Comparison of two nitroxide labile esters for delivering electron paramagnetic resonance probes into mouse brain

Journal of Pharmaceutical Sciences

Volumn 99, Issue 8, 2010, Pages 3594-3600

  Miyake, Minoru ^a   Burks, Scott R ^b,c   Weaver, John ^a   Tsai, Pei ^b,c,d   Liu, Wenlan ^a   Bigio, David ^e   Bauer, Kenneth S ^d   Liu, Ke Jian ^a   Rosen, Gerald M ^b,c,d   Kao, Joseph P Y ^b,c  

^a UNIVERSITY OF NEW MEXICO   (United States)

^b UNIVERSITY OF MARYLAND SCHOOL OF MEDICINE   (United States)

^c UNIVERSITY OF MARYLAND BIOTECHNOLOGY INSTITUTE   (United States)

^d UNIVERSITY OF MARYLAND SCHOOL OF PHARMACY   (United States)

^e UNIVERSITY OF MARYLAND   (United States)

Author keywords

Blood brain barrier; CNS; Membrane transport; Pharmacokinetics pharmacodynamics; Site specific delivery

Indexed keywords

3 ACETOXYMETHOXYCARBONYL 2,2,5,5 TETRAMETHYL 1 PYRROLIDINYLOXYL; 3 CARBOXY 2,2,5,5 TETRAMETHYL 1 PYRROLIDINYLOXY; 3 PENTANOYLOXYMETHOXYCARBONYL 2,2,5,5 TETRAMETHYL 1 PYRROLIDINYLOXYL; CARBOXYL GROUP; DEUTERIUM; ESTER; ESTER DERIVATIVE; ESTERASE; NITROXIDE; OXYGEN; PENTANOYLOXYMETHYLESTER; UNCLASSIFIED DRUG; 3-(2-IODOACETAMIDO)-2,2,5,5-TETRAMETHYL-1-PYRROLIDINYLOXYL; 3-ACETOXYMETHOXYCARBONYL-2,2,5,5-TETRAMETHYL-1-PYRROLIDINYLOXYL; AMINE OXIDE; DYES, REAGENTS, INDICATORS, MARKERS AND BUFFERS; LIPID; NITROGEN OXIDE; SPIN LABELING;

ANIMAL EXPERIMENT; ANIMAL TISSUE; AREA UNDER THE CURVE; ARTICLE; BLOOD BRAIN BARRIER; BRAIN TISSUE; CHEMICAL STRUCTURE; CONTROLLED STUDY; DRUG CLEARANCE; DRUG ELIMINATION; DRUG HALF LIFE; DRUG STRUCTURE; ELECTRON SPIN RESONANCE; HYDROLYSIS; LIPOPHILICITY; MAXIMUM PLASMA CONCENTRATION; MOUSE; NONHUMAN; SENSITIVITY ANALYSIS; SUBSTITUTION REACTION; TIME TO MAXIMUM PLASMA CONCENTRATION; ANIMAL; BLOOD; BRAIN LEVEL; C57BL MOUSE; CALIBRATION; CHEMISTRY; COMPARATIVE STUDY; DIAGNOSTIC IMAGING; PHYSIOLOGY; SPIN LABELING;

ANIMALS; AREA UNDER CURVE; BLOOD-BRAIN BARRIER; BRAIN CHEMISTRY; CALIBRATION; CYCLIC N-OXIDES; DIAGNOSTIC IMAGING; ELECTRON SPIN RESONANCE SPECTROSCOPY; ESTERS; HYDROLYSIS; INDICATORS AND REAGENTS; LIPIDS; MICE; MICE, INBRED C57BL; NITROGEN OXIDES; SPIN LABELS;

EID: 77955110837     PISSN: 00223549     EISSN: 15206017     Source Type: Journal    
DOI: 10.1002/jps.22102     Document Type: Article

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