Fragrance materials review on isoamyl alcohol

Food and Chemical Toxicology

Volumn 48, Issue SUPPL. 4, 2010, Pages

  McGinty, D ^a   Lapczynski, A ^a   Scognamiglio, J ^a   Letizia, C S ^a   Api, A M ^a  

^a RESEARCH INSTITUTE FOR FRAGRANCE MATERIALS   (United States)

Author keywords

Frangrance; Review

Indexed keywords

FRAGRANCE; HYDROXYL GROUP; HYPOXANTHINE PHOSPHORIBOSYLTRANSFERASE; ISOPENTYL ALCOHOL; METHYL GROUP;

ACUTE TOXICITY; CALCULATION; CARCINOGENICITY; CHEMICAL STRUCTURE; CHRONIC TOXICITY; COMET ASSAY; CONCENTRATION (PARAMETERS); ERYTHROCYTE COUNT; EXPOSURE; EYE IRRITATION; FETUS MALFORMATION; GENOTOXICITY; GLUCURONIDATION; HALF LIFE TIME; HEMODYNAMICS; HUMAN; INHALATION; LD 50; LUNG TOXICITY; MICRONUCLEUS TEST; NEUROTOXICITY; NONHUMAN; PATCH TEST; PHYSICAL CHEMISTRY; PRENATAL EXPOSURE; REPRODUCTIVE TOXICITY; REVIEW; SKELETON MALFORMATION; SKIN; SKIN EXPOSURE; SKIN IRRITATION; SKIN SENSITIZATION; SKIN TOXICITY; SURVIVAL TIME; TOXICOKINETICS; URINARY EXCRETION;

ANIMALS; DERMATITIS, ALLERGIC CONTACT; DERMATITIS, PHOTOTOXIC; EYE INJURIES; HUMANS; PENTANOLS; PERFUME;

EID: 77955116777     PISSN: 02786915     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.fct.2010.05.040     Document Type: Review

References (52)

1. Arctander, S., 1969. Perfume and Flavor Chemicals (Aroma Chemicals). vol. I, no. 126. S. Arctander, Montclair, New Jersey.
2. Astill B.D., Gingell R., Guest D., Hellwig J., Hodgson J.R., Kuettler K., Mellert W., Murphy S.R., Sielken R.L., Tyler T.R. Oncogenicity testing of 2-ethylhexanol in Fischer 344 rats and B6C3F1 mice. Fundamental and Applied Toxicology 1996, 31(1):29-41.
3. Belsito D., Bickers D., Bruze M., Calow P., Greim H., Hanifin J.M., Rogers A.E., Saurat J.H., Sipes I.G., Tagami H. A safety assessment of branched chain saturated alcohols when used as fragrance ingredients. Food Chem. Toxicol. 2010, 48(S4):S1-S46.
4. Cadby P., Troy W., Vey M. Consumer exposure to fragrance ingredients: providing estimates for safety evaluation. Regulatory Toxicology and Pharmacology 2002, 36:246-252.
5. Carpanini F.M.B., Gaunt I.F., Kiss I.S., Grasso P., Gangolli S.D. Short-term toxicity of isoamyl alcohol in rats. Food and Cosmetics Toxicology 1973, 11(5):713-724.
6. Chvapil M., Zahradnik R., Cmuchalova B. Influence of alcohols and potassium salts of xanthogenic acids on various biological objects. Archives of International Pharmacodyn 1962, 135(3-4):330-343.
7. Council of Europe Partial Agreement in the Social and Public Health Field. Partial Agreement in the Social and Public Health Field. Chemically-defined Flavouring Substances. Group 2.1.3 Aliphatic Alcohols, Branched Chain 2000, vol. 51. Council of Europe Publishing, Strasbourg, p. 58.
8. EPA (Environmental Protection Agency) Estimation Programs Interface Suite™ for Microsoft® Windows, v 4.00 or Insert Version Used 2010, United States Environmental Protection Agency, Washington, DC, USA.
9. FDA (Food and Drug Administration). Code of Federal Regulations, 21 CFR 172.515. Title 21 - Food and Drugs, vol. 3. Food and Drug Administration, Department of Health and Human Services. Part 172 - Food Additives Permitted for Direct Addition to Food for Human Consumption. Subpart F - Flavoring Agents and Related Substances, 515 - Synthetic Flavoring Substances and Adjuvants (Chapter I).
10. FEMA (Flavor and Extract Manufacturers Association) Recent progress in the consideration of flavoring ingredients under the food additives amendment 3. GRAS substances. Food Technology 1965, 19(2, Part 2):151-197.
11. Ford R., Domeyer B., Easterday O., Maier K., Middleton J. Criteria for development of a database for safety evaluation of fragrance ingredients. Regulatory Toxicology and Pharmacology 2000, 31:166-181.
12. Frantik E., Hornychova M., Horvath M. Relative acute neurotoxicity of solvents: isoeffective air concentrations of 48 compounds evaluated in rats and mice. Environmental Research 1994, 66(2):173-185.
13. Gaillard D., Derache R. Metabolism of different alcohols, present in alcoholic beverages, in the rat. Travaux de la Société de Pharmacie de Montpellier 1965, 25(1):51-62.
14. Gibel V.W., Lohs V.W., Wildner G.P. Experimental study on carcinogenic activity of propanol-1,2-methylpropanol-1, and 3-methylbutanol-1. Archives Geschwulstforsch 1975, 45(1):19-24.
15. Golovinskaya L.I. Water and electrolyte metabolic disturbances in poisoning by home brew and higher alcohols. Sudebno-Meditsinskaya Ekspertiza 1976, 19(2):33-35.
16. Greenberg L.A. The appearance of some congeners of alcoholic beverages and their metabolites in blood. Quarterly Journal of Pharmacy and Pharmacology 1970, 5(Suppl.):20-25.
17. Haggard H.W., Miller D.P., Greenberg L.A. The amyl alcohols and their ketones: their metabolic fates and comparative toxicities. The Journal of Industrial Hygiene and Toxicology 1945, 27(1):1-14.
18. Hedlund S.-G., Kiessling K.-H. The physiological mechanism involved in hangover. 1. The oxidation of some lower aliphatic fusel alcohols and aldehydes in rat liver and their effect on the mitochondrial oxidation of various substrates. Acta Pharmacologica et Toxicologica 1969, 27:381-396.
19. IFRA (International Fragrance Association), 2004. Use Level Survey, August 2004.
20. IFRA (International Fragrance Association), 2007. Volume of Use Survey, February 2007.
21. Iwersen S., Schmoldt A. ADH Independent metabolism of aliphatic alcohols: comparison of oxidation and glucuronidation. Advances in Forensic Sciences Proceedings of the International Association of Forensic Sciences 1995, 13(4):19-22.
22. JECFA (Joint Expert Committee on Food Additives) Safety evaluation of certain food additives. Prepared by the forty-sixth meeting of the joint FAO/WHO expert committee on food additives (JECFA) 1996, World Health Organization, Geneva.
23. Jurowich S., Sticht G., Käferstein H. Glucuronidation of aliphatic alcohols in human liver microsomes in vitro. Alcohol 2004, 32:187-194.
24. Kamil I.A., Smith J.N., Williams R.T. Studies in detoxication. 46. The metabolism of aliphatic alcohols. The glucuronic acid conjugation of acyclic aliphatic alcohols. Biochemical Journal 1953, 53:129-136.
25. Kanada M., Miyagawa M., Sato M., Hasegawa H., Honma T. Neurochemical profile of effects of 28 neurotoxic chemicals on the central nervous system in rats. (1) Effects of oral administration on brain contents of biogenic amines and metabolites. Industrial Health 1994, 32(3):145-164.
26. Kane L.E., Dombroske R., Alarie Y. Evaluation of sensory irritation from some common industrial solvents. American Industrial Hygiene Association Journal (AIHAJ) 1980, 41(6):451-455.
27. Klimisch H.J., Hellwig J. Studies on the prenatal toxicity of 3-methyl-1-butanol and 2-methyl-1-propanol in rats and rabbits following inhalation exposure. Fundamental and Applied Toxicology 1995, 27(1):77-89.
28. Kreja L., Seidel H.J. Evaluation of the genotoxic potential of some microbial volatile organic compounds (MVOC) with the comet assay, the micronucleus assay and the HPRT gene mutation assay. Mutation Research 2002, 513(1-2):143-150.
29. Kumagai S., Oda H., Matsunaga I., Kosaka H., Akasaka S. Uptake of 10 polar organic solvents during short-term respiration. Toxicological Sciences (formerly Fundamental and Applied Toxicology) 1998, 48(2):255-263.
30. Leclerc S., Heydel J.-M., Amosse V., Gradinaru D., Cattarelli M., Artur Y., Goudonnet H., Magdalou J., Netter P., Pelczar H., Minn A. Glucurinidation of odorant molecules in the rat olfactory system. Activity, expression and age-linked modifications of UDP-glucuronosyltransferase isoforms, UGT1A6 and UGT2A1, and relation to mitral cell activity. Mutation Research 2002, 107:201-213.
31. Macht D.I. A toxicological study of some alcohols, with especial reference to isomers. The Journal of Pharmacology and Experimental Therapeutics 1920, 16:1-10.
32. Munch J.C. Aliphatic alcohols and alkyl esters: narcotic and lethal potencies to tadpoles and to rabbits. Industrial Medicine and Surgery 1972, 41(4):31-33.
33. Nakajima D., Ishii R., Kageyama S., Onji Y., Mineki S., Morooka N., Takatori K., Goto S. Genotoxicity of microbial volatile organic compounds. Journal of Health Science 2006, 52(2):148-153.
34. Nakano J., Kessinger M. Cardiovascular effects of ethanol, its cogeners and synthetic bourbon in dogs. European Journal of Pharmacology 1972, 17:195-201.
35. Nishimura H., Saito S., Kishida F., Matsuo M. Analysis of acute toxicity (LD50-value) of organic chemicals to mammals by solubility parameter (delta). 1. Acute oral toxicity to rats. Sangyo Igaku 1994, 36(5):314-323. (Japanese Journal Industrial Health).
36. Opdyke D.L.J. Monograph on 2-ethylhexanol. Food and Cosmetics Toxicology 1979, 17:775-777.
37. Pietruszko R., Crawford K., Lester D. Comparison of substrate specificity of alcohol dehydrogenases from human liver, horse liver, and yeast towards saturated and 2-enoic alcohols and aldehydes. Archives of Biochemistry and Biophysics 1973, 159:50-60.
38. Purchase I.F.H. Studies in kaffir corn malting and brewing. XXII. The acute toxicity of some fusel oils found in Bantu beer. South African Medical Journal 1969, 43(25):795-798.
39. RIFM (Research Institute for Fragrance Materials, Inc.,), 1976a. Acute Toxicity Studies in Rats, Mice, Rabbits and Guinea Pigs. RIFM Report Number 2019, August 8. RIFM, Woodcliff Lake, NJ, USA.
40. RIFM (Research Institute for Fragrance Materials, Inc.), 1976b. Report on Human Maximization Studies. RIFM Report Number 1797, June 1. RIFM, Woodcliff Lake, NJ, USA.
41. RIFM (Research Institute for Fragrance Materials, Inc.), 1979. Acute Toxicity Studies on Isoamyl Alcohol. Unpublished Report from BASF, Report Number 55359. RIFM, Woodcliff Lake, NJ, USA.
42. RIFM (Research Institute for Fragrance Materials, Inc.), 1990a. Prenatal Toxicity of Isoamyl Alcohol in Wistar Rats after Inhalation. Unpublished Report from BASF, Report Number 55360, RIFM, Woodcliff Lake, NJ, USA.
43. RIFM (Research Institute for Fragrance Materials, Inc.), 1990b. Prenatal Toxicity of Isoamyl Alcohol in Rabbits after Inhalation. Unpublished Report from BASF, Report Number 55361. RIFM, Woodcliff Lake, NJ, USA.
44. RIFM (Research Institute for Fragrance Materials, Inc.), 1991. Study on the Oral Toxicity of Isoamyl Alcohol in Rats. Unpublished Report from BASF, Report Number 55354. RIFM, Woodcliff Lake, NJ, USA.
45. RIFM (Research Institute for Fragrance Materials, Inc.), 2008. Micronucleus Assay in Bone Marrow Cells of the Mouse with Isoamyl Alcohol. RIFM in DRAFT. RIFM, Woodcliff Lake, NJ, USA.
46. Schilling K., Kayser M., Deckardt K., Kuttler K., Klimisch H.J. Subchronic toxicity studies of 3-methyl-1-butanol and 2-methyl-1-propanol in rats. Human and Experimental Toxicology 1997, 16(12):722-726.
47. Smyth H.F., Carpenter C.P., Weil C.S., Pozzani U.C., Striegel J.A., Nycum J.S. Range-finding toxicity data: list VII. American Industrial Hygiene Association Journal (AIHAJ) 1969, 30(5):470-476.
48. Strubelt O., Deters M., Pentz R., Siegers C.P., Younes M. The toxic and metabolic effects of 23 aliphatic alcohols in the isolated perfused rat liver. Toxicological Science 1999, 49:133-142.
49. VCF (Volatile Compounds in Food), 1963-2009. Database. In: Nijssen, L.M., Ingen-Visscher, C.A., van Donders, J.J.H. (Eds.), TNO Quality of Life, Version 11.1.1. Zeist, The Netherlands.
50. Wilkin J.K., Fortner G. Cutaneous vascular sensitivity to lower aliphatic alcohols and aldehydes in orientals. Alcoholism: Clinical and Experimental Research 1985, 9:522-525.
51. Wilkin J.K., Fortner G. Ethnic contact urticaria to alcohol. Contact Dermatitis 1985, 12(2):118-120.
52. Wilkin J.K., Stewart J.H. Substrate specificity of human cutaneous alcohol dehydrogenase and erythema provoked by lower aliphatic alcohols. Journal of Investigative Dermatology 1987, 88(4):452-454.