NB-LRR proteins: Pairs, pieces, perception, partners, and pathways

Current Opinion in Plant Biology

Volumn 13, Issue 4, 2010, Pages 472-477

  Eitas, Timothy K ^a   Dangl, Jeffery L ^a,b  

^a UNIVERSITY OF NORTH CAROLINA   (United States)

^b UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

NUCLEOTIDE; VEGETABLE PROTEIN;

AMINO ACID SEQUENCE; ANIMAL; BINDING SITE; CHEMISTRY; HUMAN; IMMUNOLOGY; METABOLISM; PLANT DISEASE; REVIEW; SIGNAL TRANSDUCTION;

ANIMALS; BINDING SITES; HUMANS; NUCLEOTIDES; PLANT DISEASES; PLANT PROTEINS; REPETITIVE SEQUENCES, AMINO ACID; SIGNAL TRANSDUCTION;

EID: 77955091927     PISSN: 13695266     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.pbi.2010.04.007     Document Type: Review

References (40)

1. Jones J.D., Dangl J.L. The plant immune system. Nature 2006, 444:323-329.
2. Ting J.P., Willingham S.B., Bergstralh D.T. NLRs at the intersection of cell death and immunity. Nat Rev Immunol 2008, 8:372-379.
3. Meyers B.C., Kozik A., Griego A., Kuang H., Michelmore R.W. Genome-wide analysis of NBS-LRR-encoding genes in Arabidopsis. Plant Cell 2003, 15:809-834.
4. Aarts N., Metz M., Holub E., Staskawicz B.J., Daniels M.J., Parker J.E. Different requirements for EDS1 and NDR1 by disease resistance genes define at least two R gene mediated signalling pathways in Arabidopsis. Proc Natl Acad Sci U S A 1998, 95:10306-10311.
5. Feys B.J., Wiermer M., Bhat R.A., Moisan L.J., Medina-Escobar N., Neu C., Cabral A., Parker J.E. Arabidopsis senescence-associated gene101 stabilizes and signals within an enhanced disease susceptibility1 complex in plant innate Immunity. Plant Cell 2005, 17:2601-2613.
6. Day B., Dahlbeck D., Staskawicz B.J. NDR1 interaction with RIN4 mediates the differential activation of multiple disease resistance pathways. Plant Cell 2006, 10:2782-2791.
7. Lukasik E., Takken F.L.W. STANDing strong, resistance proteins instigators of plant defence. Curr Opin Plant Biol 2009, 427-436.
8. Gutierrez J.R., Balmuth A.L., Ntoukakis V., Mucyn T.S., Gimenez-Ibanez S., Jones A.M., Rathjen J.P. Prf immune complexes of tomato are oligomeric and contain multiple Pto-like kinases that diversify effector recognition. Plant J 2009, 61:507-518.
9. Mestre P., Baulcombe D.C. Elicitor-mediated oligomerization of the tobacco N disease resistance protein. Plant Cell 2006, 18:491-501.
10. Shirasu K. The HSP90-SGT1 chaperone complex for NLR immune sensors. Annu Rev Plant Biol 2008, 60:139-164.
11. Collier S.M., Moffett P. NB-LRRs work a " bait and switch" on pathogens. Trends Plant Sci 2009, 14:521-529.
12. Caplan J., Padmanabhan M., Dinesh-Kumar S.P. Plant NB-LRR immune receptors: from recognition to transcriptional reprogramming. Cell Host Microbe 2008, 3:126-135.
13. Flor H.H. Current status of the gene-for-gene concept. Annu Rev Phytopathol 1971, 9:275-296.
14. Sinapidou E., Williams K., Nott L., Bahkt S., Tor M., Crute I., Bittner-Eddy P., Beynon J. Two TIR:NB:LRR genes are required to specify resistance to Peronospora parasitica isolate Cala2 in Arabidopsis. Plant J 2004, 38:898-909.
15. Peart J.R., Mestre P., Lu R., Malcuit I., Baulcombe D.C. NRG1, a CC-NB-LRR protein, together with N, a TIR-NB-LRR protein, mediates resistance against tobacco mosaic virus. Curr Biol 2005, 15:968-973.
16. Eitas T.K., Nimchuk Z.L., Dangl J.L. Arabidopsis TAO1 is a TIR-NB-LRR protein that contributes to disease resistance induced by the Pseudomonas syringae effector AvrB. Proc Natl Acad Sci U S A 2008, 105:6475-6480.
17. Deslandes L., Olivier J., Theulieres F., Hirsch J., Feng D.X., Bittner-Eddy P., Beynon J., Marco Y. Resistance to Ralstonia solanacearum in Arabidopsis thaliana is conferred by the recessive RRS1-R gene, a member of a novel family of resistance genes. Proc Natl Acad Sci U S A 2002, 99:2404-2409.
18. Gassmann W., Hinsch M.E., Staskawicz B.J. The Arabidopsis RPS4 bacterial-resistance gene is a member of the TIR-NBS-LRR family of disease-resistance genes. Plant J 1999, 20:265-277.
19. Narusaka M., Shirasu K., Noutoshi Y., Kubo Y., Shiraishi T., Iwabuchi M., Narusaka Y. RRS1 and RPS4 provide a dual Resistance-gene system against fungal and bacterial pathogens. Plant J 2009, 218-226.
20. Loutre C., Wicker T., Travella S., Galli P., Scofield S., Fahima T., Feuillet C., Keller B. Two different CC-NBS-LRR genes are required for Lr10-mediated leaf rust resistance in tetraploid and hexaploid wheat. Plant J 2009, 60:1043-1054.
21. Lee S.K., Song M.Y., Seo Y.S., Kim H.K., Ko S., Cao P.J., Suh J.P., Yi G., Roh J.H., Lee S., et al. Rice Pi5-mediated resistance to Magnaporthe oryzae requires the presence of two CC-NB-LRR genes. Genetics 2009, 1627-1638.
22. Ashikawa I., Hayashi N., Yamane H., Kanamori H., Wu J., Matsumoto T., Ono K., Yano M. Two adjacent nucleotide-binding site-leucine-rich repeat class genes are required to confer pikm-specific rice blast resistance. Genetics 2008, 2267-2276.
23. Birker D.H.K., Takahara H., Narusaka M., Deslandes L., Narusaka Y., Reymond M., Parker J.E., O'Connell R. A locus conferring resistance to Colletotrichum higginsianum is shared by four geographically distinct Arabidopsis accessions. Plant J 2009, 60:602-613.
24. Swiderski M.R.B.D., Jones J.D. The TIR domain of TIR-NB-LRR resistance proteins is a signaling domain involved in cell death induction. MPMI 2009, 9:157-165.
25. Wirthmueller L., Zhang Y., Jones J.D., Parker J.E. Nuclear accumulation of the Arabidopsis immune receptor RPS4 is necessary for triggering EDS1-dependent defense. Curr Biol 2007, 17:2023-2029.
26. Zhang Y., Dorey S., Swiderski M., Jones J.D. Expression of RPS4 in tobacco induces an AvrRps4-independent HR that requires EDS1, SGT1 and HSP90. Plant J 2004, 213-224.
27. Rairdan G.J., Collier S.M., Sacco M.A., Baldwin T.T., Boettrich T., Moffett P. The coiled-coil and nucleotide binding domains of the Potato Rx disease resistance protein function in pathogen recognition and signaling. Plant Cell 2008, 20:739-751.
28. Boter M., Amigues B., Peart J., Breuer C., Kadota Y., Casais C., Moore G., Kleanthous C., Ochsenbein F., Shirasu K., et al. Structural and functional analysis of SGT1 reveals that its interaction with HSP90 is required for the accumulation of Rx, an R protein involved in plant immunity. Plant Cell 2007, 19:3791-3804.
29. Century K.S., Holub E.B., Staskawicz B.J. NDR1, a locus of Arabidopsis thaliana that is required for disease resistance to both a bacterial and a fungal pathogen. Proc Natl Acad Sci U S A 1995, 92:6597-6601.
30. Holt B.F., Belkhadir Y., Dangl J.L. Antagonistic control of disease resistance protein stability in the plant immune system. Science 2005, 309:929-932.
31. Tameling W.I.L., Vossen J.H., Albrecht M., Lengauer T., Berden J.A., Haring M.A., Cornelissen B.J.C., Takken F.L.W. Mutations in the NB-ARC domain of I-2 that impair ATP hydrolysis cause autoactivation. Plant Physiol 2006, 140:1233-1245.
32. Tao Y., Yuan F., Leister R.T., Ausubel F.M., Katagiri F. Mutational analysis of the Arabidopsis nucleotide binding site-leucine-rich repeat resistance gene RPS2. Plant Cell 2000, 12:2541-2554.
33. Ade J., DeYoung B.J., Golstein C., Innes R.W. Indirect activation of a plant nucleotide binding site-leucine-rich repeat protein by a bacterial protease. Proc Natl Acad Sci U S A 2007, 104:2531-2536.
34. Caplan J.L., Mamillapalli P., Burch-Smith T.M., Czymmek K., Dinesh-Kumar S.P. Chloroplastic protein NRIP1 mediates innate immune receptor recognition of a viral effector. Cell 2008, 132:449-462.
35. Zhang Y., Goritschnig S., Dong X., Li X. A gain-of-function mutation in a plant disease resistance gene leads to constitutive activation of downstream signal transduction pathways in suppressor of npr1-1, constitutive 1. Plant Cell 2003, 15:2636-2646.
36. Cheng Y.T., Germain H., Wiermer M., Bi D., Xu F., García A.V., Wirthmueller L., Després C., Parker J.E., Zhang Y., Li X. Nuclear pore complex component MOS7/Nup88 is required for innate immunity and nuclear accumulation of defense regulators in Arabidopsis. Plant Cell 2009, 21:2503-2516.
37. Venugopal S.C., Jeong R.D., Mandal M.K., Zhu S., Chandra-Shekara A.C., Xia Y., Hersh M., Stromberg A.J., Navarre D., Kachroo A., et al. Enhanced disease susceptibility 1 and salicylic acid act redundantly to regulate resistance gene-mediated signaling. PLoS Genet 2009, 5:e1000545.
38. Ting J.P., Duncan J.A., Lei Y. How the noninflammasome NLRs function in the innate immune system. Science 2010, 327:286-290.
39. Takeuchi O., Sato S., Horiuchi T., Hoshino K., Takeda K., Dong Z., Modlin R.L., Akira S. Cutting edge: role of Toll-like receptor 1 in mediating immune response to microbial lipoproteins. J Immunol 2002, 169.
40. Hsu L.C., Ali S.R., McGillivray S., Tseng P.H., Mariathasan S., Humke E.W., Eckmann L., Powell J.J., Nizet V., Dixit V.M., Karin M. A NOD2-NALP1 complex mediates caspase-1-dependent IL-1beta secretion in response to Bacillus anthracis infection and muramyl dipeptide. Proc Natl Acad Sci U S A 2008, 105:7803-7808.