A new paradigm of bacteria-gut interplay brought through the study of Shigella

Proceedings of the Japan Academy Series B: Physical and Biological Sciences

Volumn 86, Issue 3, 2010, Pages 229-243

  Sasakawa, Chihiro ^a  

^a UNIVERSITY OF TOKYO   (Japan)

Author keywords

Epithelial cells; Infection; Innate immunity; Pathogenicity; Shigella; Shigellosis

Indexed keywords

ANIMAL; GASTROINTESTINAL TRACT; HOST PATHOGEN INTERACTION; HUMAN; IMMUNOLOGY; INNATE IMMUNITY; INTESTINE CELL; MICROBIOLOGY; PATHOLOGY; PHYSIOLOGY; REVIEW; SHIGELLA; SHIGELLOSIS;

ANIMALS; DYSENTERY, BACILLARY; ENTEROCYTES; GASTROINTESTINAL TRACT; HOST-PATHOGEN INTERACTIONS; HUMANS; IMMUNITY, INNATE; SHIGELLA;

BACTERIA (MICROORGANISMS); SHIGELLA;

EID: 77955097442     PISSN: 03862208     EISSN: 13492896     Source Type: Journal    
DOI: 10.2183/pjab.86.229     Document Type: Review

References (51)

1. Ogawa, M., Handa, Y., Ashida, H., Suzuki, M. and Sasakawa, C. (2008) The versatility of Shigella effectors. Nat. Rev. Microbiol. 6, 11-16.
2. Ashida, H., Ogawa, M., Mimuro, H. and Sasakawa, C. (2009) Shigella infection of intestinal epithelium and circumvention of the host innate defense system. Curr. Top. Microbiol. Immunol. 337, 231-255.
3. Shiga, K. (1898) Ueber den errenger der dysenterie in Japan. Zent. Bakteriol. Microbiol. Hyg. 23, 599-600.
4. Trofa, A.F., Ueno-Olsen, H., Oiwa, R. and Yoshikawa, M. (1999) Dr. Kiyoshi Shiga: discovery of the dysentery bacillus. Clin. Infect. Dis. 29, 1303-1306.
5. DuPont, H.L., Levine, M.M., Hornick, R.B. and Formal, S.B. (1989) Inoculum size in shigellosis and implications for expected mode of transmission. J. Infect. Dis. 159, 1126-1128.
6. Keusch, G.T. (2001) Shigella. Mol. Med. Microbiol. (ed. Sussman, M.) 2, Academic Press, London, pp. 1279-1290.
7. Sasakawa, C. (2004) Shigella invasion. Adv. Mol. Cell. Microbiol. (ed. Lamont, R.J.). Cambridge University Press, Cambridge, U.K., pp. 25-58.
8. Sansonetti, P.J. and Di, Santo. J.P. (2007) Debugging how bacteria manipulate the immune response. Immunity 26, 149-161.
9. Suzuki, T., Nakanishi, K., Tsutsui, H., Iwai, H., Akira, S., Inohara, N. et al. (2005) A novel Caspase-1/Toll-like receptor 4-independent pathway of cell death induced by cytosolic Shigella in infected macrophages. J. Biol. Chem. 280, 14042-14050.
10. Suzuki, T., Franchi, L., Toma, C, Ashida, H., Ogawa, M., Yoshikawa, Y. et al. (2007) Differential regulation of caspase-1 activation, pyroptosis and autophagy via Ipaf and ASC in Shigella-infected macrophages. PLos. Pathog. 3, e111.
11. Bergsbaken, T., Fink, S.L. and Cookson, B.T. (2009) Pyroptosis: host cell death and inflammation. Nat. Rev. Microbiol. 7, 99-109.
12. Kufer, T.A., Kremmer, E., Adam, A.C., Philpott, D.J. and Sansonetti, P.J. (2007) The pattern-recognition molecule Nod1 is localized at the plasma membrane at sites of bacterial interaction. Cell. Microbiol. 10, 477-486.
13. Tattoli, I., Carneiro, L.A., Jéhanno, M., Magalhaes, J.G., Shu, Y., Philpott, D.J. et al. (2008) NLRX1 is a mitochondrial NOD-like receptor that amplifies NF-κB and JNK pathways by inducing reactive oxygen species production. EMBO Rep. 9, 293-300.
14. Carneiro, L.A., Travassos, L.H., Soares, F., Tattoli, I., Magalhaes, J.G., Bozza, M.T. et al. (2009) Shigella induces mitochondrial dysfunction and cell death in nonmyleoid cells. Cell. Host. Microbe. 5, 123-136.
15. Ohya, K., Handa, Y., Ogawa, M., Suzuki, M. and Sasakawa, C. (2005) IpgB1 is a novel Shigella effector protein involved in bacterial invasion of host cells: its activity to promote membrane ruflng via Rac1 and Cdc42 activation. J. Biol. Chem. 280, 24022-24034.
16. Handa, Y., Suzuki, M., Ohya, K., Iwai, H., Ishijima, N., Koleske, A.J. et al. (2007) Shigella IpgB1 promotes bacterial entry through the ELMO-Dock180 machinery. Nat. Cell. Biol. 9, 121-128.
17. Huang, Z., Sutton, S.E., Wallenfang, A.J., Orchard, R.C., Wu, X., Feng, Y. et al. (2009) Structure insights into host GTPase isoform selection by a family of bacterial GEF mimics. Nat. Strct. Mol. Biol. 16, 853-860.
18. Ogawa, H., Nakamura, A. and Nakaya, R. (1968) Cinemicroscopic study of tissue cell cultures infected with Shigella flexneri. Jpn. J. Med. Sci. Biol. 21, 259-273.
19. Makino, S., Sasakawa, C, Kamata, K., Kurata, T. and Yoshikawa, M. (1986) A genetic determinant required for continuous reinfection of adjacent cells on large plasmid in S. flexneri 2a. Cell 46, 551-555.
20. Lett, M.C., Sasakawa, C, Okada, N., Sakai, T., Makino, S., Yamada, M. et al. (1989) virG, a plasmid-coded virulence gene of Shigella flexneri: identification of the virG protein and determination of the complete coding sequence. J. Bacteriol. 171, 353-359.
21. Bernardini, M.L., Mounier, J., d'Hauteville, H., Coquis-Rondon, M. and Sansonetti, P.J. (1989) Identification of icsA, a plasmid locus of Shigella flexneri that governs bacterial intra- and intercellular spread through interaction with F-actin. Proc. Natl. Acad. Sci. USA 86, 3867-3871.
22. Cossart, P. and Sansonetti, P.J. (2004) Bacterial invasion: the paradigms of enteroinvasive pathogens. Science 303, 242-248.
23. Gouin, E., Welch, M.D. and Cossart, P. (2005) Actin-based motility of intracellular pathogens. Curr. Opin. Microbiol. 8, 35-45.
24. Suzuki, T., Miki, H., Takenawa, T. and Sasakawa, C. (1998) Neural Wiskott-Aldrich syndrome protein is implicated in the actin-based motility of Shigella flexneri. EMBO J. 17, 2767-2776.
25. Suzuki, T., Mimuro, H., Miki, H., Takenawa, T., Sasaki, T., Nakanishi, H. et al. (2000) Rho family GTPase Cdc42 is essential for the actin-based motility of Shigella in mammalian cells. J. Exp. Med. 191, 1905-1920.
26. Leung, Y., Ally, S. and Goldberg, M.B. (2008) Bacterial actin assembly requires Toca-1 to relieve N-WASP autoinhibition. Cell Host Microbe 3, 39-47.
27. Yoshida, S., Katayama, E., Kuwae, A., Mimuro, H., Suzuki, T. and Sasakawa, C. (2002) Shigella deliver an effector protein to trigger host microtubule destabilization, which promotes Rac1 activity and efficient bacterial internalization. EMBO J. 21, 2923-2935.
28. Yoshida, S., Handa, Y., Suzuki, T., Ogawa, M., Suzuki, M., Tamai, A. et al. (2006) Microtuble-severing activity of Shigella is pivotal for intercellular spreading. Science 314, 985-989.
29. Ashida, H., Toyotome, T., Nagai, T. and Sasakawa, C. (2007) Shigella chromosomal IpaH proteins are secreted via the type III secretion system and act as effectors. Mol. Microbiol. 63, 680-693.
30. Ashida, H., Kim, M., Schmidt-Supprian, M., Ma, A., Ogawa, M. and Sasakawa, C. (2010) A bacterial E3 ubiquitin ligase IpaH9.8 effector targets NEMO/ IKKγ to dampen the host NF-κB-mediated inflammatory response. Nat. Cell Biol. 12, 66-73.
31. Rohde, J.R., Breitkreutz, A., Chenal, A., Sansonetti, P.J. and Parsot, C. (2007) Type III secretion effectors of the IpaH family are E3 ubiquitin ligase. Cell Host Microbe 1, 77-83.
32. Deretic, V. and Levine, B. (2009) Autophagy, immunity, and microbial adaptations. Cell Host Microbe 18, 527-549.
33. Ogawa, M. and Sasakawa, C. (2006) Shigella and autophagy. Autophagy 2, 171-174.
34. Ogawa, M., Yoshimori, T., Suzuki, T., Sagara, H., Mizushima, N. and Sasakawa, C. (2005) Escape of intracellular Shigella from autophagy. Science 307, 727-731.
35. Ogawa, M., Suzuki, T., Tatsuno, I., Abe, H. and Sasakawa, C. (2003) IcsB, secreted via the type III secretion system, is chaperoned by IpgA and required at the post-invasion stage of Shigella pathogenicity. Mol. Microbiol. 48, 913-931.
36. Dupont, N., Lacas-Gervais, S., Bertout, J., Paz, I., Freche, B., Tran, V. et al. (2009) Shigella phagocytic vacuolar membrane remnants participate in the cellular response to pathogen invasion and are regulated by autophagy. Cell Host Microbe 6, 137-149.
37. Yoshikawa, Y., Ogawa, M., Hain, T., Yoshida, M., Kim, M., Mimuro, H. et al. (2009) Listeria monocytogenes ActA-mediated escape from autophagic recognition. Nat. Cell Biol. 11, 1233-1240.
38. Radtke, F. and Clevers, H. (2005) Self-renewal and cancer of the gut: two sides of a coin. Science 307, 1904-1909.
39. Iwai, H., Kim, M., Yoshikawa, Y., Ashida, H., Ogawa, M., Fujita, Y. et al. (2007) A bacterial effector targets Mad2L2, an APC inhibitor, to modulate host cell cycling. Cell 130, 611-623.
40. Mimuro, H., Suzuki, T., Nagai, S., Rieder, G., Suzuki, M., Fujita, Y. et al. (2007) Helicobacter pylori dampens gut epithelial self-renewal by inhibiting apoptosis, a bacterial strategy to enhance colonization of the stomach. Cell Host Microbe 11, 250-263.
41. Nougayrède, J.P., Taieb, F., De Rycke, J. and Oswald, E. (2005) Cyclomodulins: bacterial effectors that modulate the eukaryotic cell cycle. Trends Microbiol. 13, 103-110.
42. Tanaka, J., Suzuki, T., Mimuro, H. and Sasakawa, C. (2003) Structural definition on the surface of Helicobacter pylori type IV secretion apparatus. Cell Microbiol. 5, 395-404.
43. Kim, M., Ogawa, M., Fujita, Y., Yoshikawa, Y., Nagai, T., Nagai, S. et al. (2009) Bacteria hijack integrin-linked kinase to stabilize focal adhesions and block cell detachment. Nature 459, 578-582.
44. Legate, K.R., Montanez, E., Kudlacek, O. and Fassler, R. (2006) ILK, PINCH and parvin: the tIPP of integrin signalling. Nat. Rev. Mol. Cell Biol. 7, 20-31.
45. McDonald, P.C., Fielding, A.B. and Dedhar, S. (2008) Integrin-linked kinase-essential roles in physiology and cancer biology. J. Cell Sci. 121, 3121-3132.
46. Mulvey, M.A., Schilling, J.D., Martinez, J.J. and Hultgren, S.J. (2000) Bad bugs and beleaguered bladders: interplay between uropathogenic Escherichia coli and innate host defenses. Proc. Natl. Acad. Sci. USA 97, 8829-8835.
47. Muenzner, P., Rohde, M., Kneitz, S. and Hauck, C.R. (2005) CEACAM engagement by human pathogens enhances cell adhesion and counteracts bacteria-induced detachment of epithelial cells. J. Cell Biol. 170, 825-836.
48. Kotloff, K.L., Winickoff, J.P., Ivanoff, B., Clemens, J.D., Swerdlow, D.L., Sansonetti, P.J. et al. (1999) Global burden of Shigella infections: implications for vaccine development and implementation of control strategies. Bulletin of the World Health Organization 77, 651-666.
49. Yoshikawa, M., Sasakawa, C, Okada, N., Takasaka, N., Nakayama, M., Yoshikawa, Y. et al. (1995) Construction and evaluation of a virG thyA double mutant of Shigella flexneri 2a as a candidate live-attenuated oral vaccine. Vaccine 13, 1436-1440.
50. Suzuki, T., Yoshikawa, Y., Ashida, H., Iwai, H., Toyotome, T., Matsui, H. and Sasakawa, C. (2006) High vaccine efficacy against shigellosis of recombinanat noninvasive Shigella mutant that express Yersinia invasin. J. Immunol. 177, 4709-4717.
51. Shim, D.H., Suzuki, T., Chang, S.Y., Park, S.M., Sansonetti, P.J., Sasakawa, C. and Kweon, M.N. (2007) New animal model of shigellosis in the guinea pig: its usefulness for protective efficacy studies. J. Immunol. 178, 2476-2482.