A 90-day oral toxicity study of nisin A, an anti-microbial peptide derived from Lactococcus lactis subsp. lactis, in F344 rats

Food and Chemical Toxicology

Volumn 48, Issue 8-9, 2010, Pages 2421-2428

  Hagiwara, Akihiro ^a   Imai, Norio ^a   Nakashima, Hironao ^a   Toda, Yosuke ^a   Kawabe, Mayumi ^a   Furukawa, Fumio ^a   Delves Broughton, Joss ^b   Yasuhara, Kazuo ^c   Hayashi, Shim mo ^c  

^a Daiyukai Research Institute for Medical Science   (Japan)

^b Danisco   (United Kingdom)

^c SAN EI GEN F F I INC   (Japan)

Author keywords

Bacteriocin; Food additive; Nisin A; Rats; Subchronic toxicity

Indexed keywords

ALANINE AMINOTRANSFERASE; ALBUMIN; ALKALINE PHOSPHATASE; ASPARTATE AMINOTRANSFERASE; CHLORINE; CHOLESTEROL; CREATININE; GLOBULIN; GLUCOSE; HEMOGLOBIN; NISIN; NISIN A; PHOSPHOLIPID; POTASSIUM; PROTEIN; SODIUM; SODIUM CHLORIDE; TRIACYLGLYCEROL; UNCLASSIFIED DRUG; ANTIINFECTIVE AGENT;

ALANINE AMINOTRANSFERASE BLOOD LEVEL; ALKALINE PHOSPHATASE BLOOD LEVEL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; CELL HYPERPLASIA; CHLORINE URINE LEVEL; CHOLESTEROL BLOOD LEVEL; CONTROLLED STUDY; CREATININE BLOOD LEVEL; ERYTHROCYTE COUNT; EYE EXAMINATION; FEMALE; FISCHER 344 RAT; FLUID INTAKE; FORESTOMACH; GLUCOSE BLOOD LEVEL; HEART WEIGHT; HEMATOCRIT; HISTOPATHOLOGY; HYPOPHYSIS; HYPOPHYSIS WEIGHT; KIDNEY MASS; LACTOCOCCUS LACTIS; LEUKOCYTE COUNT; LIVER WEIGHT; MALE; MEAN CORPUSCULAR HEMOGLOBIN; MEAN CORPUSCULAR VOLUME; NONHUMAN; ORGAN WEIGHT; PHOSPHOLIPID BLOOD LEVEL; POTASSIUM BLOOD LEVEL; POTASSIUM URINE LEVEL; RAT; RELATIVE DENSITY; SALIVARY GLAND; SALIVARY GLAND WEIGHT; SEX DIFFERENCE; SODIUM BLOOD LEVEL; SODIUM URINE LEVEL; SQUAMOUS CELL; TESTIS WEIGHT; THROMBOCYTE COUNT; THYROID WEIGHT; TRIACYLGLYCEROL BLOOD LEVEL; UREA NITROGEN BLOOD LEVEL; URINE LEVEL; URINE PH; URINE VOLUME; UTERUS WEIGHT; ANIMAL; BLOOD ANALYSIS; BLOOD CELL COUNT; BODY WEIGHT; CHEMISTRY; DIET; DOSE RESPONSE; DRUG EFFECTS; EATING; ORGAN SIZE; SEXUAL DEVELOPMENT; STANDARD; TOXICITY;

ANIMALS; ANTI-INFECTIVE AGENTS; BLOOD CELL COUNT; BLOOD CHEMICAL ANALYSIS; BODY WEIGHT; DIET; DOSE-RESPONSE RELATIONSHIP, DRUG; EATING; FEMALE; LACTOCOCCUS LACTIS; MALE; NISIN; ORGAN SIZE; RATS; RATS, INBRED F344; REFERENCE STANDARDS; SEX CHARACTERISTICS;

ANIMALIA; LACTOCOCCUS LACTIS SUBSP. LACTIS; RATTUS;

EID: 77955096108     PISSN: 02786915     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.fct.2010.06.002     Document Type: Article

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