Quantification of gemcitabine incorporation into human DNA by LC/MS/MS as a surrogate measure for target engagement

Analytical Chemistry

Volumn 82, Issue 15, 2010, Pages 6576-6583

  Wickremsinhe, Enaksha R ^a   Lutzke, Barry S ^a   Jones, Barry R ^b   Schultz, Gary A ^b   Freeman, Angela B ^a   Pratt, Susan E ^a   Bones, Angela M ^a   Ackermann, Bradley L ^a  

^a ELI LILLY AND COMPANY   (United States)

^b Advion BioSciences Inc   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANALYTES; ANTI-TUMOR ACTIVITIES; CLINICAL USE; COLLISION ENERGIES; DEOXYGUANOSINE (DG); DETUNED; DIRECT DETERMINATION; DNA INCORPORATION; DNA SAMPLES; DNA SYNTHESISS; DOSE OPTIMIZATION; END POINTS; GEMCITABINE; LC-ESI-MS/MS; LC/MS/MS; RELATIVE ABUNDANCE; SELECTED REACTION MONITORING; STABLE ISOTOPE LABELED INTERNAL STANDARDS; TARGET ENGAGEMENTS; TUMOR CELLS;

BIOMOLECULES; DNA; DRUG PRODUCTS; ISOTOPES; SYNTHESIS (CHEMICAL);

GENES;

ANTINEOPLASTIC ANTIMETABOLITE; DEOXYCYTIDINE; DEOXYGUANOSINE; DNA; DRUG DERIVATIVE; GEMCITABINE;

ANIMAL; CHEMISTRY; CONFERENCE PAPER; DOG; ELECTROSPRAY MASS SPECTROMETRY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; METHODOLOGY; TUMOR CELL LINE;

ANIMALS; ANTIMETABOLITES, ANTINEOPLASTIC; CELL LINE, TUMOR; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DEOXYCYTIDINE; DEOXYGUANOSINE; DNA; DOGS; HUMANS; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION;

EID: 77955164024     PISSN: 00032700     EISSN: None     Source Type: Journal    
DOI: 10.1021/ac100984h     Document Type: Conference Paper

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