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A genetic screen for compromised recognition of Turnip crinkle virus resulted in the identification of CRT1. CRT1 encodes an ATPase that was found to interact with the NB-ARC domains of HRT and two other NB-LRR R proteins (Rx and RPS2). CRT1 thereby represents the first reported plant interactor of an NB-ARC domain. Its functional involvement in defence signalling (but not HR) triggered by distinct classes of NB-LRR proteins identified this protein as an important factor in downstream signalling.
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The tomato R gene products I-2 and Mi-1 are functional ATP binding proteins with ATPase activity
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Plant disease resistance genes encode members of an ancient and diverse protein family within the nucleotide-binding superfamily
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Chloroplastic protein NRIP1 mediates innate immune receptor recognition of a viral effector
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This elegant study clarifies the sequence of recognition events for the TNL R protein N after virus infection. The N-receptor interacting protein 1 (NRIP1) was found to encode a chloroplastic protein that only associates with the TIR domain of N when bound to the Tobacco Mosaic Virus effector protein p50. P50 binding to NRIP results in its translocalization from chloroplast to nucleus and cytoplasm where the complex is bound by N. This event activates the N protein that triggers virus resistance and HR.
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The tomato NBARC-LRR protein Prf interacts with Pto kinase in vivo to regulate specific plant immunity
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Initiation of RPS2-specified disease resistance in Arabidopsis is coupled to the AvrRpt2-directed elimination of RIN4
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Axtell M.J., and Staskawicz B.J. Initiation of RPS2-specified disease resistance in Arabidopsis is coupled to the AvrRpt2-directed elimination of RIN4. Cell 112 (2003) 369-377
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Arabidopsis RIN4 is a target of the type III virulence effector AvrRpt2 and modulates RPS2-mediated resistance
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Mackey D., Belkhadir Y., Alonso J.M., Ecker J.R., and Dangl J.L. Arabidopsis RIN4 is a target of the type III virulence effector AvrRpt2 and modulates RPS2-mediated resistance. Cell 112 (2003) 379-389
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Mackey D., Holt III B.F., Wiig A., and Dangl J.L. RIN4 interacts with Pseudomonas syringae type III effector molecules and is required for RPM1-mediated resistance in Arabidopsis. Cell 108 (2002) 743-754
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An evolutionarily conserved mediator of plant disease resistance gene function is required for normal Arabidopsis development
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Holt III B.F., Boyes D.C., Ellerstrom M., Siefers N., Wiig A., Kauffman S., Grant M.R., and Dangl J.L. An evolutionarily conserved mediator of plant disease resistance gene function is required for normal Arabidopsis development. Dev Cell 2 (2002) 807-817
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A duplicated pair of Arabidopsis RING-finger E3 ligases contribute to the RPM1- and RPS2-mediated hypersensitive response
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Kawasaki T., Nam J., Boyes D.C., Holt III B.F., Hubert D.A., Wiig A., and Dangl J.L. A duplicated pair of Arabidopsis RING-finger E3 ligases contribute to the RPM1- and RPS2-mediated hypersensitive response. Plant J 44 (2005) 258-270
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RAR1 positively controls steady state levels of barley MLA resistance proteins and enables sufficient MLA6 accumulation for effective resistance
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Heat shock protein 90 and its co-chaperone protein phosphatase 5 interact with distinct regions of the tomato I-2 disease resistance protein
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de la Fuente van Bentem S., Vossen J.H., de Vries K.J., van Wees S., Tameling W.I.L., Dekker H.L., de Koster C.G., Haring M.A., Takken F.L.W., and Cornelissen B.J.C. Heat shock protein 90 and its co-chaperone protein phosphatase 5 interact with distinct regions of the tomato I-2 disease resistance protein. Plant J 43 (2005) 284-298
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Cytosolic HSP90 associates with and modulates the Arabidopsis RPM1 disease resistance protein
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Hubert D.A., Tornero P., Belkhadir Y., Krishna P., Takahashi A., Shirasu K., and Dangl J.L. Cytosolic HSP90 associates with and modulates the Arabidopsis RPM1 disease resistance protein. EMBO J 22 (2003) 5679-5689
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Liu Y., Burch-Smith T., Schiff M., Feng S., and Dinesh-Kumar S.P. Molecular chaperone Hsp90 associates with resistance protein N and its signaling proteins SGT1 and Rar1 to modulate an innate immune response in plants. J Biol Chem 279 (2004) 2101-2108
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