Recent insights into fatty acid acquisition and metabolism in malarial parasites

F1000 Biology Reports

Volumn 2, Issue 1, 2010, Pages

  Jayabalasingham, Bamini ^a   Menard, Robert ^b   Fidock, David A ^a  

^a Columbia University ^*  (United States)

^b INSTITUT PASTEUR   (France)

Author keywords

[No Author keywords available]

Indexed keywords

FATTY ACID; LIPID;

CELL MEMBRANE; FATTY ACID METABOLISM; HOST CELL; HOST PARASITE INTERACTION; MALARIA; NONHUMAN; PLASMODIUM; REVIEW;

MAMMALIA;

EID: 77955083967     PISSN: 17404118     EISSN: 1757594X     Source Type: Journal    
DOI: 10.3410/B2-24     Document Type: Review

References (29)

1. Vial HJ, Thuet MJ, Philippot JR: Phospholipid biosynthesis in synchronous Plasmodium falciparum cultures. J Protozool 1982, 29:258-63.
2. Grellier P, Rigomier D, Clavey V, Fruchart JC, Schrevel J: Lipid traffic between high density lipoproteins and Plasmodium falciparum-infected red blood cells. J Cell Biol 1991, 112:267-77. (Pubitemid 21909617)
3. Krishnegowda G, Gowda DC: Intraerythrocytic Plasmodium falciparum incorporates extraneous fatty acids to its lipids without any structural modification. Mol Biochem Parasitol 2003, 132:55-8.
4. Moll GN, Vial HJ, Ancelin ML, Op den Kamp JAF, Roelofsen B, van Deenen LLM: Phospholipid uptake by Plasmodium knowlesi infected erythrocytes. FEBS Letters 1988, 232:341-6.
5. Ofulla AV, Okoye VC, Khan B, Githure JI, Roberts CR, Johnson AJ, Martin SK: Cultivation of Plasmodium falciparum parasites in a serum-free medium. Am J Trop Med Hyg 1993, 49:335-40. (Pubitemid 23289392)
6. Mi-Ichi F, Kita K, Mitamura T: Intraerythrocytic Plasmodium falciparum utilize a broad range of serum-derived fatty acids with limited modification for their growth. Parasitology 2006, 133:399-410.
7. Palacpac NMQ, Hiramine Y, Mi-ichi F, Torii M, Kita K, Hiramatsu R, Horii T, Mitamura T: Developmental-stage-specific triacylglycerol biosynthesis, degradation and trafficking as lipid bodies in Plasmodium falciparum-infected erythrocytes. J Cell Sci 2004, 117:1469-80.
8. Mi-Ichi F, Kano S, Mitamura T: Oleic acid is indispensable for intraerythrocytic proliferation of Plasmodium falciparum. Parasitology 2007, 134:1671-7.
9. Lombard M-N, Bazin R, Durand D, Beauge F, Baccam D, Milgen F, Landau I: Rodent Plasmodium development in livers of genetically obese Zucker rats (fa/fa). Eur J Protistol 1998, 34:78-81. (Pubitemid 28153650)
10. Kohler S, Delwiche CF, Denny PW, Tilney LG, Webster P, Wilson RJM, Palmer JD, Roos DS: A plastid of probable green algal origin in Apicomplexan parasites. Science 1997, 275:1485-9.
11. McFadden GI, Reith ME, Munholland J, Lang-Unnasch N: Plastid in human parasites. Nature 1996, 381:482.
12. Gardner MJ, Hall N, Fung E, White O, Berriman M, Hyman RW, Carlton JM, Pain A, Nelson KE, Bowman S, Paulsen IT, James K, Eisen JA, Rutherford K, Salzberg SL, Craig A, Kyes S, Chan M-S, Nene V, Shallom SJ, Suh B, Peterson J, Angiuoli S, Pertea M, Allen J, Selengut J, Haft D, Mather MW, Vaidya AB, Martin DMA, et al.: Genome sequence of the human malaria parasite Plasmodium falciparum. Nature 2002, 419:498-511.
13. Ralph SA, van Dooren GG, Waller RF, Crawford MJ, Fraunholz MJ, Foth BJ, Tonkin CJ, Roos DS, McFadden GI: Tropical infectious diseases: metabolic maps and functions of the Plasmodium falciparum apicoplast. Nat Rev Microbiol 2004, 2:203-16.
14. Foth B, Stimmler LM, Handman E, Crabb B, Hodder AN, McFadden G: The malaria parasite Plasmodium falciparum has only one pyruvate dehydrogenase complex, which is located in the apicoplast. Mol Microbiol 2005, 55:39-53.
15. Sharma S, Sharma SK, Modak R, Karmodiya K, Surolia N, Surolia A: Mass spectrometry-based systems approach for identification of inhibitors of Plasmodium falciparum fatty acid synthase. Antimicrob Agents Chemother 2007, 51:2552-8. (Pubitemid 47047336)
16. Daily JP, Scanfeld D, Pochet N, Le Roch K, Plouffe D, Kamal M, Sarr O, Mboup S, Ndir O, Wypij D, Levasseur K, Thomas E, Tamayo P, Dong C, Zhou Y, Lander ES, Ndiaye D, Wirth D, Winzeler EA, Mesirov JP, Regev A: Distinct physiological states of Plasmodium falciparum in malaria-infected patients. Nature 2007, 450:1091-5.
17. Bozdech Z, Llinas M, Pulliam BL, Wong ED, Zhu J, DeRisi JL: The transcriptome of the intraerythrocytic developmental cycle of Plasmodium falciparum. PLoS Biol 2003, 1:e5.
18. Yu M, Kumar TR, Nkrumah LJ, Coppi A, Retzlaff S, Li CD, Kelly BJ, Moura PA, Lakshmanan V, Freundlich JS, Valderramos JC, Vilcheze C, Siedner M, Tsai JH, Falkard B, Sidhu AB, Purcell L, Gratraud P, Kremer L, Waters A, Schiehser G, Jacobus DP, Janse C, Ager A, Jacobs WR, Sacchettini JC, Heussler V, Sinnis P, Fidock DA: The fatty acid biosynthesis enzyme FabI plays a key role in the development of liver-stage malarial parasites. Cell Host Microbe 2008, 4:567-78.
19. Vaughan AM, O'Neill MT, Tarun AS, Camargo N, Phuong TM, Aly ASI, Cowman AF, Kappe SHI: Type II fatty acid synthesis is essential only for malaria parasite late liver stage development. Cell Microbiol 2009, 11:506-20.
20. Pei Y, Tarun AS, Vaughan AM, Herman RW, Soliman JMB, Erickson-Wayman A, Kappe SH: Plasmodium pyruvate dehydrogenase activity is only essential for the parasite's progression from liver infection to blood infection. Mol Microbiol 2010, [Epub ahead of print].
21. Tarun AS, Peng X, Dumpit RF, Ogata Y, Silva-Rivera H, Camargo N, Daly TM, Bergman LW, Kappe SH: A combined transcriptome and proteome survey of malaria parasite liver stages. Proc Natl Acad Sci U S A 2008, 105:305-10.
22. Rodrigues CD, Hannus M, Prudencio M, Martin C, Goncalves LA, Portugal S, Epiphanio S, Akinc A, Hadwiger P, Jahn-Hofmann K, Rohl I, van Gemert GJ, Franetich J, Luty AJ, Sauerwein R, Mazier D, Koteliansky V, Vornlocher HP, Echeverri CJ, Mota MM: Host scavenger receptor SR-BI plays a dual role in the establishment of malaria parasite liver infection. Cell Host Microbe 2008, 4:271-82.
23. Yalaoui S, Huby T, Franetich J, Gego A, Rametti A, Moreau M, Collet X, Siau A, van Gemert GJ, Sauerwein RW, Luty AJ, Vaillant JC, Hannoun L, Chapman J, Mazier D, Froissard P: Scavenger receptor BI boosts hepatocyte permissiveness to Plasmodium infection. Cell Host Microbe 2008, 4:283-92.
24. Silvie O, Charrin S, Billard M, Franetich J-F, Clark KL, van Gemert G-J, Sauerwein RW, Dautry F, Boucheix C, Mazier D, Rubinstein E: Cholesterol contributes to the organization of tetraspanin-enriched microdomains and to CD81-dependent infection by malaria sporozoites. J Cell Sci 2006, 119:1992-2002.
25. Silvie O, Rubinstein E, Franetich J, Prenant M, Belnoue E, Renia L, Hannoun L, Eling W, Levy S, Boucheix C, Mazier D: Hepatocyte CD81 is required for Plasmodium falciparum and Plasmodium yoelii sporozoite infectivity. Nat Med 2003, 9:93-6.
26. Mikolajczak SA, Jacobs-Lorena V, MacKellar DC, Camargo N, Kappe SH: L-FABP is a critical host factor for successful malaria liver stage development. Int J Parasitol 2007, 37:483-9. (Pubitemid 46399713)
27. Mueller AK, Labaied M, Kappe SH, Matuschewski K: Genetically modified Plasmodium parasites as a protective experimental malaria vaccine. Nature 2005, 433:164-7.
28. Sharma A, Yogavel M, Akhouri RR, Gill J, Sharma A: Crystal structure of soluble domain of malaria sporozoite protein UIS3 in complex with lipid. J Biol Chem 2008, 283:24077-88.
29. Gratraud P, Huws E, Falkard B, Adjalley S, Fidock DA, Berry L, Jacobs WR, Baird MS, Vial H, Kremer L: Oleic acid biosynthesis in Plasmodium falciparum: characterization of the stearoyl-CoA desaturase and investigation as a potential therapeutic target. PLoS ONE 2009, 4:e6889.