Fragrance material review on 3,4,5,6,6-pentamethylheptan-2-ol

Food and Chemical Toxicology

Volumn 48, Issue SUPPL. 4, 2010, Pages

  McGinty, D ^a   Scognamiglio, J ^a   Letizia, C S ^a   Api, A M ^a  

^a RESEARCH INSTITUTE FOR FRAGRANCE MATERIALS   (United States)

Author keywords

Fragrance; Review

Indexed keywords

3,4,5,6,6 PENTAMETHYLHEPTAN 2 OL; ALCOHOL DERIVATIVE; COSMETIC; FRAGRANCE; HYDROXYL GROUP; METHYL GROUP; UNCLASSIFIED DRUG;

ACUTE TOXICITY; APPLICATION SITE REACTION; CALCULATION; CHEMICAL STRUCTURE; CONCENTRATION (PARAMETERS); EXPOSURE; EYE IRRITATION; GENOTOXICITY; HUMAN; MICRONUCLEUS TEST; NONHUMAN; PATCH TEST; PHYSICAL CHEMISTRY; REVIEW; SKIN EXPOSURE; SKIN IRRITATION; SKIN SENSITIZATION; SKIN TOXICITY;

ANIMALS; DERMATITIS, ALLERGIC CONTACT; DERMATITIS, PHOTOTOXIC; EYE INJURIES; FATTY ALCOHOLS; HUMANS; PERFUME;

EID: 77955114975     PISSN: 02786915     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.fct.2010.05.030     Document Type: Review

References (15)

1. Belsito D., Bickers D., Bruze M., Greim H., Hanifin J.H., Rogers A.E., Saurat J.H., Sipes I.G., Smith R.L., Tagami H. A safety assessment of branched chain saturated alcohols when used as fragrance ingredients. Food and Chemical Toxicology 2010, 48(S4):S1-S46.
2. Cadby P., Troy W., Vey M. Consumer exposure to fragrance ingredients: providing estimates for safety evaluation. Regulatory Toxicology and Pharmacology 2002, 36:246-252.
3. EPA (Environmental Protection Agency) Estimation Programs Interface Suite™ for Microsoft® Windows, v 4.00 or Insert Version Used 2010, United States Environmental Protection Agency, Washington, DC, USA.
4. Ford R., Domeyer B., Easterday O., Maier K., Middleton J. Criteria for development of a database for safety evaluation of fragrance ingredients. Regulatory Toxicology and Pharmacology 2000, 31:166-181.
5. IFRA (International Fragrance Association), 2004. Use Level Survey, August 2004.
6. IFRA (International Fragrance Association), 2007. Volume of Use Survey, February 2007.
7. RIFM (Research Institute for Fragrance Materials, Inc.), 1983. Evaluation of Potential Irritation and Sensitization Hazards by Dermal Contact: Repeated Insult Patch Test with 3,4,5,6,6-Pentamethylheptan-2-ol. Unpublished Report from International Flavors and Fragrances, 27 October. Report Number 48462, RIFM, Woodcliff Lake, NJ, USA.
8. RIFM (Research Institute for Fragrance Materials, Inc.), 1984a. Acute Oral LD50 Determination in the Rat on 3,4,5,6,6-Pentamethylheptan-2-ol. Unpublished Report from International Flavors and Fragrances, Report Number 47552, RIFM, Woodcliff Lake, NJ, USA.
9. RIFM (Research Institute for Fragrance Materials, Inc.), 1984b. Primary Dermal Irritation Test of 3,4,5,6,6-Pentamethylheptan-2-ol on the Rabbit. Unpublished Report from International Flavors and Fragrances, Report Number 47792, RIFM, Woodcliff Lake, NJ, USA.
10. RIFM (Research Institute for Fragrance Materials, Inc.), 1984c. Acute Eye Irritation/Corrosion Test to the Rabbit of 3,4,5,6,6-Pentamethylheptan-2-ol. Unpublished Report from International Flavors and Fragrances, Report Number 47677, RIFM, Woodcliff Lake, NJ, USA.
11. RIFM (Research Institute for Fragrance Materials, Inc.), 1985a. Acute Dermal Toxicity to the Rat of 3,4,5,6,6-Pentamethylheptan-2-ol. Unpublished Report from International Flavors and Fragrances, Report Number 47587, RIFM, Woodcliff Lake, NJ, USA.
12. RIFM (Research Institute for Fragrance Materials, Inc.), 1985b. Microbial Metabolic Activation Test to Assess the Potential Mutagenic Effect of 3,4,5,6,6-Pentamethylheptan-2-ol. Unpublished Report from International Flavors and Fragrances, Report Number 48164, RIFM, Woodcliff Lake, NJ, USA.
13. RIFM (Research Institute for Fragrance Materials, Inc.), 1985c. Micronucleus Test (MNT) OECD on 3,4,5,6,6-Pentamethylheptan-2-ol. Unpublished Report from International Flavors and Fragrances, Report Number 48252, RIFM, Woodcliff Lake, NJ, USA.
14. RIFM (Research Institute for Fragrance Materials, Inc.), 1985d. Twenty-eight Day Dermal Irritation Study in Rabbits with 3,4,5,6,6-Pentamethylheptan-2-ol. Unpublished Report from International Flavors and Fragrances, Report Number 47793, RIFM, Woodcliff Lake, NJ, USA.
15. RIFM (Research Institute for Fragrance Materials, Inc.), 1986. Twenty-eight Day Dermal Irritation Study in Rabbits with 3,4,5,6,6-Pentamethylheptan-2-ol. Unpublished Report from International Flavors and Fragrances, Report Number 48027, RIFM, Woodcliff Lake, NJ, USA.