Endotoxin tolerance: Mechanisms and clinical applicability

Yearbook of Intensive Care and Emergency Medicine 2009

Volumn , Issue , 2007, Pages 51-58

  Draisma, A ^a   Van Der Hoeven, J G ^a   Pickkers, P ^a  

^a RADBOUD UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 77955121648     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1007/978-0-387-92278-2_5     Document Type: Chapter

References (39)

1. Favorite GO, Morgan HR (1942) Effects produced by the intravenous injection in man of a toxic antigenic material derived from eberhtella typhosa: clinical, hematological, chemical and serological studies. J Clin Invest 21: 589-599
2. Sato S, Nomura F, Kawai T, et al (2000) Synergy and cross-tolerance between toll-like receptor (TLR) 2- and TLR4-mediated signaling pathways. J Immunol 165: 7096-7101
3. Lehner MD, Morath S, Michelsen KS, Schumann RR, Hartung T (2001) Induction of cross-tolerance by lipopolysaccharide and highly purified lipoteichoic acid via different Toll-like receptors independent of paracrine mediators. J Immunol 166: 5161-5167
4. Jiang W, Sun R, Wei H, Tian Z (2005) Toll-like receptor 3 ligand attenuates LPS-induced liver injury by down-regulation of toll-like receptor 4 expression on macrophages. Proc Natl Acad Sci U S A 102: 17077-17082
5. Mizel SB, Snipes JA (2002) Gram-negative flagellin-induced self-tolerance is associated with a block in interleukin-1 receptor-associated kinase release from toll-like receptor 5. J Biol Chem 277: 22414-22420
6. Draisma A, Dorresteijn M, Pickkers P, van der Hoeven JG (2008) The effect of systemic iNOS inhibition during human endotoxemia on the development of tolerance to different TLRstimuli. Innate Immun 14: 153-159
7. Shimauchi H, Ogawa T, Okuda K, Kusumoto Y, Okada H (1999) Autoregulatory effect of interleukin-10 on proinflammatory cytokine production by Porphyromonas gingivalis lipopolysaccharide-tolerant human monocytes. Infect Immun 67: 2153-2159
8. Frankenberger M, Pechumer H, Ziegler-Heitbrock HW (1995) Interleukin-10 is upregulated in LPS tolerance. J Inflamm 45: 56-63
9. Randow F, Syrbe U, Meisel C, et al (1995) Mechanism of endotoxin desensitization: involvement of interleukin 10 and transforming growth factor beta. J Exp Med 181: 1887-1892
10. Sly LM, Rauh MJ, Kalesnikoff J, Song CH, Krystal G (2004) LPS-induced upregulation of SHIP is essential for endotoxin tolerance. Immunity 21: 227-239
11. Berg DJ, Kuhn R, Rajewsky K, et al (1995) Interleukin-10 is a central regulator of the response to LPS in murine models of endotoxic shock and the Shwartzman reaction but not endotoxin tolerance. J Clin Invest 96: 2339-2347
12. Draisma A, Pickkers P, Bouw M, van der Hoeven J (2008) Development of endotoxin tolerance in humans in vivo. Crit Care Med (in press)
13. Zhang X, Morrison DC (1993) Lipopolysaccharide structure-function relationship in activation versus reprogramming of mouse peritoneal macrophages. J Leukoc Biol 54: 444-450
14. Cavaillon JM, Adib-Conquy M (2006) Bench-to-bedside review: endotoxin tolerance as a model of leukocyte reprogramming in sepsis. Crit Care 10: 233-240
15. Wang P, Ba ZF, Chaudry IH (1994) Administration of tumor necrosis factor-alpha in vivo depresses endothelium-dependent relaxation. Am J Physiol 266: H2535-H2541
16. Clapp BR, Hingorani AD, Kharbanda RK, et al (2004) Inflammation-induced endothelial dysfunction involves reduced nitric oxide bioavailability and increased oxidant stress. Cardiovasc Res 64: 172-178
17. Bhagat K, Vallance P (1997) Inflammatory cytokines impair endothelium-dependent dilatation in human veins in vivo. Circulation 96: 3042-3047
18. Wang P, Ba ZF, Chaudry IH (1995) Endothelium-dependent relaxation is depressed at the macro- and microcirculatory levels during sepsis. Am J Physiol 269: R988-R994
19. Pleiner J, Mittermayer F, Schaller G, MacAllister RJ, Wolzt M (2002) High doses of vitamin C reverse Escherichia coli endotoxin-induced hyporeactivity to acetylcholine in the human forearm. Circulation 106: 1460-1464
20. Heitzer T, Schlinzig T, Krohn K, Meinertz T, Munzel T (2001) Endothelial dysfunction, oxidative stress, and risk of cardiovascular events in patients with coronary artery disease. Circulation 104: 2673-2678
21. Faure E, Thomas L, Xu H, Medvedev A, Equils O, Arditi M (2001) Bacterial lipopolysaccharide and IFN-gamma induce Toll-like receptor 2 and Toll-like receptor 4 expression in human endothelial cells: role of NF-kappa B activation. J Immunol 166: 2018-2024
22. Hingorani AD, Cross J, Kharbanda RK, et al (2000) Acute systemic inflammation impairs endothelium-dependent dilatation in humans. Circulation 102: 994-999
23. Pickkers P, Dorresteijn MJ, Bouw MP, van der Hoeven JG, Smits P (2006) In vivo evidence for nitric oxide-mediated calcium-activated potassium-channel activation during human endotoxemia. Circulation 114: 414-421
24. van Deventer SJ, Buller HR, ten Cate JW, Aarden LA, Hack CE, Sturk A (1990) Experimental endotoxemia in humans: analysis of cytokine release and coagulation, fibrinolytic, and complement pathways. Blood 76: 2520-2526
25. Sakr Y, Dubois MJ, De Backer D, Creteur J, Vincent JL (2004) Persistent microcirculatory alterations are associated with organ failure and death in patients with septic shock. Crit Care Med 32: 1825-1831
26. Creteur J, Carollo T, Soldati G, Buchele G, De Backer D, Vincent JL (2007) The prognostic value of muscle StO2 in septic patients. Intensive Care Med 33: 1549-1556
27. Colletti LM, Remick DG, Campbell DA Jr (1994) LPS pretreatment protects from hepatic ischemia/reperfusion. J Surg Res 57: 337-343
28. Dominguez FE, Siemers F, Flohe S, Nau M, Schade FU (2002) Effects of endotoxin tolerance on liver function after hepatic ischemia/reperfusion injury in the rat. Crit Care Med 30: 165-170
29. Fernandez ED, Flohe S, Siemers F, et al (2000) Endotoxin tolerance protects against local hepatic ischemia/reperfusion injury in the rat. J Endotoxin Res 6: 321-328
30. Yoshidome H, Kato A, Edwards MJ, Lentsch AB (1999) Interleukin-10 suppresses hepatic ischemia/reperfusion injury in mice: implications of a central role for nuclear factor kappaB. Hepatology 30: 203-208
31. Obermaier R, Drognitz O, Grub A, et al (2003) Endotoxin preconditioning in pancreatic ischemia/reperfusion injury. Pancreas 27: e51-e56
32. Friedrich I, Spillner J, Lu EX, et al (2003) Induction of endotoxin tolerance improves lung function after warm ischemia in dogs. Am J Physiol Lung Cell Mol Physiol 284: L224-L231
33. Markart P, Schmidt R, Ruppert C, et al (2005) Ischemic and endotoxin pre-conditioning reduce lung reperfusion injury-induced surfactant alterations. J Heart Lung Transplant 24: 1680-1689
34. Godet C, Goujon JM, Petit I, et al (2006) Endotoxin tolerance enhances interleukin-10 renal expression and decreases ischemia-reperfusion renal injury in rats. Shock 25: 384-388
35. Heemann U, Szabo A, Hamar P, et al (2000) Lipopolysaccharide pretreatment protects from renal ischemia/reperfusion injury : possible connection to an interleukin-6-dependent pathway. Am J Pathol 156: 287-293
36. Rongen GA, Oyen WJ, Ramakers BP, et al (2005) Annexin A5 scintigraphy of forearm as a novel in vivo model of skeletal muscle preconditioning in humans. Circulation 111: 173-178
37. Riksen NP, Zhou Z, Oyen WJ, et al (2006) Caffeine prevents protection in two human models of ischemic preconditioning. J Am Coll Cardiol 48: 700-707
38. Riksen NP, Oyen WJ, Ramakers BP, et al (2005) Oral therapy with dipyridamole limits ischemia-reperfusion injury in humans. Clin Pharmacol Ther 78: 52-59
39. Yellon DM, Hausenloy DJ (2007) Myocardial reperfusion injury. N Engl J Med 357: 1121-1135