritic rats. Brain Res. 1210 (2008) 76-83
41. Zhang Y.Q., Gao X., Ji G.C., Huang Y.L., Wu G.C., and Zhao Z.Q. Expression of 5-HT1A receptor mRNA in rat lumbar spinal dorsal horn neurons after peripheral inflammation. Pain 98 (2002) 287-295