Transcriptional regulation of metastatic [Id]entity by KLF17

Genome Biology

Volumn 10, Issue 11, 2009, Pages

  Iwanicki, Marcin P ^a   Brugge, Joan S ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ID1 PROTEIN, HUMAN; INHIBITOR OF DIFFERENTIATION 1; KLF17 PROTEIN, HUMAN; TRANSCRIPTION FACTOR;

BIOLOGICAL MODEL; BIOSYNTHESIS; DISEASE COURSE; EPITHELIUM; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; GENETICS; HUMAN; MESODERM; METABOLISM; METASTASIS; NEOPLASM; REVIEW;

DISEASE PROGRESSION; EPITHELIUM; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; INHIBITOR OF DIFFERENTIATION PROTEIN 1; MESODERM; MODELS, BIOLOGICAL; NEOPLASM METASTASIS; NEOPLASMS; TRANSCRIPTION FACTORS;

EID: 77955085370     PISSN: None     EISSN: 1474760X     Source Type: Journal    
DOI: 10.1186/gb-2009-10-11-244     Document Type: Short Survey

References (26)

1. Fidler IJ. The pathogenesis of cancer metastasis: the 'seed and soil' hypothesis revisited. Nat Rev Cancer 2003, 3:453-458. 10.1038/nrc1098, 12778135.
2. Smith SC, Theodorescu D. Learning therapeutic lessons from metastasis suppressor proteins. Nat Rev Cancer 2009, 9:253-264. 10.1038/nrc2594, 19242414.
3. Gumireddy K, Li A, Gimotty PA, Klein-Szanto AJ, Showe LC, Katsaros D, Coukos G, Zhang L, Huang Q. KLF17 is a negative regulator of epithelial-mesenchymal transition and metastasis in breast cancer. Nat Cell Biol 2009, 11:1297-1304. 10.1038/ncb1974, 19801974.
4. Nguyen DX, Bos PD, Massague J. Metastasis: from dissemination to organ-specific colonization. Nat Rev Cancer 2009, 9:274-284. 10.1038/nrc2622, 19308067.
5. Kizaka-Kondoh S, Tanaka S, Harada H, Hiraoka M. The HIF-1-active microenvironment: an environmental target for cancer therapy. Adv Drug Deliv Rev 2009, 61:623-632. 10.1016/j.addr.2009.01.006, 19409433.
6. Weinberg RA. Mechanisms of malignant progression. Carcinogenesis 2008, 29:1092-1095. 10.1093/carcin/bgn104, 18453542.
7. Rak J, Mitsuhashi Y, Bayko L, Filmus J, Shirasawa S, Sasazuki T, Kerbel RS. Mutant ras oncogenes upregulate VEGF/VPF expression: implications for induction and inhibition of tumor angiogenesis. Cancer Res 1995, 55:4575-4580.
8. Pal S, Datta K, Khosravi-Far R, Mukhopadhyay D. Role of protein kinase Czeta in Ras-mediated transcriptional activation of vascular permeability factor/vascular endothelial growth factor expression. J Biol Chem 2001, 276:2395-2403. 10.1074/jbc.M007818200, 11060301.
9. Wang SP, Wang WL, Chang YL, Wu CT, Chao YC, Kao SH, Yuan A, Lin CW, Yang SC, Chan WK, Li KC, Hong TM, Yang PC. p53 controls cancer cell invasion by inducing the MDM2-mediated degradation of Slug. Nat Cell Biol 2009, 11:694-704. 10.1038/ncb1875, 19448627.
10. Fong S, Itahana Y, Sumida T, Singh J, Coppe JP, Liu Y, Richards PC, Bennington JL, Lee NM, Debs RJ, Desprez PY. Id-1 as a molecular target in therapy for breast cancer cell invasion and metastasis. Proc Natl Acad Sci USA 2003, 100:13543-13548. 263850, 14578451, 10.1073/pnas.2230238100.
11. Thiery JP. Epithelial-mesenchymal transitions in development and pathologies. Curr Opin Cell Biol 2003, 15:740-746. 10.1016/j.ceb.2003.10.006, 14644200.
12. Polyak K, Weinberg RA. Transitions between epithelial and mesenchymal states: acquisition of malignant and stem cell traits. Nat Rev Cancer 2009, 9:265-273. 10.1038/nrc2620, 19262571.
13. Mani SA, Guo W, Liao MJ, Eaton EN, Ayyanan A, Zhou AY, Brooks M, Reinhard F, Zhang CC, Shipitsin M, Campbell LL, Polyak K, Brisken C, Yang J, Weinberg RA. The epithelial-mesenchymal transition generates cells with properties of stem cells. Cell 2008, 133:704-715. 2728032, 18485877, 10.1016/j.cell.2008.03.027.
14. Friedl P, Wolf K. Tumour-cell invasion and migration: diversity and escape mechanisms. Nat Rev Cancer 2003, 3:362-374. 10.1038/nrc1075, 12724734.
15. Yang Y, Goldstein BG, Chao HH, Katz JP. KLF4 and KLF5 regulate proliferation, apoptosis and invasion in esophageal cancer cells. Cancer Biol Ther 2005, 4:1216-1221.
16. Perk J, Iavarone A, Benezra R. Id family of helix-loop-helix proteins in cancer. Nat Rev Cancer 2005, 5:603-614. 10.1038/nrc1673, 16034366.
17. Li Y, Yang J, Luo JH, Dedhar S, Liu Y. Tubular epithelial cell dedifferentiation is driven by the helix-loop-helix transcriptional inhibitor ID1. J Am Soc Nephrol 2007, 18:449-460. 10.1681/ASN.2006030236, 17202424.
18. Edme N, Downward J, Thiery JP, Boyer B. Ras induces NBT-II epithelial cell scattering through the coordinate activities of Rac and MAPK pathways. J Cell Sci 2002, 115:2591-2601.
19. Boyer B, Roche S, Denoyelle M, Thiery JP. Src and Ras are involved in separate pathways in epithelial cell scattering. EMBO J 1997, 16:5904-5913. 1170221, 9312048, 10.1093/emboj/16.19.5904.
20. Larue L, Bellacosa A. Epithelial-mesenchymal transition in development and cancer: role of phosphatidylinositol 3' kinase/AKT pathways. Oncogene 2005, 24:7443-7454. 10.1038/sj.onc.1209091, 16288291.
21. Ling MT, Lau TC, Zhou C, Chua CW, Kwok WK, Wang Q, Wang X, Wong YC. Overexpression of Id-1 in prostate cancer cells promotes angiogenesis through the activation of vascular endothelial growth factor (VEGF). Carcinogenesis 2005, 26:1668-1676. 10.1093/carcin/bgi128, 15905202.
22. Tan NY, Khachigian LM. Sp1 phosphorylation and its regulation of gene transcription. Mol Cell Biol 2009, 29:2483-2488. 2682032, 19273606, 10.1128/MCB.01828-08.
23. Scansite. , http://scansite.mit.edu/
24. Black AR, Black JD, Azizkhan-Clifford J. Sp1 and kruppel-like factor family of transcription factors in cell growth regulation and cancer. J Cell Physiol 2001, 188:143-160. 10.1002/jcp.1111, 11424081.
25. Kavurma MM, Santiago FS, Bonfoco E, Khachigian LM. Sp1 phosphorylation regulates apoptosis via extracellular FasL-Fas engagement. J Biol Chem 2001, 276:4964-4971. 10.1074/jbc.M009251200, 11053446.
26. Tan NY, Midgley VC, Kavurma MM, Santiago FS, Luo X, Peden R, Fahmy RG, Berndt MC, Molloy MP, Khachigian LM. Angiotensin II-inducible platelet-derived growth factor-D transcription requires specific Ser/Thr residues in the second zinc finger region of Sp1. Circ Res 2008, 102:e38-51. 10.1161/CIRCRESAHA.107.167395, 18258854.