Autoimmune and infectious skin diseases that target desmogleins

Proceedings of the Japan Academy Series B: Physical and Biological Sciences

Volumn 86, Issue 5, 2010, Pages 524-537

  Amagai, Masayuki ^a  

^a KEIO UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

Cadherin; ELISA; Impetigo; Mouse model; Pemphigus; SSSS

Indexed keywords

AUTOANTIBODY; DESMOGLEIN; IMMUNOGLOBULIN G; ISOPROTEIN;

ANIMAL; AUTOIMMUNE DISEASE; HUMAN; IMMUNOLOGY; REVIEW; SKIN INFECTION;

ANIMALS; AUTOANTIBODIES; AUTOIMMUNE DISEASES; DESMOGLEINS; HUMANS; IMMUNOGLOBULIN G; PROTEIN ISOFORMS; SKIN DISEASES, INFECTIOUS;

MUS; STAPHYLOCOCCUS AUREUS;

EID: 77955098889     PISSN: 03862208     EISSN: 13492896     Source Type: Journal    
DOI: 10.2183/pjab.86.524     Document Type: Review

References (56)

1. Beutner, E.H. and Jordon, R.E. (1964) Demonstration of skin antibodies in sera of pemphigus vulgaris patients by indirect immunofluorescent staining. Proc. Soc. Exp. Biol. Med. 117, 505-510.
2. Schiltz, J.R. and Michel, B. (1976) Production of epidermal acantholysis in normal human skin in vitro by the IgG fraction from pemphigus serum. J. Invest. Dermatol. 67, 254-260.
3. Anhalt, G.J., Labib, R.S., Voorhees, J.J., Beals, T.F. and Diaz, L.A. (1982) Induction of pemphigus in neonatal mice by passive transfer of IgG from patients with the disease. N. Engl. J. Med. 306, 1189-1196.
4. Stanley, J.R., Yaar, M., Hawley, N.P. and Katz, S.I. (1982) Pemphigus antibodies identify a cell surface glycoprotein synthesized by human and mouse keratinocytes. J. Clin. Invest. 70, 281-288.
5. Hashimoto, T., Ogawa, M.M., Konohana, A. and Nishikawa, T. (1990) Detection of pemphigus vulgaris and pemphigus foliaceus antigens by immunoblot analysis using different antigen sources. J. Invest. Dermatol. 94, 327-331.
6. Koch, P.J., Walsh, M.J., Schmelz, M., Goldschmidt, M.D., Zimbelmann, R. and Franke, W.W. (1990) Identification of desmoglein, a constitutive desmosomal glycoprotein, as a member of the cadherin family of cell adhesion molecules. Eur. J. Cell Biol. 53, 1-12.
7. Amagai, M., Klaus-Kovtun, V. and Stanley, J.R. (1991) Autoantibodies against a novel epithelial cadherin in pemphigus vulgaris, a disease of cell adhesion. Cell 67, 869-877.
8. Anhalt, G.J., Kim, S., Stanley, J.R., Korman, N.J., Jabs, D.A., Kory, M. et al. (1990) Paraneoplastic pemphigus. An autoimmune mucocutaneous disease associated with neoplasia. N. Engl. J. Med. 323, 1729-1735.
9. Anhalt, G.J. (1997) Paraneoplastic pemphigus. Adv. Dermatol. 12, 77-97.
10. Fullerton, S.H., Woodley, D.T., Smoller, B.R. and Anhalt, G.J. (1992) Paraneoplastic pemphigus with autoantibody deposition in bronchial epithelium after autologous bone marrow transplantation. JAMA 267, 1500-1502.
11. Nousari, H.C., Deterding, R., Wojtczack, H., Aho, S., Uitto, J., Hashimoto, T. et al. (1999) The mechanism of respiratory failure in paraneoplastic pemphigus. N. Engl. J. Med. 340, 1406-1410.
12. Takeichi, M. (1991) Cadherin cell adhesion receptors as a morphogenetic regulator. Science 251, 1451-1455.
13. Nagafuchi, A., Shirayoshi, Y., Okazaki, K., Yasuda, K. and Takeichi, M. (1987) Transformation of cell adhesion properties by exogenously introduced E-cadherin cDNA. Nature 329, 341-343.
14. Nose, A., Tsuji, K. and Takeichi, M. (1990) Localization of specificity determining sites in cadherin cell adhesion molecules. Cell 61, 147-155.
15. Shapiro, L., Fannon, A.M., Kwong, P.D., Thompson, A., Lehmann, M.S., Grubel, G. et al. (1995) Structural basis of cell-cell adhesion by cadherins. Nature 374, 327-337.
16. Amagai, M. (1995) Adhesion molecules I: keratinocyte-keratinocyte interactions, cadherins and pemphigus. J. Invest. Dermatol. 104, 146-152.
17. Green, K.J. and Gaudry, C.A. (2000) Are desmosomes more than tethers for intermediate filaments? Nat. Rev. Mol. Cell Biol. 1, 208-216.
18. Amagai, M., Fujimori, T., Masunaga, T., Shimizu, H., Nishikawa, T., Shimizu, N. et al. (1995) Delayed assembly of desmosomes in keratinocytes with disrupted classic cadherin-mediated cell adhesion by a dominant negative mutant. J. Invest. Dermatol. 104, 27-32.
19. Schafer, S., Koch, P.J. and Franke, W.W. (1994) Identification of the ubiquitous human desmoglein, Dsg2, and the expression catalogue of the desmoglein subfamily of desmosomal cadherins. Exp. Cell Res. 211, 391-399.
20. Kljuic, A., Bazzi, H., Sundberg, J.P., Martinez-Mir, A., O'Shaughnessy, R., Mahoney, M.G. et al. (2003) Desmoglein 4 in hair follicle differentiation and epidermal adhesion: evidence from inherited hypotrichosis and acquired pemphigus vulgaris. Cell 113, 249-260.
21. Sams, W.M.J. and Jordon, R.E. (1971) Correlation of pemphigoid and pemphigus antibody titres with activity of disease. Br. J. Dermatol. 84, 7-13.
22. Cheng, S.W., Kobayashi, M., Tanikawa, A., Kinoshita-Kuroda, K., Amagai, M. and Nishikawa, T. (2002) Monitoring disease activity in pemphigus with enzyme-linked immunosorbent assay using recombinant desmoglein 1 and 3. Br. J. Dermatol. 147, 261-265.
23. Amagai, M., Karpati, S., Prussick, R., Klaus-Kovtun, V. and Stanley, J.R. (1992) Autoantibodies against the amino-terminal cadherin-like binding domain of pemphigus vulgaris antigen are pathogenic. J. Clin. Invest. 90, 919-926.
24. Amagai, M., Hashimoto, T., Shimizu, N. and Nishikawa, T. (1994) Absorption of pathogenic autoantibodies by the extracellular domain of pemphigus vulgaris antigen (Dsg3) produced by baculovirus. J. Clin. Invest. 94, 59-67.
25. Amagai, M., Hashimoto, T., Green, K.J., Shimizu, N. and Nishikawa, T. (1995) Antigen-specific immunoadsorption of pathogenic autoantibodies in pemphigus foliaceus. J. Invest. Dermatol. 104, 895-901.
26. Tsunoda, K., Ota, T., Aoki, M., Yamada, T., Nagai, T., Nakagawa, T. et al. (2003) Induction of pemphigus phenotype by a mouse monoclonal antibody against the amino-terminal adhesive interface of desmoglein 3. J. Immunol. 170, 2170-2178.
27. Payne, A.S., Ishii, K., Kacir, S., Lin, C., Li, H., Hanakawa, Y. et al. (2005) Genetic and functional characterization of human pemphigus vulgaris monoclonal autoantibodies isolated by phage display. J. Clin. Invest. 115, 888-899.
28. Ishii, K., Amagai, M., Hall, R.P., Hashimoto, T., Takayanagi, A., Gamou, S. et al. (1997) Characterization of autoantibodies in pemphigus using antigen-specific ELISAs with baculovirus expressed recombinant desmogleins. J. Immunol. 159, 2010-2017.
29. Amagai, M., Komai, A., Hashimoto, T., Shirakata, Y., Hashimoto, K., Yamada, T. et al. (1999) Usefulness of enzyme-linked immunosorbent assay (ELISA) using recombinant desmogleins 1 and 3 for serodiagnosis of pemphigus. Br. J. Dermatol. 140, 351-357.
30. Mahoney, M.G., Wang, Z., Rothenberger, K.L., Koch, P.J., Amagai, M. and Stanley, J.R. (1999) Explanation for the clinical and microscopic localization of lesions in pemphigus foliaceus and vulgaris. J. Clin. Invest. 103, 461-468.
31. Amagai, M. (1999) Autoimmunity against desmosomal cadherins in pemphigus. J. Dermatol. Sci. 20, 92-102.
32. Melish, M.E. and Glasgow, L.A. (1970) The staphylococcal scalded skin syndrome: Development of an experimental model. N. Engl. J. Med. 282, 1114-1119.
33. Amagai, M., Matsuyoshi, N., Wang, Z.H., Andl, C. and Stanley, J.R. (2000) Toxin in bullous impetigo and staphylococcal scalded skin syndrome targets desmoglein 1. Nat. Med. 6, 1275-1277.
34. Amagai, M., Yamaguchi, T., Hanakawa, Y., Nishifuji, K., Sugai, M. and Stanley, J.R. (2002) Staphylococcal exfoliative toxin B specifically cleaves desmoglein 1. J. Invest. Dermatol. 118, 845-850.
35. Yamaguchi, T., Nishifuji, K., Sasaki, M., Fudaba, Y., Aepfelbacher, M., Takata, T. et al. (2002) Identification of Staphylococcus aureus etd pathogenicity island which encodes a novel exfoliative toxin, ETD, and EDIN-B. Infect. Immun. 70, 5835-5845.
36. Vath, G.M., Earhart, C.A., Rago, J.V., Kim, M.H., Bohach, G.A., Schlievert, P.M. et al. (1997) The structure of the superantigen exfoliative toxin A suggests a novel regulation as a serine protease. Biochemistry 36, 1559-1566.
37. Cavarelli, J., Prevost, G., Bourguet, W., Moulinier, L., Chevrier, B., Delagoutte, B. et al. (1997) The structure of Staphylococcus aureus epidermolytic toxin A, an atypic serine protease, at 1.7 Å resolution. Structure 5, 813-824.
38. Vath, G.M., Earhart, C.A., Monie, D.D., Iandolo, J.J., Schlievert, P.M. and Ohlendorf, D.H. (1999) The crystal structure of exfoliative toxin B: a superantigen with enzymatic activity. Biochemistry 38, 10239-10246.
39. Stanley, J.R. and Amagai, M. (2006) Pemphigus, bullous impetigo, and the staphylococcal scalded-skin syndrome. N. Engl. J. Med. 355, 1800-1810.
40. Anzai, H., Stanley, J.R. and Amagai, M. (2006) Production of low titers of anti-desmoglein 1 IgG autoantibodies in some patients with staphylococcal scalded skin syndrome. J. Invest. Dermatol. 126, 2139-2141.
41. Sekiguchi, M., Futei, Y., Fujii, Y., Iwasaki, T., Nishikawa, T. and Amagai, M. (2001) Dominant autoimmune epitopes recognized by pemphigus antibodies map to the N-terminal adhesive region of desmogleins. J. Immunol. 167, 5439-5448.
42. Amagai, M., Tsunoda, K., Suzuki, H., Nishifuji, K., Koyasu, S. and Nishikawa, T. (2000) Use of autoantigen knockout mice to develop an active autoimmune disease model of pemphigus. J. Clin. Invest. 105, 625-631.
43. Ishii, K., Lin, C., Siegel, D.L. and Stanley, J.R. (2008) Isolation of pathogenic monoclonal anti-desmoglein 1 human antibodies by phage display of pemphigus foliaceus autoantibodies. J. Invest. Dermatol. 128, 939-948.
44. Boggon, T.J., Murray, J., Chappuis-Flament, S., Wong, E., Gumbiner, B.M. and Shapiro, L. (2002) C-cadherin ectodomain structure and implications for cell adhesion mechanisms. Science 296, 1308-1313.
45. MacDonald, H.R. (1989) Mechanisms of immunological tolerance. Science 246, 982.
46. Goodnow, C.C. (1996) Balancing immunity and tolerance: deletion and tuning lymphocyte repertoires. Proc. Natl. Acad. Sci. USA 93, 2264-2271.
47. Koch, P.J., Mahoney, M.G., Ishikawa, H., Pulkkinen, L., Uitto, J., Shultz, L. et al. (1997) Targeted disruption of the pemphigus vulgaris antigen (desmoglein 3) gene in mice causes loss of keratinocyte cell adhesion with a phenotype similar to pemphigus vulgaris. J. Cell Biol. 137, 1091-1102.
48. Ohyama, M., Amagai, M., Tsunoda, K., Ota, T., Koyasu, S., Umezawa, A. et al. (2002) Immunologic and histopathologic characterization of active disease mouse model for pemphigus vulgaris. J. Invest. Dermatol. 118, 199-204.
49. Tsunoda, K., Ota, T., Suzuki, H., Ohyama, M., Nagai, T., Nishikawa, T. et al. (2002) Pathogenic autoantibody production requires loss of tolerance against desmoglein 3 in both T and B cells in experimental pemphigus vulgaris. Eur. J. Immunol. 32, 627-633.
50. Takae, Y., Nishikawa, T. and Amagai, M. (2009) Pemphigus mouse model as a tool to evaluate various immunosuppressive therapies. Exp. Dermatol. 18, 252-260.
51. Takahashi, H., Amagai, M., Nishikawa, T., Fujii, Y., Kawakami, Y. and Kuwana, M. (2008) Novel system evaluating in vivo pathogenicity of desmoglein 3-reactive T cell clones using murine pemphigus vulgaris. J. Immunol. 181, 1526-1535.
52. Takahashi, H., Kuwana, M. and Amagai, M. (2009) A single helper T cell clone is sufficient to commit polyclonal naive B cells to produce pathogenic IgG in experimental pemphigus vulgaris. J. Immunol. 182, 1740-1745.
53. Rickman, L., Simrak, D., Stevens, H.P., Hunt, D.M., King, I.A., Bryant, S.P. et al. (1999) N-terminal deletion in a desmosomal cadherin causes the autosomal dominant skin disease striate palmoplantar keratoderma. Hum. Mol. Genet. 8, 971-976.
54. Nagasaka, T., Nishifuji, K., Ota, T., Whittock, N.V. and Amagai, M. (2004) Defining the pathogenic involvement of desmoglein 4 in pemphigus and staphylococcal scalded skin syndrome. J. Clin. Invest. 114, 1484-1492.
55. Pilichou, K., Nava, A., Basso, C., Beffagna, G., Bauce, B., Lorenzon, A. et al. (2006) Mutations in desmoglein-2 gene are associated with arrhyth-mogenic right ventricular cardiomyopathy. Circulation 113, 1171-1179.
56. Awad, M.M., Dalal, D., Cho, E., Amat-Alarcon, N., James, C., Tichnell, C. et al. (2006) DSG2 mutations contribute to arrhythmogenic right ventricular dysplasia/cardiomyopathy. Am. J. Hum. Genet. 79, 136-142.